Affiliations 

  • 1 Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • 2 Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia
  • 3 Division of Nephrology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
  • 4 Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, Korea
  • 5 MIOT International Hospital, Chennai, India
  • 6 Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia
  • 7 Department of Cardiology, Hue University Hospital, Hue University, Hue City, Vietnam
  • 8 Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • 9 Department of Medicine, School of Medicine National Yang-Ming University, Taipei, Taiwan
  • 10 University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines
  • 11 Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
  • 12 Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, Korea
  • 13 Fatima Memorial Hospital, Lahore, Pakistan
  • 14 Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines
  • 15 Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Thailand
  • 16 Department of General Medicine, Tan Tock Seng Hospital, Singapore City, Singapore
  • 17 Department of Internal Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan
  • 18 Department of Physiology, King George's Medical University, Lucknow, India
  • 19 Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 20 Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, The Shanghai Institute of Hypertension, Shanghai, China
J Clin Hypertens (Greenwich), 2020 Mar;22(3):415-422.
PMID: 31816178 DOI: 10.1111/jch.13752

Abstract

Hypertension is an important public health concern. The prevalence keeps increasing, and it is a risk factor for several adverse health outcomes including a decline in cognitive function. Recent data also show that the prevalence of hypertension and age-related dementia is rising in Asian countries, including in the oldest old group. This study aims to discuss possible treatments for high blood pressure in the elderly and propose an optimal target for BP relative to cognitive outcomes. This review discusses several studies on related blood pressure treatments that remain controversial and the consequences if the treatment target is too low or aggressive. Longitudinal, cross-sectional, and RCT studies were included in this review. An optimum systolic blood pressure of 120-130 mm Hg is recommended, especially in nondiabetic hypertensive patients with significant risk factors. In the oldest old group of patients, hypertension might have a protective effect. The use of calcium channel blockers (CCB) and angiotensin receptor blocker (ARB) is independently associated with a decreased risk of dementia in older people. However, personalized care for patients with hypertension, especially for patients who are frail or very old, is encouraged.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.