Browse publications by year: 2024

  1. Zhou XD, Chen QF, Yang W, Zuluaga M, Targher G, Byrne CD, et al.
    EClinicalMedicine, 2024 Dec;78:102958.
    PMID: 39640937 DOI: 10.1016/j.eclinm.2024.102958
    [This corrects the article DOI: 10.1016/j.eclinm.2024.102848.].
  2. Fang J, Tan YC, Tai VC, Janasekaran S, Kee CC, Wang D, et al.
    Heliyon, 2024 Nov 30;10(22):e40200.
    PMID: 39641018 DOI: 10.1016/j.heliyon.2024.e40200
    This paper provides an in-depth review of the advancements and challenges associated with Titanium Matrix Composites (TMCs) in Selective Laser Melting (SLM). Material selection, SLM processing parameters, and their influence on the microstructure and properties of TMCs are discussed. The relationship between processing parameters, material characteristics, and the development of defects such as balling, porosity, and cracking is examined. Critical factors influencing the evolution of microstructure and defect formation in TMCs processed by SLM are highlighted. Strengthening mechanisms such as dislocation movements, grain refinement, the Orowan process, and load-bearing capacity are analyzed, and their roles in enhancing hardness, tensile strength, corrosion resistance, and wear resistance are explored. It is indicated by key findings that less than 5 % reinforcement content by volume can significantly enhance mechanical properties, achieving maximum hardness values of approximately 1000 HV and tensile strength close to 1500 MPa. However, this improvement is accompanied by a notable decrease in elongation. The importance of optimizing SLM parameters such as laser power, scan speed, hatch distance, layer thickness, and particle contents to minimize defects and enhance material performance is underscored. Existing research gaps in defect management and material distribution are identified. Future research directions on improving TMCs performance through advanced SLM techniques are suggested.
  3. Nugroho A, Kozin M, Mamat R, Bo Z, Ghazali MF, Kamil MP, et al.
    Heliyon, 2024 Nov 30;10(22):e39742.
    PMID: 39641056 DOI: 10.1016/j.heliyon.2024.e39742
    The transition to electric vehicles (EVs) calls for sustainable advancements in automotive lubricants, as traditional fossil-fuel-based products pose environmental challenges. Palm oil-based biolubricants enriched with nanoparticles present a promising eco-friendly alternative that meets the thermal and tribological demands of EVs. This paper aims to analyze the development of nanoparticle-enriched palm oil-based biolubricants, aimed at improving the sustainability and performance of electric vehicle (EV) lubrication systems. The critical findings highlight that integrating nanoparticles such as graphene, titanium dioxide, and aluminum oxide into palm oil-based lubricants significantly enhances their tribological properties. These enhancements include a 26.21%-34% reduction in coefficient of friction (COF), a 12.99%-30% reduction in wear, and improved thermal stability. The study found that nanoparticle-enriched biolubricants outperformed traditional options in terms of friction and wear under high-temperature and pressure conditions, as supported by regression analysis. The study demonstrates that nanoparticle-enriched biolubricants offer a viable eco-friendly alternative to conventional lubricants, lowering the environmental impact by reducing greenhouse gas emissions and energy consumption. This innovation has significant implications for both the environment and industry, offering a sustainable solution that reduces dependency on fossil fuels, enhances EV efficiency, and aligns with global sustainability goals. Besides, this paper discusses biolubricants drawbacks and future studies direction.
  4. Alotaibi MA, Malik T, Naeem A, Khan AS, Ud Din I, Shaharun MS
    Heliyon, 2024 Nov 30;10(22):e40521.
    PMID: 39641067 DOI: 10.1016/j.heliyon.2024.e40521
    Deep eutectic solvents are a novel class of solvents that have gained much attention with time due to their biodegradability, non-volatility, non-toxicity and low-cost. In this work, a novel ternary deep eutectic solvent (TDES) was synthesized using ethaline (ChCl:EG) and glycine, with the addition of carboxylic acids. The synthesized material was characterized through Fourier-transform infrared spectroscopy (FTIR). While the thermal stability and physical properties such as density, viscosity, surface tension and refractive index were also determined). To estimate the critical properties, modified version of Lyderson-Joback-Reid (LJR) and Lee-Kesler mixing (Alkhatib et al., 2020) [1] methods were used. The density of the DES was calculated using the Spencer and Danner correlation and the obtained values were compared with experimental data. FTIR analysis confirmed that hydrogen bonding is the main driving force responsible for the formation of the deep eutectic solvents. The physical properties of the binary DES system, such as viscosity, density,and thermal stability of the system were enhanced after the incorporation of a third component (carboxylic acid) to the system. However, the surface tension of the TDES system decrease with the increasing amounts of the third component, likely due to increase in the void radius of the TDES. Thus investigation is considering as novel work to check the influence of carboxylic acids on the physical properties of binary deep eutectic solvent systems.
  5. Eusufzai SZ, Then BYK, Jamayet NB, Maqbool M, Noorani TY, Ahmad WMAW, et al.
    Work, 2024;79(3):1465-1475.
    PMID: 38848148 DOI: 10.3233/WOR-220174
    BACKGROUND: Obstructive Sleep Apnea (OSA) is a temporary airflow obstruction during periods of sleep. Patients with OSA often suffer from poor work performance, compromised sleep quality, and low quality of life which may lead to a life-threatening event. Adequate knowledge and a positive attitude toward OSA among medical and dental practitioners are crucial to the initial diagnosis and treatment.

