Browse publications by year: 2024

  1. Kadir NANA, Abdul-Razak S, Daher AM, Nasir NM
    J Family Med Prim Care, 2024 Aug;13(8):2900-2911.
    PMID: 39228540 DOI: 10.4103/jfmpc.jfmpc_1761_23
    BACKGROUND: Erectile dysfunction (ED) is an independent predictor for cardiovascular diseases (CVD). The prevalence increases with age, but little is known about the relationship between handgrip strength (HGS) and ED, especially among men with a high risk of CVD. This study aimed to determine the prevalence of ED among men aged ≥40 years with metabolic syndrome (MetS) and its association with HGS.

    MATERIALS AND METHODS: A cross-sectional study at an institutional primary care clinic in Malaysia was conducted between June 2021 and October 2021. HGS and erectile function were assessed using a hand dynamometer and International Index of Erectile Function (IIEF-5) questionnaire, respectively. Multiple logistic regression analyses were performed to determine the association between sociodemographics, clinical characteristics, and HGS with ED.

    RESULTS: A total of 334 participants were recruited. The prevalence of ED was 79% (95% confidence interval [CI]: 0.75-0.84). ED was associated with elderly aged ≥60 years (odds ratio [OR] 3.27, 95%CI: 1.60-6.69), low HGS (OR 15.34, 95%CI: 5.64-41.81) and high total cholesterol (OR 0.36, 95%CI: 0.16-0.78).

    CONCLUSION: In conclusion, age above 60 years and those with low HGS are at higher risk of ED. Thus, robust screening of ED among men with MetS and improving muscle strength and physical fitness may be warranted.

