METHODOLOGY: Briefly, 200 blood samples (100 cases and 100 controls) were collected at Life Center of Breast Cancer Control, Ibb City, Yemen. The whole blood samples were tested immediately for complete blood count (CBC) parameters. Socio-demographic and reproductive characteristics were collected by using a standardized questionnaire. Kolmogorov-Smirnov test, Unpaired t-test, Mann-Whitney test, Fisher's exact test and chi-square test for trends were calculated using GraphPad Prism 8.0.1. P-values ≤0.05 were statistically significant.
RESULTS: The mean and standard deviation (SD) revealed significant differences between BC group and the healthy control group attributed to the variables of age (P<0.0001), weight (P<0.0001), residence (P=0.0218), employment state (P<0.0001), economic state (P=0.0003), education levels (P<0.0001), regular exercise (P<0.0001) and a strict diet (P<0.0008). Marital state, marital age, number of births, and use of contraceptives demonstrated statistical significance (P<0.0001, P=0.0008, P=0.0009, and P<0.0001, respectively). Additionally, Hb, RBCs, WBCs count, neutrophils, lymphocytes and monocytes displayed significant differences (P=0.0393, P=0.0045, P=0.0327, P=0.0441, P=0.0098 and P<0.0001, respectively).
CONCLUSION: Hb, RBCs, WBCs, neutrophils, lymphocytes, monocytes and other parameters scored high points of evidence for BC surveillance. Further studies are required to evaluate hematological parameter differences and biochemical parameters after or during chemotherapy or mastectomy.
METHODS: A systematic search of the Web of Science, PubMed, and Cochrane Library databases was conducted using PRISMA guidelines. Ten studies investigating serum metabolite biomarkers of CRC and polyps using different analytical platforms and study populations were included. QUADOMICS tool was used to analyse the quality of the included studies. All reported metabolites were then enriched into the pathways using MetaboAnalyst 5.0.
RESULTS: We found that several potential signature metabolites overlapped between studies, including tyrosine, lysine, cystine, arabinose, and lactate for CRC and lactate and glutamate for polyps. The most affected pathways related to CRC were the urea cycle, glutathione metabolism, purine metabolism, glutamate metabolism, and ammonia recycling. In contrast, those affected in the polyps were the urea cycle, glutamate metabolism, glutathione metabolism, arginine and proline metabolism, and carnitine synthesis.
CONCLUSIONS: This review has found commonly detected serum metabolites for polyps and CRC with huge potential to be used in clinical settings. However, the differences between altered pathways in polyps and CRC, other external factors, and their effects on the regulation level, sensitivity, and specificity of each identified metabolite remained unclear, which could benefit from a further extensive cohort study and well-defined analysis equipment.
METHODS: This study is a cross-sectional study information was gathered from among 353 secondary school students in the Klang Valley using a questionnaire. The instrument that was used in this study was Pittsburgh Sleep Quality Index (PSQI) Malay version, screen-based media usage (SCREENS-Q) and Hopkins Symptom Check List-25 (HSCL-25) Malay version. The sampling method was stratified and convenience sampling method. The analysis study used the Smart Partial least squares (PLS) method to analyze the data.
RESULTS: Using the Smart PLS technique, we examined the relationship between these variables and identified revealed that screen time has a direct, positive, and significant impact on anxiety level (Mean = 0.134, β = 0.123, p 0.05) and depression (Mean = 0.044, β = 0.043, p
METHODS: In this study, bidirectional Mendelian randomization (MR) analysis, which includes MR-Egger, weighted median, weighted mode, and inverse variance weighted (IVW) approaches, was utilized to evaluate the bidirectional causal relationship between peripheral immune cell counts and the risk of PCa.
RESULTS: The primary analysis using the IVW method suggests a potential causal association between basophil counts and the risk of prostate cancer (PCa), with an odds ratio (OR) of 1.111 and a 95% confidence interval (CI) of 1.011-1.222 (P = 0.028). Conversely, non-causal associations have been observed between other peripheral immune cell types, such as white blood cells, neutrophils, lymphocytes, eosinophils, or monocytes, and the incidence of PCa (P values > 0.05). Furthermore, although reverse analysis indicated a causal link between PCa and the counts of leukocytes and neutrophils (OR = 1.013; 95% CI = 1.002-1.225; P = 0.018 and OR = 1.013; 95% CI = 1.002-1.025; P = 0.019), no causal association was detected between PCa and basophil count (P value > 0.050).
CONCLUSION: This study suggests a potential bidirectional link between peripheral immune cells and prostate cancer, but inconsistencies in Mendelian Randomization methods mean these findings are preliminary and require further investigation.
METHODS: We retrospectively collected data from January 2019 to December 2022 at Hospital Kuala Lumpur. The Myasthenia Gravis Activities of Daily Living (MG-ADL) scoring and the Myasthenia Gravis Foundation of America's Post Interventional Score (MGFA-PIS) measured our primary outcome. Secondary outcomes included surgery-related morbidity. All patients underwent a UVATS thymectomy, with the incision at the right anterior axillary line at the 5th intercostal space.
