Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats

Ablat A 1 , Halabi MF 2 , Mohamad J 3 , Hasnan MH 4 , Hazni H 5 , Teh SH 6 Show all authors , Shilpi JA 4 , Mohamed Z 5 , Awang K 4

Affiliations 

  • 1 Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 3 Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. jamal@um.edu.my
  • 4 Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 5 Center for Natural Products and Drug discovery (CENAR), University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 6 Genetics and Molecular Biology Unit, Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
BMC Complement Altern Med, 2017 Feb 06;17(1):94.
PMID: 28166749 DOI: 10.1186/s12906-017-1610-x

Abstract

Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate with their pharmacological activities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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