  2. Bashir M, Hucheng M, Geok SK, Akbar S, Zhang D
    J Sports Sci Med, 2024 Sep;23(1):628-637.
    PMID: 39228773 DOI: 10.52082/jssm.2024.628
    This study aimed to explore the impact of functional training on the physical fitness of young elite field hockey players. The study comprised 40 young elite male field hockey players with the following characteristics (mean ± SD age: 21.5 ± 0.8 years; height: 176.9 ± 2.6 cm; weight: 68.4 ± 5.1 kg; BMI: 21.8 ± 1.3; training experience: 51.2 ± 5.4 months). Twenty participants were allocated to two groups: the functional training group (FTG) and the control training group (CG). Each group received 60-minute training sessions three times per week for 12 weeks. Generalized estimating equation analysis and a Bonferroni test for pairwise comparisons were used to assess the intervention's efficacy. Before the start of the exercise program, no statistically significant differences were observed in physical fitness measures between the FTG and CG (p > 0.05). However, by the sixth week, a significant difference appeared in both the T-Agility test (p < 0.001) and endurance (p = 0.024) between the two groups, while no notable distinctions were detected in other fitness parameters (p > 0.05). After a 12-week training program, the FTG demonstrated improvements in all physical fitness measures [flexibility (p < 0.001); Illinois agility test (p < 0.001); T-agility test (p = 0.020); endurance (p < 0.001)] except speed, which exhibited no significant impact (p = 0.175). Notable enhancements in T-agility and endurance were evident after just six weeks of functional training, and a 12-week functional training regimen showed superiority over standard training approaches in young elite male field hockey players. These findings encourage the efficacy of functional training exercises over traditional methods in enhancing athletes' fitness parameters.
    MeSH terms: Humans; Male; Physical Endurance/physiology; Muscle Strength/physiology; Athletic Performance/physiology; Young Adult; Physical Conditioning, Human/methods
  3. Yang C, Shi L, Lu Y, Wu H, Yu D
    J Sports Sci Med, 2024 Sep;23(1):611-618.
    PMID: 39228782 DOI: 10.52082/jssm.2024.611
    Drop jump (DJ) and squat jump (SJ) exercises are commonly used in rhythmic gymnastics training. However, the acute effects of DJ and SJ on countermovement jump (CMJ) performance have not been investigated. This study aimed to verify the post-activation performance enhancement (PAPE) responses induced by DJ and SJ with optimal power load and evaluate the relationship between peak PAPE effects and strength levels. Twenty female rhythmic gymnasts completed the following exercises in a randomized order on three separate days: 6 repetitions of DJs; 6 repetitions of SJs with optimal power load; and no exercise (control condition). Jump height was assessed before (baseline) and at 30 seconds and 3, 6, and 9 minutes after each exercise. DJs significantly improved jump height by 0.8 cm (effect size (ES) = 0.25; P = 0.003) at 30 seconds post-exercise compared with baseline. Jump height significantly decreased by -0.14 cm (ES = -0.61; P = 0.021) at 9 minutes after the control condition. SJs significantly improved jump height by 1.02 cm (ES = 0.36; P = 0.005) at 9 minutes post-exercise compared to the control condition. Jump height and relative back squat one-repetition maximum were positively related after performing DJs (r = 0.63; P = 0.003) and SJs (r = 0.64; P = 0.002). DJ and SJ exercises effectively improved countermovement jump height. DJ improved jump height early, while SJ produced greater potentiation effects later. Athletes with a higher strength level benefited the most from these exercises.
    MeSH terms: Adolescent; Female; Humans; Movement/physiology; Young Adult
  4. Song Y, Sheykhlouvand M
    J Sports Sci Med, 2024 Sep;23(1):672-683.
    PMID: 39228785 DOI: 10.52082/jssm.2024.672
    Technique-specific high-intensity interval training (HIITTS) has been proven to be an effective method to enhance the sport-specific bio-motor abilities of taekwondo athletes. However, studies regarding its effects on comprehensive measures of cardiorespiratory fitness are limited. Furthermore, there is a lack of clarity regarding the extent of individual adaptations to this method compared to HIIT in the form of repeated sprints (HIITRS). This study compared the individual adaptations to HIITRS and HIITTS on cardiorespiratory fitness and anaerobic power in trained taekwondo athletes (age = 19.8 ± 1.3 years; body mass = 75.4 ± 9.1 kg; height = 1.73 ± 0.0 .m). All participants completed three sessions per week of a 60-minute regular taekwondo training. Following the 60-minute training, participants completed 3 sets of 10 × 4 s all-out HIITRS or same sets of repeated kicks with both legs (HIITTS) over a 6-week training period. In both groups, rest intervals were set at 15 seconds between efforts and one minute between sets. Before and after the training period, participants underwent a series of lab- and field-based tests to evaluate cardiorespiratory fitness and bio-motor abilities. Both interventions resulted in significant improvements in maximum oxygen uptake (V̇O2max), O2 pulse (V̇O2/HR), first ventilatory threshold (VT1), second ventilatory threshold (VT2), cardiac output (Q̇max), stroke volume (SV), peak power output (PPO), average power output (APO), squat jump (SJ), and countermovement jump (CMJ). However, linear speed (20-m speed time) and taekwondo-specific agility test (TSAT) only responded to HIITRS. HIITRS resulted in greater changes in V̇O2max, V̇O2/HR, VT2, and Q̇max, and higher percentage of responders in measured parameters than HIITTS. In addition, HIITRS elicited lower inter-individual variability (CV) in percent changes from pre- to post-training in all measured variables. These results suggest that incorporating 3 sessions per week of HIITRS into regular taekwondo training results in significantly greater and more homogenized adaptations in cardiorespiratory fitness and bio-motor abilities than HIITTS among trained taekwondo athletes.
    MeSH terms: Adaptation, Physiological; Female; Heart Rate/physiology; Humans; Male; Oxygen Consumption*; Anaerobic Threshold/physiology; Athletic Performance/physiology; Young Adult
  5. Hanapi NA, Halim SA, Razak AA, Sapiai NA
    Radiol Case Rep, 2024 Nov;19(11):4736-4740.
    PMID: 39228953 DOI: 10.1016/j.radcr.2024.07.087
    According to the most recent edition of the DSM V, neurocognitive disorder (NCD), formerly referred to as dementia, is a debilitating condition that progressively diminishes quality of life. It impacts both physical and cognitive domains, including memory and aberrant behavior. If usual presentation is uncertain, perfusion, functional, and molecular imaging are useful. Gold standard marker for the diagnosis of Alzheimer's disease (AD) is FDG PET imaging. Recent studies have shown promising results, whereby the cerebral blood flow in arterial spin labeling (ASL) of MRI and the hypometabolism FDG PET both show a consistent regional abnormality. Therefore, ASL MRI imaging carries a potential role in assisting diagnosis of neurocognitive disorder.
  6. Aye LM, Tan JEH, Ramasamy S
    J Public Health Afr, 2024;15(1):562.
    PMID: 39229342 DOI: 10.4102/jphia.v15i1.562
    BACKGROUND: Following the implementation of the Movement Control Order (MCO) during the coronavirus disease 2019 (COVID-19) pandemic, academicians from the universities in Malaysia needed to ensure that the quality-of-service delivery to the stakeholders is undisturbed by adopting new challenging norms. This compromises the work-life balance (WLB), causes more stress and potentially affects their quality of life (QoL).

