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Association analysis identifies 65 new breast cancer risk loci

Michailidou K 1 , Lindström S 2 , Dennis J 1 , Beesley J 3 , Hui S 4 , Kar S 5 Show all authors , Lemaçon A 6 , Soucy P 6 , Glubb D 3 , Rostamianfar A 4 , Bolla MK 1 , Wang Q 1 , Tyrer J 5 , Dicks E 5 , Lee A 1 , Wang Z 7 , Allen J 1 , Keeman R 8 , Eilber U 9 , French JD 3 , Qing Chen X 3 , Fachal L 5 , McCue K 3 , McCart Reed AE 10 , Ghoussaini M 5 , Carroll JS 11 , Jiang X 12 , Finucane H 12 , Adams M 13 , Adank MA 14 , Ahsan H 15 , Aittomäki K 16 , Anton-Culver H 17 , Antonenkova NN 18 , Arndt V 19 , Aronson KJ 20 , Arun B 21 , Auer PL 22 , Bacot F 23 , Barrdahl M 9 , Baynes C 5 , Beckmann MW 24 , Behrens S 9 , Benitez J 25 , Bermisheva M 26 , Bernstein L 27 , Blomqvist C 28 , Bogdanova NV 18 , Bojesen SE 29 , Bonanni B 30 , Børresen-Dale AL 31 , Brand JS 32 , Brauch H 33 , Brennan P 34 , Brenner H 19 , Brinton L 35 , Broberg P 36 , Brock IW 37 , Broeks A 8 , Brooks-Wilson A 38 , Brucker SY 39 , Brüning T 40 , Burwinkel B 41 , Butterbach K 19 , Cai Q 42 , Cai H 42 , Caldés T 43 , Canzian F 44 , Carracedo A 45 , Carter BD 46 , Castelao JE 47 , Chan TL 48 , David Cheng TY 49 , Seng Chia K 50 , Choi JY 51 , Christiansen H 52 , Clarke CL 53 , NBCS Collaborators , Collée M 54 , Conroy DM 5 , Cordina-Duverger E 55 , Cornelissen S 8 , Cox DG 56 , Cox A 37 , Cross SS 57 , Cunningham JM 58 , Czene K 32 , Daly MB 59 , Devilee P 60 , Doheny KF 13 , Dörk T 61 , Dos-Santos-Silva I 62 , Dumont M 6 , Durcan L 63 , Dwek M 64 , Eccles DM 65 , Ekici AB 66 , Eliassen AH 67 , Ellberg C 36 , Elvira M 68 , Engel C 69 , Eriksson M 32 , Fasching PA 24 , Figueroa J 35 , Flesch-Janys D 70 , Fletcher O 71 , Flyger H 72 , Fritschi L 73 , Gaborieau V 34 , Gabrielson M 32 , Gago-Dominguez M 45 , Gao YT 74 , Gapstur SM 46 , García-Sáenz JA 43 , Gaudet MM 46 , Georgoulias V 75 , Giles GG 76 , Glendon G 77 , Goldberg MS 78 , Goldgar DE 79 , González-Neira A 25 , Grenaker Alnæs GI 31 , Grip M 80 , Gronwald J 81 , Grundy A 82 , Guénel P 55 , Haeberle L 24 , Hahnen E 83 , Haiman CA 84 , Håkansson N 85 , Hamann U 86 , Hamel N 23 , Hankinson S 87 , Harrington P 5 , Hart SN 88 , Hartikainen JM 89 , Hartman M 50 , Hein A 24 , Heyworth J 90 , Hicks B 91 , Hillemanns P 61 , Ho DN 92 , Hollestelle A 93 , Hooning MJ 93 , Hoover RN 35 , Hopper JL 94 , Hou MF 95 , Hsiung CN 96 , Huang G 86 , Humphreys K 32 , Ishiguro J 97 , Ito H 97 , Iwasaki M 98 , Iwata H 99 , Jakubowska A 81 , Janni W 100 , John EM 101 , Johnson N 71 , Jones K 91 , Jones M 102 , Jukkola-Vuorinen A 103 , Kaaks R 9 , Kabisch M 86 , Kaczmarek K 81 , Kang D 51 , Kasuga Y 104 , Kerin MJ 105 , Khan S 106 , Khusnutdinova E 26 , Kiiski JI 106 , Kim SW 107 , Knight JA 108 , Kosma VM 89 , Kristensen VN 31 , Krüger U 36 , Kwong A 48 , Lambrechts D 109 , Le Marchand L 110 , Lee E 84 , Lee MH 111 , Lee JW 