Browse publications by year: 2018

  1. Bradley, Sani SFA, Shafiqah ASS, Collins SM, Hugtenburg RP, Rashid HAA, et al.
    Appl Radiat Isot, 2018 Aug;138:65-72.
    PMID: 28427834 DOI: 10.1016/j.apradiso.2017.04.019
    Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer focuses on its favourable uptake in metabolically active bone metastases. Such treatment benefits from the high linear energy transfer (LET) and associated short path length (<100µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, investigation has been made of the TL yield of various forms of Ge-doped SiO2 fibres, including photonic crystal fibre (PCF) collapsed, PCF uncollapsed, flat and single-mode fibres. Irradiations of the fibres were performed at the UK National Physical Laboratory (NPL). Notable features are the considerable sensitivity of the dosimeters and an effective atomic number Zeff approaching that of bone, the glass fibres offering the added advantage of being able to be placed directly into liquid. The outcome of present research is expected to inform development of doped fibre dosimeters of versatile utility, including for applications as detailed herein.
    MeSH terms: Alpha Particles; Glass; Humans; Male; Palliative Care; Radioisotopes; Radium; Silicon Dioxide; Thermoluminescent Dosimetry; Linear Energy Transfer; Prostatic Neoplasms, Castration-Resistant; Radiation Dosimeters
  2. Fan YV, Lee CT, Klemeš JJ, Chua LS, Sarmidi MR, Leow CW
    J Environ Manage, 2018 Jun 15;216:41-48.
    PMID: 28427880 DOI: 10.1016/j.jenvman.2017.04.019
    Home composting can be an effective way to reduce the volume of municipal solid waste. The aim of this study is to evaluate the effect of Effective Microorganism™ (EM) for the home scale co-composting of food waste, rice bran and dried leaves. A general consensus is lacking regarding the efficiency of inoculation composting. Home scale composting was carried out with and without EM (control) to identify the roles of EM. The composting parameters for both trials showed a similar trend of changes during the decomposition. As assayed by Fourier Transform Infrared Spectroscopy (FTIR), the functional group of humic acid was initially dominated by aliphatic structure but was dominated by the aromatic in the final compost. The EM compost has a sharper peak of aromatic CC bond presenting a better degree of humification. Compost with EM achieved a slightly higher temperature at the early stage, with foul odour suppressed, enhanced humification process and a greater fat reduction (73%). No significant difference was found for the final composts inoculated with and without EM. The properties included pH (∼7), electric conductivity (∼2), carbon-to-nitrogen ratio (C: N 100%), humic acid content (4.5-4.8%) and pathogen content (no Salmonella, <1000 Most Probable Number/g E. coli). All samples were well matured within 2 months. The potassium and phosphate contents in both cases were similar however the EM compost has a higher nitrogen content (+1.5%). The overall results suggested the positive effect provided by EM notably in odour control and humification.
    MeSH terms: Escherichia coli*; Humic Substances*; Soil; Solid Waste
  3. Balaji R, Lee Siang H, Yaakob O, Koh KK, Adnan FAB, Ismail NB, et al.
    Environ Technol, 2018 May;39(9):1102-1114.
    PMID: 28425309 DOI: 10.1080/09593330.2017.1321691
    Waste heat recovery from shipboard machineries could be a potential source for heat treatment of ballast water. Similar to a shipboard schematic arrangement, a laboratory-scale engine-heat exchanger set-up harvesting waste heat from jacket water and exhaust gases was erected to test the level of species' mortalities. Mortalities were also assessed under experimental conditions for cultured and natural plankton communities at laboratory level. Effect of pump impellers on species' mortalities were also tested. Exposures between 60°C and 70°C for 60 sec resulted in 80-100% mortalities. Mortalities due to pump impeller effects were observed in the range of 70-100% for zooplankton. On the laboratory-scale arrangement, >95% mortalities of phytoplankton, zooplankton and bacteria were recorded. It was demonstrated that the temperature of tropical sea waters used as secondary coolant can be raised to cause species' mortalities, employing engine exhaust gases. The results also indicated that pump impeller effects will enhance species' mortalities. The limitations of the shipboard application of this method would be the large ballast volumes, flow rates and time for treatment.
    MeSH terms: Animals; Hot Temperature*; Plankton; Ships*; Water; Zooplankton*; Water Purification; Waste Water*
  4. Tee PF, Abdullah MO, Tan IAW, Amin MAM, Nolasco-Hipolito C, Bujang K
    Environ Technol, 2018 Apr;39(8):1081-1088.
    PMID: 28417676 DOI: 10.1080/09593330.2017.1320433
    A microbial fuel cell (MFC) integrated with adsorption system (MFC-AHS) is tested under various operating temperatures with palm oil mill effluent as the substrate. The optimum operating temperature for such system is found to be at ∼35°C with current, power density, internal resistance (Rin), Coulombic efficiency (CE) and maximum chemical oxygen demand (COD) removal of 2.51 ± 0.2 mA, 74 ± 6 mW m-3, 25.4 Ω, 10.65 ± 0.5% and 93.57 ± 1.2%, respectively. Maximum current density increases linearly with temperature at a rate of 0.1772 mA m-2 °C-1, whereas maximum power density was in a polynomial function. The temperature coefficient (Q10) is found to be 1.20 between 15°C and 35°C. Present studies have demonstrated better CE performance when compared to other MFC-AHSs. Generally, MFC-AHS has demonstrated higher COD removals when compared to standalone MFC regardless of operating temperatures.

    ABBREVIATIONS: ACFF: activated carbon fiber felt; APHA: American Public Health Association; CE: Coulombic efficiency; COD: chemical oxygen demand; ECG: electrocardiogram; GAC: granular activated carbon; GFB: graphite fiber brush; MFC: microbial fuel cell; MFC-AHS: microbial fuel cell integrated with adsorption hybrid system; MFC-GG: microbial fuel cell integrated with graphite granules; POME: palm oil mill effluent; PTFE: polytetrafluoroethylene; SEM: scanning electron microscope.

    MeSH terms: Adsorption; Bioelectric Energy Sources*; Electricity; Electrodes; Temperature; Biological Oxygen Demand Analysis
  5. Thangatorai R, Lim FC, Nalliah S
    J Matern Fetal Neonatal Med, 2018 Jun;31(12):1638-1645.
    PMID: 28412851 DOI: 10.1080/14767058.2017.1319930
    BACKGROUND: Preterm births occur frequently in multiple pregnancies with a short cervix. The cervical pessary is a potential intervention for prevention of preterm births.

    OBJECTIVE: To assess the effectiveness of cervical pessary in the prevention of preterm births in multiple pregnancies with a short cervix (<25 mm).

    SEARCH STRATEGY: Major databases from 2006 to 20th November 2016 were searched for relevant terms.

    SELECTION CRITERIA: We included randomized controlled trials that assessed the effectiveness of cervical pessary on pregnancy outcomes in multiple pregnancies with a short cervix.

    DATA COLLECTION AND ANALYSIS: Risk ratio was used as the summary measure with random effects model. We assessed heterogeneity between studies using the I2 index. Quality assessment was done based on Cochrane Handbook Method.

    MAIN RESULTS: Pooled data showed no benefit of using cervical pessary in the prevention of preterm births, birth weights less than 1500 g, less than 2500 g, adverse neonatal events and fetal/neonatal deaths in twin pregnancies with a short cervix.

    CONCLUSION: We are unable to show benefit of using cervical pessary in preventing preterm births in twin pregnancies with a short cervix. However, as cervical pessary is a reasonable intervention, there is a need for more randomized controlled trials in this area.

    MeSH terms: Female; Humans; Pessaries*; Pregnancy; Pregnancy, Multiple*; Premature Birth/prevention & control*
  6. Sengupta P, Borges E, Dutta S, Krajewska-Kulak E
    Hum Exp Toxicol, 2018 Mar;37(3):247-255.
    PMID: 28413887 DOI: 10.1177/0960327117703690
    PURPOSE: To investigate whether the sperm concentration of European men is deteriorating over the past 50 years of time.