    OBJECTIVE: This study aimed to identify the differences in knowledge and attitude toward OSA between medical and dental practitioners working in North-Eastern Peninsular Malaysia.

    METHODS: A comparative cross-sectional study was performed from February 2020 to February 2021. A total of fifty-two medical practitioners and fifty-two dental practitioners working at university-based outpatient clinics, government health clinics, and oral health clinics located in Kelantan State of Malaysia participated in the study, and data were collected by the structured questionnaire including sociodemographic inquiry and OSAKA questionnaire by non-probability stratified random sampling. The Mann-Whitney U test was used to compare knowledge and attitude scores between the two groups.

    RESULTS: The mean age of the respondents was 34.6 years. The current study shows that 92.3% of medical doctors and 96.1% of dental doctors were able to correctly answer the question "Most of the patients with OSA snore" a significant finding in our study. Only 1% of medical professionals could answer seventeen questions correctly with a median score of 11, and only 1% of dental professionals could answer sixteen questions correctly with a median score of 9. None of them could provide an accurate answer to all the knowledge questions. Medical and dental practitioners exhibited different knowledge levels on OSA (z- statistics=-4.39, U = 827.00 with p <  0.05, and effect size, r = 0.61). However, no significant differences were found in total knowledge score by gender (p-value>0.05), ethnicity (p-value>0.05), total service years (p-value>0.05), and training attended. In addition, significant differences in attitude levels between medical and dental practitioners have been observed (z-statistics=-3.42, U = 725.00 with p <  0.05, and effect size, r = 0.47). Nevertheless, no significant differences have been seen in total attitude score by ethnicity (p-value >  0.05), total service years (p-value >  0.05), attending training on OSA (p-value >  0.05), and professional status (p-value >  0.05) except gender (p-value <  0.05).

    CONCLUSION: A Significant difference is evident concerning knowledge and attitude toward OSA diagnosis and management between medical and dental practitioners working in North-Eastern Peninsular Malaysia. Medical practitioners in this study recorded a higher knowledge and attitude score compared to dental practitioners.