    AIM: This study investigates how perceived stress (PS) impacts the QoL of Malaysian academicians during the COVID-19 pandemic, focusing on the mediating role of WLB.

    SETTING: Academics working in Malaysia during COVID-19 pandemic.

    METHODS: A cross-sectional study, using a voluntary response sampling method, was conducted among 417 academicians from universities in Malaysia in September 2021. A self-reported online questionnaire, measuring PS, WLB and QoL, was distributed.

    RESULTS: The QoL scored a mean of 50 (standard deviation [s.d.] = 9.84), PS scored a mean of 24.26 (s.d. = 8.19) and WLB had a mean score of 51.12 (s.d. = 18.73). Work-life balance was a significant mediator of PS and QoL (β = -0.43, 95% confidence interval [CI] = -0.52 to -0.35, p = 0.0001). Perceived stress was a significant predictor of WLB (β = 1.62, p = 0.0001).

    CONCLUSION: Institutions should consider implementing flexible working arrangements, and providing workshops on crisis management, time management, and resilience. Stress coping methods are recommended for enhancing WLB among academicians.

    CONTRIBUTION: This study contributes to the pool of evidence to support intervention strategies and policy recommendations aimed to enhance well-being.

  7. Cheng WM, Lee CH
    J Acute Med, 2024 Sep 01;14(3):108-115.
    PMID: 39229354 DOI: 10.6705/j.jacme.202409_14(3).0002
    BACKGROUND: Emergency medicine (EM) is a growing specialty both clinically and academically. Academic EM development can be measured by number of scientific publications. This study aimed to evaluate the academic international cooperation trend of Taiwan emergency departments (EDs) in the past two decades using social network analysis (SNA).

    METHODS: The study population were publications with first author affiliated with Taiwan EDs and the study duration was publication year before 2021. The enrolled publications were categorized into two groups: Group one, all authors were affiliated with Taiwan (domestic publications) and Group two, authors were affiliated with Taiwan and other countries (international publications). The primary outcome measurement was the degree centrality of Taiwan before 2021. The secondary outcome measurements included the trend in annual publication number of Group one and Group two, the trend in country number of each year in Group two, the top five countries that collaborate with Taiwan, the difference between the median of citation numbers in Group one and Group two, and the difference between the median of author numbers in Group one and Group two.

    RESULTS: A total 4,363 publications were enrolled, of which 4,046 publications were classified in Group one and 317 publications were in Group two. The annual publication number of both groups increased significantly. The annual country number of collaboration with Taiwan ED publications had also significantly increased. The median of citation number and author number in Group two were both significantly higher than Group one. The top five countries collaborating with Taiwan were the United States, China, Malaysia, Japan, and Australia.

    CONCLUSIONS: Taiwan EDs' growing international collaboration in the past two decades indicated a capacity to conduct multi-country research. International collaboration publications obtained higher citations compared to domestic publications. Researchers should enhance international collaborations for academic advancement.

