Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis

Manikam SD 1 , Manikam ST , Stanslas J

Affiliations 

  • 1 Faculty of Medicine and Health Sciences, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
J Pharm Pharmacol, 2009 Jan;61(1):69-78.
PMID: 19126299 DOI: 10.1211/jpp/61.01.0010

Abstract

The growth inhibiting potential of andrographolide was evaluated in three acute promyelocytic leukaemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2).

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