112 , Neng Lee C 113 , Lejbkowicz F 114 , Li J 32 , Lilyquist J 88 , Lindblom A 115 , Lissowska J 116 , Lo WY 33 , Loibl S 117 , Long J 42 , Lophatananon A 118 , Lubinski J 81 , Luccarini C 5 , Lux MP 24 , Ma ESK 48 , MacInnis RJ 76 , Maishman T 63 , Makalic E 94 , Malone KE 119 , Kostovska IM 120 , Mannermaa A 89 , Manoukian S 121 , Manson JE 122 , Margolin S 123 , Mariapun S 124 , Martinez ME 125 , Matsuo K 126 , Mavroudis D 75 , McKay J 34 , McLean C 127 , Meijers-Heijboer H 14 , Meindl A 128 , Menéndez P 129 , Menon U 130 , Meyer J 58 , Miao H 50 , Miller N 105 , Taib NAM 131 , Muir K 118 , Mulligan AM 132 , Mulot C 133 , Neuhausen SL 27 , Nevanlinna H 106 , Neven P 134 , Nielsen SF 29 , Noh DY 135 , Nordestgaard BG 29 , Norman A 88 , Olopade OI 136 , Olson JE 88 , Olsson H 36 , Olswold C 88 , Orr N 71 , Pankratz VS 137 , Park SK 51 , Park-Simon TW 61 , Lloyd R 138 , Perez JIA 139 , Peterlongo P 140 , Peto J 62 , Phillips KA 94 , Pinchev M 114 , Plaseska-Karanfilska D 120 , Prentice R 22 , Presneau N 64 , Prokofyeva D 68 , Pugh E 13 , Pylkäs K 141 , Rack B 142 , Radice P 143 , Rahman N 144 , Rennert G 114 , Rennert HS 114 , Rhenius V 5 , Romero A 43 , Romm J 13 , Ruddy KJ 145 , Rüdiger T 146 , Rudolph A 9 , Ruebner M 24 , Rutgers EJT 147 , Saloustros E 148 , Sandler DP 149 , Sangrajrang S 150 , Sawyer EJ 151 , Schmidt DF 94 , Schmutzler RK 83 , Schneeweiss A 41 , Schoemaker MJ 102 , Schumacher F 152 , Schürmann P 61 , Scott RJ 153 , Scott C 88 , Seal S 144 , Seynaeve C 93 , Shah M 5 , Sharma P 154 , Shen CY 155 , Sheng G 84 , Sherman ME 156 , Shrubsole MJ 42 , Shu XO 42 , Smeets A 134 , Sohn C 157 , Southey MC 158 , Spinelli JJ 159 , Stegmaier C 160 , Stewart-Brown S 118 , Stone J 138 , Stram DO 84 , Surowy H 41 , Swerdlow A 102 , Tamimi R 12 , Taylor JA 149 , Tengström M 89 , Teo SH 124 , Beth Terry M 161 , Tessier DC 23 , Thanasitthichai S 162 , Thöne K 163 , Tollenaar RAEM 164 , Tomlinson I 165 , Tong L 15 , Torres D 86 , Truong T 55 , Tseng CC 84 , Tsugane S 166 , Ulmer HU 167 , Ursin G 168 , Untch M 169 , Vachon C 88 , van Asperen CJ 170 , Van Den Berg D 84 , van den Ouweland AMW 54 , van der Kolk L 171 , van der Luijt RB 172 , Vincent D 23 , Vollenweider J 58 , Waisfisz Q 14 , Wang-Gohrke S 173 , Weinberg CR 174 , Wendt C 123 , Whittemore AS 175 , Wildiers H 134 , Willett W 122 , Winqvist R 141 , Wolk A 85 , Wu AH 84 , Xia L 84 , Yamaji T 98 , Yang XR 35 , Har Yip C 176 , Yoo KY 177 , Yu JC 178 , Zheng W 42 , Zheng Y 179 , Zhu B 91 , Ziogas A 17 , Ziv E 180 , ABCTB Investigators , ConFab/AOCS Investigators , Lakhani SR 10 , Antoniou AC 1 , Droit A 6 , Andrulis IL 77 , Amos CI 181 , Couch FJ 58 , Pharoah PDP 1 , Chang-Claude J 9 , Hall P 32 , Hunter DJ 12 , Milne RL 76 , García-Closas M 35 , Schmidt MK 8 , Chanock SJ 35 , Dunning AM 5 , Edwards SL 3 , Bader GD 4 , Chenevix-Trench G 3 , Simard J 6 , Kraft P 12 , Easton DF 1

