Resistance to extended-spectrum beta-lactams by the emergence of SHV-12 and the loss of OmpK35 in Klebsiella pneumoniae and Escherichia coli in Malaysia

Palasubramaniam S 1 , Muniandy S , Navaratnam P

Affiliations 

  • 1 Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
J Microbiol Immunol Infect, 2009 Apr;42(2):129-33.
PMID: 19597644

Abstract

In addition to beta-lactamase production, loss of porins confers resistance to extended-spectrum beta-lactams in Klebsiella pneumoniae and Escherichia coli infection. This study describes the detection of SHV-12 extended-spectrum beta-lactamase (ESBL) subtype and the loss of OmpK35 porin in 4 strains of K. pneumoniae and E. coli.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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