    MATERIALS AND METHODS: We analysed the data published in English language articles in the past 50 years in altering sperm concentration in European men.

    RESULTS: A time-dependent decline of sperm concentration ( r = -0.307, p = 0.02) in the last 50 years and an overall 32.5% decrease in mean sperm concentration was noted.

    CONCLUSION: This comprehensive, evidence-based meta-analysis concisely presents the evidence of decreased sperm concentration in European male over the past 50 years to serve the scientific research zone related to male reproductive health.

    MeSH terms: Adult; Europe; Fertility*; Humans; Male; Middle Aged; Sperm Count/trends*; Spermatozoa/physiology*; Time Factors; Young Adult; Reproductive Health/trends*
  7. Ahmed AA, Xue Li C
    J Forensic Sci, 2018 Jan;63(1):112-121.
    PMID: 28397244 DOI: 10.1111/1556-4029.13506
    Cloud storage service allows users to store their data online, so that they can remotely access, maintain, manage, and back up data from anywhere via the Internet. Although helpful, this storage creates a challenge to digital forensic investigators and practitioners in collecting, identifying, acquiring, and preserving evidential data. This study proposes an investigation scheme for analyzing data remnants and determining probative artifacts in a cloud environment. Using pCloud as a case study, this research collected the data remnants available on end-user device storage following the storing, uploading, and accessing of data in the cloud storage. Data remnants are collected from several sources, including client software files, directory listing, prefetch, registry, network PCAP, browser, and memory and link files. Results demonstrate that the collected remnants data are beneficial in determining a sufficient number of artifacts about the investigated cybercrime.
    MeSH terms: Cloud Computing; Data Collection; Filing; Registries; Software; Artifacts; Internet
  8. Abu Bakar AR, Manaharan T, Merican AF, Mohamad SB
    Nat Prod Res, 2018 Feb;32(4):473-476.
    PMID: 28391727 DOI: 10.1080/14786419.2017.1312393
    Ficus deltoidea leaves extract are known to have good therapeutic properties such as antioxidant, anti-inflammatory and anti-diabetic. We showed that 50% ethanol-water extract of F. deltoidea leaves and its pungent compounds vitexin and isovitexin exhibited significant (p 
    MeSH terms: alpha-Amylases/antagonists & inhibitors*; alpha-Amylases/metabolism; alpha-Amylases/chemistry; Antioxidants/pharmacology; Drug Evaluation, Preclinical/methods; Enzyme Inhibitors/pharmacology*; Enzyme Inhibitors/chemistry; Plant Extracts/pharmacology*; Plant Extracts/chemistry; Plant Leaves/chemistry; Ficus/chemistry*; Apigenin/metabolism; Apigenin/pharmacology*; Apigenin/chemistry; Molecular Dynamics Simulation; Molecular Docking Simulation
  9. García JR, Sedran U, Zaini MAA, Zakaria ZA
    Environ Sci Pollut Res Int, 2018 Feb;25(6):5076-5085.
    PMID: 28391459 DOI: 10.1007/s11356-017-8975-8