  8. Mutthumanickam G, Supramanian RK, Lim YC
    Cureus, 2024 Aug;16(8):e66077.
    PMID: 39229394 DOI: 10.7759/cureus.66077
    Introduction Occupational noise-induced hearing loss (NIHL) continues to be a significant public health issue globally, with Malaysia being no exception. In Malaysia, the majority of NIHL cases are reported from the manufacturing sector, with Selangor among the states with the highest number of confirmed cases. This study aimed to assess the prevalence of and factors associated with occupational NIHL among palm oil mill workers in Selangor, Malaysia. Methods A cross-sectional study was conducted to analyze the data from the data collection form, noise risk assessment reports, and audiometric test results done between 2021 and 2022 with a comparable baseline audiometric test. Results A total of 143 participants from three palm oil mills joined this study. The prevalence of NIHL was 42.7% (n = 61). Following the logistic regression model, NIHL was significantly associated with a duration of employment of 10 years and above, a history of occupational noise exposure at the previous workplace, and the use of personal hearing protectors at the current workplace with an adjusted OR of 2.41 (95% CI (1.14, 5.07)), 5.89 (95% CI (2.38, 14.53)), and 0.36 (95% CI (0.16, 0.83)), respectively. Conclusion The prevalence of NIHL among the study participants was high, and the associated factors are modifiable factors that can be prevented with a comprehensive hearing conservation program in the palm oil mills.
  9. Zhang S, An HK, Yin H
    Heliyon, 2024 Aug 30;10(16):e35889.
    PMID: 39229535 DOI: 10.1016/j.heliyon.2024.e35889
    The GM(1,1) model's prediction accuracy is significantly influenced by the accuracy of background value estimation. The traditional trapezoidal background value can only be applied to a specific data sequence. Therefore, this study proposes a GM(1,1) model background value reconstruction approach based on the combination of intelligent trapezoidal and variable weights in order to increase the model's application as well as its prediction accuracy. The trapezoidal background value function with slope and point position parameters is called model I. Then, a set of point position parameter sequences, with a new background value function is constructed, called model II. A genetic algorithm is utilized to seek for the values of the parameters to be determined in both models I and II. The results showed that for the exponential growth data series, model I and II have higher prediction accuracy compared to traditional models. For data sequences, taking the traffic volume series of a road from 2014 to 2023, the prediction accuracy of this paper's model I method can be improved by 0.3643 % and 0.2725 % compared with Deng's and Wang's models. The prediction accuracy of this paper's model II method has been further improved by 0.1075 % compared with that of model I.
  10. Mohamed IE, Osman EE, Saeed A, Ming LC, Goh KW, Razi P, et al.
    Heliyon, 2024 Aug 30;10(16):e35943.
    PMID: 39229544 DOI: 10.1016/j.heliyon.2024.e35943
    Memory loss is becoming an increasingly significant health problem, largely due to Alzheimer's disease (AD), which disrupts the brain in several ways, including causing inflammation and weakening the body's defenses. This study explores the potential of medicinal plants as a source of novel therapeutic agents for AD. First, we tested various plant extracts against acetylcholinesterase (AChE) in vitro, following molecular docking simulations with key AD-related protein targets such as MAO-B, P-gp, GSK-3β, and CD14. Rosemary extract was found to be the most inhibitory towards AChE. The compounds found in rosemary (oleanolic acid), sage (pinocembrin), and cinnamon (italicene) showed promise in potentially binding to MAO-B. These chemicals may interact with a key protein in the brain and alter the production and removal of amyloid-β. Luteolin (from rosemary), myricetin (from sage), chamigrene, and italicene (from cinnamon) exhibited potential for inhibiting tau aggregation. Additionally, ursolic acid found in rosemary, sage, and chamigrene from cinnamon could modulate CD14 activity. For the first time, our findings shed light on the intricate interplay between neuroinflammation, neuroprotective mechanisms, and the immune system's role in AD. Further research is needed to validate the in vivo efficacy and safety of these plant-derived compounds, as well as their interactions with key protein targets, which could lead to the development of novel AD therapeutics.
  11. Rus Bakarurraini NAA, Kamarudin AA, Jamal R, Abu N
    Immunotherapy, 2024;16(14-15):987-998.
    PMID: 39229803 DOI: 10.1080/1750743X.2024.2391733
    Colorectal cancer (CRC) is a major contributor to global cancer incidence and mortality. Conventional treatments have limitations; hence, innovative approaches are imperative. Recent advancements in cancer research have led to the development of personalized targeted therapies and immunotherapies. Immunotherapy, in particular, T cell-based therapies, exhibited to be promising in enhancing cancer treatment outcomes. This review focuses on the landscape of engineered T cells as a potential option for the treatment of CRC. It highlights the approaches, challenges and current advancements in this field. As the understanding of molecular mechanisms increases, engineered T cells hold great potential in revolutionizing cancer treatment. To fully explore their safety efficacy in improving patient outcomes, further research and clinical trials are necessary.
    MeSH terms: Animals; Humans; Immunotherapy/methods
  12. Daood U, Ilyas MS, Ashraf M, Akbar M, Asif A, Khan AS, et al.
    J Oral Maxillofac Surg, 2024 Sep;82(9):1147-1162.
    PMID: 38830601 DOI: 10.1016/j.joms.2024.05.004
    BACKGROUND: Treated or coated sutures promise to prevent contamination of wounds.

