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Microencapsulation of fish oil using supercritical antisolvent process

Karim FT 1 , Ghafoor K 2 , Ferdosh S 3 , Al-Juhaimi F 2 , Ali E 4 , Yunus KB 3 Show all authors , Hamed MH 5 , Islam A 6 , Asif M 7 , Sarker MZI 8

Affiliations 

  • 1 Faculty of Pharmacy, International Islamic University Malaysia, Kuantan Campus, 25200 Kuantan, Pahang, Malaysia
  • 2 Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
  • 3 Faculty of Science, International Islamic University Malaysia (IIUM), Kuantan Campus, 25200 Kuantan, Pahang, Malaysia
  • 4 Nanotechnology and Catalysis Research Centre (NanoCat), University of Malaya, Kuala Lumpur 50603, Malaysia
  • 5 Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor DE, Malaysia
  • 6 Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh
  • 7 Department of Chemical Engineering, King Saud University, Riyadh 11421, Saudi Arabia
  • 8 Faculty of Pharmacy, International Islamic University Malaysia, Kuantan Campus, 25200 Kuantan, Pahang, Malaysia. Electronic address: zaidul@iium.edu.my
J Food Drug Anal, 2017 Jul;25(3):654-666.
PMID: 28911651 DOI: 10.1016/j.jfda.2016.11.017

Abstract

In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. The suitability of the model for predicting the optimum response value was evaluated at the conditions of temperature at 60°C, pressure at 150 bar, and feed rate at 1.36 mL/min. At the optimum conditions, particle size of 58.35 μm was obtained. The surface morphology of the micronized fish oil was also evaluated using field emission scanning electron microscopy where it showed that particles formed spherical structures with no internal voids. Moreover, in vitro release of oil showed that there are significant differences of release percentage of oil between the formulations and the results proved that there was a significant decrease in the in vitro release of oil from the powder when the polymer concentration was high.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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