Browse publications by year: 2023

  1. Lee WL, Danaee M, Abdullah A, Wong LP
    Cardiol Res, 2023 Dec;14(6):437-445.
    PMID: 38187511 DOI: 10.14740/cr1569
    BACKGROUND: The popular wrist-worn wearables recording a variety of health metrics such as blood pressure (BP) in real time could play a potential role to advance precision medicine, but these devices are often insufficiently validated for their performance to enhance confidence in its use across diverse populations. The accuracy of BP-enabled smartwatch is assessed among the multi-ethnic Malaysians, and findings is discussed in comparison with conventional automated upper-arm BP device.

    METHODS: Validation procedures followed the guidelines by the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018). Quota sampling was employed to obtain eligible patients with normal and abnormal BP as per guideline. The measurements of BP were taken at wrist using HUAWEI WATCH D (test BP); and the readings were assessed against reference BP by the mercury sphygmomanometer. Agreement statistics and linear regression analyses were performed.

    RESULTS: BP measurements (234 data pairs) from 78 patients that fulfilled AAMI/ESH/ISO protocol were analyzed. The BP readings taken by the HUAWEI WATCH D were comparable to reference BP by sphygmomanometer based on 1) Criterion 1: systolic blood pressure (SBP) = -0.034 (SD 5.24) and diastolic blood pressure (DBP) = -0.65 (SD 4.66) mm Hg; and 2) Criterion 2: SBPs = -0.034 (SD 4.18) and DBPs = -0.65 (SD 3.94) mm Hg. Factors of sociodemographic characteristics, anthropometric measurements, cardiovascular comorbidities, and wrist hair density were not significantly associated with the mean BP differences.

    CONCLUSIONS: HUAWEI WATCH D fulfilled criteria 1 and 2 of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) guidelines. It can be recommended for clinical use across a wider population. The rich data from real-time BP measurements in concurrent with other health-related parameters recorded by the smartwatch wearable offer opportunities to drive precision medicine in tackling therapeutic inertia by personalizing BP control regimen.

  2. Mohd Iqbal HA, Ho WS, Zanudin A, Hisham H, Mohd Nordin NA
    World J Clin Cases, 2023 Dec 26;11(36):8595-8602.
    PMID: 38188206 DOI: 10.12998/wjcc.v11.i36.8595
    BACKGROUND: Herein, we report the case of a 13-year-old boy with spastic quadriplegia cerebral palsy (CP) at Gross Motor Function Classification System (GMFCS) level II, engaging in a 6-wk video game-based therapy (VBT) program. This study aimed to offer essential insights regarding VBT's impact on enhancing the physical function and improving the quality of life (QoL) of adolescents diagnosed with CP. This report provides a distinctive viewpoint that can inform and direct future clinical practices and research endeavors.

    CASE SUMMARY: The boy presented with moderate mobility, balance, and overall well-being. He faced challenges with diminished lower limb strength, which affected his daily living and physical fitness capabilities. Our participant was diagnosed with spastic quadriplegic CP at GMFCS level II. He participated in a 6-wk program of VBT using a play station. This innovative approach incorporates warm-up exercises, interactive activities, and cool-down routines, targeting various movements, including single-leg stance, weight shifting, kicking, jumping, marching, and squatting. After VBT, the strength of the left hip extensor significantly increased from 199.3 N to 541.3 N. Distance covered as part of a 6-min walk test increased by 82 m. His Paediatric QoL Inventory score increased dramatically by 25.9%.

    CONCLUSION: VBT is an innovative, individualized therapy that enhances physical function and QoL in CP, emphasizing its role in ambulatory patients.

  3. Tan PL, Kanesan J, Chuah JH, Badruddin IA, Abdellatif A, Kamangar S, et al.
    Biomed Mater Eng, 2023 Dec 28.
    PMID: 38189746 DOI: 10.3233/BME-230150
    BACKGROUND: The scientific revolution in the treatment of many illnesses has been significantly aided by stem cells. This paper presents an optimal control on a mathematical model of chemotherapy and stem cell therapy for cancer treatment.

