Browse publications by year: 2025

  1. Apparoo Y, Phan CW, Kuppusamy UR, Wei Chiang EC
    Neuroscience, 2025 Jan 26;565:277-291.
    PMID: 39643233 DOI: 10.1016/j.neuroscience.2024.11.082
    A decline in mitochondrial functions associated with ageing is the key factor of free radical generation which contributes to age-related pathologies. Protecting healthy functional mitochondrial networks with antioxidants is critical in promoting healthy ageing. This study aimed to investigate the protective effect of ergothioneine (EGT)-rich Lentinula edodes extract (LE-ETH) against tert-butyl hydroperoxide (t-BHP) assaulted senescent HT22 cells. Mitochondrial function was evaluated by measuring mitochondrial membrane potential (MMP), ATP levels and mitochondrial toxicity. The protective mechanisms were elucidated via the exploration of antioxidant and mitochondrial biogenesis signalling pathways. Our results revealed that a low dose of t-BHP increases mitochondrial toxicity. The pretreatment with 100 µg/mL of LE-ETH and the equimolar concentration of EGT for 8 h significantly improve the mitochondrial function and reduced inflammation. Through gene expression studies, we demonstrated that pretreatment of LE-ETH significantly improves the antioxidant and mitochondrial biogenesis pathway via Nrf2 signaling axis. However, the downstream genes of the mitochondrial biogenesis pathway were unaffected by equimolar EGT concentration. Gas chromatography-mass spectrum (GC-MS) analysis was carried out to identify the bioactive compounds that are present in LE-ETH extract which contributed to its efficacy in improving the mitochondrial functions. A total of 23 compounds consisting of phenols, fatty acids, and sterols were identified in the ethanolic extract. Pentanoic acid was the major compound identified in LE-ETH. These findings demonstrated that EGT-rich L.edodes mushroom is a potential neuroprotective agent which could serve as a potential therapeutic strategy for the preservation of mitochondrial functions in healthy ageing explorations.
    MeSH terms: Animals; Cell Line; Signal Transduction/drug effects; Cell Aging/drug effects; Oxidative Stress/drug effects; Neuroprotective Agents/pharmacology; tert-Butylhydroperoxide/pharmacology; NF-E2-Related Factor 2/metabolism; Mice
  2. Ong CS, Ng QH, Ahmad AL, Low SC
    Anal Chim Acta, 2025 Jan 15;1335:343423.
    PMID: 39643293 DOI: 10.1016/j.aca.2024.343423
    Effective electrochemical sensing requires optimal signal output value and sensitivity, which often pose a challenge due to their counter-intuitive relationship. In order to enhance both aspects, this study designs a modified screen-printed electrode (Nafion-PSS/SPE) comprising a composite formed by two sulfonate-rich polymers, namely Nafion and poly(sodium 4-styrenesulfonate) (PSS). The Nafion-PSS/SPE was utilized in the electrochemical determination of lead (Pb2+) and cadmium (Cd2+) via square wave anodic stripping voltammetry (SWASV). This innovative approach aims to improve detection limits and overall analytical performance in complex matrices. (84) RESULTS: The addition of hydrophilic PSS positively improves surface wettability of Nafion-PSS/SPE, as confirmed by water contact angle analysis. Despite the improved wettability, the modified sensor maintains a high selectivity towards heavy metal ions. Cyclic voltammetry (CV) reveals a large electrochemically active surface area (ECSA) for cations (0.5646 cm2) and a relatively low ECSA for anions (0.3221 cm2). Under optimized conditions, the stripping responses for Pb2+ and Cd2+ exhibited linearity within the concentration ranges of 0.025-0.7 ppm and 0.0125-0.4 ppm, respectively. The detection limits achieved by the modified sensor are 6.478 ppb (Pb2+) and 5.277 ppb (Cd2+). The enhancement observed can be ascribed to the following factors, including presence of sulfonate ligands (Nafion and PSS), enhanced wettability (PSS), and surface selectivity (Nafion). Furthermore, even in the presence of interfering ions replicating the composition of effluent from the pesticide industry, the Nafion-PSS/SPE showcases remarkable selectivity for the target Pb2+ and Cd2+ ions. (148) SIGNIFICANCE: This work presents a facile screen-printing technique that could be potentially adopted for batch production of heavy metal sensing devices. Besides, by scrutinizing the surface properties of the modified sensor, this work aims to provide insights on how the proposed modification approach can help to improve the sensor's detection performance. (50).
  3. Sulwarajan K, Jaafar Z, Md Sari NA, Hamzah SH, Yusop FD, Hamid S, et al.
    Patient Educ Couns, 2025 Feb;131:108580.
    PMID: 39644532 DOI: 10.1016/j.pec.2024.108580
    OBJECTIVE: Exercise adherence and motivation can benefit from technology, but the specific factors influencing these improvements remain unclear. This scoping review aimed to outline the types and features of technology used in exercise prescription within healthcare, focusing on enhancing users' adherence to exercise.