    Palm oil mill wastes (palm kernel shell (PKS)) were used to prepare activated carbons, which were tested in the removal of colorants from water. The adsorbents were prepared by 1-h impregnation of PKS with ZnCl2 as the activating agent (PKS:ZnCl2 mass ratios of 1:1 and 2:1), followed by carbonization in autogenous atmosphere at 500 and 550 °C during 1 h. The characterization of the activated carbons included textural properties (porosity), surface chemistry (functional groups), and surface morphology. The dye removal performance of the different activated carbons was investigated by means of the uptake of methylene blue (MB) in solutions with various initial concentrations (25-400 mg/L of MB) at 30 °C, using a 0.05-g carbon/50-mL solution relationship. The sample prepared with 1:1 PKS:ZnCl2 and carbonized at 550 °C showed the highest MB adsorption capacity (maximum uptake at the equilibrium, q max = 225.3 mg MB / g adsorbent), resulting from its elevated specific surface area (BET, 1058 m2/g) and microporosity (micropore surface area, 721 m2/g). The kinetic experiments showed that removals over 90% of the equilibrium adsorptions were achieved after 4-h contact time in all the cases. The study showed that palm oil mill waste biomass could be used in the preparation of adsorbents efficient in the removal of colorants in wastewaters.
    MeSH terms: Adsorption; Charcoal/chemistry*; Coloring Agents/chemistry*; Industrial Waste; Methylene Blue/chemistry*; Nuts/chemistry; Waste Disposal, Fluid/instrumentation; Waste Disposal, Fluid/methods*; Water Pollutants, Chemical/chemistry*
  10. Shadan AF, Mahat NA, Wan Ibrahim WA, Ariffin Z, Ismail D
    J Forensic Sci, 2018 Jan;63(1):80-85.
    PMID: 28383137 DOI: 10.1111/1556-4029.13512
    As consumption of stingless bee honey has been gaining popularity in many countries including Malaysia, ability to identify accurately its geographical origin proves pertinent for investigating fraudulent activities for consumer protection. Because a chemical signature can be location-specific, multi-element distribution patterns may prove useful for provenancing such product. Using the inductively coupled-plasma optical emission spectrometer as well as principal component analysis (PCA) and linear discriminant analysis (LDA), the distributions of multi-elements in stingless bee honey collected at four different geographical locations (North, West, East, and South) in Johor, Malaysia, were investigated. While cross-validation using PCA demonstrated 87.0% correct classification rate, the same was improved (96.2%) with the use of LDA, indicating that discrimination was possible for the different geographical regions. Therefore, utilization of multi-element analysis coupled with chemometrics techniques for assigning the provenance of stingless bee honeys for forensic applications is supported.
    MeSH terms: Animals; Bees*; Consumer Product Safety; Geography*; Honey/analysis*; Humans; Malaysia; Spectrophotometry; Principal Component Analysis; Food Safety
  11. Ahmed AS, Mandal UK, Taher M, Susanti D, Jaffri JM
    Pharm Dev Technol, 2018 Oct;23(8):751-760.
    PMID: 28378604 DOI: 10.1080/10837450.2017.1295067
    The development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. Polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels loaded with asiaticoside, a standardized rich fraction of Centella asiatica, were successfully developed using the freeze-thaw method. Response surface methodology with Box-Behnken experimental design was employed to optimize the hydrogels. The hydrogels were characterized and optimized by gel fraction, swelling behavior, water vapor transmission rate and mechanical strength. The formulation with 8% PVA, 5% PEG 400 and five consecutive freeze-thaw cycles was selected as the optimized formulation and was further characterized by its drug release, rheological study, morphology, cytotoxicity and microbial studies. The