Antibacterial efficacy of quaternized chitosan/poly (vinyl alcohol) nanofiber membrane crosslinked with blocked diisocyanate

Wu JY 1 , Ooi CW 2 , Song CP 2 , Wang CY 3 , Liu BL 4 , Lin GY 1 Show all authors , Chiu CY 1 , Chang YK 5

Affiliations 

  • 1 Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan
  • 2 Chemical Engineering Discipline and Advanced Engineering Platform, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia
  • 3 International Ph. D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, 243303, Taiwan
  • 4 Department of Applied Chemistry, Chaoyang University of Technology, Taichung, 413310, Taiwan
  • 5 Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan. Electronic address: ykchang@mail.mcut.edu.tw
Carbohydr Polym, 2021 Jun 15;262:117910.
PMID: 33838797 DOI: 10.1016/j.carbpol.2021.117910

Abstract

N-[(2-hydroxyl-3-trimethylammonium) propyl] chitosan chloride (HTCC), which is a type of chitosan derivative with quaternary ammonium groups, possesses a higher antibacterial activity as compared to the pristine chitosan. The nanofiber membranes made of HTCC are attractive for applications demanding for antibacterial function. However, the hydrophilic nature of HTCC makes it unsuitable for electrospinning of nanofibers. Hence, biodegradable polyvinyl alcohol (PVA) was proposed as an additive to improve the electrospinnability of HTCC. In this work, PVA/HTCC nanofiber membrane was crosslinked with the blocked diisocyanate (BI) to enhance the stability of nanofiber membrane in water. Microbiological assessments showed that the PVA/HTCC/BI nanofiber membranes possessed a good antibacterial efficacy (∼100 %) against E. coli. Moreover, the biocompatibility of PVA/HTCC/BI nanofiber membrane was proven by the cytotoxicity test on mouse fibroblasts. These promising results indicated that the PVA/HTCC/BI nanofiber membrane can be a promising material for food packaging and as a potential wound dressing for skin regeneration.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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