    OBJECTIVE: To develop effective hybrid techniques that combine the optimal control theory (OCT) with the evolutionary algorithm and multi-objective swarm algorithm. The developed technique is aimed to reduce the number of cancerous cells while utilizing the minimum necessary chemotherapy medications and minimizing toxicity to protect patients' health.

    METHODS: Two hybrid techniques are proposed in this paper. Both techniques combined OCT with the evolutionary algorithm and multi-objective swarm algorithm which included MOEA/D, MOPSO, SPEA II and PESA II. This study evaluates the performance of two hybrid techniques in terms of reducing cancer cells and drug concentrations, as well as computational time consumption.

    RESULTS: In both techniques, MOEA/D emerges as the most effective algorithm due to its superior capability in minimizing tumour size and cancer drug concentration.

    CONCLUSION: This study highlights the importance of integrating OCT and evolutionary algorithms as a robust approach for optimizing cancer chemotherapy treatment.

  4. Javed E, Khan HM, Shahzad Q, Shahzad Y, Yasin H, Ul-Haq Z, et al.
    Saudi Pharm J, 2023 Dec;31(12):101860.
    PMID: 38192284 DOI: 10.1016/j.jsps.2023.101860
    Croton bonplandianus, a natural source traditionally used for treating various illnesses, including rheumatoid arthritis, was evaluated in this study. The effects of ethanolic extracts (CBEE) and aqueous fractions (CBAF) of C. bonplandianus leaves on arthritis-induced inflammation were studied using an albino rat model of inflammation induced by Freund's complete adjuvant. Eight test groups (n = 5 per group) and one vehicle control were used to evaluate the antiarthritic effects of different doses of CBEE and CBAF (125 mg.kg-1, 250 mg.kg-1, and 500 mg.kg-1) on days 5, 10, 15, and 20 compared to arthritic and vehicle controls. Arthritis severity was assessed using macroscopic arthritis grading, histological analysis, body weights, and paw thickness. CBEE and CBAF were found to reduce the prevalence of arthritis, increase body weight, and decrease paw inflammation compared to the vehicle control group by the 23rd day. In addition, they showed no effect on biochemical parameters, but a significant difference (p 
  5. Muhammed Yusuf N, Abu Bakar K, Isyaku B, Abdelmaboud A, Nagmeldin W
    PeerJ Comput Sci, 2023;9:e1698.
    PMID: 38192471 DOI: 10.7717/peerj-cs.1698
    Software-defined networking (SDN) is a networking architecture with improved efficiency achieved by moving networking decisions from the data plane to provide them critically at the control plane. In a traditional SDN, typically, a single controller is used. However, the complexity of modern networks due to their size and high traffic volume with varied quality of service requirements have introduced high control message communications overhead on the controller. Similarly, the solution found using multiple distributed controllers brings forth the 'controller placement problem' (CPP). Incorporating switch roles in the CPP modelling during network partitioning for controller placement has not been adequately considered by any existing CPP techniques. This article proposes the controller placement algorithm with network partition based on critical switch awareness (CPCSA). CPCSA identifies critical switch in the software defined wide area network (SDWAN) and then partition the network based on the criticality. Subsequently, a controller is assigned to each partition to improve control messages communication overhead, loss, throughput, and flow setup delay. The CPSCSA experimented with real network topologies obtained from the Internet Topology Zoo. Results show that CPCSA has achieved an aggregate reduction in the controller's overhead by 73%, loss by 51%, and latency by 16% while improving throughput by 16% compared to the benchmark algorithms.
  6. Zerdoumi S, Jhanjhi NZ, Ariyaluran Habeeb RA, Hashem IAT
    PeerJ Comput Sci, 2023;9:e1465.
    PMID: 38192476 DOI: 10.7717/peerj-cs.1465