    MeSH terms: Adult; Attitude of Health Personnel; Cross-Sectional Studies; Female; Humans; Health Knowledge, Attitudes, Practice*; Malaysia; Male; Middle Aged; Physicians/psychology; Physicians/statistics & numerical data; Surveys and Questionnaires
  6. Purushothaman VK, Ramalingam V, Subbarayalu AV, Raman V, Prabaharan S, Subramaniam A, et al.
    Work, 2024;79(3):1557-1565.
    PMID: 39121147 DOI: 10.3233/WOR-230745
    BACKGROUND: The global implementation of full-time telework became widespread during the new normal conditions following the pandemic, resulting in reduced physical activity (PA) among teleworkers and young adults. It is vital to comprehend how telehealth interventions favorably impact PA levels and overall well-being of young adults who face increasingly blurred boundaries between work and home life.

    OBJECTIVES: The aim of this study is to examine the effect of telerehabilitation (TR) on PA levels and quality of life (QoL) in young adult teleworkers.

    METHODS: A quasi-experimental study was conducted on 82 teleworkers (54 females and 28 males). Levels of PA and QoL were assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF) and the Health-Related Quality of Life (HRQOL-14) questionnaire. TR was provided to all participants for four weeks, three times a week, for 40 minutes per session. Levels of PA and QoL were evaluated at baseline and after four weeks of the intervention. Data were analyzed using descriptive and inferential statistics.

    RESULTS: After four weeks of TR, there has been a significant improvement in the scores of IPAQ and HRQOL-14 (p 

    MeSH terms: Telerehabilitation*; Adult; Female; Humans; Male; Surveys and Questionnaires; Young Adult
  7. Finn D, Cardini F, Aspell JE, Swami V, Todd J
    Body Image, 2024 Dec;51:101777.
    PMID: 39128330 DOI: 10.1016/j.bodyim.2024.101777
    Interpersonal distance (IPD) refers to the distance naturally maintained during social interactions, while peripersonal space (PPS) refers to the immediate space surrounding the body, or the space within reaching distance. Previous research has preliminarily indicated that IPD is associated with body image disturbances. We sought to expand extant literature by exploring associations between aspects of positive and negative body image, IPD, and PPS. Seventy-five women from the United Kingdom aged 18-40 years completed measures of body appreciation, body image flexibility, body shame, body surveillance, and body dissatisfaction. IPD boundaries were estimated using a lab-based comfort-distance task, whereas PPS boundaries were estimated using an audio-tactile reaction-time task. Measures of body acceptance by others and fear of negative evaluation were completed as potential mediators. Overall, we identified positive associations between IPD, body surveillance, and fear of negative evaluation, with no statistically significant associations identified between the other indices. The association between active IPD and body surveillance was mediated by fear of negative evaluation, even after controlling for demographic factors. These findings suggest a nuanced relationship between IPD and body image-related factors, highlighting the role of social evaluation anxiety. Future investigations should use experimental designs to further understand these relationships and their implications.
    MeSH terms: Adolescent; Adult; Female; Great Britain; Humans; Interpersonal Relations; Personal Space*; Self Concept; Shame; Social Distance; Young Adult
  8. Tagiling N, Ngo HW, Sahran NF, Mohamad Kamarulzaman MD, Wong MK, Mustaffa N, et al.
    J Gastroenterol Hepatol, 2024 Nov;39(11):2465-2467.
    PMID: 39188097 DOI: 10.1111/jgh.16729
  9. Collet C, Sakai K, Mizukami T, Ohashi H, Bouisset F, Caglioni S, et al.
    JACC Cardiovasc Imaging, 2024 Dec;17(12):1463-1476.
    PMID: 39269414 DOI: 10.1016/j.jcmg.2024.07.018
    BACKGROUND: Approximately one-half of the patients with angina and nonobstructive coronary artery disease (ANOCA) have evidence of coronary microvascular dysfunction (CMD).

    OBJECTIVES: This study aims to characterize patients with ANOCA by measuring their minimal microvascular resistance and to examine the pattern of vascular remodeling associated with these measurements.

    METHODS: The authors prospectively included patients with ANOCA undergoing continuous thermodilution assessment. Lumen volume and vessel-specific myocardial mass were quantified using coronary computed tomography angiography (CTA). CMD was defined as coronary flow reserve <2.5 and high minimal microvascular resistance as >470 WU.