    METHODS: A comprehensive systematic literature search was conducted from January 2000 to February 2023 across Web of Science, Google Scholar, and MEDLINE via PubMed. The review sought studies on technology-based exercise prescriptions for adults ≥ 18 years, evaluating features that enhance motivation or adherence.

    RESULTS: Out of 1724 articles reviewed, 45 met the criteria, demonstrating that mobile applications, exercise gaming, wearable trackers, and websites are commonly used technologies for prescribing exercise in healthcare setting. Common features, special features, and motivating features were found to be important in all technology-based exercise tools to enhance users' adherence and motivation.

    CONCLUSION: This review provides a comprehensive overview of the technological types and approaches that can support and improve exercise adherence among health service users. The findings also emphasize on specific features that can address current gaps in technology-driven fitness interventions.

    PRACTICE IMPLICATIONS: Healthcare professionals should make informed decisions when recommending these tools to health service users, since technology does play a significant role in promoting long-term adherence to exercise programs.

    MeSH terms: Humans; Motivation*; Internet; Mobile Applications
  4. Mondal R, Ritu RB, Kitaoka K, Azahar NM, Moniruzzaman M, Ogata S, et al.
    Atherosclerosis, 2025 Feb;401:119074.
    PMID: 39644613 DOI: 10.1016/j.atherosclerosis.2024.119074
    BACKGROUND AND AIMS: Knowledge about the association between oral microbiome diversity within individuals and cardiovascular disease (CVD) and non-CVD mortality is scarce. Besides, variation by sex and racial and ethnic groups, and the potential mediators of these associations remain unclear. We aimed to investigate the associations of oral microbiome alpha diversity with all-cause, CVD, and non-CVD mortality, and the interaction effects of sex and racial and ethnic groups and potential mediators in the associations.

    METHODS: The National Health and Nutrition Examination Survey (NHANES) is a population-based observational study, conducted periodically in Mexican American, Other Hispanic, Non-Hispanic (NH) White, NH Black, and other racial/ethnic participants. We linked 2009-12 survey data of 8199 adults to the mortality data until 2019. By analyzing RNA gene sequences from oral rinse samples, microbiome alpha diversity within individuals was assessed using operational taxonomic unit (OTU) richness. Potential mediators included obesity, diabetes mellitus, dyslipidemia, hypertension, and periodontitis. Multivariable Cox proportional hazards regression and causal mediation analysis were used.

    RESULTS: Baseline mean ± standard deviation (SD) age was 42.1 ± 15.1 years. Over a median follow-up of 9.1 years, 405 all-cause mortality occurred (CVD, 105; non-CVD, 300). Each 1-SD increment in OTU richness was inversely associated with all-cause mortality (hazard ratio [HR] 0.92, 95 % confidence interval [CI] 0.90-0.95), CVD mortality (HR, 0.92; 95 % CI, 0.90-0.95), and non-CVD mortality (HR, 0.92; 95 % CI, 0.90-0.95). With evidence of significant racial and ethnic groups-interaction (p <0.05), these associations were evident in Mexican American, NH White, and others racial/ethnic participants. None of the potential mediators significantly mediated the associations of OTU richness with all-cause, CVD, and non-CVD mortality.

    CONCLUSIONS: Lower oral microbiome alpha diversity is associated with higher risk for all-cause, CVD, and non-CVD mortality, and the associations are varied by racial and ethnic groups.

