METHODS: Participants in this prospective interventional study at a rehabilitation institution for people aging with disabilities included learners, the chief executive officer of the institution, program auditors, and community members. A customized CBR curriculum was developed using systems thinking design. Thirty-five learners were trained through 36 instructional contact hours and 60 hours of guided self-directed learning. Learners completed pre-training self-reported questionnaires regarding knowledge and experience of CBR. During training, learners were evaluated continuously through observation, assignments, self-reported feedback questionnaires, and CBR projects. The chief executive officer was interviewed during the study. The program auditors were interviewed and wrote reports on the curriculum and observations regarding the CBR projects. Learners reported on community participation in these projects.
RESULTS: Thirty-three of 35 learners completed the program, 31 (94%) of whom had no prior knowledge of CBR. Learners implemented nine community engagement CBR projects, in which 1,293 community members participated. The auditors commended the curriculum content and its positive impact on learners and the community. The chief executive officer implemented inclusive community engagement at work. A CBR curriculum was dynamically developed for multidisciplinary rehabilitation team training to promote community engagement.
CONCLUSIONS: The custom-designed CBR curriculum enabled multidisciplinary teams to practice community engagement at work. Equipped with CBR knowledge and skills, teams engaged with multiple sectors of the community to enhance patients' rehabilitation potential and increase public awareness through the implemented projects.
METHODS: Using the Dimensions and Lens.org databases with Boolean operators combined the keywords a total of 40,046 peer-reviewed international publications were initially assessed. The article was selected from 2014 to December 2023. Through rigorous application of inclusion and exclusion criteria using an advanced search, a subset of 134 papers emerged to meet the high relevance standards. This subset, constituting a representative sample, was selected for in-depth bibliometric analysis.
RESULTS AND CONCLUSION: The result shows a clear upward trend in the number of publications, with a notable increase in 2018. After 2018, there is decrease in the number of publications, but it has an upward trend, reaching a peak of 215 in 2022. Chaitanya Nallan CSK leads the list of authors with four publications and a respectable total citation count of 12. Cairo University is the leading institution in this data set, with the 8 number of publications and 11 citations. The analysis revealed that at the top of the list is the "Egyptian Dental Journal" from Egypt, with six publications, four citations, and a link strength of two. In the second position is "BMC Oral Health" from the United Kingdom, with five publications, one citation, and a link strength of three. This study offers valuable insights for future research, clinical practice, and policy decisions.
METHODOLOGY: A triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA)-based experimental resin infiltrate was prepared. Initial mixing was done manually for 1 h at room temperature, followed by another mix for 30 min on a magnetic stirrer. This prepared resin, called "PURE RESIN" was then further incorporated with three different types of bioactive glasses, i.e., Bioglass (45S5), boron-substituted (B-BG), and fluoride-substituted (F-BG). Initial manual mixing for 1 h, followed by ultrasonic mixing for 3 min and then proceeded for the final mixing on a magnetic stirrer for 24 h in a dark room at ambient temperature. Human-extracted teeth were demineralized, and the experimental resins were infiltrated on the demineralized surface. The surface area, pore size, and volume of the demineralized surface were measured. The microleakage and penetration depth were analyzed with the stereomicroscope and micro-CT, respectively. The samples were challenged with the pH cycle for 14 days, followed by a scanning electron microscope (SEM). Thermocycling (5,000 cycles) and chemical aging (4 weeks) were conducted, followed by microhardness, surface roughness, and SEM analyses. Statistical analyses were conducted after each test.
RESULTS: The F-BG group achieved the highest initial and day 14 penetration coefficients. There was a superior dye penetration with the microleakage analysis in the F-BG group. The 45S5 group had the highest average penetration depth via micro-CT analysis. After thermocycling and chemical aging, the micro-hardness was reduced (non-significantly) among all samples except the F-BG group in post-chemical aging analysis, whereas the surface roughness was significantly increased. SEM images showed the presence of micro-pits on the surfaces after the thermal and chemical aging.
CONCLUSION: The F-BG group achieved the highest initial and day 14 penetration coefficients. There was a superior dye penetration with the microleakage analysis in the F-BG group. The 45S5 group had the highest average penetration depth via micro-CT analysis. After thermocycling and chemical aging, the micro-hardness was reduced (non-significantly) among all samples except the F-BG group in post-chemical aging analysis, whereas the surface roughness was significantly increased. SEM images showed the presence of micro-pits on the surfaces after the thermal and chemical aging.
