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Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study

Naudin S 1 , Li K 1 , Jaouen T 1 , Assi N 1 , Kyrø C 2 , Tjønneland A 2 Show all authors , Overvad K 3 , Boutron-Ruault MC 4 , Rebours V 5 , Védié AL 5 , Boeing H 6 , Kaaks R 7 , Katzke V 7 , Bamia C 8 , Naska A 8 , Trichopoulou A 8 , Berrino F 9 , Tagliabue G 10 , Palli D 11 , Panico S 12 , Tumino R 13 , Sacerdote C 14 , Peeters PH 15 , Bueno-de-Mesquita HBA 16 , Weiderpass E 17 , Gram IT 17 , Skeie G 17 , Chirlaque MD 18 , Rodríguez-Barranco M 19 , Barricarte A 19 , Quirós JR 20 , Dorronsoro M 21 , Johansson I 22 , Sund M 23 , Sternby H 24 , Bradbury KE 25 , Wareham N 26 , Riboli E 27 , Gunter M 28 , Brennan P 29 , Duell EJ 30 , Ferrari P 1

Affiliations 

  • 1 Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, Lyon, France
  • 2 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 3 Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
  • 4 CESP, INSERM U1018, University of Paris-Sud, UVSQ, University of Paris-Saclay, Villejuif, France
  • 5 Pancreatology Unit, Beaujon Hospital, Clichy, France
  • 6 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Potsdam, Germany
  • 7 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 8 Hellenic Health Foundation, Athens, Greece
  • 9 Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • 10 Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • 11 Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
  • 12 Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
  • 13 Cancer Registry and Histopathology Department, Civic M.P.Arezzo Hospital, Ragusa, Italy, Ragusa, Italy
  • 14 Unit of Cancer Epidemiology, Hospital and Center for Cancer Prevention (CPO), Città della Salute e della Scienza University, Turin, Italy
  • 15 Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
  • 16 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • 17 Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
  • 18 Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
  • 19 CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain
  • 20 Public Health Directorate, Asturias, Spain
  • 21 Subdirección de Salud Pública de Gipuzkoa, Gobierno Vasco, San Sebastian, Spain
  • 22 Department of Odontology, Cariology, Umeå University, Umeå, Sweden
  • 23 Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
  • 24 Department of Surgery, Institution of Clinical Sciences Malmö, Lund University, Malmö, Sweden
  • 25 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  • 26 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
  • 27 School of Public Health, Imperial College London, London, United Kingdom
  • 28 Nutrition and Epidemiology Group, International Agency for Research on Cancer, Lyon, France
  • 29 Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
  • 30 Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-Idibell), Barcelona, Spain
Int J Cancer, 2018 Aug 15;143(4):801-812.
PMID: 29524225 DOI: 10.1002/ijc.31367

Abstract

Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.

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