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Malaysian endophytic fungal extracts-induced anti-inflammation in Lipopolysaccharide-activated BV-2 microglia is associated with attenuation of NO production and, IL-6 and TNF-α expression

Harun A 1 , Vidyadaran S 2 , Lim SM 3 , Cole AL 4 , Ramasamy K 5

Affiliations 

  • 1 Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. azzaly83@yahoo.com
  • 2 Neuroinflammation Group, Immunology Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor Darul Ehsan, Malaysia. sharmili@medic.upm.edu.my
  • 3 Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. stevenlim79@yahoo.com
  • 4 School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. tony.cole@canterbury.ac.nz
  • 5 Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. kalav922@puncakalam.uitm.edu.my
BMC Complement Altern Med, 2015;15:166.
PMID: 26047814 DOI: 10.1186/s12906-015-0685-5

Abstract

Excessive production of inflammatory mediators such as nitric oxide (NO) and proinflammatory cytokines like tumour necrosis factor-alpha (TNF-α) from activated microglia contributes to uncontrolled inflammation in neurodegenerative diseases. This study investigated the protective role of five endophytic extracts (HAB16R12, HAB16R13, HAB16R14, HAB16R18 and HAB8R24) against LPS-induced inflammatory events in vitro. These endophytic extracts were previously found to exhibit potent neuroprotective effect against LPS-challenged microglial cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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