    RESULTS: A total of 153 patients were evaluated; 68 had CMD, and 22 of them showed high microvascular resistance. In patients with CMD, coronary flow reserve was 1.9 ± 0.38 vs 3.2 ± 0.81 in controls (P < 0.001). Lumen volume was significantly correlated with minimal microvascular resistance (r = -0.59 [95% CI: -0.45 to -0.71]; P < 0.001). In patients with CMD and high microvascular resistance, lumen volume was 40% smaller than in controls (512.8 ± 130.3 mm3 vs 853.2 ± 341.2 mm3; P < 0.001). Epicardial lumen volume assessed by coronary CTA was independently associated with minimal microvascular resistance (P < 0.001). The predictive capacity of lumen volume from coronary CTA for detecting high microvascular resistance showed an area under the curve of 0.79 (95% CI: 0.69-0.88).

    CONCLUSIONS: Patients with CMD and high minimal microvascular resistance have smaller epicardial vessels than those without CMD. Coronary CTA detected high minimal microvascular resistance with very good diagnostic capacity. Coronary CTA could potentially aid in the diagnostic pathway for patients with ANOCA.

    MeSH terms: Aged; Angina Pectoris/etiology; Angina Pectoris/physiopathology; Coronary Circulation*; Female; Humans; Male; Microcirculation*; Middle Aged; Predictive Value of Tests*; Prospective Studies; Thermodilution; Vascular Resistance*; Case-Control Studies; Coronary Angiography*; Fractional Flow Reserve, Myocardial; Vascular Remodeling*; Computed Tomography Angiography*
  10. Arora E, Regan R, Surendra VU, Arumugam A
    Diabetes Metab Syndr, 2024 Sep;18(9):103124.
    PMID: 39326343 DOI: 10.1016/j.dsx.2024.103124
    BACKGROUND: Peripheral arterial disease (PAD) is a prevalent complication of type 2 diabetes mellitus (T2DM). As India ranks second in the population afflicted by T2DM, and the objective of this systematic review was to estimate the pooled prevalence of PAD in individuals living with T2DM in India.

    METHODS: Five databases (Cochrane (CENTRAL), MEDLINE (via PubMed), CINAHL (via EBSCO), PEDro, and Scopus) were searched using database-specific search terms from inception to August 2023. Inclusion criteria included studies reporting the prevalence of PAD in Indian adults diagnosed with T2DM of either or both sexes, employing ankle brachial index measurements with a Doppler test or sphygmomanometer. The risk of bias was evaluated using the JBI checklist, and the certainty of evidence was determined via the GRADE approach.

    RESULTS: Twenty-three articles met the inclusion criteria which comprised of 196,883 individuals with T2DM aged between 30 and 70 years from nine states and one union territory. Utilizing a random effects model, the meta-analysis revealed that the pooled prevalence of PAD among individuals with T2DM in India was 18 % (95 % confidence interval: 10-28 %), with statistically significant heterogeneity observed between studies (I2 = 100 %, P 