optimized formulation showed more than 90% drug release at 12 hours. The rheological properties exhibited that the formulation has viscoelastic behavior and remains stable upon storage. Cell culture studies confirmed the biocompatible nature of the optimized hydrogel formulation. In the microbial limit tests, the optimized hydrogel showed no microbial growth. The developed optimized PVA/PEG hydrogel using freeze-thaw method was swellable, elastic, safe, and it can be considered as a promising new wound dressing formulation.
    MeSH terms: Anti-Infective Agents/administration & dosage*; Anti-Infective Agents/chemistry; Bandages; Biocompatible Materials/chemistry*; Cell Line; Freezing; Humans; Polyethylene Glycols/chemistry*; Polyvinyl Alcohol/chemistry*; Rheology; Tensile Strength; Triterpenes/administration & dosage*; Triterpenes/chemistry; Drug Delivery Systems; Hydrogels/chemistry*; Drug Liberation
  12. Tang KL, Wimmer BC, Akkawi ME, Ming LC, Ibrahim B
    Res Social Adm Pharm, 2018 Mar;14(3):317-319.
    PMID: 28365153 DOI: 10.1016/j.sapharm.2017.03.053
    MeSH terms: Child; Developing Countries; Hospital Departments/statistics & numerical data; Humans; Malaysia; Medication Errors/statistics & numerical data*; Incidence; Tertiary Care Centers/statistics & numerical data
  13. Salvage SC, Chandrasekharan KH, Jeevaratnam K, Dulhunty AF, Thompson AJ, Jackson AP, et al.
    Br J Pharmacol, 2018 Apr;175(8):1260-1278.
    PMID: 28369767 DOI: 10.1111/bph.13807
    Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation, supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the Ca2+ -mediated, catecholaminergic polymorphic ventricular tachycardia (CPVT). However, flecainide can also exert pro-arrhythmic effects most notably following myocardial infarction and when used to diagnose Brugada syndrome (BrS). These divergent actions result from its physiological and pharmacological actions at multiple, interacting levels of cellular organization. These were studied in murine genetic models with modified Nav channel or intracellular ryanodine receptor (RyR2)-Ca2+ channel function. Flecainide accesses its transmembrane Nav 1.5 channel binding site during activated, open, states producing a use-dependent antagonism. Closing either activation or inactivation gates traps flecainide within the pore. An early peak INa related to activation of Nav channels followed by rapid de-activation, drives action potential (AP) upstrokes and their propagation. This is diminished in pro-arrhythmic conditions reflecting loss of function of Nav 1.5 channels, such as BrS, accordingly exacerbated by flecainide challenge. Contrastingly, pro-arrhythmic effects attributed to prolonged AP recovery by abnormal late INaL following gain-of-function modifications of Nav 1.5 channels in LQTS3 are reduced by flecainide. Anti-arrhythmic effects of flecainide that reduce triggering in CPVT models mediated by sarcoplasmic reticular Ca2+ release could arise from its primary actions on Nav channels indirectly decreasing [Ca2+ ]i through a reduced [Na+ ]i and/or direct open-state RyR2-Ca2+ channel antagonism. The consequent [Ca2+ ]i alterations could also modify AP propagation velocity and therefore arrhythmic substrate through its actions on Nav 1.5 channel function. This is consistent with the paradoxical differences between flecainide actions upon Na+ currents, AP conduction and arrhythmogenesis under circumstances of normal and increased RyR2 function.

