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Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Shu X 1 , Long J 1 , Cai Q 1 , Kweon SS 2 , Choi JY 3 , Kubo M 4 Show all authors , Park SK 3 , Bolla MK 5 , Dennis J 5 , Wang Q 5 , Yang Y 1 , Shi J 1 , Guo X 1 , Li B 6 , Tao R 7 , Aronson KJ 8 , Chan KYK 9 , Chan TL 10 , Gao YT 11 , Hartman M 12 , Kee Ho W 13 , Ito H 14 , Iwasaki M 15 , Iwata H 16 , John EM 17 , Kasuga Y 18 , Soon Khoo U 9 , Kim MK 19 , Kong SY 20 , Kurian AW 21 , Kwong A 10 , Lee ES 20 , Li J 22 , Lophatananon A 23 , Low SK 4 , Mariapun S 24 , Matsuda K 25 , Matsuo K 26 , Muir K 23 , Noh DY 27 , Park B 28 , Park MH 29 , Shen CY 30 , Shin MH 2 , Spinelli JJ 31 , Takahashi A 4 , Tseng C 32 , Tsugane S 33 , Wu AH 32 , Xiang YB 11 , Yamaji T 15 , Zheng Y 34 , Milne RL 35 , Dunning AM 36 , Pharoah PDP 5 , García-Closas M 37 , Teo SH 24 , Shu XO 1 , Kang D 38 , Easton DF 5 , Simard J 39 , Zheng W 40

Affiliations 

  • 1 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
  • 2 Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea
  • 3 Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
  • 4 RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  • 5 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • 6 Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA
  • 7 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
  • 8 Department of Public Health Sciences and Queen's Cancer Research Institute, Queen's University, Kingston, ON, Canada
  • 9 Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
  • 10 Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR, China
  • 11 State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
  • 12 Department of Surgery, National University Hospital, Singapore, Singapore
  • 13 Department of Applied Mathematics, Faculty of Engineering, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia
  • 14 Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan
  • 15 Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
  • 16 Department of Breast Oncology, Aichi Cancer Center, Nagoya, Aichi, Japan
  • 17 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA
  • 18 Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan
  • 19 Division of Cancer Epidemiology and Management, National Cancer Center, Goyang, Korea
  • 20 National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea
  • 21 Departments of Health Research and Policy, School of Medicine, Stanford University, California, CA, USA
  • 22 Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • 23 Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK
  • 24 Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia
  • 25 Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
  • 26 Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
  • 27 Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
  • 28 Department of Medicine, Hanyang University College of Medicine, Seoul, Korea
  • 29 Department of Surgery, Chonnam National University Medical School, Seoul, Korea
  • 30 College of Public Health, China Medical University, Taichong, Taiwan
  • 31 Population Oncology, BC Cancer, Vancouver, BC, Canada
  • 32 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
  • 33 Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
  • 34 Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
  • 35 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia
  • 36 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
  • 37 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
  • 38 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 39 Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, Canada
  • 40 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu
Nat Commun, 2020 Mar 05;11(1):1217.
PMID: 32139696 DOI: 10.1038/s41467-020-15046-w

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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