    MeSH terms: Humans; India/epidemiology; Prognosis; Prevalence
  11. Makeswaran P, Shah SA, Safian N
    Am J Trop Med Hyg, 2024 Dec 04;111(6):1280-1289.
    PMID: 39353414 DOI: 10.4269/ajtmh.24-0224
    Tuberculosis (TB) occurs as one of the highest in the state of Selangor, Malaysia and its causes are currently underexplored especially from patients' perspectives of the disease. This study assesses perspectives from patients in relations to determinants of delayed presentation, diagnosis, and treatment of TB. The study utilises a qualitative methodology involving focus group discussions and in-depth interviews with patients selected based on specific inclusion and exclusion criteria. The research covered components which include social demographic, sociocultural factors, health-seeking behaviors, social support and resources, previous knowledge and experience as a TB patient, and treatment pathway. Thematic analysis was performed using NVivo 12 analysis software to interpret the data. This study aims to identify key barriers and facilitators of prompt presentation and diagnosis of TB patients. Results revealed that socioeconomic status, challenges faced during TB diagnosis and treatment, knowledge of TB, patient and healthcare-related factors, and health-seeking behaviours were the main emerging themes. Improvements are required in the areas of access to healthcare facilities, minimizing cost, providing specific clinics and proximity of health facilities to facilitate a prompt response, increasing capacity to isolate infected persons, and provision of adequate treatment. It is revealed that financial constraints, inaccessibility and long distance to healthcare facilities, poor knowledge of TB, and lack of family and social support contributed to delayed TB presentation and diagnosis. Findings from this study can be utilized to develop effective, locally tailored interventions to address delayed presentation and diagnosis of TB patients in the nation.
    MeSH terms: Adolescent; Adult; Aged; Female; Health Services Accessibility*; Humans; Health Knowledge, Attitudes, Practice*; Malaysia/epidemiology; Male; Middle Aged; Patient Acceptance of Health Care*; Social Support; Focus Groups; Qualitative Research*; Young Adult; Delayed Diagnosis
  12. Wang Y, Chong KC, Ren C
    Environ Res, 2024 Dec 15;263(Pt 2):120091.
    PMID: 39368600 DOI: 10.1016/j.envres.2024.120091
    BACKGROUND: Multiple studies have reported the profound influence of various climate factors on dengue fever infection, while the effects of joint exposure to warm and wet environment, a condition favouring dengue vectors, on disease transmission were less evaluated. This study aims to investigate the impact of various compound temperature, rainfall, and relative humidity exposures on dengue fever infection in the South and Southeast Asia regions.

    METHODS: Weekly dengue fever surveillance data from 2012 to 2020 were collected from 48 locations in four countries named Singapore (1 location), Sri Lanka (15 locations), Malaysia (9 locations), and Thailand (23 locations, with 11 locations having different study periods). The distributed lag non-linear models were built to assess the impacts of compound temperature, rainfall, and relative humidity exposures on dengue fever infection risks.

    RESULTS: A total of 1,359,993 dengue fever cases were reported with 9.33%, 24.02%, 48.73%, and 17.91% cases contributed by Singapore, Sri Lanka, Malaysia, and Thailand, respectively. Compared to non-warm-non-wet, compound warm-wet was associated with an increased dengue risk (RR:1.32, 95% CI:1.21-1.44). Compared to moderate temperature-humidity, warm-wet environment was also associated with an increase in dengue risk (RR:1.37, 95% CI:1.22-1.55). In comparison to weeks with moderate temperature-rainfall, warm-wet weeks was linked to an elevated dengue risk (RR:1.39, 95% CI:1.27-1.52), whereas cold-dry weather would significantly reduce the infection risk (RR:0.70, 95% CI:0.62-0.80). Modification effects showed that the hot effect on dengue infection was more pronounced under higher humidity, while the impact of rainfall increased with warmer temperature.

    CONCLUSION: Warm-wet events were associated with an increased dengue fever risk, while the infection risk would decline in cold-dry environment, and modification effects exist among exposures. Findings from this study highlight the importance of considering joint temperature, humidity, and rainfall dependency of dengue fever infection in disease prevention and control.

