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Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects

Mohamad NA 1 , Ramachandran V 2 , Mohd Isa H 3 , Chan YM 1 , Ngah NF 4 , Ching SM 5 Show all authors , Hoo FK 6 , Wan Sulaiman WA 6 , Inche Mat LN 6 , Mohamed MH 7

Affiliations 

  • 1 Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43400, Serdang, Selangor DE, Malaysia
  • 2 Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43400, Serdang, Selangor DE, Malaysia. vasudevan@upm.edu.my
  • 3 Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur, Malaysia
  • 4 Department of Ophthalmology, Hospital Selayang, Lebuhraya Selayang-Kepong, 68100, Batu Caves, Malaysia
  • 5 Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor DE, Malaysia
  • 6 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor DE, Malaysia
  • 7 Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor DE, Malaysia
Hum Genomics, 2019 02 22;13(1):13.
PMID: 30795802 DOI: 10.1186/s40246-019-0197-3

Abstract

BACKGROUND: The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes.

RESULTS: Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P = 0.018 (OR = 1.52, 95% CI = 1.07-215) and ARMS2 rs10490924 at P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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