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The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Rajasuriar R 1 , Kong YY 2 , Nadarajah R 3 , Abdullah NK 4 , Spelman T 5 , Yuhana MY 6 Show all authors , Ponampalavanar S 7 , Kamarulzaman A 8 , Lewin SR 9

Affiliations 

  • 1 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. reena@um.edu.my
  • 2 Centre of Excellence for Research in AIDS (CERiA), University of Malaya, 50603, Kuala Lumpur, Malaysia. yong.yeankong@gmail.com
  • 3 Centre of Excellence for Research in AIDS (CERiA), University of Malaya, 50603, Kuala Lumpur, Malaysia. n.reshika@gmail.com
  • 4 Centre of Excellence for Research in AIDS (CERiA), University of Malaya, 50603, Kuala Lumpur, Malaysia. la_falcon00@yahoo.com
  • 5 Centre for Population Health, Burnet Institute, 3004, Melbourne, Australia. tim@burnet.edu.au
  • 6 Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. aleeyuhana@hotmail.com
  • 7 Centre of Excellence for Research in AIDS (CERiA), University of Malaya, 50603, Kuala Lumpur, Malaysia. sasheela@gmail.com
  • 8 Centre of Excellence for Research in AIDS (CERiA), University of Malaya, 50603, Kuala Lumpur, Malaysia. adeeba@ummc.edu.my
  • 9 Department of Infectious Diseases, Monash University and Alfred Hospital, 3004, Melbourne, Australia. sharon.lewin@unimelb.edu.au
J Transl Med, 2015;13:30.
PMID: 25622527 DOI: 10.1186/s12967-015-0391-6

Abstract

HIV-infected individuals have an increased risk of cardiovascular disease (CVD). T-allele carriers of the CD14 C-260T single-nucleotide polymorphism (SNP) have reported increased expression of the LPS-binding receptor, CD14 and inflammation in the general population. Our aim was to explore the relationship of this SNP with monocyte/macrophage activation and inflammation and its association with sub-clinical atherosclerosis in HIV-infected individuals.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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