Fulltext

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Li J 1 , Lindström LS 2 , Foo JN 3 , Rafiq S 4 , Schmidt MK 5 , Pharoah PD 6 Show all authors , Michailidou K 7 , Dennis J 7 , Bolla MK 7 , Wang Q 7 , Van 't Veer LJ 8 , Cornelissen S 8 , Rutgers E 9 , Southey MC 10 , Apicella C 11 , Dite GS 11 , Hopper JL 12 , Fasching PA 13 , Haeberle L 14 , Ekici AB 15 , Beckmann MW 14 , Blomqvist C 16 , Muranen TA 17 , Aittomäki K 18 , Lindblom A 19 , Margolin S 20 , Mannermaa A 21 , Kosma VM 21 , Hartikainen JM 21 , Kataja V 22 , Chenevix-Trench G 23 , kConFab Investigators , Phillips KA 24 , McLachlan SA 25 , Lambrechts D 26 , Thienpont B 26 , Smeets A 27 , Wildiers H 27 , Chang-Claude J 28 , Flesch-Janys D 29 , Seibold P 28 , Rudolph A 28 , Giles GG 30 , Baglietto L 30 , Severi G 30 , Haiman CA 31 , Henderson BE 32 , Schumacher F 31 , Le Marchand L 32 , Kristensen V 33 , Alnæs GI 34 , Borresen-Dale AL 34 , Nord S 34 , Winqvist R 35 , Pylkäs K 35 , Jukkola-Vuorinen A 36 , Grip M 36 , Andrulis IL 37 , Knight JA 38 , Glendon G 39 , Tchatchou S 40 , Devilee P 41 , Tollenaar R 42 , Seynaeve C 43 , Hooning M 43 , Kriege M 43 , Hollestelle A 43 , van den Ouweland A 44 , Li Y 3 , Hamann U 45 , Torres D 46 , Ulmer HU 47 , Rüdiger T 48 , Shen CY 49 , Hsiung CN 50 , Wu PE 51 , Chen ST 52 , Teo SH 53 , Taib NA 54 , Har Yip C 54 , Fuang Ho G 55 , Matsuo K 56 , Ito H 57 , Iwata H 58 , Tajima K 57 , Kang D 59 , Choi JY 60 , Park SK 59 , Yoo KY 61 , Maishman T 4 , Tapper WJ 4 , Dunning A 62 , Shah M 62 , Luben R 7 , Brown J 7 , Khor CC 3 , Eccles DM 4 , Nevanlinna H 17 , Easton D 6 , Humphreys K 63 , Liu J 3 , Hall P 63 , Czene K 63

Affiliations 

  • 1 1] Human Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore [3]
  • 2 1] Department of Surgery, University of California at San Francisco (UCSF), San Francisco, California 94143, USA [2] Department of Biosciences and Nutrition, Karolinska Institutet and University Hospital, SE-171 77 Stockholm, Sweden [3]
  • 3 Human Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore
  • 4 Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton SO16 6YD, UK
  • 5 1] Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands [2] Division of Molecular Pathology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands
  • 6 1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
  • 7 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
  • 8 Division of Molecular Pathology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands
  • 9 Department of Surgery, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
  • 10 Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, 5th floor, West Wing, Medical Building 181, Melbourne, Victoria 3010, Australia
  • 11 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia
  • 12 1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Department of Health Science and Services, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
  • 13 1] University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany [2] Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
  • 14 University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany
  • 15 Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Schlossplatz 4, 91054 Erlangen, Germany
  • 16 Department of Oncology, University of Helsinki and Helsinki University Central Hospital, FI-00029 HUS Helsinki, Finland
  • 17 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FI-00029 Helsinki, Finland
  • 18 Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FI-00029 Helsinki, Finland
  • 19 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden
  • 20 Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden
  • 21 1] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Yliopistonranta 1C, FI-70211 Kuopio, Finland [2] Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [3] Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland
  • 22 1] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Yliopistonranta 1C, FI-70211 Kuopio, Finland [2] Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland [3] Jyväskylä Central Hospital, Keskussairaalantie 19, 40620 Jyväskylä, Finland
  • 23 Department of Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, Queensland 4006, Australia
  • 24 1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Sir Peter MacCallum Department of Oncology, University of Melbourne, St Andrews Place East, East Melbourne, Victoria 3002, Australia
  • 25 Department of Oncology, St Vincent's Hospital Melbourne, 9 Princes Street, Fitzroy, Victoria 3065, Australia
  • 26 1] Vesalius Research Center (VRC), VIB, Herestraat 49, 3000 Leuven, Belgium [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
  • 27 Multidisciplinary Breast Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
  • 28 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
  • 29 1] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany [2] Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany [3] Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
  • 30 1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Cancer Epidemiology Centre, Cancer Council Victoria, 1 Rathdowne Street, Melbourne, Victoria 3053, Australia
  • 31 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 San Pablo Street, Los Angeles, California 90033, USA
  • 32 University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, Hawaii 96813, USA
  • 33 1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway [2] K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway [3] Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital, Sykehusveien 25, 1478 Lørenskog, Norway
  • 34 1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway [2] K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway
  • 35 Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Aapistie 5A, FI-90220 Oulu, Finland
  • 36 Laboratory of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220 Oulu, Finland
  • 37 1] Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5 [2] Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
  • 38 1] Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5 [2] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7
  • 39 Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5
  • 40 Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5
  • 41 1] Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands [2] Department of Pathology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
  • 42 Department of Surgical Oncology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
  • 43 Department of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands
  • 44 Department of Clinical Genetics, Erasmus University Medical Center, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands
  • 45 Molecular Genetics of Breast Cancer, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
  • 46 1] Molecular Genetics of Breast Cancer, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany [2] Institute of Human Genetics, Pontificia University Javeriana, Carrera 7, Bogotá 11001000, Colombia
  • 47 Frauenklinik der Stadtklinik Baden-Baden, D-7570 Baden-Baden, Germany
  • 48 Institute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany
  • 49 1] Institute of Biomedical Sciences, Academia Sinica, Academia Road Nankang, Taipei 115, Taiwan [2] College of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan
  • 50 Institute of Biomedical Sciences, Academia Sinica, Academia Road Nankang, Taipei 115, Taiwan
  • 51 Taiwan Biobank, Academia Sinica, Academia Road Nankang, Taipei 115, Taiwan
  • 52 Department of Surgery, Changhua Christian Hospital, No. 135, Nanhsiao Street, Changhua 500, Taiwan
  • 53 1] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS 12/1A, Subang Jaya47500, Selangor, Malaysia [2] Breast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia
  • 54 Breast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia
  • 55 Department of Oncology, Faculty of Medicine, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia
  • 56 Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • 57 Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681, Aichi, Japan
  • 58 Department of Breast Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681, Aichi, Japan
  • 59 1] Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
  • 60 Department of Biomedical Sciences, Seoul National University Graduate School, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
  • 61 Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
  • 62 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
  • 63 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
Nat Commun, 2014 Jun 17;5:4051.
PMID: 24937182 DOI: 10.1038/ncomms5051

Abstract

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications