Genome-wide analysis of oral squamous cell carcinomas revealed over expression of ISG15, Nestin and WNT11

Vincent-Chong VK 1 , Ismail SM , Rahman ZA , Sharifah NA , Anwar A , Pradeep PJ Show all authors , Ramanathan A , Karen-Ng LP , Kallarakkal TG , Mustafa WM , Abraham MT , Tay KK , Zain RB

Affiliations 

  • 1 Oral Cancer Research and Coordinating Center, Faculty of Dentistry, Department of Oral Maxillofacial Surgery, University of Malaya, Kuala Lumpur, Malaysia
Oral Dis, 2012 Jul;18(5):469-76.
PMID: 22251088 DOI: 10.1111/j.1601-0825.2011.01894.x

Abstract

Multistep pathways and mechanisms are involved in the development of oral cancer. Chromosomal alterations are one of such key mechanisms implicated oral carcinogenesis. Therefore, this study aims to determine the genomic copy number alterations (CNAs) in oral squamous cell carcinoma (OSCC) using array comparative genomic hybridization (aCGH) and in addition attempt to correlate CNAs with modified gene expression.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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