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European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Ho WK 1 , Tan MM 2 , Mavaddat N 3 , Tai MC 4 , Mariapun S 2 , Li J 5 Show all authors , Ho PJ 5 , Dennis J 3 , Tyrer JP 6 , Bolla MK 3 , Michailidou K 3 , Wang Q 3 , Kang D 7 , Choi JY 8 , Jamaris S 9 , Shu XO 10 , Yoon SY 4 , Park SK 7 , Kim SW 11 , Shen CY 12 , Yu JC 13 , Tan EY 14 , Chan PMY 14 , Muir K 15 , Lophatananon A 15 , Wu AH 16 , Stram DO 16 , Matsuo K 17 , Ito H 17 , Chan CW 18 , Ngeow J 19 , Yong WS 20 , Lim SH 21 , Lim GH 21 , Kwong A 22 , Chan TL 22 , Tan SM 23 , Seah J 23 , John EM 24 , Kurian AW 24 , Koh WP 25 , Khor CC 5 , Iwasaki M 26 , Yamaji T 26 , Tan KMV 20 , Tan KTB 20 , Spinelli JJ 27 , Aronson KJ 28 , Hasan SN 4 , Rahmat K 29 , Vijayananthan A 29 , Sim X 30 , Pharoah PDP 3 , Zheng W 10 , Dunning AM 31 , Simard J 32 , van Dam RM 30 , Yip CH 33 , Taib NAM 9 , Hartman M 34 , Easton DF 3 , Teo SH 35 , Antoniou AC 3

Affiliations 

  • 1 School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih, 43500, Selangor, Malaysia. weangkee.ho@nottingham.edu.my
  • 2 School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih, 43500, Selangor, Malaysia
  • 3 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, Cambridge, UK
  • 4 Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia
  • 5 Human Genetics, Genome Institute of Singapore, 60 Biopolis St, 138672, Singapore, Singapore
  • 6 Strangeways Research Laboratory, University of Cambridge, 2 Worts' Causeway, Cambridge, UK
  • 7 Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro, Jongno-Gu, 03080, Seoul, Korea
  • 8 Department of Biomedical Sciences, Seoul National University Graduate School, 103 Daehak-Ro, Jongno-Gu, 03080, Seoul, Korea
  • 9 Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, 50630, Kuala Lumpur, Malaysia
  • 10 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # D3300, Nashville, TN, 37232, USA
  • 11 Department of Surgery, Daerim Saint Mary's Hospital, 657 Siheung-Daero, Daerim-Dong, Yeongdeungpo-Gu, 07442, Seoul, Korea
  • 12 Institute of Biomedical Sciences, Academia Sinica, 115128, Section 2, Academia Road, Taipei, Taiwan
  • 13 Department of Surgery, Tri-Service General Hospital, Taipei, 114, Taiwan
  • 14 Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, Singapore
  • 15 Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, The University of Manchester, Oxford Road, M13 9PL, Manchester, UK
  • 16 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, CA, USA
  • 17 Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-Ku, 464-8681, Nagoya, Japan
  • 18 Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore
  • 19 Division of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore, Singapore
  • 20 Division of Surgical Oncology, National Cancer Centre, Singapore, Singapore
  • 21 Breast Department, KK Women's and Children's Hospital, Singapore, 100 Bukit Timah Road, 229899, Singapore
  • 22 Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, 18A Kung Ngam Village Road, Happy Valley, Hong Kong
  • 23 General Surgery, Changi General Hospital, Singapore, Singapore
  • 24 Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, 780 Welch Road, Suite CJ250C, Stanford, 94304 CA, USA
  • 25 Health Services and Systems Research, Duke-NUS Medical School, Stanford University School of Medicine, 8 College Road, 169857, Singapore, Singapore
  • 26 Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-Ku, 104-0045, Tokyo, Japan
  • 27 Population Oncology, BC Cancer, 675 West 10th Avenue, Vancouver, V5Z 1G1 BC, Canada
  • 28 Department of Public Health Sciences, and Cancer Research Institute, Queen's University, 10 Stuart Street, Kingston, K7L 3N6 ON, Canada
  • 29 Biomedical Imaging Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 30 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, 117549, Singapore, Singapore
  • 31 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Worts' Causeway, CB1 8RN, Cambridge, UK
  • 32 Genomics Center, CHU de Québec-Université Laval Research 2705 Blvd Laurier Québec (Québec) G1V 4G2, Quebec, Canada
  • 33 Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia
  • 34 Department of Surgery, National University Hospital and NUHS, 1E Kent Ridge Road, 119228, Singapore, Singapore
  • 35 Cancer Research Malaysia, 1 Jalan SS12/1A, Subang Jaya, 47500, Selangor, Malaysia. soohwang.teo@cancerresearch.my
Nat Commun, 2020 07 31;11(1):3833.
PMID: 32737321 DOI: 10.1038/s41467-020-17680-w

Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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