Impact of bovine and human serum albumin on Curcumin in vitro activity against Staphylococcus aureus

Teow SY 1 , Ali SA 1

Affiliations 

  • 1 Cluster of Oncological and Radiological Sciences, Advanced Medical and Dental Institute (AMDI), University Sains Malaysia (USM), Bertam, Kepala Batas, Pulau Pinang, Malaysia
Pak J Pharm Sci, 2017 May;30(3):891-895.
PMID: 28653935

Abstract

This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus). Minimal inhibitory concentrations (MICs) of Curcumin against S. aureus were statistically indifferent (p>0.05) at pH7.4 and pH6.5. Activity of Curcumin against S. aureus was reduced by two folds in the presence of 1.25-5% BSA/HSA.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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