Lactobacillus Strains Alleviated Aging Symptoms and Aging-Induced Metabolic Disorders in Aged Rats

Hor YY 1 , Ooi CH 2 , Khoo BY 3 , Choi SB 4 , Seeni A 2 , Shamsuddin S 5 Show all authors , Oon CE 3 , Ong KL 6 , Jeong WS 7 , Liong MT 1

Affiliations 

  • 1 1 Division of Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia
  • 2 3 Cluster of Lifestyle Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang, Malaysia
  • 3 4 Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia
  • 4 5 School of Data Sciences, Perdana University, MARDI Complex, Selangor, Malaysia
  • 5 2 USM-RIKEN International Centre for Aging Science (URICAS), Universiti Sains Malaysia, Penang, Malaysia
  • 6 7 Clinical Nutrition Intl (M) Sdn. Bhd., Selangor, Malaysia
  • 7 8 Department of Food and Life Sciences, Inje University, Gimhae, Korea
J Med Food, 2019 Jan;22(1):1-13.
PMID: 30592688 DOI: 10.1089/jmf.2018.4229

Abstract

Aging is an inevitable and ubiquitous progress that affects all living organisms. A total of 18 strains of lactic acid bacteria (LAB) were evaluated on the activation of adenosine monophosphate-activated protein kinase (AMPK), an intracellular energy sensor mediating lifespan extension. The cell-free supernatant (CFS) of Lactobacillus fermentum DR9 (LF-DR9), Lactobacillus paracasei OFS 0291 (LP-0291), and Lactobacillus helveticus OFS 1515 (LH-1515) showed the highest activation of AMPK and was further evaluated. The phosphorylation of AMPK by these three LAB strains was more evident in U2OS and C2C12 cells, compared to the other cell lines and control (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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