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Pluripotent Human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy

Yap MS 1 , Tang YQ 2 , Yeo Y 3 , Lim WL 4 , Lim LW 5 , Tan KO 6 Show all authors , Richards M 7 , Othman I 8 , Poh CL 9 , Heng BC 10

Affiliations 

  • 1 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. mayshin.yap@gmail.com
  • 2 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. yinquant@sunway.edu.my
  • 3 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. yy0812@live.com.my
  • 4 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. weilingl@sunway.edu.my
  • 5 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. limlw@hku.hk
  • 6 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. jefft@sunway.edu.my
  • 7 School of Chemical & Life Sciences, Nanyang Polytechnic, 180 Ang Mo Kio Avenue 8, Singapore, 569830, Singapore. Mark_RICHARDS@nyp.gov.sg
  • 8 Jeffrey Cheah School of Medicine, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia. iekhsan.othman@monash.edu
  • 9 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. pohcl@sunway.edu.my
  • 10 Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, , Selangor Darul Ehsan, Malaysia. alexish@hku.hk
Virol J, 2016 Jan 06;13:5.
PMID: 26738773 DOI: 10.1186/s12985-015-0454-6

Abstract

The incidence of neurological complications and fatalities associated with Hand, Foot & Mouth disease has increased over recent years, due to emergence of newly-evolved strains of Enterovirus 71 (EV71). In the search for new antiviral therapeutics against EV71, accurate and sensitive in vitro cellular models for preliminary studies of EV71 pathogenesis is an essential prerequisite, before progressing to expensive and time-consuming live animal studies and clinical trials.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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