    PURPOSE: The purpose of the study was to coat surgical sutures with a new quaternary ammonium silane (QAS) antimicrobial compound at two different application temperatures and then to evaluate the resulting structural, physical, mechanical, and biological properties.

    STUDY DESIGN, SETTING, SAMPLE: In vitro and in vivo studies were conducted using male albino Wistar rats approved by the Joint Ethical Committee of IMU and Postgraduate Medical Institute, Lahore. Only suture samples, coated uniformly with verified presence of the compound and of adequate length were used. Samples which were not coated uniformly and with inadequate length or damaged were excluded.

    PREDICTOR VARIABLE: Predictor variables were sutures with and without QAS coatings and different temperatures. Sutures were coated with QAS at 0.5 and 1.0% wt/vol using the dip coating technique and sutures with and without QAS coating were tested at 25 and 40 °C temperatures.

    MAIN OUTCOME VARIABLE(S): Outcome variables of structural and physico-mechanical properties of QAS-coated and non-coated sutures were measured using Fourier transform infrared spectroscopy (for structural changes), confocal laser and scanning electron (for diameter changes), and tensile strength/modulus (for mechanical testing). Biologic outcome variables were tested (bacterial viability); macrophage cultures from Wistar rats were tested (M1/M2 polarization detecting IL-6 and IL-10). Macrophage cells were analyzed with CD80+ (M1) and CD163+ (M2). Chemotaxis index was calculated as a ratio of quantitative fluorescence of cells.

    COVARIATES: Not applicable.

    ANALYSES: Ordinal data among groups were compared using the Wilcoxon Mann-Whitney U test along with the comparison of histological analysis using the Wilcoxon Sign-rank test (P 

