Fulltext

Recurrent depression predicts high leptin concentrations in patients with coronary artery disease over an 18-months follow-up period: Findings from the prospective multicenter randomized controlled SPIRR-CAD Trial

Ladwig KH 1 , Marten-Mittag B 2 , Olliges E 3 , Johar H 4 , Atasoy S 5 , Holdenrieder S 6 Show all authors , Albus C 7 , Deter HC 8 , DeZwaan M 9 , Fritzsche K 10 , Jünger J 11 , Petrowski K 12 , Michal M 13 , Söllner W 14 , Weber CS 8 , Herrmann-Lingen C 15 , Ronel J 16

Affiliations 

  • 1 Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partnersite Munich Heart Alliance, Munich, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany. Electronic address: karl-heinz.ladwig@tum.de
  • 2 Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
  • 3 Department of Psychosomatic Medicine and Psychotherapy, Klinik Barmelweid AG, Barmelweid, Switzerland
  • 4 Department of Psychosomatic Medicine and Psychotherapy, University of Gießen and Marburg, Gießen, Germany; Global Public Health, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia
  • 5 Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Department of Psychosomatic Medicine and Psychotherapy, University of Gießen and Marburg, Gießen, Germany
  • 6 Institute of Laboratory Medicine, Deutsches Herzzentrum Munich, Technische Universität München, Munich, Germany
  • 7 Department of Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany
  • 8 Department of Psychosomatics and Psychotherapy, Charité Universitaetsmedizin, Campus Benjamin Franklin, Berlin, Germany
  • 9 Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany
  • 10 Department of Psychosomatic Medicine and Psychotherapy, Universitätsklinikum Freiburg, Freiburg, Germany
  • 11 University Heidelberg, Medical Faculty, MME Study Programme, Heidelberg, Germany; Institut für Kommunikations- und Prüfungsforschung gGmbH, Heidelberg, Germany
  • 12 Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
  • 13 Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
  • 14 Department of Psychosomatic Medicine and Psychotherapy, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany
  • 15 Department of Psychosomatic Medicine and Psychotherapy, University of Goettingen Medical Center, Georg-August University, Göttingen, Germany; Medical Center and German Center for Cardiovascular Research, Partner Site Göttingen, Göttingen, Germany
  • 16 Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Department of Psychosomatic Medicine and Psychotherapy, Klinik Barmelweid AG, Barmelweid, Switzerland
J Affect Disord, 2025 Jan 15;369:174-181.
PMID: 39321975 DOI: 10.1016/j.jad.2024.09.146

Abstract

BACKGROUND: Leptin, an adipokine suspected to play a role in coronary artery disease (CAD), may also be associated with deteriorated mental health. We investigated the prospective impact of recurrent depressed mood (RDM) on heightened plasma leptin levels in CAD patients.

METHODS: Derived from the randomized SPIRR-CAD trial, plasma leptin were measured by the Human Leptin DuoSet ELISA at baseline in 539 patients (including 115 (21.3 %) women and 424 (78.7 %) men) and in 373 participants after 18-months follow up (T3). RDM was based on the clinical course from baseline to follow-up assessed by the Hamilton Depression Rating Scale (HAMD). Multivariate binary logistic regression models identified predictors for heightened leptin at T3.

RESULTS: At baseline, highest leptin level (3rd tertile) was associated with type 2 diabetes (p = 0.009), heart failure symptoms (NYHA III) (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications