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Risk factors for anti tuberculous drugs induced hepatitis: a prospective survey from a chest clinic in a general hospital

Fauzi ARM 1 , Shah A 2 , Rathor MY 3 , Satwi S 4

Affiliations 

  • 1 A R M Fauzi, MRCP. Department of Internal Medicine, Kulliyah of Medicine, P.O. Box 141, 25710 Kuantan, Pahang, Malaysia
  • 2 A Shah, MBBS. Department of Internal Medicine, Kulliyah of Medicine, P.O. Box 141, 25710 Kuantan, Pahang, Malaysia
  • 3 M Y Rathor, MD. Department of Internal Medicine, Kulliyah of Medicine, P.O. Box 141, 25710 Kuantan, Pahang, Malaysia
  • 4 S Satwi, MMed. Department of Medicine, Hospital Tengku Ampuan Afzan, Kuantan, 25150 Pahang
Med J Malaysia, 2004 Mar;59(1):72-7.
PMID: 15535339

Abstract

A prospective survey on 14 consecutive cases with tuberculous drug induced hepatitis was done at our chest clinic in a state general hospital over a period of 15 months. There were 30 controls chosen randomly from the chest clinic register. The cases had lower mean body mass index (P<0.008), serum albumin (P<0.005) and higher serum globulin (P<0.04). Serum liver transaminases and total bilirubin rose significantly during the acute episode of drug induced hepatitis. Among the risk factors studied, only chronic hepatitis B carrier status was found to be more prevalent among the cases. There was one death (7.1%) over the whole study period.
Study site: Chest clinic, Hospital Tengku Ampuan Afzan (HTAA), Kuantan, Pahang, Malaysia

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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