    LINKED ARTICLES: This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.

    MeSH terms: Animals; Anti-Arrhythmia Agents/pharmacology*; Anti-Arrhythmia Agents/therapeutic use; Arrhythmias, Cardiac/drug therapy; Arrhythmias, Cardiac/physiopathology*; Calcium/physiology; Flecainide/pharmacology*; Flecainide/therapeutic use; Humans; Potassium Channels/physiology; Ryanodine Receptor Calcium Release Channel/physiology; Potassium Channel Blockers/pharmacology*; Potassium Channel Blockers/therapeutic use
  14. Aruldass CA, Masalamany SRL, Venil CK, Ahmad WA
    Environ Sci Pollut Res Int, 2018 Feb;25(6):5164-5180.
    PMID: 28361404 DOI: 10.1007/s11356-017-8855-2
    Violacein, violet pigment produced by Chromobacterium violaceum, has attracted much attention recently due to its pharmacological properties including antibacterial activity. The present study investigated possible antibacterial mode of action of violacein from C. violaceum UTM5 against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) strains. Violet fraction was obtained by cultivating C. violaceum UTM5 in liquid pineapple waste medium, extracted, and fractionated using ethyl acetate and vacuum liquid chromatography technique. Violacein was quantified as major compound in violet fraction using HPLC analysis. Violet fraction displayed bacteriostatic activity against S. aureus ATCC 29213 and methicillin-resistant S. aureus ATCC 43300 with minimum inhibitory concentration (MIC) of 3.9 μg/mL. Fluorescence dyes for membrane damage and scanning electron microscopic analysis confirmed the inhibitory effect by disruption on membrane integrity, morphological alternations, and rupture of the cell membranes of both strains. Transmission electron microscopic analysis showed membrane damage, mesosome formation, and leakage of intracellular constituents of both bacterial strains. Mode of action of violet fraction on the cell membrane integrity of both strains was shown by release of protein, K+, and extracellular adenosine 5'-triphosphate (ATP) with 110.5 μg/mL, 2.34 μg/mL, and 87.24 ng/μL, respectively, at 48 h of incubation. Violet fraction was toxic to human embryonic kidney (HEK293) and human fetal lung fibroblast (IMR90) cell lines with LC50 value of 0.998 ± 0.058 and 0.387 ± 0.002 μg/mL, respectively. Thus, violet fraction showed a strong antibacterial property by disrupting the membrane integrity of S. aureus and MRSA strains. This is the first report on the possible mode of antibacterial action of violet fraction from C. violaceum UTM5 on S. aureus and MRSA strains.
    MeSH terms: Anti-Bacterial Agents/isolation & purification; Anti-Bacterial Agents/pharmacology*; Anti-Bacterial Agents/toxicity; Cell Line; Cell Membrane/drug effects; Cell Membrane/ultrastructure; Cell Survival/drug effects; Chromobacterium/chemistry*; Humans; Indoles/isolation & purification; Indoles/pharmacology*; Indoles/toxicity; Microbial Sensitivity Tests; Staphylococcus aureus/drug effects*; Staphylococcus aureus/ultrastructure; Microbial Viability/drug effects; Methicillin-Resistant Staphylococcus aureus/drug effects*; Methicillin-Resistant Staphylococcus aureus/ultrastructure; HEK293 Cells
  15. Eseyin OA, Daniel A, Paul TS, Attih E, Emmanuel E, Ekarika J, et al.
    Nat Prod Res, 2018 Feb;32(4):444-447.
    PMID: 28361553 DOI: 10.1080/14786419.2017.1308366
    The 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical, nitric oxide, reducing power, hydrogen peroxide scavenging, and total antioxidant activities of the methanol extract, n-hexane, dichloromethane, ethyl acetate, butanol and aqueous fractions of the seed of Telfairia occidentalis were evaluated. Total phenolic content was determined using the Folin-Ciocalteu method. The dichloromethane fraction exhibited the highest DPPH radical scavenging, reducing power and total antioxidant activities. Two pure compounds which were identified by FTIR, H-and 2D NMR and Mass spectroscopy as 9-octadecenoic acid (TOS B) and 10-hydroxyoctadecanoic acid (TOS C) and four oily isolates, TOS A, TOS D, TOS E and TOS F were obtained from the dichloromethane fraction. TOS E had the highest DPPH radical scavening activity comparable to that of ascorbic acid. GC-MS analysis revealed the major compounds in TOS E as 4-(2,2-Dimethyl-6-methylene cyclohexylidene)-2-butanol; 3-(3-hydroxybutyl)-2,4,4-trimethyl-2-cyclohexene-1-one and 1,2-Benzenedicarboxylic acid disooctyl ester. Thus, the seed of T. occidentalis can be consumed for its antioxidant property.
    MeSH terms: Butanols/chemistry; Antioxidants/pharmacology*; Antioxidants/chemistry*; Chromatography, Gas; Hexanes/chemistry; Magnetic Resonance Spectroscopy; Phenols/analysis; Phenols/chemistry; Seeds/chemistry; Stearic Acids/analysis; Stearic Acids/chemistry; Spectroscopy, Fourier Transform Infrared; Oleic Acid/analysis; Cucurbitaceae/chemistry*; Phytochemicals/analysis; Phytochemicals/pharmacology
  16. Lee KR, Peng LY, Iqbal TB, Subrayan V
    Ocul Immunol Inflamm, 2018;26(8):1146-1149.
    PMID: 28362518 DOI: 10.1080/09273948.2017.1298821
    PURPOSE: To report a case of systemic lupus erythematosus-induced choroidal vasculitis.

    METHODS: A 34-year-old woman with a long-standing history of systemic lupus erythematosus had a sudden painless loss of vision in the right eye over 12 hours. Ocular examination revealed a visual acuity of counting fingers of 1 foot on the right eye and 20/20 on the left. There was a relative afferent pupillary defect on the right side with a pink, distinct optic disk margin.