    Based on the results of this research, a new method for separating Arabic offline text is presented. This method finds the core splitter between the "Middle" and "Lower" zones by looking for sharp character degeneration in those zones. With the exception of script localization and the essential feature of determining which direction a starting point is pointing, the baseline also functions as a delimiter for horizontal projections. Despite the fact that the bottom half of the characteristics is utilized to differentiate the modifiers in zones, the top half of the characteristics is not. This method works best when the baseline is able to divide features into the bottom zone and the middle zone in a complex pattern where it is hard to find the alphabet, like in ancient scripts. Furthermore, this technique performed well when it came to distinguishing Arabic text, including calligraphy. With the zoning system, the aim is to decrease the number of different element classes that are associated with the total number of alphabets used in Arabic cursive writing. The components are identified using the pixel value origin and center reign (CR) technique, which is combined with letter morphology to achieve complete word-level identification. Using the upper baseline and lower baseline together, this proposed technique produces a consistent Arabic pattern, which is intended to improve identification rates by increasing the number of matches. For Mediterranean keywords (cities in Algeria and Tunisia), the suggested approach makes use of indicators that the correctness of the Othmani and Arabic scripts is greater than 98.14 percent and 90.16 percent, respectively, based on 84 and 117 verses. As a consequence of the auditing method and the assessment section's structure and software, the major problems were identified, with a few of them being specifically highlighted.
  7. Bhardwaj A, Vishnoi A, Bharany S, Abdelmaboud A, Ibrahim AO, Mamoun M, et al.
    PeerJ Comput Sci, 2023;9:e1771.
    PMID: 38192478 DOI: 10.7717/peerj-cs.1771
    The Internet of Things has a bootloader and applications responsible for initializing the device's hardware and loading the operating system or firmware. Ensuring the security of the bootloader is crucial to protect against malicious firmware or software being loaded onto the device. One way to increase the security of the bootloader is to use digital signature verification to ensure that only authorized firmware can be loaded onto the device. Additionally, implementing secure boot processes, such as a chain of trust, can prevent unauthorized access to the device's firmware and protect against tampering during the boot process. This research is based on the firmware bootloader and application dataflow taint analysis and security assessment of IoT devices as the most critical step in ensuring the security and integrity of these devices. This process helps identify vulnerabilities and potential attack vectors that attackers could exploit and provides a foundation for developing effective remediation strategies.
  8. Ong LT, Fan SWD
    Innov Clin Neurosci, 2023;20(10-12):40-47.
    PMID: 38193097
    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by early-onset impairments in socialization, communication, repetitive behaviors, and restricted interests. ASD exhibits considerable heterogeneity, with clinical presentations varying across individuals and age groups. The pathophysiology of ASD is hypothesized to be due to abnormal brain development influenced by a combination of genetic and environmental factors. One of the most consistent morphological parameters for assessing the abnormal brain structures in patients with ASD is cortical thickness. Studies have shown changes in the cortical thickness within the frontal, temporal, parietal, and occipital lobes of individuals with ASD. These changes in cortical thickness often correspond to specific clinical features observed in individuals with ASD. Furthermore, the aberrant brain anatomical features and cortical thickness alterations may lead to abnormal brain connectivity and synaptic structure. Additionally, ASD is associated with cortical hyperplasia in early childhood, followed by a cortical plateau and subsequent decline in later stages of development. However, research in this area has yielded contradictory findings regarding the cortical thickness across various brain regions in ASD.
  9. Kamalzadeh L, de Filippis R, El Hayek S, Heidari Mokarar M, Jatchavala C, Koh EBY, et al.
    Front Psychiatry, 2023;14:1307277.
    PMID: 38193134 DOI: 10.3389/fpsyt.2023.1307277
  10. Ajay R, JafarAbdulla MU, Sivakumar JS, Baburajan K, Rakshagan V, Eyeswarya J
    J Contemp Dent Pract, 2023 Aug 01;24(8):521-544.
    PMID: 38193174 DOI: 10.5005/jp-journals-10024-3514
    AIM: The present systematic review aimed to report the studies concerning the primers in improving bond strength and identifying pertinent primers for a particular dental alloy by adhering to PRISMA precepts.

    MATERIALS AND METHODS: PubMed and Semantic Scholar databases were scoured for articles using 10 search terms. In vitro studies satisfying the inclusion criteria were probed which were meticulously screened and scrutinized for eligibility adhering to the 11 exclusion criteria. The quality assessment tool for in vitro studies (QUIN Tool) containing 12 criteria was employed to assess the risk of bias (RoB).

