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Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers

Haugen J 1 , Ulak M 2 , Chandyo RK 3 , Henjum S 4 , Thorne-Lyman AL 5 , Ueland PM 6 Show all authors , Midtun Ø 7 , Shrestha PS 8 , Strand TA 9

Affiliations 

  • 1 Innlandet Hospital Trust, Lillehammer 2609, Norway. johanne_haugen@hotmail.com
  • 2 Department of Child Health, Institute of Medicine, Tribhuvan University, Kathmandu 8212, Nepal. manjeswori@gmail.com
  • 3 Department of Child Health, Institute of Medicine, Tribhuvan University, Kathmandu 8212, Nepal. ram.chandyo@cih.uib.no
  • 4 Department of Nursing and Health Promotion, Oslo and Akershus University College of Applied Sciences, Oslo 0130, Norway. sigrun.henjum@hioa.no
  • 5 Johns Hopkins Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. athorne1@jhu.edu
  • 6 Department of Clinical Science, University of Bergen, Bergen 5007, Norway. per.ueland@ikb.uib.no
  • 7 Department of Clinical Science, University of Bergen, Bergen 5007, Norway. oivind.midttun@bevital.no
  • 8 Department of Child Health, Institute of Medicine, Tribhuvan University, Kathmandu 8212, Nepal. prakashsunder@hotmail.com
  • 9 Innlandet Hospital Trust, Lillehammer 2609, Norway. tors@me.com
Nutrients, 2016 Dec 21;8(12).
PMID: 28009810 DOI: 10.3390/nu8120825

Abstract

BACKGROUND: Describing vitamin D status and its predictors in various populations is important in order to target public health measures.

OBJECTIVES: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants.

METHODS: 500 randomly selected Nepalese mother and infant pairs were included in a cross-sectional study. Plasma 25(OH)D concentrations were measured by LC-MS/MS and multiple linear regression analyses were used to identify predictors of vitamin D status.

RESULTS: Among the infants, the prevalence of vitamin D insufficiency (25(OH)D <50 nmol/L) and deficiency (<30 nmol/L) were 3.6% and 0.6%, respectively, in contrast to 59.8% and 14.0% among their mothers. Infant 25(OH)D concentrations were negatively associated with infant age and positively associated with maternal vitamin D status and body mass index (BMI), explaining 22% of the variability in 25(OH)D concentration. Global solar radiation, maternal age and BMI predicted maternal 25(OH)D concentration, explaining 9.7% of its variability.

CONCLUSION: Age and maternal vitamin D status are the main predictors of vitamin D status in infants in Bhaktapur, Nepal, who have adequate vitamin D status despite poor vitamin D status in their mothers.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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