Affiliations 

  • 1 Department of Information Technology, M. Kumarasamy College of Engineering, Thalavapalayam, Karur, Tamil Nadu, India
  • 2 School of Computer Science and Engineering, Vellore Institute of Technology, Chennai, Tamil Nadu, India
  • 3 Department of Software Engineering & Division of Electronics and Information Engineering, Jeonbuk National University, Jeonju-si, 54896, Republic of Korea. chojh@jbnu.ac.kr
  • 4 School of Engineering and Technology, Sunway University, No. 5, Jalan Universiti, Bandar Sunway, Petaling Jaya, 47500, Selangor Darul Ehsan, Malaysia
Sci Rep, 2024 Dec 30;14(1):31641.
PMID: 39738223 DOI: 10.1038/s41598-024-80472-5

Abstract

Cervical cancer is a deadly disease in women globally. There is a greater chance of getting rid of cervical cancer in case of earliest diagnosis. But for some patients, there is a chance of recurrence. The chances of treating the Recurrence of cervical carcinoma arelimited. The main objective of a research is to find the key features that will predict the cervical cancer recurrence and survival rates accurately by utilizing a neural network that is bidirectionally recurrent. The goal is to reduce risk factors of cervical cancer recurrence by identifying genes with positive coefficients and targeting them for preventive interventions. First step is identification of risk factors for cervical carcinoma recurrence by utilising clinical attributes. This research uses following Random forest, Logistic regression, Gradient boosting and support vector machine algorithms are applied for classification. Random forest offers the maximum precision of these four techniques at 91.2%. The second step is identifying long noncoding RNA (lnRNA) gene signatures among people with cervical carcinomaby implementingHSIC model. Intended to discover biomarkers in initial cervical carcinoma clinical data from people who experienced a distant repetition that could be connected to lnRNA gene signatures and utilized for forecasting survival rates using a bidirectional recurrent neural network(Bi-RNN). The results shows that Bi-RNN model effectively forecast the cervical cancer recurrence and survival.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.