    RESULTS: A total of 48 studies assessing shear bond strength (SBS) and 15 studies evaluating tensile bond strength (TBS) were included in the qualitative synthesis. Concerning SBS, 33.4% moderate and 66.6% high RoB was observed. Concerning TBS, 26.8% moderate and 73.2% high RoB was discerned. Seventeen and two studies assessing SBS and TBS, respectively, were included in meta-analyses.

    CONCLUSIONS: Shear bond strength and TBS increased for the primed alloys. Cyclic disulfide primer is best-suited for noble alloys when compared with thiol/thione primers. Phosphoric acid- and phosphonic acid ester-based primers are opportune for base alloys.

    CLINICAL SIGNIFICANCE: The alloy-resin interface (ARI) would fail if an inappropriate primer was selected. Therefore, the selection of an appropriate alloy adhesive primer for an alloy plays a crucial role in prosthetic success. This systematic review would help in the identification and selection of a congruous primer for a selected alloy.

    MeSH terms: Dental Alloys*; Dental Cements*; Disulfides; Thiones*; Databases, Factual
  11. Zainal Arifen ZN, Haron H, Shahar S, Harun Z, Michael V, You YX, et al.
    Public Health Nutr, 2023 Dec 15;27(1):e12.
    PMID: 38098442 DOI: 10.1017/S136898002300277X
    OBJECTIVE: To explore the perspectives, barriers and enablers on salt reduction in out-of-home sectors in Malaysia among street food vendors, caterers and consumers.

    DESIGN: A qualitative study involving twenty-two focus group discussions and six in-depth interviews was conducted, recorded and transcribed verbatim. An inductive thematic analysis approach was employed to analyse the data.

    SETTING: Two in-depth interviews and twenty-two focus group discussions were conducted face-to-face. Four in-depth interviews were conducted online.

    PARTICIPANTS: Focus group discussions were conducted among twenty-three street food vendors, twenty-one caterers and seventy-six consumers of various eateries. In-depth interviews were conducted among two street food vendors and four caterers, individually.

    RESULTS: Consumers and food operators perceived a high-salt intake within Malaysia's out-of-home food sectors. Food operators emphasised the necessity for a comprehensive salt reduction policy in the out-of-home sector involving all stakeholders. Consumers faced limited awareness and knowledge, counterproductive practices among food operators and challenges in accessing affordable low-Na food products, whereas food operators faced the lack of standardised guidelines and effective enforcement mechanisms and uncooperative consumer practices. Both groups expressed that food quality and price of salt were also the barriers, and they advocated for awareness promotion, enhanced regulation of manufactured food products and stricter enforcement targeting vendors. Consumers also suggested promoting and recognising health-conscious food premises, whereas food operators suggested on knowledge enhancement tailored to them, strategies for gaining consumers acceptance and maintaining food quality.

    CONCLUSIONS: These findings provide valuable insights that serve as foundational evidence for developing and implementing salt reduction policies within Malaysia's out-of-home sectors.

    MeSH terms: Food; Food Services*; Humans; Malaysia; Sodium Chloride, Dietary*; Qualitative Research
  12. Moy FM, Ng YH, Tan SS
    J Nutr Sci Vitaminol (Tokyo), 2023;69(6):463-470.
    PMID: 38171819 DOI: 10.3177/jnsv.69.463
    Metabolic syndrome (MetS) poses increased risks for non-communicable diseases, increasing all-cause mortality, disability, and healthcare costs. Beta-carotene as the major carotenoid is identified to play an important role in the pathophysiology of MetS. The present study aimed to investigate the association between serum beta-carotene levels with metabolic syndrome and metabolic risk factors among a cohort of teachers in Peninsular Malaysia. This cross-sectional study investigated a sub-sample of 645 serum samples which were randomly selected for beta-carotene determination. Socio-demographic, lifestyle and metabolic risk factors were measured following standard protocols. There were equal proportions of males and females, with majority Malays (69%) followed by the Chinese (24%) and Indians (6.5%). The prevalence of MetS was 24.8% with abnormal waist circumference and high blood pressure as the most commonly reported metabolic risk factors. The median serum beta-carotene was 5.15 (5.07) μmol/L. Serum beta-carotene in the lowest quartile (Q1) was found to be significantly associated with MetS (OR: 5.81; 95% CI: 2.96, 11.38) and metabolic risk factors, namely triglycerides (OR: 6.38; 95% CI: 3.04, 13.35), fasting blood sugar (OR: 3.32; 95% CI: 1.48, 7.43), HDL-cholesterol (OR: 2.88; 95% CI: 1.58, 5.26) and waist circumference (OR: 2.94; 95% CI: 1.73, 5.01), after adjusted for potential confounders. In summary, participants with lower serum beta-carotene had higher odds for MetS and the above-mentioned metabolic risk factors.
    MeSH terms: Cross-Sectional Studies; Female; Humans; Malaysia/epidemiology; Male; Risk Factors; Triglycerides; Prevalence; beta Carotene; Waist Circumference
  13. Sartika RAD, Sigit FS, Purwanto E, Aris N, Marjan AQ, Putra WKY, et al.
    Ann Pediatr Endocrinol Metab, 2023 Dec;28(4):267-274.
    PMID: 38173382 DOI: 10.6065/apem.2346146.073
    PURPOSE: We aimed to investigate the association of birth weight with the risk of diabetes mellitus in adolescence and early adulthood in the Indonesian population.

