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Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation

Loughland JR 1 , Minigo G 2 , Sarovich DS 2 , Field M 3 , Tipping PE 2 , Montes de Oca M 4 Show all authors , Piera KA 2 , Amante FH 4 , Barber BE 2 , Grigg MJ 2 , William T 5 , Good MF 6 , Doolan DL 3 , Engwerda CR 4 , Anstey NM 2 , McCarthy JS 4 , Woodberry T 2

Affiliations 

  • 1 Menzies School of Health Research, Darwin, Australia and Charles Darwin University, Darwin, Australia. jessica.loughland@menzies.edu.au
  • 2 Menzies School of Health Research, Darwin, Australia and Charles Darwin University, Darwin, Australia
  • 3 Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia
  • 4 QIMR Berghofer Medical Research Institute, Brisbane, Australia
  • 5 Infectious Diseases Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia
  • 6 Griffith University, Gold Coast, Australia
Sci Rep, 2017 06 01;7(1):2596.
PMID: 28572564 DOI: 10.1038/s41598-017-02096-2

Abstract

Plasmacytoid dendritic cells (pDC) are activators of innate and adaptive immune responses that express HLA-DR, toll-like receptor (TLR) 7, TLR9 and produce type I interferons. The role of human pDC in malaria remains poorly characterised. pDC activation and cytokine production were assessed in 59 malaria-naive volunteers during experimental infection with 150 or 1,800 P. falciparum-parasitized red blood cells. Using RNA sequencing, longitudinal changes in pDC gene expression were examined in five adults before and at peak-infection. pDC responsiveness to TLR7 and TLR9 stimulation was assessed in-vitro. Circulating pDC remained transcriptionally stable with gene expression altered for 8 genes (FDR 

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