    MeSH terms: Adult; Cause of Death; Female; Humans; Male; Middle Aged; Mouth/microbiology; Nutrition Surveys*; Risk Factors; United States/epidemiology; Risk Assessment; European Continental Ancestry Group; Microbiota*
  5. Desbois AP, Brunton LA, Henriksson PJG, Luthman O, Troell M, Green DM
    Sci Total Environ, 2025 Jan 01;958:177785.
    PMID: 39644642 DOI: 10.1016/j.scitotenv.2024.177785
    Antimicrobial resistance (AMR) demands collective action to reduce and mitigate its threats. The Quadripartite collaboration of the World Health Organization (WHO), Food and Agriculture Organization of the United Nations (FAO), United Nations Environment Programme (UNEP) and World Organization for Animal Health (WOAH) has led development and implementation of National Action Plans (NAPs) that describe approaches each country will take to tackle AMR. All antimicrobial users and sectors should be included, and the Quadripartite encourages a One Health approach. Aquaculture has received mixed coverage in NAPs: Here, we argue why aquaculture requires special consideration. Aquaculture is a diverse, global collection of industries and activities, with heterogeneity in systems and species greatly exceeding terrestrial food-animal production, with products traded internationally in huge volumes. Almost 6 % of global total antibiotic usage is estimated to be applied in aquaculture, with per-biomass quantities in some species exceeding usage in human and terrestrial food-animals. The watery nature of aquaculture interconnects it with other One Health compartments: humans, other animals and the wider environment. Rapid industry growth challenges relatively detached stakeholders such as regulators and NAP creators to remain abreast of changing practices, whilst support capabilities and capacity, e.g., health services, typically lag behind growing needs. To integrate aquaculture effectively into next-generation NAPs, ensuring policies cover the One Health spectrum, NAP creators need to recognise the diversity of aquaculture and initiate engagement across associated value chains, especially health service providers. Disentangling the industry can assist formulation of realistic policies for heterogenous contexts and identify pathways to implementation. Resource allocation must be appropriate and include relevant government departments, whilst improved ways to track and monitor AMR, including those international activities that impact AMR domestically, through suitable data collection are key to monitoring and evaluating policies. Better NAPs are crucial to addressing AMR and this coordinated global approach provides our best opportunity for success.
    MeSH terms: Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Aquaculture*
  6. Lynch M
    Soc Sci Med, 2025 Jan;365:117592.
    PMID: 39644779 DOI: 10.1016/j.socscimed.2024.117592
    This research highlights the ways by which processes of caring for our environments can contribute to health and well-being for the minded body. Drawing upon rich ethnographic accounts of urban cultivation practices and experiences, this research unfolds in the birthplace of the 'Healthy City' concept-Kuching, Malaysia-which is an ethnically diverse city home to Chinese, Malay, Indigenous and other groups. Building from situated political ecologies-and more specifically, emotional political ecology and the political ecology of religion-I examine the relational values produced through practices of urban cultivation and related benefits for mind-body-environments. I find spirituality, religion, gender, generation, class, and ethnicity are embodied in socionatural relationships facilitated through urban agriculture. Through affective encounters with non-human animals, spiritual meanings inferred from the materiality of plants, and strengthened socionatural relationships with friends, family, even strangers, and the divine, practices of urban cultivation can nurture minds, bodies, and environments in deeply interconnected ways. This adds to a growing literature that reveals the importance of relational values for well-being and argues that socionatural relationships of care can contribute to a meaningful life. With a careful attention to relational dynamics and differentiated embodied experiences, I show that cultivators engage in the production of ecologies of care that confront neoliberal modes of interacting with themselves and others. Recognizing that care is embodied, situated and political can foster more nuanced understandings of the politics of socioecological transformation.
    MeSH terms: Agriculture; Animals; Anthropology, Cultural; Emotions*; Female; Humans; Malaysia; Male; Spirituality*; Flowers
  7. Fong MWK, Lim KS, Fong SL, Chen C, Kwan SY, Lee CC, et al.
    Neurophysiol Clin, 2025 Jan;55(1):103033.
    PMID: 39644808 DOI: 10.1016/j.neucli.2024.103033
    BACKGROUND: Invasive/ intracranial EEG forms an important component of assessment for epilepsy surgery in many patients with Drug-Resistant Epilepsy (DRE). Intracranial EEG has been poorly utilized though Southeast Asia (SEA) and Oceania. This study aimed to document the development of stereo-EEG (SEEG) across the region and highlight regional barriers to utilization and access.