    MeSH terms: Asia, Southeastern/epidemiology; Humans; Humidity*; Malaysia/epidemiology; Rain; Sri Lanka/epidemiology; Temperature*; Thailand/epidemiology
  13. Mo L, Crowther TW, Maynard DS, van den Hoogen J, Ma H, Bialic-Murphy L, et al.
    Nat Ecol Evol, 2024 Dec;8(12):2195-2212.
    PMID: 39406932 DOI: 10.1038/s41559-024-02564-9
    The density of wood is a key indicator of the carbon investment strategies of trees, impacting productivity and carbon storage. Despite its importance, the global variation in wood density and its environmental controls remain poorly understood, preventing accurate predictions of global forest carbon stocks. Here we analyse information from 1.1 million forest inventory plots alongside wood density data from 10,703 tree species to create a spatially explicit understanding of the global wood density distribution and its drivers. Our findings reveal a pronounced latitudinal gradient, with wood in tropical forests being up to 30% denser than that in boreal forests. In both angiosperms and gymnosperms, hydrothermal conditions represented by annual mean temperature and soil moisture emerged as the primary factors influencing the variation in wood density globally. This indicates similar environmental filters and evolutionary adaptations among distinct plant groups, underscoring the essential role of abiotic factors in determining wood density in forest ecosystems. Additionally, our study highlights the prominent role of disturbance, such as human modification and fire risk, in influencing wood density at more local scales. Factoring in the spatial variation of wood density notably changes the estimates of forest carbon stocks, leading to differences of up to 21% within biomes. Therefore, our research contributes to a deeper understanding of terrestrial biomass distribution and how environmental changes and disturbances impact forest ecosystems.
    MeSH terms: Wood*; Biomass; Forests*
  14. Wang ZJ, Zhan XY, Ma LY, Yao K, Dai HY, Kumar Santhanam R, et al.
    Biochem Pharmacol, 2024 Dec;230(Pt 2):116577.
    PMID: 39427919 DOI: 10.1016/j.bcp.2024.116577
    Triple-negative breast cancer (TNBC) is currently the only subtype lacking efficient targeted therapies. Taxol is the primary chemotherapeutic agent for TNBC. However, Taxol resistance often develops in the treatment of TNBC patients, which importantly contributes to high mortality and poor prognosis in TNBC patients. Recent preclinical studies have shown that the inhibition of Notch pathway by γ-secretase inhibitors can slow down the progression of TNBC. Our studies in bioinformatic analysis of breast cancer patients and TNBC/Taxol cells in vitro showed that there was high correlation between the activation of Notch pathway and Taxol resistance in TNBC. Increased γ-secretase activity (by the overexpression of catalytic core PSEN-1) significantly reduced Taxol sensitivity of TNBC cells, and enhanced biological characteristics of malignancy in vitro, and tumour growth in vivo. Mechanistically, increased γ-secretase activity led to the accumulation of NICD in the nucleus, promoting the interaction between NICD and PXR to activate PXR, which triggered the transcription of PXR downstream associated drug resistance genes. Furthermore, we showed that pharmacological inhibition of γ-secretase with γ-secretase inhibitors (Nirogacestat and DAPT) can reverse Taxol resistance in vivo and in vitro. Our results for the first time demonstrate that the activation of γ -secretase/NCD-PXR/Notch pathway is one of important mechanisms to cause Taxol resistance in TNBC, and the blockades of this pathway may represent a new therapeutic strategy for overcoming Taxol resistance in TNBC.
    MeSH terms: Animals; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Agents, Phytogenic/therapeutic use; Female; Humans; Mice, Nude; Xenograft Model Antitumor Assays/methods; Cell Line, Tumor; Mice
  15. Swami V, Graf HM, Biebl S, Schmid T, Siebenhandl A, Willinger D, et al.
    Body Image, 2024 Dec;51:101803.
    PMID: 39490064 DOI: 10.1016/j.bodyim.2024.101803
    Previous studies have shown that exposure to simulated natural environments can elevate state body appreciation, but stimulus sets have been limited to the use of images and 2-dimensional (2D) film. To extend this work, we examined the relative impact of images, 2D film, and a 360° immersive film on immediate, state body appreciation. A total of 136 German-speaking adults from Austria (71.3 % women; age range 18-69 years) were randomly assigned to one of three conditions, in which they viewed an image set, a 2D film, or a 360° film depicting the same natural environment. Before and after viewing the stimuli, they completed measures of state body appreciation, affect, and desire for aesthetics. Our results showed that state body appreciation improved in all three conditions, with effect sizes ranging from Cohen's d = 0.26 (2D film) to 0.52 (360° film). Presentation modality did not significantly shape improvements in state body appreciation; that is, the elevation in state body appreciation was equivalent across all three groups. Participants also experienced improvements in feelings of pleasantness, but again this was independent of the experimental group. These results suggest exposure to simulated nature may improve state body appreciation irrespective of the presentation modality.