RESULTS: Out of 26 patients, 22 were analysed. The MG-ADL scores indicated a significant mean score reduction post-surgery [6.9; 95% confidence interval (CI): 4.42 to 9.67; P<0.001]. NTMG patients exhibited a greater decrease in MG-ADL mean score than TMG patients {9.5 [standard deviation (SD) 4.8] vs. 6.1 (SD 5.4) P<0.001}. The MGFA-PIS showed complete stable remission (CSR) rates of 43% for TMG and 25% for NTMG patients. Surgical morbidity was observed in 13% of patients, of which were myasthenic crisis, difficult extubation due to carbon dioxide (CO2) retention and subcutaneous emphysema.
CONCLUSIONS: Thymectomy via UVATS is an effective and safe approach for improving symptoms in both TMG and NTMG patients.
METHODS: We primarily endeavored to comprehensively investigate the prognostic and predictive value of PSMD11 in patients with LUAD. Additionally, we aimed to further clarify the underlying mechanisms of PSMD11 in LUAD tumorigenesis and progression via rigorous bioinformatics analyses, including expression analysis, survival analysis, clinicopathological analysis, immune microenvironment analysis, somatic mutation analysis, drug analysis, and cuproptosis analysis. Subsequently, we examined effect of PSMD11 expression on immune escape in a non-small cell lung cancer (NSCLC) cell-T cell coculture model.
RESULTS: We found that PSMD11 had a significantly higher expression in LUAD tissues than in normal lung tissues. Three clinical characteristics (age, stage, and overall survival event) exhibited significant differences between the PSMD11 high- and low-expression groups. In biological function, PSMD11 appears to exert its tumorigenic effects predominantly in pathways related to DNA replication and membrane-gated channel functions. Notably, we observed that PSMD11 exhibited the strongest positive correlation with T helper 2 cells, gamma-delta T cells, and T regulatory cells and the highest negative correlation with B cells, mast cells, and CD8+ T cells. Furthermore, we found that the expression of cuproptosis genes (DLAT, DLD, and PDHA1) was positively correlated with the expression of PSMD11 (P<0.001).
CONCLUSIONS: These results indicate that PSMD11 has the potential to be a novel therapeutic target and sensitive biomarker for patients with LUAD.
METHODS: Using the China Comprehensive Social Survey as the data source and considering social mentality and social identity, we constructed corresponding statistical models to explore how sports participation influences the social identity (class identity, economic status, and emotional belonging) of Chinese university students.
RESULTS: Regarded from a holistic perspective, sports participation can enhance the social identity of college students in all its aspects, and the benefits of sports participation are positively related to its frequency. Under the condition of social mentality, sports participation has a positive effect on the social identity of college students in general and a nonsignificant effect only on certain dimensions. Under the social identity condition, the significance of sports participation for college students' social identity decreases from lower to higher levels of education.
CONCLUSION: Sports participation significantly enhances the social identity of Chinese university students, and the specific mechanism of the enhancement varies across the social mentality and social identity conditions. In this context, strengthening the role of sports participation in promoting the social identity of college students in the new era is necessary. Deepening the ideological content of physical education courses should be taken as the starting point to enhance the effectiveness of sports participation on the social identity of college students under the condition of social mentality. The effectiveness of sports participation on the social identity of college students with different social identities should be differentiated and enhanced.
METHODS: This study develops a veterinary talent competitiveness evaluation index based on the characteristics of veterinary talent. It proposes a visual method to analyze the level and spatiotemporal evolution of veterinary talent competitiveness using the Entropy method and ArcGIS tools, with Western China as a case study. Data is collected from 12 regions in Western China, spanning 2015 to 2021.
RESULTS: The results show that the method not only evaluates the current state of veterinary talent competitiveness but also considers temporal and spatial evolution, achieving good evaluation effectiveness and high accuracy, thereby guiding the improvement of veterinary education and talent cultivation.
DISCUSSION: Based on the research findings, the study suggests improving the quality of veterinary education and talent cultivation through measures such as strengthening talent resource development, addressing regional imbalances, and promoting spatial integration to achieve a virtuous cycle between veterinary education and industrial development.
METHODS: The extracts were prepared and initially assessed for their phytochemical composition and antibacterial activity. Then, AgNPs were synthesized from these extracts at room temperature, and various analytical techniques, including UV-visible spectroscopy, X-ray diffraction (XRD), ATIR-FTIR, zeta sizer, scanning electron microscopy (SEM), and energy-dispersive X-ray analysis (EDXA), were used to characterize the NPs. After confirmation of prepared NPs, they were subjected to their antibacterial activity.
RESULTS: HPLC analysis demonstrated the presence of eight phytoconstituents in organic ginger extracts. The absorption spectra of the silver suspension exhibited surface plasmon resonance peaks with maxima between 420 and 448 nm. Functional groups like C-H, N-H, OH, C-O-C, C=O, and C-O were identified in both the organic and aqueous extracts of Z. officinale, playing a key role in the formation of AgNPs, as characterized by ATR-FTIR analysis. Both ginger organic and aqueous extract synthesized AgNPs crystalline structure was shown in XRD analysis and the particle size distribution showed average diameter of 200.5 nm of AgNPs from aqueous extracts. Scanning Electron Microscopy displayed spherical structure and EDA results showed the percentage of elements in synthesized AgNPs using plant extracts. Most promising antibacterial activity was obtained against Escherichia coli ie 20.83±0.53 for 100 µg/mL.
CONCLUSION: The results of the current study showed that AgNPs synthesized from different ginger extracts have promising antibacterial properties and can be potential candidates for alternative treatment options for bacterial infections.