    METHODS: A survey was developed by multicenter consensus. The survey captured institutional characteristics, geographic distributions, intracranial EEG utilization, and barriers to SEEG. Respondents were representative epilepsy centers across the region.

    RESULTS: Four epilepsy centers with established intracranial/ SEEG and two centers from a country without any access to SEEG participated. The responses identified that 1. Access to SEEG remained highly restricted across the region with an estimated one capable epilepsy center per 100 million people; 2. The region includes over half a billion people living in countries with no access to SEEG; 3. Staffing/ financial constraints were universal factors that limited growth of services or development of new services; 4. SEEG numbers have plateaued as a result of these challenges.

    CONCLUSION: The study puts into real numbers the challenges faced by the region in accessing SEEG. SEEG remains highly underutilized and future approaches should focus on regional training and referral pathways.

    MeSH terms: Drug Resistant Epilepsy/diagnosis; Drug Resistant Epilepsy/surgery; Electrocorticography/methods; Asia, Southeastern; Epilepsy/diagnosis; Epilepsy/surgery; Health Services Accessibility/statistics & numerical data; Humans; Surveys and Questionnaires; Stereotaxic Techniques; Oceania
  8. Velayutham TS, Khyasudeen MF, Zahid NI, Gopal SR, Ibrahim AR, Abou-Zied OK
    PMID: 39644819 DOI: 10.1016/j.saa.2024.125549
    This study investigates the photophysical and electrical properties of 4-heptamethyl-trisiloxanyl-n-undecyloxy-4'-nitrostilbene (SNS), a low molar mass organosiloxane liquid crystal containing a nitrostilbene chromophore. Real-time monitoring of the absorption and fluorescence spectra of the nitrostilbene moiety was conducted in dichloromethane solution and thin films (in both crystalline and Smectic C (SmC) phases). A charge transfer excited state is formed following vibrational cooling and solvent interaction within 0.4 to 1.6 ps, which then relaxes to the ground state in 1.6 ns. Five distinct lifetime components were identified in thin films, attributed to the heterogeneous local environment and aggregate formation. Notable differences in excited-state lifetimes were observed between the crystalline and SmC phases, with slower dynamics in the former due to the rigidity of the crystalline phase. Photoconductivity under UV irradiation was examined in SmC, Smectic A (SmA), and isotropic phases, showing a significant increase in current response, particularly in the SmC phase. Polarizing optical microscopy revealed morphological changes post-UV exposure, such as reduced SmC domain size and decreased birefringence. Dielectric measurements indicated distinct relaxation peaks in SmC and SmA phases, reflecting more disordered molecular arrangements. The study reveals that UV exposure significantly enhances SNS conductivity, particularly within the SmC phase. This enhancement is likely attributed to UV excitation promoting the formation of an intramolecular charge transfer state within the trans-stilbene moiety. These findings provide valuable insights into the potential applications of nitrostilbene-functionalized organosiloxane liquid crystals in optoelectronic devices, such as light switches and photodetectors.
  9. Han M, Zhu X, Li D, Si Q, Zhu T, Zhou Z, et al.
    PMID: 39644864 DOI: 10.1016/j.cbd.2024.101369