    METHODS: This study analyzed data from the Indonesian Family Life Survey, a longitudinal study of the Indonesian population with repeated measurements at 3 time points (1997, 2007, and 2014). The subjects observed were children aged 0-59 months in 1997, who were 10-15 years old in 2007, and 17-22 years in 2014. We performed a generalized linear model to investigate the association between birth weight at baseline and the level of hemoglobin A1c (HbA1c) at the 2 follow-up periods. We adjusted the association for the characteristics of the children, parents, and household.

    RESULTS: The mean±standard deviation level of HbA1c was 7.35%±0.95% in 2007 and decreased to 5.30%±0.85% in 2014. The crude β (95% confidence interval [CI]) of the association between birth weight and HbA1c was 0.150 (-0.076, 0.377) in 2007 and 0.146 (-0.060, 0.351) in 2014. After adjustment for the sociodemographic characteristics of the children, parents, and confounding factors, the adjusted β (95% CI) was 1.12 (0.40-1.85) in 2007 and 0.92 (0.35-1.48) in 2014. The HbA1c of the parents, father's employment status, percentage of food expenditure, and underweight were the covariates that had significant associations with HbA1c.

    CONCLUSION: HbA1c level was higher in adolescence than in early adulthood. Birth weight was associated with HbA1c level in both periods. The HbA1c of the parents, father's employment, percentage of food expenditure, and underweight partly explained the association between birth weight and the HbA1c level.

  14. Li W, Manoharan P, Cui X, Liu F, Liu K, Dai L
    Front Hum Neurosci, 2023;17:1304929.
    PMID: 38173798 DOI: 10.3389/fnhum.2023.1304929
    INTRODUCTION: Metacognition and self-directed learning are key components in educational research, recognized for their potential to enhance learning efficiency and problem-solving skills. This study explores the effects of musical feedback training on these competencies.

    METHODS: The study involved 84 preservice teachers aged 18 to 21. Participants were randomly assigned to either an experimental group, which received musical feedback training, or a control group.

    RESULTS: The findings indicate that musical feedback training effectively improved metacognitive abilities. However, its impact on the readiness for self-directed learning was inconclusive. A notable difference in metacognition and self-directed learning readiness was observed between the experimental and control groups during the session, indicating a significant interaction effect. Furthermore, a positive correlation was identified between metacognition and self-directed learning.

    DISCUSSION: These results contribute to educational discourse by providing empirical evidence on the utility of musical feedback training in fostering metacognition. They also highlight the importance of consistent and long-term engagement in self-directed learning practices. The significance of these findings advocates for incorporating music feedback training into music education curricula to enhance metacognition and improve overall learning efficiency.

  15. Putra RH, Astuti ER, Nurrachman AS, Putri DK, Ghazali AB, Pradini TA, et al.
    Imaging Sci Dent, 2023 Dec;53(4):271-281.
    PMID: 38174035 DOI: 10.5624/isd.20230058
    PURPOSE: The objective of this scoping review was to investigate the applicability and performance of various convolutional neural network (CNN) models in tooth numbering on panoramic radiographs, achieved through classification, detection, and segmentation tasks.

