Pulse wave analysis as a tool to assess endothelial function following lipid lowering intervention in hypercholesterolemia

Ibrahim NNIN 1 , Rasool AHG 2 , Rahman RA 3 , Azlan M 4 , Aziz AA 5

Affiliations 

  • 1 Department of Pharmacology, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Pakar USM, Jalan Raja Perempuan Zainab II, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: izah@usm.my
  • 2 Department of Pharmacology, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Pakar USM, Jalan Raja Perempuan Zainab II, 16150 Kubang Kerian, Kelantan, Malaysia
  • 3 Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Pakar USM, Jalan Raja Perempuan Zainab II, 16150 Kubang Kerian, Kelantan, Malaysia
  • 4 School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • 5 Faculty of Medicine, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, Malaysia
Microvasc Res, 2024 Nov 23.
PMID: 39586372 DOI: 10.1016/j.mvr.2024.104772

Abstract

BACKGROUND: Pulse wave analysis (PWA) assesses endothelial dependent vasodilation (EDV) via the change in augmentation index (AIx) and has been used as a tool to assess endothelial function. However, its effectiveness in assessing the response to lipid lowering treatment has not been evaluated. The study aimed to describe and correlate the change in EDV following lipid lowering intervention in patients with hypercholesterolemia.

METHODS: 48 newly diagnosed patients with hypercholesterolemia underwent 6 months intervention with statin and/or therapeutic lifestyle changes (TLC) in clinical setting. Lipid profile measurement and endothelial function assessment using PWA were performed pre- and post-intervention.

RESULTS: Significant reductions in low density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C) and total cholesterol (TC) with corresponding significant improvement in EDV (2.94 ± 3.69 % to 7.50 ± 3.79 %, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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