    This study investigated the effects of short-term exposure to flavonoids, specifically quercetin and taxifolin, on the transcriptomic responses of Chinese sucker (Myxocyprinus asiaticus) to validate their influence on gene expression related to immunity, antioxidant activity, and metabolism. Using transcriptomic data, we also analyzed their influence on relevant immune genes and examined the Chinese suckers' resistance to A. hydrophila. Oxidative stress, immune defense, and glucose metabolism of Chinese suckers were tested to assess potential enhancements. Significant alterations were observed in multiple immune-related Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in the liver of Chinese suckers, notably the complement and coagulation cascades, degradation of aromatic compounds, and xenobiotic metabolism by cytochrome P450. The key immune markers such as UGT, MPO, C3, and C4 were highlighted in these pathways, underlining their importance in fish immunity. Additionally, oxidative stress related KEGG pathways were notably influenced after exposure to quercetin and taxifolin, displaying markers such as CYP3A, superoxide dismutase, GST, malondialdehyde, and catalase. Quercetin particularly affected the enzymatic activity of glucose oxidase, hexokinase, phosphofructokinase, and ATPase, which are enzymes related to stress responses in fish. Antimicrobial tests revealed that both flavonoids enhanced Chinese suckers' defense against A. hydrophila by bolstering oxidative stress resistance and immunity. These results provided valuable insights for using flavonoids to enhance fish immunity.
    MeSH terms: Animals; Antioxidants/pharmacology; Cypriniformes/genetics; Cypriniformes/immunology; Gram-Negative Bacterial Infections/drug therapy; Gram-Negative Bacterial Infections/immunology; Gram-Negative Bacterial Infections/veterinary; Oxidative Stress/drug effects; Transcriptome/drug effects; Disease Resistance/drug effects
  10. Perez-Chadid DA, Dange RM, Eyre HA, Fieggen G, Vaughan KA, Sheth SA, et al.
    World Neurosurg, 2025 Jan;193:1165-1167.
    PMID: 39645077 DOI: 10.1016/j.wneu.2024.11.123
  11. Tan SN, Kotaki Y, Teng ST, Lim HC, Gao C, Lundholm N, et al.
    Harmful Algae, 2025 Jan;141:102769.
    PMID: 39645396 DOI: 10.1016/j.hal.2024.102769
    The benthic pennate diatom Nitzschia navis-varingica, known for producing domoic acid (DA) and its isomers, is widely distributed in the Western Pacific (WP) region. To investigate the genetic differentiation and gene flow patterns among the populations in the WP, the genetic diversity of 354 strains of N. navis-varingica was analysed using two nuclear-encoded rDNA loci: the large subunit rDNA (LSU rDNA) and the internal transcribed spacer 2 (ITS2). Frustule morphology of each strain was examined by TEM. The LSU rDNA phylogeny revealed a monophyletic lineage encompassing all strains, with sequence divergences of <0.9 %. Phylogenetic and population genetic analyses of ITS2 identified eight distinct clades (designated as Groups A to H) with moderate to high genetic heterogeneity (0.5-19.7 %). The low genetic differentiations between the geographically separated populations (pairwise FST of <0.03) suggested high gene flow and lack of spatial genetic structuring. Molecular clock analysis of the ITS2 phylogeny traced the evolutionary history of N. navis-varingica to the Eocene Epoch, and the split between clades likely occurred from the mid-Miocene to Pleistocene Epochs (10.8-1.2 Ma). The population dispersal in the WP were likely influenced by historical events like the Quarternary glacial cycles during the period, contributing to its homogenous distributions in the region.
    MeSH terms: DNA, Ribosomal/genetics; Pacific Ocean; Phylogeny*; Genetic Variation*; Gene Flow*
  12. Burney PGJ, Potts J, Knox-Brown B, Erhabor G, Hacene Cherkaski H, Mortimer K, et al.
    Pulmonology, 2025 Dec 31;31(1):2430491.
    PMID: 39641354 DOI: 10.1080/25310429.2024.2430491
    Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age2 and height2, separately for men and women. We regressed FVC against age, age2 and height2, and FEV1/FVC against age and height2, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age2, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height2. Regional differences in the constant and coefficients for FEV1/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV1/FVC ratio.
    MeSH terms: Adult; Africa/epidemiology; Age Factors; Aged; Cross-Sectional Studies; Europe/epidemiology; Female; Forced Expiratory Volume/physiology; Humans; Lung/physiopathology; Male; Middle Aged; Vital Capacity/physiology; Principal Component Analysis
  13. Lee SH, Khoo AS, Griffiths JR, Mat Lazim N
    Int J Cancer, 2025 Feb 01;156(3):488-498.
    PMID: 39291683 DOI: 10.1002/ijc.35192
    The Epstein-Barr virus (EBV), the first identified human tumour virus, infects over 95% of the individuals globally and has the potential to induce different types of cancers. It is increasingly recognised that EBV infection not only alters cellular metabolism, contributing to neoplastic transformation, but also utilises several non-cell autonomous mechanisms to shape the metabolic milieu in the tumour microenvironment (TME) and its constituent stromal and immune cells. In this review, we explore how EBV modulates metabolism to shape the interactions between cancer cells, stromal cells, and immune cells within a hypoxic and acidic TME. We highlight how metabolites resulting from EBV infection act as paracrine factors to regulate the TME, and how targeting them can disrupt barriers to immunotherapy.
    MeSH terms: Animals; Humans; Stromal Cells/metabolism; Stromal Cells/pathology; Stromal Cells/virology; Tumor Microenvironment*
  14. Bandyopadhyay U, Sen D, Ahuja D, Mahapatra SP, Biswas D, Maiti R, et al.
    J Steroid Biochem Mol Biol, 2025 Jan;245:106624.
    PMID: 39389269 DOI: 10.1016/j.jsbmb.2024.106624
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is recognized for inducing severe respiratory symptoms like cough, and shortness of breathing. Although symptom severity varies, some individuals remain asymptomatic. This virus has sparked a global pandemic, imposing a substantial rate of mortality or morbidity, with extended periods of illness reported. People with underlying medical issues and the elderly are more likely to experience adverse results. The virus's frequent mutations pose challenges for medical professionals, necessitating adaptable therapeutic and preventive strategies. Vitamin D, a versatile regulatory molecule, not only influences physiological processes such as serum calcium regulation but also exhibits immunomodulatory functions. Calcium ions play a crucial role as secondary signal transduction molecules, impacting diverse cellular functions and maintaining homeostasis through ion channel regulation. Parathormone, another key regulator of serum calcium, often acts antagonistically to vitamin D. This review delves into the interplay of vitamin D, calcium, and parathormone, exploring their possible influence on the progression of COVID-19. The intricate signaling involving these elements contributes to adverse prognosis, emphasizing the need for comprehensive understanding. Monitoring and controlling these physiological factors and associated pathways have shown the potential to alter disease outcomes, underscoring the importance of a holistic approach.
    MeSH terms: Humans
  15. Halimi SN, Rowett D, Luetsch K
    Res Social Adm Pharm, 2025 Jan;21(1):22-31.
    PMID: 39406627 DOI: 10.1016/j.sapharm.2024.10.006
    BACKGROUND: Various programs aimed at fostering the resilience of students have been implemented into healthcare undergraduate and postgraduate educational courses and degree programs. Which of these increase their participants' resilience under which circumstances, for whom and why remains uncertain.

