VEGF Polymorphisms Among Neovascular Age-Related Macular Degenerative Subjects in a Multiethnic Population

Mohamad NA 1 , Ramachandran V 1 , Ismail P 2 , Mohd Isa H 3 , Chan YM 1 , Ngah NF 4 Show all authors , Md Bakri N 1 , Ching SM 5 , Hoo FK 6 , Wan Sulaiman WA 6

Affiliations 

  • 1 1 Malaysian Research Institute on Ageing , Universiti Putra Malaysia, Serdang, Malaysia
  • 2 2 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia , Serdang, Malaysia
  • 3 3 Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre , Cheras, Malaysia
  • 4 5 Department of Ophthalmology, Hospital Selayang , Batu Caves, Malaysia
  • 5 6 Department of Family Medicine, Universiti Putra Malaysia , Serdang, Malaysia
  • 6 7 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia , Serdang, Malaysia
Genet Test Mol Biomarkers, 2017 Oct;21(10):600-607.
PMID: 28926292 DOI: 10.1089/gtmb.2017.0079

Abstract

AIM: To determine the association of vascular endothelial growth factor (VEGF) polymorphisms with neovascular age-related macular degeneration (nAMD).

MATERIALS AND METHODS: One hundred thirty-five nAMD patients and 135 controls were recruited to determine the association of the -460 C/T, the -2549 I/D, and the +405 G/C polymorphisms with the VEGF gene. Genotyping was conducted using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach, and association analyses were conducted using chi-square analysis and logistic regression analysis.

RESULTS: A significant association was observed between nAMD and the VEGF +405 G/C genotypes (p = 0.002) and alleles (odds ratio = 1.36, 95% confidence interval = 1.12-1.62, p = < 0.001) compared with the controls. This association was confirmed by logistic regression analyses, using two different genetic models (additive and dominant) resulting in p-values of p = 0.001 and p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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