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A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment

Yee A 1 , Loh HS 2 , Loh HH 3 , Riahi S 4 , Ng CG 5 , Sulaiman AHB 5

Affiliations 

  • 1 1Department of Psychological Medicine, University Malaya Center of Addition Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 2Clinical Academic Unit, Newcastle University Medicine Malaysia, No.1 Jalan Sarjana 1, Kota Ilmu, Educity@Iskandar, 79200 Nusajaya, Johor Malaysia
  • 3 3Department of Medicine, Faculty of Medicine and Health Sciences, University of Malaysia Sarawak, Jalan Dato Muhammad Musa, 94300 Kota Samarahan, Sarawak Malaysia
  • 4 4Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 5 5Department of Psychological Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Ann Gen Psychiatry, 2019;18:25.
PMID: 31649742 DOI: 10.1186/s12991-019-0249-z

Abstract

Background: Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT).

Methods: This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires.

Results: There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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