    METHODS: A realist review of articles reporting program outcomes as measures of resilience through the use of via validated psychometric surveys was conducted to investigate which contexts favour the development of resilience of healthcare and health sciences students and which mechanisms have to be activated to achieve this outcome.

    RESULTS: Thirteen Context-Mechanism-Outcome Configurations were synthesised from data presented in 43 articles. These were combined with theories explaining the theoretical and psychological frameworks underpinning programs to develop a program theory of how and why resilience fostering programs work. Contexts which favour the development of resilience were the use of validated psychological frameworks as program foundation, e.g. Cognitive Behavioural Therapy, mindfulness-based training. Expert facilitation, longitudinal integration into curricula, flexible and multi-modal design and delivery, and opportunities for students to apply and practice resilience-building strategies also created favourable contexts. Meeting students' or practitioners' needs activated mechanisms of trust, engagement and recognition of a program's value and real-world benefits. An increase in resilience was achieved by students developing reflective skills, metacognitive awareness and positive habits of mind.

    CONCLUSION: The program theory established via a realist review provides guidance on how the individual resilience of healthcare students can be fostered throughout their undergraduate, postgraduate degrees and early practice, potentially supporting them to flourish and remain long-term in their chosen professional roles.

    MeSH terms: Curriculum; Humans; Students, Health Occupations/psychology; Resilience, Psychological*
  16. Ouaissa M, Laidi M, Benkortbi O, Maarof H
    J Mol Graph Model, 2025 Jan;134:108896.
    PMID: 39476630 DOI: 10.1016/j.jmgm.2024.108896
    A robust Quantitative Structure-Property Relationship (QSPR) model was presented to predict the surface tension property of psychoanaleptic (psychostimulant and antidepressant) drugs. A dataset of 112 molecules was utilized, and three feature selection methods were applied: genetic algorithm combined with Ordinary Least Squares (GA-OLS), Partial Least Squares (GA-PLS), and Support Vector Machines (GA-SVM), each identifying ten pertinent AlvaDesc descriptors. The models were constructed using the Dragonfly Algorithm combined with the Support Vector Regressor (DA-SVR), with the GA-SVM-based model emerging as the top performer. Rigorous statistical metrics validate its superior predictive accuracy (R2 = 0.98142, Q2LOO = 0.98142, RMSE = 1.12836, AARD = 0.78746). Furthermore, an external test set of ten compounds was employed for model validation and extrapolation, along with assessing the applicability domain, further underscoring the model's reliability. The selected descriptors (X0Av, VE1sign_B(e), ATSC1e, MATS6v, P_VSA_ppp_A, TDB01u, E1s, R2m+, N-067, SssO) collectively elucidate the key structural factors influencing surface tension in the studied drugs. The model provides excellent predictions and can be used to determine the surface tension of new psychoanaleptic drugs. Its outcomes will guide the design of novel medications with targeted surface tension properties.
    MeSH terms: Algorithms*; Models, Molecular; Surface Tension*; Least-Squares Analysis; Quantitative Structure-Activity Relationship*; Support Vector Machine*
  17. Ismail EN, Zakuan N, Othman Z, Vidyadaran S, Mohammad H, Ishak R
    Inflammopharmacology, 2025 Feb;33(2):759-765.
    PMID: 39636381 DOI: 10.1007/s10787-024-01607-8
    The term "inflammatory bowel disease" (IBD) refers to a group of chronic inflammatory gastrointestinal disorders, which include ulcerative colitis and Crohn's disease. The necessity for alternative therapeutic approaches is underscored by the fact that although present medicines are successful, they frequently result in considerable adverse effects. Naturally occurring substances included in fruits and vegetables called polyphenols have been shown to have the capacity to control important inflammatory pathways including NF-κB and JAK/STAT, which are essential for the pathophysiology of IBD. The processes by which polyphenols, such as curcumin, EGCG, resveratrol, and quercetin, reduce inflammation are examined in this article. Polyphenols may have therapeutic advantages by blocking the synthesis of cytokines and the activation of immune cells by targeting these pathways. Preclinical study indicates a reduction in intestinal inflammation, which is encouraging. However, more clinical research is needed to determine the clinical relevance of polyphenols in the therapy of IBD, especially with regard to their long-term safety and bioavailability.
    MeSH terms: Animals; Anti-Inflammatory Agents/pharmacology; Humans; Inflammation/drug therapy; Inflammation/metabolism
  18. Roy M, Willoughby AR, Haque S
    Memory, 2025 Mar;33(3):295-305.
    PMID: 39636950 DOI: 10.1080/09658211.2024.2434211
    This study, involving 34 Malaysian adults, investigated if the memory of cultural life script congruent and incongruent events was better than life script neutral events. We created a 1500-word hypothetical life story of a Malaysian girl comprising six life script congruent, six life script incongruent, and six life script neutral events. Half of those events were high-frequent, and half were low-frequent life script events. Participants first read the story on a computer screen and then completed a free recall test ten minutes later and again one week later. They recalled as many details as they could from the 18 events presented in the story. The results revealed that participants retrieved more information from the life script incongruent events than from life script congruent events at both recall points. The memory for high-frequent life script events was better than for low-frequent and life script-neutral events. Overall, the recall rate was higher in the immediate than in the late phase. The results confirm the isolation effects or Von Restorff effect, which predicts that unusual and distinctive events are more memorable than typical, commonly expected events.
    MeSH terms: Adolescent; Adult; Culture; Female; Humans; Life Change Events; Malaysia; Male; Mental Recall*; Young Adult; Memory, Episodic
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