    MeSH terms: Quaternary Ammonium Compounds/pharmacology; Quaternary Ammonium Compounds/chemistry; Animals; Anti-Infective Agents/pharmacology; Male; Materials Testing; Microscopy, Electron, Scanning; Surface Properties; Sutures*; Tensile Strength; Rats, Wistar*; Spectroscopy, Fourier Transform Infrared; Microscopy, Confocal; Rats
  13. Kong EQZ, Subramaniyan V, Lubau NSA
    Animal Model Exp Med, 2024 Aug;7(4):444-459.
    PMID: 38853347 DOI: 10.1002/ame2.12436
    This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health, elucidating the underlying mechanisms involving the Toll-like receptor 4 (TLR4)/Nuclear factor kappa light chain enhancer of activated B cells (NF-kB) pathway and the Cytochrome P450 2E1 (CYP2E1)/reactive oxygen species (ROS)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathways. The TLR4/NF-kB pathway, crucial for inflammatory and immune responses, triggers the production of pro-inflammatory agents and type-1 interferon, disrupting the balance between inflammatory and antioxidant responses when tissues are chronically exposed to alcohol. Alcohol-induced dysbiosis in gut microbes heightens gut wall permeability to pathogen-associated molecular patterns (PAMPs), leading to liver cell infection and subsequent inflammation. Concurrently, CYP2E1-mediated alcohol metabolism generates ROS, causing oxidative stress and damaging cells, lipids, proteins, and deoxyribonucleic acid (DNA). To counteract this inflammatory imbalance, Nrf2 regulates gene expression, inhibiting inflammatory progression and promoting antioxidant responses. Excessive alcohol intake results in elevated liver enzymes (ADH, CYP2E1, and catalase), ROS, NADH, acetaldehyde, and acetate, leading to damage in vital organs such as the heart, brain, and lungs. Moreover, alcohol negatively affects reproductive health by inhibiting the hypothalamic-pituitary-gonadal axis, causing infertility in both men and women. These findings underscore the profound health concerns associated with alcohol-induced damage, emphasizing the need for public awareness regarding the intricate interplay between immune responses and the multi-organ impacts of alcohol consumption.
    MeSH terms: Ethanol/pharmacology; Animals; Female; Humans; Male; Signal Transduction/drug effects; Reproductive Health*
  14. Zhao ZY, Zang Y, Li J, Choo YM, Xiong J, Hu JF
    Chem Biodivers, 2024 Dec;21(12):e202401520.
    PMID: 39221607 DOI: 10.1002/cbdv.202401520
    A previously undescribed triterpenoid (fortunefuroic acid J, 1) was isolated from the endangered conifer Keteleeria hainanensis, along with 20 other known terpenoids. Compound 1 is characterized by an unusual 3,4-seco-9βH-lanost-3-oic acid motif, featuring a rare furoic acid moiety in its lateral chain. The structure elucidation of this compound was achieved through a combination of spectroscopic and computational methods. The C-15 epimers of 15-methoxypinusolidic acid (15R-8 and 15S-9) were successfully separated and identified for the first time. Compound 1 demonstrated dual inhibitory effects against ATP-citrate lyase (ACL, IC50: 0.92 μM) and acetyl-CoA carboxylase 1 (ACC1, IC50: 10.76 μM). Compounds 2 and 11 exclusively inhibited ACL, exhibiting IC50 values of 2.64 and 6.35 μM, respectively. Compound 1 is classified among the fortunefuroic acid-type compounds, previously isolated from K. fortunei, distinguished by the presence of a rare furoic acid moiety in their lateral chain. The chemotaxonomic significance of the 9βH-lanost-26-oic acids in Keteleeria was briefly discussed. These findings highlight the importance of conserving plant species diversity, thereby enhancing the exploration of structurally diverse compounds and potential avenues for developing new therapeutics targeting ACL/ACC1-associated diseases.
    MeSH terms: Dose-Response Relationship, Drug; Structure-Activity Relationship; Molecular Docking Simulation
  15. Anggreini SN, Said FM, Ayudytha Ezdha AU, Filri DE, Wahyuni F, Ovari I
    J Pak Med Assoc, 2024 May;74(5 (Supple-5)):S27-S30.
    PMID: 39221794 DOI: 10.47391/JPMA.Ind-RInC-08
    OBJECTIVES: To determine the effect of hypertension education on self-care management in hypertensive patients in a rural setting.

    METHODS: The quasi-experimental study was conducted in January and February 2022 at the Senderak Village Health Centre, Bengkalis, Indonesia, and comprised hypertension patients without any complications referred to the community health centre between August 2021 and January 2022. The subjects underwent self-care education intervention. The knowledge level was assessed at baseline and post-intervention using the Hypertension Self-Management Behaviour Questionnaire. Data was analysed using IBM SPSS Statistic v23 software.

    RESULTS: All the 30(100%) patients were females, 12(40%) were aged 46-55 years, 20(66.7%) had received elementary school education and 25(83.3%) were housewives. There were 21(70%) respondents with stage II hypertension having systolic blood pressure ≥160mmHg. The mean level of knowledge about self-care management of hypertension increased significantly post-intervention (p<0.0001).

    CONCLUSION: Health education could improve knowledge on self-care management of hypertension in hypertensive patients.

    MeSH terms: Adult; Female; Humans; Indonesia; Health Knowledge, Attitudes, Practice*; Male; Middle Aged; Rural Population
  16. Awaluddin, Pristika A
    J Pak Med Assoc, 2024 May;74(5 (Supple-5)):S51-S54.
    PMID: 39221800 DOI: 10.47391/JPMA.Ind-RInC-14
    OBJECTIVE: To determine the effect of young coconut water on reducing blood pressure in hypertensive patients.