Affiliations 

  • 1 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • 2 Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA
  • 3 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
  • 4 The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
  • 5 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
  • 6 Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Quebec, Canada
  • 7 Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA
  • 8 Division of Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
  • 9 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 10 UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia
  • 11 Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK
  • 12 Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
  • 13 Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • 14 Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
  • 15 Center for Cancer Epidemiology and Prevention, The University of Chicago, Chicago, Illinois, USA
  • 16 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
  • 17 Department of Epidemiology, University of California Irvine, Irvine, California, USA
  • 18 N. N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus
  • 19 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 20 Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada
  • 21 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  • 22 Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
  • 23 McGill University and Génome Québec Innovation Centre, Montréal, Quebec, Canada
  • 24 Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany
  • 25 Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain
  • 26 Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia
  • 27 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA
  • 28 Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
  • 29 Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark
  • 30 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy
  • 31 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
  • 32 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • 33 Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
  • 34 International Agency for Research on Cancer, Lyon, France
  • 35 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
  • 36 Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden
  • 37 Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
  • 38 Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
  • 39 Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany
  • 40 Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany
  • 41 Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
  • 42 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
  • 43 Medical Oncology Department, Hospital Clínico San Carlos, IdISSC (Centro Investigacion Biomedica en Red), CIBERONC (Instituto de Investigación Sanitaria San Carlos), Madrid, Spain
  • 44 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 45 Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago De Compostela, Spain
  • 46 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
  • 47 Oncology and Genetics Unit, Instituto de Investigacion Biomedica (IBI) Orense-Pontevedra-Vigo, Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain
  • 48 Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong
  • 49 Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA
  • 50 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
  • 51 Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea
  • 52 Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
  • 53 Westmead Institute for Medical Research, University of Sydney, Sydney, Australia
  • 54 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
  • 55 Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France
  • 56 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
  • 57 Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK
  • 58 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
  • 59 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • 60 Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
  • 61 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
  • 62 Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
  • 63 Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK
  • 64 Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK
  • 65 Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK
  • 66 Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany
  • 67 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • 68 Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia
  • 69 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
  • 70 Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • 71 Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
  • 72 Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark
  • 73 School of Public Health, Curtin University, Perth, Australia
  • 74 Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
  • 75 Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece
  • 76 Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia
  • 77 Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
  • 78 Department of Medicine, McGill University, Montréal, Quebec, Canada
  • 79 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA
  • 80 Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland
  • 81 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
  • 82 Centre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Université de Montréal, Montréal, Quebec, Canada
  • 83 Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany
  • 84 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
  • 85 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  • 86 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 87 Department of Biostatistics & Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA
  • 88 Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
  • 89 Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland
  • 90 School of Population Health, University of Western Australia, Perth, Australia
  • 91 Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
  • 92 Department of Pathology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong
  • 93 Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
  • 94 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
  • 95 Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 96 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
  • 97 Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
  • 98 Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
  • 99 Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
  • 100 Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany
  • 101 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA
  • 102 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK
  • 103 Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland
  • 104 Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan
  • 105 School of Medicine, National University of Ireland, Galway, Ireland
  • 106 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
  • 107 Department of Surgery, Daerim Saint Mary's Hospital, Seoul, South Korea
  • 108 Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
  • 109 Vesalius Research Center, VIB, Leuven, Belgium
  • 110 University of Hawaii Cancer Center, Honolulu, Hawaii, USA
  • 111 Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, South Korea
  • 112 Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
  • 113 Department of Surgery, National University Health System, Singapore, Singapore
  • 114 Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
  • 115 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
  • 116 Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland
  • 117 German Breast Group GmbH, Neu Isenburg, Germany
  • 118 Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK
  • 119 Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
  • 120 Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov", Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia
  • 121 Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy
  • 122 Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
  • 123 Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
  • 124 Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia
  • 125 Moores Cancer Center, University of California San Diego, La Jolla, California, USA
  • 126 Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • 127 Anatomical Pathology, The Alfred Hospital, Melbourne, Australia
  • 128 Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany
  • 129 Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain
  • 130 Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, UK
  • 131 Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia
  • 132 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
  • 133 Université Paris Sorbonne Cité, INSERM UMR-S1147, Paris, France
  • 134 Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
  • 135 Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea
  • 136 Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois, USA
  • 137 University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, USA
  • 138 The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Australia
  • 139 Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain
  • 140 IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy
  • 141 Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland
  • 142 Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, Germany
  • 143 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy
  • 144 Section of Cancer Genetics, The Institute of Cancer Research, London, UK
  • 145 Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
  • 146 Institute of Pathology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany
  • 147 Department of Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
  • 148 Hereditary Cancer Clinic, University Hospital of Heraklion, Heraklion, Greece
  • 149 Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
  • 150 National Cancer Institute, Bangkok, Thailand
  • 151 Research Oncology, Guy's Hospital, King's College London, London, UK
  • 152 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
  • 153 Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, Australia
  • 154 Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
  • 155 School of Public Health, China Medical University, Taichung, Taiwan
  • 156 Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland, USA
  • 157 National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
  • 158 Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia
  • 159 Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada
  • 160 Saarland Cancer Registry, Saarbrücken, Germany
  • 161 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
  • 162 National Cancer Institute, Ministry of Public Health, Nonthaburi, Thailand
  • 163 Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • 164 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • 165 Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK
  • 166 Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
  • 167 Frauenklinik der Stadtklinik Baden-Baden, Baden-Baden, Germany
  • 168 Cancer Registry of Norway, Oslo, Norway
  • 169 Department of Gynecology and Obstetrics, Helios Clinics Berlin-Buch, Berlin, Germany
  • 170 Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
  • 171 Family Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
  • 172 Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
  • 173 Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany
  • 174 Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
  • 175 Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA
  • 176 Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia
  • 177 Seoul National University College of Medicine, Seoul, South Korea
  • 178 Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  • 179 Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
  • 180 Department of Medicine, Institute for Human Genetics, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
  • 181 Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA
Nature, 2017 Nov 02;551(7678):92-94.
PMID: 29059683 DOI: 10.1038/nature24284

Abstract

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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