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Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Obón-Santacana M 1 , Luján-Barroso L 2 , Freisling H 3 , Naudin S 3 , Boutron-Ruault MC 4 , Mancini FR 4 Show all authors , Rebours V 5 , Kühn T 6 , Katzke V 6 , Boeing H 7 , Tjønneland A 8 , Olsen A 8 , Overvad K 9 , Lasheras C 10 , Rodríguez-Barranco M 11 , Amiano P 11 , Santiuste C 11 , Ardanaz E 11 , Khaw KT 12 , Wareham NJ 13 , Schmidt JA 14 , Aune D 15 , Trichopoulou A 16 , Thriskos P 16 , Peppa E 16 , Masala G 17 , Grioni S 18 , Tumino R 19 , Panico S 20 , Bueno-de-Mesquita B 21 , Sciannameo V 22 , Vermeulen R 23 , Sonestedt E 24 , Sund M 25 , Weiderpass E 26 , Skeie G 27 , González CA 2 , Riboli E 15 , Duell EJ 2

Affiliations 

  • 1 Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain
  • 2 Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
  • 3 Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, Lyon, France
  • 4 CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France
  • 5 Pancreatology Department, Beaujon Hospital, DHU Unity, AP-HP, Clichy, and Paris-Diderot University, Paris, France
  • 6 Division of Cancer Epidemiology, German Cancer Reserach Center (DKFZ), Heidelberg, Germany
  • 7 Department of Epidemiology, German Institute of Human Nutrition (DIfE) Postdam-Rehbrücke, Nuthetal, Germany
  • 8 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 9 Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
  • 10 Department of Functional Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain
  • 11 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
  • 12 Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  • 13 MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
  • 14 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  • 15 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • 16 Hellenic Health Foundation, Athens, Greece
  • 17 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
  • 18 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
  • 19 Cancer Registry and Histopathology Department, "Civic - M. P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy
  • 20 Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
  • 21 Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
  • 22 Unit of Epidemiology, Regional Health Service ASL TO3, Turin, Italy
  • 23 Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
  • 24 Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
  • 25 Department of Surgical and Preoperative Sciences, Umeå University, Umeå, Sweden
  • 26 Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
  • 27 Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway
Int J Cancer, 2020 Jan 01;146(1):76-84.
PMID: 31107546 DOI: 10.1002/ijc.32415

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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