Anti-nociceptive mechanisms of flavonoids-rich methanolic extract from Terminalia coriacea (Roxb.) Wight & Arn. leaves

Ali Khan MS 1 , Ahmed N 2 , Misbah 3 , Arifuddin M 4 , Zakaria ZA 5 , Al-Sanea MM 6 Show all authors , Khundmiri SUK 3 , Ahmed I 7 , Ahmed S 7 , Mok PL 8

Affiliations 

  • 1 Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al Jouf Province, Saudi Arabia; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, 43400, Selangor Darul Ehsan, Malaysia; Department of Pharmacology, Anwarul Uloom College of Pharmacy Affiliated to Jawaharlal Nehru Technological University, Hyderabad, Telangana State, India. Electronic address: mskhan@ju.edu.sa
  • 2 Department of Pharmacology, Anwarul Uloom College of Pharmacy Affiliated to Jawaharlal Nehru Technological University, Hyderabad, Telangana State, India; Department of Pharmacology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, 30001, Saudi Arabia
  • 3 Department of Pharmacology, Anwarul Uloom College of Pharmacy Affiliated to Jawaharlal Nehru Technological University, Hyderabad, Telangana State, India
  • 4 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad, 500037, Telangana State, India
  • 5 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, 43400, Selangor Darul Ehsan, Malaysia
  • 6 Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University University, Sakaka, Al Jouf Province, Saudi Arabia
  • 7 Department of Pharmacology, Nizam Institute of Pharmacy Affiliated to Jawaharlal Nehru Technological University, Hyderabad, Telangana State, India
  • 8 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, 43400, Selangor Darul Ehsan, Malaysia; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University University, Sakaka, Al Jouf Province, Saudi Arabia
Food Chem Toxicol, 2018 May;115:523-531.
PMID: 29555329 DOI: 10.1016/j.fct.2018.03.021

Abstract

In view of the report on anti-nociceptive activity of Leathery Murdah, Terminalia coriacea {Roxb.} Wight & Arn. (Combretaceae) leaves, the present study was conducted to isolate the active constituents and identify the underlying mechanisms. The methanolic extract of T. coriacea leaves (TCLME) at doses 125, 250 and 500 mg/kg orally, was subjected to various in-vivo assays in acetic acid induced writhing and formalin induced paw-licking tests with aspirin (100 mg/kg) and morphine (5 mg/kg) as reference drugs. Three flavonoids, rutin, robinin and gossypetin 3-glucuronide 8-glucoside were isolated and characterized from TCLME for the first time. The extract showed significant (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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