    RESULTS: Optical coherence tomography of the macula and fundus fluorescein angiogram for the eyes were normal. The MRI brain and orbit with the cerebral MRA did not show signs of optic neuritis or occipital vasculitic changes. However, the indocyanine green angiography revealed patches of ill-defined areas of choroidal hypofluorescence in the early- to mid-phase in the macula region.

    CONCLUSION: ICGA becomes the crucial tool in unmasking the presence of choroidal vasculitis.
    MeSH terms: Administration, Oral; Adult; Choroiditis/diagnosis*; Choroiditis/drug therapy; Coloring Agents/administration & dosage; Female; Fluorescein Angiography*; Glucocorticoids/therapeutic use; Hospitals, University; Humans; Indocyanine Green/administration & dosage; Infusions, Intravenous; Lupus Erythematosus, Systemic/diagnosis*; Lupus Erythematosus, Systemic/drug therapy; Magnetic Resonance Imaging; Malaysia; Methylprednisolone/therapeutic use; Prednisolone/therapeutic use; Vision Disorders/diagnosis*; Vision Disorders/drug therapy; Visual Acuity; Immunoglobulins, Intravenous/therapeutic use; Tomography, Optical Coherence
  17. Syarifah-Noratiqah SB, Naina-Mohamed I, Zulfarina MS, Qodriyah HMS
    Curr Drug Targets, 2018;19(8):927-937.
    PMID: 28356027 DOI: 10.2174/1389450118666170328122527
    Neurodegenerative disease is an incurable disease which involves the degeneration or death of the nerve cells. Alzheimer's Disease (AD) is a neurodegenerative disease discovered in 1906 by Alois Alzheimer, a German clinical psychiatrist and neuroanatomist. The main pathological hallmarks of this disease are the formation of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangle (NFT). The accumulation of the amyloid protein aggregates in the brain of AD patients leads to oxidative stress and inflammation. Other postulated reasons for the development of this disease are cholinergic depletion and excessive glutamatergic neurotransmission. The current drugs approved and marketed for the treatment of AD are cholinesterase inhibitors (ChEIs) and N-methyl-Daspartate (NMDA) receptor antagonists. The function of ChEIs is to avoid cholinergic depletion; whereas the function of NMDA receptor antagonist is to block excessive glutamatergic neurotransmission. Unfortunately, the current drugs prescribed for AD show only modest improvement in terms of symptomatic relief and delay the progression of the disease. This review will discuss about several polyphenolic compounds as potential natural treatment options for AD. Three compounds are highlighted in this review - Curcumin (Cur), Resveratrol (Rsv) and Epigallocatechin-3- gallate (EGCG). These compounds have huge potential for AD treatment, especially due to their low frequency of adverse events. However, the current conventional pharmaceutical drugs remain as the mainstay of treatment for AD.
    MeSH terms: Alzheimer Disease/drug therapy*; Alzheimer Disease/physiopathology; Animals; Catechin/adverse effects; Catechin/analogs & derivatives; Catechin/pharmacology; Curcumin/adverse effects; Curcumin/pharmacology; Humans; Amyloid beta-Peptides/metabolism; Oxidative Stress/drug effects; Disease Progression; Neuroprotective Agents/pharmacology*; Polyphenols/adverse effects; Polyphenols/pharmacology*
  18. Kariya P, Tandon S, Singh S, Tewari N
    J Investig Clin Dent, 2018 Feb;9(1).
    PMID: 28349669 DOI: 10.1111/jicd.12266
    AIM: The aim of the present study was to evaluate the timing and sequence of the eruption of deciduous teeth in Indian children.

    METHOD: This cross-sectional study focused on children aged 5-36 months. One hospital was randomly selected from four geographic zones of the city. A total of 400 children from each hospital, fulfilling the inclusion criteria, constituted the sample. The examination was carried out by a single, trained examiner. The tooth was recorded as "present" or "absent" on the day of examination. The mean age of emergence was calculated using a probit model. Independent sample t-test was used to assess the statistical significance of differences in the mean age of tooth emergence.