    MATERIAL AND METHODS: An online search was performed of the PubMed, Science Direct, and Scopus databases. Based on the selection process, 12 studies were included in this review.

    RESULTS: Eleven studies utilized a CNN model for detection tasks, 5 for classification tasks, and 3 for segmentation tasks in the context of tooth numbering on panoramic radiographs. Most of these studies revealed high performance of various CNN models in automating tooth numbering. However, several studies also highlighted limitations of CNNs, such as the presence of false positives and false negatives in identifying decayed teeth, teeth with crown prosthetics, teeth adjacent to edentulous areas, dental implants, root remnants, wisdom teeth, and root canal-treated teeth. These limitations can be overcome by ensuring both the quality and quantity of datasets, as well as optimizing the CNN architecture.

    CONCLUSION: CNNs have demonstrated high performance in automated tooth numbering on panoramic radiographs. Future development of CNN-based models for this purpose should also consider different stages of dentition, such as the primary and mixed dentition stages, as well as the presence of various tooth conditions. Ultimately, an optimized CNN architecture can serve as the foundation for an automated tooth numbering system and for further artificial intelligence research on panoramic radiographs for a variety of purposes.

  16. Parmar MP, Kaleem S, Samuganathan P, Ishfaq L, Anne T, Patel Y, et al.
    Cureus, 2023 Dec;15(12):e49883.
    PMID: 38174181 DOI: 10.7759/cureus.49883
    Proton pump inhibitors (PPIs) are widely prescribed medications for the management of various gastrointestinal disorders, primarily gastroesophageal reflux disease (GERD) and peptic ulcers. However, recent concerns have emerged regarding their potential adverse effects on kidney function and their role in the progression of chronic kidney disease (CKD). This systematic review aims to comprehensively analyze the existing literature to assess the impact of PPI use on kidney function and CKD progression. We took information from PubMed, PubMed Central (PMC), and Google Scholar articles from the last 10 years, from 2013 to 2023, and looked for links between PPI use and a number of kidney-related outcomes. These included acute kidney injury, a drop in the estimated glomerular filtration rate (eGFR), and new cases of CKD. The findings of this systematic review highlight the need for a thorough evaluation of the benefits and risks associated with PPI use, particularly in patients with pre-existing kidney conditions, in order to inform clinical decision-making and improve were taken out and looked at to see if there were any links between PPI use and different kidney-related events, such as acute kidney injury, a drop in the estimated eGFR, and the development of CKD. The review also explores potential mechanisms underlying PPI-induced nephrotoxicity. The findings of this systematic review highlight the need for a thorough evaluation of the benefits and risks associated with PPI use, particularly in patients with pre-existing kidney conditions, in order to inform clinical decision-making and improve patient care. Further research is warranted to better understand the complex interplay between PPIs, kidney function, and CKD progression.
  17. Sohor NJ, Loh WC, Pang RY, Khan AH, Chia PK, Sulaiman WAW, et al.
    Neurol India, 2023;71(6):1260-1262.
    PMID: 38174472 DOI: 10.4103/0028-3886.391392
    Methanol toxicity remains as major problem in the medical field.[1],[2],[3] With its active metabolite, formic acid often leads to severe metabolic acidosis and to some extend brain damaged.[4],[5],[6] We are reporting a case of brain hemorrhage at the right external capsule and left basal ganglia with mass effect and obstructive hydrocephalus in a methanol poisoning patient. A confused 29-year-old gentleman was brought into hospital. Initial investigation showed severe metabolic acidosis with raised anion gap. Initial brain CT scan was normal. Subsequently, serum methanol was reported to be high (112 mg/dL). Intravenous (IV) ethanol 10% was given without any delayed. As there was no improvement in his consciousness level, a repeat brain CT was performed and it showed multiple cerebral hemorrhage with obstructive hydrocephalus. Hence, clinicians should have high index of suspicion for cerebral hemorrhage in a patient with methanol toxicity, who presented with altered mental status and severe metabolic acidosis.
    MeSH terms: Adult; Methanol; Alcoholism*; Cerebral Hemorrhage/chemically induced; Humans; Hydrocephalus*; Male
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