METHODS: In a prospective, open-label, multicenter pharmacokinetic study, intensive care unit (ICU) patients prescribed azoles, echinocandins, or polyene antifungals for treatment or prophylaxis of invasive fungal disease were enrolled. Blood samples were collected on two occasions, with three samples taken during a single dosing interval on each occasion. Total concentrations were centrally measured using validated chromatographic methods. Pharmacokinetic parameters were estimated using noncompartmental methods. Antifungal dosing adequacy was assessed using predefined PK/PD targets.
RESULTS: We included 339 patients from 30 ICUs across 12 countries. Median age 62 (interquartile range [IQR], 51-70) years, median APACHE II score 22 (IQR, 17-28), and 61% males. Antifungal therapy was primarily prescribed for treatment (80.8%). Fluconazole was the most frequently prescribed antifungal (40.7%). The most common indication for treatment was intra-abdominal infection (30.7%). Fungi were identified in 45% of patients, of which only 26% had a minimum inhibitory concentration available. Target attainment was higher for patients receiving prophylaxis (> 80% for most drugs). For patients receiving treatment, low target attainment was noted for voriconazole (57.1%), posaconazole (63.2%), micafungin (64.1%) and amphotericin B (41.7%).
CONCLUSION: This study highlights the varying degrees of target attainment across antifungal agents in critically ill patients. While a significant proportion of patients achieved the predefined PK/PD targets, wide variability and subtherapeutic exposures persist.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03136926, 2017-04-21.
AIMS: This study aims to contribute to the existing knowledge by investigating the association and time lags (TLs) between daily microclimate (DM), mosquito indices (MIs), and dengue cases at the residence level.
METHODS: In this longitudinal study, field data were collected over 26 weeks using data loggers, gravid oviposit sticky (GOS) traps, and non-structural 1 (NS1) test kits in both non-dengue hotspot (NDH) and dengue hotspots (DH). The collected data encompassed DM variables, vegetation cover (VC), MIs, and number of dengue cases. An autocorrelation analysis was conducted to determine the TLs between MIs and their preceding values, while a cross-correlation analysis revealed the TLs between MIs and DM variables.
RESULTS: The study indicated there are positive correlations between the adult index (AI) of Ae. albopictus, their preceding values and rainfall at an NDH. Conversely, the AIs of total Aedes at the DH exhibited positive correlations with their preceding values, temperature, rainfall, and maximum relative humidity (RH), but negative correlations with the mean and maximum RH. The dengue-positive trap index (DPTI) of total Aedes at DHs demonstrated positive associations with their preceding values, mean temperature, minimum temperature, maximum RH, and rainfall, with negative correlations observed for the maximum temperature, mean RH, and minimum RH. Similar trends were identified for the Ae. aegypti and Ae. albopictus at DHs. The association between dengue cases, DM, and MIs was inconclusive due to underreported cases.
CONCLUSIONS: This study highlighted the DM and TLs of dengue virus-infected and non-infected adult female Aedes mosquitoes using onsite data collection. Furthermore, this study presents a replicable methodology that can be adopted by researchers worldwide for investigating the dynamics of dengue transmission in similar settings. The findings offer valuable insights for decision-makers, providing them with evidence-based information to implement targeted interventions and strategies aimed at controlling Aedes mosquito populations and mitigating the spread of dengue virus infections.
METHOD: An open-labeled, randomized control trial performed from April 2023 to July 2023 in the nephrology unit of a tertiary care setting in Peshawar Pakistan. Those patients who met the inclusion criteria were randomized into two groups 1:1, i.e., control and intervention group. Clinical pharmacists identified the DRPs at baseline using Pharmaceutical Care Network Europe (PCNE) 9.1 guidelines. The QoL of patients were assessed at baseline and endpoint by using the Functional Assessment of Non-Life-Threatening Conditions (FANLTC) questionnaire.
RESULTS: A total of 100 patients were recruited having 50 in each group. The pharmacist identified a total of n = 230 DRPs in the intervention group, majority of the DRPs were attributed to inappropriate drug selection according to guidelines/formulary"; "inappropriate combinations of drugs or with herbal medications or dietary supplements"; and situations where "too many different drugs or active ingredients were prescribed". There was 46.52% reduction in the DRPs while comparing baseline and endpoint interventions suggested by pharmacist in the intervention group. The clinical pharmacist provided interventions in order to resolve the DRPs, and 37.40% interventions were accepted and fully implemented; 31.30% of the interventions were accepted and partially implemented. The clinical pharmacist identification and proposed intervention for DRPs contributed to a statistically significant improvement in QoL, from mean ± SD scored 58.64 ± 9.10 at the baseline to 74.48 ± 10.11 at the endpoint, with a p-value of