Lactobacillus sp. improved microbiota and metabolite profiles of aging rats

Hor YY 1 , Lew LC 1 , Jaafar MH 1 , Lau AS 2 , Ong JS 2 , Kato T 3 Show all authors , Nakanishi Y 3 , Azzam G 4 , Azlan A 5 , Ohno H 6 , Liong MT 7

Affiliations 

  • 1 School of Industrial Technology, Universiti Sains Malaysia, 11800, Penang, Malaysia; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
  • 2 School of Industrial Technology, Universiti Sains Malaysia, 11800, Penang, Malaysia
  • 3 Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, 230-0045, Japan; Division of Immunobiology, Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University, Kanagawa, 230-0045, Japan
  • 4 School of Biological Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
  • 5 School of Biological Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia
  • 6 Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, 230-0045, Japan; Division of Immunobiology, Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University, Kanagawa, 230-0045, Japan; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia. Electronic address: hiroshi.ohno@riken.jp
  • 7 School of Industrial Technology, Universiti Sains Malaysia, 11800, Penang, Malaysia; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia. Electronic address: mintze.liong@usm.my
Pharmacol Res, 2019 08;146:104312.
PMID: 31207344 DOI: 10.1016/j.phrs.2019.104312

Abstract

Aging is closely associated with altered gut function and composition, in which elderly were reported with reduced gut microbiota diversity and increased incidence of age-related diseases. Probiotics have been shown to exert beneficial health-promoting effects through modulation of intestinal microflora biodiversity, thus the effects of probiotics administration on D-galactose (D-gal) senescence-induced rat were evaluated based on the changes in gut microbiota and metabolomic profiles. Upon senescence induction, the ratio of Firmicutes/ Bacteroidetes was significantly lowered, while treatment with Lactobacillus helveticus OFS 1515 and L. fermentum DR9 increased the ratio at the phylum level (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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