    MeSH terms: Adolescent; Adult; Aged; Austria; Esthetics; Female; Humans; Male; Middle Aged; Motion Pictures as Topic*; Personal Satisfaction; Random Allocation; Nature; Young Adult
  16. Al-Obaidi MMJ, Al Siyabi MSK, Muthanna A, Mohd Desa MN
    Tissue Barriers, 2024 Dec 04.
    PMID: 39629682 DOI: 10.1080/21688370.2024.2434764
    This review investigates the pathogenic processes through which Streptococcus pneumoniae crosses the blood-brain barrier (BBB) to cause meningitis, with a focus on the interaction with host receptors in the central nervous system (CNS). S. pneumoniae a primary cause of bacterial meningitis, utilizes unique receptor-mediated pathways to infiltrate the BBB. The bacterial interaction with the platelet-activating factor receptor (PAFR) and the polymeric immunoglobulin receptor (pIgR) is looked at in this study. The goal is to understand how this interaction helps the bacterium move across the BBB and cause infection in the CNS. We examine the functions of cellular and molecular participants at the endothelium level, such as cytokines, chemokines, and matrix metalloproteinases (MMP), which have a role in the development of the disease. This study consolidates data from multiple studies, providing a thorough summary of the interactions between S. pneumoniae and the BBB. It also explores potential treatment targets that could reduce the significant illness and death rates associated with pneumococcal meningitis.
  17. Ajit Singh V, Ying Jing O, Santharalinggam RD, Yasin NF
    J Orthop Surg (Hong Kong), 2024;32(3):10225536241306917.
    PMID: 39629838 DOI: 10.1177/10225536241306917
    Background: Bipolar hip endoprosthesis replacement is a commonly employed procedure in orthopaedic oncology that requires the resection and reconstruction of the proximal femur. With improving survival rates, issues of implant durability and acetabular wear have become increasingly important. The decision to replace the acetabulum in bipolar hip endoprosthesis replacement procedures remains a topic of debate. Aim: This study aimed to assess the prevalence of secondary osteoarthritis following bipolar hip replacement, the need for revision to total joint replacement post-procedure, the functional status of patients in relation to radiological findings of joint degeneration, and the survivorship of bipolar hip replacements. Methods: Patients with orthopaedic oncology cases who underwent bipolar hip endoprosthesis replacement between 2006 and October 2021, with a minimum follow-up of six months, were included. Both clinical and radiological evaluations were carried out. The clinical evaluation utilised the Musculoskeletal Tumor Society (MSTS), Toronto Extremity Salvage Score (TESS), and modified Harris Hip Score (mHHS) systems. The radiological assessment focused on identifying acetabular erosion. Results: Forty eligible patients were identified. Radiological assessments revealed 21 patients (52.5%) with grade 0, 17 patients (42.5%) with grade 1, and 2 patients (5.0%) with grade 2 acetabular erosion. No patients exhibited grade 3 acetabular erosion. One patient (2.5%) required revision surgery from proximal femoral bipolar replacement to total hip replacement due to recurrent postoperative hip dislocation. There was no statistically significant difference in MSTS and mHHS scores but a significant difference in TESS scores. The ten-year implant survival rate was 77.8%, while the overall patient survivorship at ten years was 72.1%. Conclusion: Bipolar hip replacement is a durable limb-preserving reconstruction that can outlast patients' lifespans and is well-tolerated by oncology patients. The incidence of acetabular erosion and revision surgery is low. Despite radiological evidence of hip degeneration, functional status in patients is not significantly impacted.
    MeSH terms: Adult; Aged; Aged, 80 and over; Bone Neoplasms/surgery; Female; Hip Prosthesis; Humans; Male; Middle Aged; Postoperative Complications/epidemiology; Prosthesis Failure; Retrospective Studies; Osteoarthritis, Hip/surgery
  18. Karupaiah T, Rahman SMM, Zhang J, Kumar N, Jamiyan B, Pokharel RK, et al.
    JMIR Pediatr Parent, 2024 Dec 04;7:e63410.
    PMID: 39630493 DOI: 10.2196/63410
    BACKGROUND: Rising childhood obesity rates in Asia are adding risk for the future adult burden of obesity and noncommunicable diseases. Weak policies across most Asian countries enable unrestricted marketing of obesogenic foods and beverages to children. Television is the common medium for food marketing to reach this audience.

