Affiliations 

  • 1 International Medical University, Kuala Lumpur, Malaysia
  • 2 University Tunku Abdul Rahman, Sungai Long, Selangor, Malaysia
  • 3 Health Clinic Rembau, Negeri Sembilan, Malaysia
  • 4 Temasek Lifesciences Laboratory, Singapore
  • 5 Programme in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore
J Med Virol, 2015 Dec;87(12):2149-53.
PMID: 26106066 DOI: 10.1002/jmv.24304

Abstract

This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyngeal swabs, our study demonstrates that PRV is among one of the common causative agents of acute URTI with cough and sore throat as the commonest presenting clinical features. Phylogenetic analysis on partial major outer and inner capsid proteins shows that these PRV strains are closely related to Melaka and Kampar viruses previously isolated in Malaysia. Further study is required to determine the public health significance of PRV infection in Southeast Asia, especially in cases where co-infection with other pathogens may potentially lead to different clinical outcomes.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.