The molecular mechanisms of probiotic strains in improving ageing bone and muscle of d-galactose-induced ageing rats

Hor YY 1 , Ooi CH 2 , Lew LC 1 , Jaafar MH 1 , Lau AS 1 , Lee BK 1 Show all authors , Azlan A 3 , Choi SB 4 , Azzam G 5 , Liong MT 1

Affiliations 

  • 1 School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia
  • 2 Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang, Malaysia
  • 3 School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 4 School of Data Sciences, Perdana University, Selangor, Malaysia
  • 5 USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, Penang, Malaysia
J Appl Microbiol, 2021 Apr;130(4):1307-1322.
PMID: 32638482 DOI: 10.1111/jam.14776

Abstract

AIM: The aim of this study was to evaluate the molecular mechanisms of Lactobacillus strains in improving ageing of the musculoskeletal system.

METHODS AND RESULTS: The anti-ageing mechanism of three probiotics strains Lactobacillus fermentum DR9, Lactobacillus paracasei OFS 0291 and L. helveticus OFS 1515 were evaluated on gastrocnemius muscle and tibia of d-galactose-induced ageing rats. Upon senescence induction, aged rats demonstrated reduced antioxidative genes CAT and SOD expression in both bone and muscle compared to the young rats (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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