    METHODS: The quasi-experimental study was conducted in the work area of the Perhentian Luas Public Health Centre, Kuantan Singingi district, Riau province, Indonesia, from June 12 to 26, 2022, and comprised people aged >35 years with stage I hypertension. They were divided into intervention group A and control group B. Group A received young coconut water 150ml for 1 week once a day in the morning. Data was collected using observation sheets and blood pressure monitoring. Data was analysed using SPSS 20.

    RESULTS: Of the 30 subjects, 15(50%) were each in each of the two groups. All the 15(100%) respondents in group A were females, while there were 10(66.7%) males and 5(33.3%) females in group B. In both the groups, there were 8(53.3%) subjects aged 26-45 years and 7(46.7%) aged >45 years. Systolic and diastolic blood pressure before and after the intervention showed significant difference in group A (p<0.05), while the difference in group B was not significant (p>0.05).

    CONCLUSION: Consuming young coconut water every day for 7 days reduced blood pressure in hypertensive patients.

    MeSH terms: Adult; Cocos*; Female; Humans; Indonesia; Male; Middle Aged; Water
  17. Kow CS, Ramachandram DS, Hasan SS, Thiruchelvam K
    Int J Rheum Dis, 2024 Sep;27(9):e15325.
    PMID: 39221822 DOI: 10.1111/1756-185X.15325
    MeSH terms: Humans; Treatment Outcome
  18. Akmal Shukri AM, Wang SM, Feng C, Chia SL, Mohd Nawi SFA, Citartan M
    Analyst, 2024 Sep 02.
    PMID: 39221970 DOI: 10.1039/d4an00812j
    Aptamers are molecular recognition elements that have been extensively deployed in a wide array of applications ranging from diagnostics to therapeutics. Due to their unique properties as compared to antibodies, aptamers were also largely isolated during the COVID-19 pandemic for multiple purposes. Typically generated by conventional SELEX, the inherent drawbacks of the process including the time-consuming, cumbersome and resource-intensive nature catalysed the move to adopt in silico approaches to isolate aptamers. Impressive performances of these in silico-derived aptamers in their respective assays have been documented thus far, bearing testimony to the huge potential of the in silico approaches, akin to the traditional SELEX in isolating aptamers. In this study, we provide an overview of the in silico selection of aptamers against SARS-CoV-2 by providing insights into the basic steps involved, which comprise the selection of the initial single-stranded nucleic acids, determination of the secondary and tertiary structures and in silico approaches that include both rigid docking and molecular dynamics simulations. The different approaches involving aptamers against SARS-CoV-2 were illuminated and the need to verify these aptamers by experimental validation was also emphasized. Cognizant of the need to continuously improve aptamers, the strategies embraced thus far for post-in silico selection modifications were enumerated. Shedding light on the steps involved in the in silico selection can set the stage for further improvisation to augment the functionalities of the aptamers in the future.
  19. Chong WK, Ng BJ, Tan LL, Chai SP
    Chem Soc Rev, 2024 Sep 02.
    PMID: 39222069 DOI: 10.1039/d3cs01040f
    Photocatalytic water splitting represents a leading approach to harness the abundant solar energy, producing hydrogen as a clean and sustainable energy carrier. Zinc indium sulfide (ZIS) emerges as one of the most captivating candidates attributed to its unique physicochemical and photophysical properties, attracting much interest and holding significant promise in this domain. To develop a highly efficient ZIS-based photocatalytic system for green energy production, it is paramount to comprehensively understand the strengths and limitations of ZIS, particularly within the framework of solar-driven water splitting. This review elucidates the three sequential steps that govern the overall efficiency of ZIS with a sharp focus on the mechanisms and inherent drawbacks associated with each phase, including commonly overlooked aspects such as the jeopardising photocorrosion issue, the neglected oxidative counter surface reaction kinetics in overall water splitting, the sluggish photocarrier dynamics and the undesired side redox reactions. Multifarious material design strategies are discussed to specifically mitigate the formidable limitations and bottleneck issues. This review concludes with the current state of ZIS-based photocatalytic water splitting systems, followed by personal perspectives aimed at elevating the field to practical consideration for future endeavours towards sustainable hydrogen production through solar-driven water splitting.
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