Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus

Vattam KK 1 , Raghavendran H 2 , Murali MR 1 , Savatey H 1 , Kamarul T 3

Affiliations 

  • 1 Tissue Engineering Group, Department of Orthopaedic Surgery, NOCERAL, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Tissue Engineering Group, Department of Orthopaedic Surgery, NOCERAL, University of Malaya, Kuala Lumpur, Malaysia tkzrea@um.edu.my hbr_bala@yahoo.com
  • 3 Tissue Engineering Group, Department of Orthopaedic Surgery, NOCERAL, University of Malaya, Kuala Lumpur, Malaysia Clinical Investigative Centre (CIC), University Malaya Medical Centre, Kuala Lumpur, Malaysia
Hum Exp Toxicol, 2016 Aug;35(8):893-901.
PMID: 26429928 DOI: 10.1177/0960327115608246

Abstract

In the present study, thirty six male Sprague Dawley rats were randomly divided into six groups and were injected with varying doses of alloxan (Ax) and nicotinamide (NA). The serum levels of glucose, insulin, and adiponectin were measured weekly up to 4 weeks.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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