    RESULTS: The deciduous mandibular central incisor was the first tooth to erupt in the oral cavity (8.15±1.69 months). Girls showed delayed eruption compared to boys; however, no interarch variation was observed in the mean age of tooth eruption. There was also no difference in the sequence of eruption of deciduous teeth, as reported in other studies.

    CONCLUSIONS: The present study establishes a chronological table for the eruption of deciduous teeth in Indian children. There was delayed eruption of deciduous teeth when compared to the reference ranges of Western populations.

    MeSH terms: Age Factors; Child, Preschool; Cross-Sectional Studies; Female; Humans; India; Infant; Male; Mandible/physiology*; Maxilla/physiology*; Reference Values; Sex Factors; Tooth Eruption/physiology*; Tooth, Deciduous/physiology*
  19. Abdullah SJ, Shaikh Mohammed J
    Assist Technol, 2018;30(4):165-175.
    PMID: 28346064 DOI: 10.1080/10400435.2017.1293193
    Independent mobility is vital to individuals of all ages, and wheelchairs have proven to be great personal mobility devices. The tasks of opening and navigating through a door are trivial for healthy people, while the same tasks could be difficult for some wheelchair users. A wide range of intelligent wheelchair controllers and systems, robotic arms, or manipulator attachments integrated with wheelchairs have been developed for various applications, including manipulating door knobs. Unfortunately, the intelligent wheelchairs and robotic attachments are not widely available as commercial products. Therefore, the current manuscript presents the modeling and simulation of a novel but simple technology in the form of a passive wheelchair accessory (straight, arm-like with a single wheel, and arc-shaped with multiple wheels) for pushing doors open from a wheelchair. From the simulations using different wheel shapes and sizes, it was found that the arc-shaped accessory could push open the doors faster and with almost half the required force as compared to the arm-like accessory. Also, smaller spherical wheels were found to be best in terms of reaction forces on the wheels. Prototypes based on the arc-shaped accessory design will be manufactured and evaluated for pushing doors open and dodging or gliding other obstacles.
    MeSH terms: Computer Simulation; Equipment Design/methods*; Wheelchairs*; Computer-Aided Design*; Mechanical Phenomena
  20. Eamsobhana P, Yong HS, Song SL, Prasartvit A, Boonyong S, Tungtrongchitr A
    J Helminthol, 2018 Mar;92(2):254-259.
    PMID: 28330511 DOI: 10.1017/S0022149X17000244
    The rat lungworm Angiostrongylus malaysiensis is a metastrongyloid nematode parasite. It has been reported in Malaysia, Thailand, Laos, Myanmar, Indonesia and Japan. In this study, A. malaysiensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in Thailand were used to determine their haplotype by means of the mitochondrial partial cytochrome c oxidase subunit I (COI) gene sequence. The results revealed high COI haplotype diversity of A. malaysiensis from Thailand. The geographical isolates of A. malaysiensis from Thailand and other countries formed a monophyletic clade distinct from the closely related A. cantonensis. In the present study, five new haplotypes were identified in addition to the four haplotypes reported in the literature. Phylogenetic analysis revealed that four of these five new haplotypes - one from Mae Hong Song (northern region), two from Tak (western region) and one from Phang Nga (southern region) - formed a distinct clade with those from Phatthalung (southern region) and Malaysia. The haplotype from Malaysia was identical to that of Phatthalung (haplotype AM1). In general, the COI sequences did not differentiate unambiguously the various geographical isolates of A. malaysiensis. This study has confirmed the presence of high COI genetic diversity in various geographical isolates of A. malaysiensis. The COI gene sequence will be suitable for studying genetic diversity, population structure and phylogeography.
    MeSH terms: Angiostrongylus/classification; Angiostrongylus/genetics*; Animals; Animals, Wild; Electron Transport Complex IV/genetics*; Lung/parasitology; Phylogeny; Thailand/epidemiology; Genetic Variation*; Strongylida Infections/epidemiology; Strongylida Infections/parasitology; DNA, Helminth/genetics; Rats; Phylogeography
External Links