    OBJECTIVE: This study aimed to assess the extent and nature of television food and nonalcoholic beverage marketing in 9 Asian countries (Bangladesh, China, India, Malaysia, Mongolia, Nepal, the Philippines, Sri Lanka, and Vietnam) with capacity building support from the International Network for Food and Obesity/Non-Communicable Disease Research, Monitoring and Action Support, who enabled harmonization of data collection method and content analyses.

    METHODS: Advertised foods were categorized as permitted or not permitted based on the nutrient profile models established by the World Health Organization regional offices for South-East Asia (SEARO) and the World Health Organization regional offices for Western Pacific (WPRO). Overall rates of food advertisements (advertisements per hour per channel) and persuasive strategy use were analyzed along with comparisons between children's peak viewing time (PVT) and non-PVT.

    RESULTS: Cross-country comparisons, irrespective of country income level, indicated that not permitted food advertising dominated children's popular television channels, especially during PVT with rates as per WPRO or SEARO criteria ranging from 2.40/2.29 (Malaysia) to 9.70/9.41 advertisements per hour per channel (the Philippines). Persuasive strategy rates were also comparatively higher during PVT. Sugar-sweetened beverages, sugar-containing solid foods, and high salt- and fat-containing snacks and fast foods were frequently advertised. Evaluation of the application of WPRO and SEARO nutrient profile models identified inconsistencies due to regional taste and cuisine variations across Asia.

    CONCLUSIONS: This study clearly showed that unhealthy food marketing through popular children's television channels is widely occurring in Asia and is a clear breach of child rights. Evidence outcomes will benefit advocacy toward stronger policy regulations to control unhealthy food marketing and strengthen strategies to promote a healthier food environment for Asia's children.

  19. Zhang J, Geok Soh K, Bai X, Mohd Anuar MA, Xiao W
    PLoS One, 2024;19(12):e0311957.
    PMID: 39630649 DOI: 10.1371/journal.pone.0311957
    BACKGROUND: There is a notable gap in systematic reviews concerning hybrid pedagogical models (PMs) integrated with the Sport Education Model (SEM) and their impact on students' outcomes.

    PURPOSE: Which hybrid PMs incorporating SEM are currently the mainstream choices in research, and what are the main factors supporting their integration? How does SEM function as a foundational model in these hybrid teaching approaches? What learning outcomes are optimized through the hybrid models that combine SEM with other PMs?

    METHODS: A systematic search was conducted in major databases in December 2023 following PRISMA guidelines. Out of the identified 1342 studies, 30 met the eligibility criteria, all of which were deemed to be of high quality.

    RESULTS: Seven hybrid types were identified, primarily composed of two PMs, among which the blend of SEM and Teaching Games for Understanding (TGfU) emerges as the mainstream in current research. SEM, serving as the foundational structure, provides a stable framework for the hybrid, termed the "SEM + 1 model," yielding positive effects on enhancing students' learning outcomes.

    CONCLUSIONS: Pedagogical models align with PMs' motivational aspects, thus enhancing learning outcomes. However, evidence for partial hybrids is lacking. Future research should explore diverse interventions, addressing coherence and teacher competence, while maintaining fidelity.

    MeSH terms: Humans; Learning*; Sports*; Students; Teaching; Models, Educational
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