Aqueous extract of Senecio candicans DC induce liver and kidney damage in a sub-chronic oral toxicity study in Wistar rats

Lakshmanan H 1 , Raman J 2 , Pandian A 3 , Kuppamuthu K 4 , Nanjian R 5 , Sabaratam V 6 Show all authors , Naidu M 7

Affiliations 

  • 1 Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, India; Mushroom Research Centre (MRC), Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: hariprasath80@um.edu.my
  • 2 Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, India; Mushroom Research Centre (MRC), Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 3 Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, India; Department of Crop Science, Tshwane University of Technology, Pretoria Campus (West), Pretoria, 0001, South Africa
  • 4 Department of Biotechnology, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, India
  • 5 Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, India
  • 6 Mushroom Research Centre (MRC), Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 7 Mushroom Research Centre (MRC), Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia; Department of Anatomy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
Regul Toxicol Pharmacol, 2016 Aug;79:25-34.
PMID: 27177820 DOI: 10.1016/j.yrtph.2016.05.010

Abstract

Senecio candicans DC. (Asteraceae) is used as a remedy for gastric ulcer and stomach pain in the Nilgiris, district, Tamil Nadu. The present investigation was carried out to evaluate the sub-chronic toxicity of an aqueous extract of Senecio candicans (AESC) plant in Wistar albino rats. The study was conducted in consideration of the OECD 408 study design (Repeated Dose 90-Day Oral Toxicity Study in Rodents) and the extract was administered via gavage at doses of 250, 500 or 750 mg/kg body weight per day for 90-days. Hematological, biochemical parameters were determined on days 0, 30, 60 and 90 of administration. Animals were euthanized after 90 d treatment and its liver and kidney sections were taken for histological study. The results of sub-chronic study showed significant increase (P 

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