Affiliations 

  • 1 Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food and Pharmaceutical Science, Ningbo University, Ningbo 315211, China
  • 2 Department of Bioprocess Technology, Faculty of Biotechnology & Bimolecular Sciences, Universiti Putra Malaysia UPM, 43400 Serdang, Selangor, Malaya, Malaysia; Institute of Bioscience, Universitiy Putra Malaysia UPM, 43400 Serdang, Selangor, Malaysia
  • 3 Department of Food Technology, Faculty of Food Science and Technology, University Putra Malaysia, Serdang, Malaysia
  • 4 Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food and Pharmaceutical Science, Ningbo University, Ningbo 315211, China. Electronic address: lingzhicheong@yahoo.com
Food Chem, 2022 Jan 15;367:130700.
PMID: 34352694 DOI: 10.1016/j.foodchem.2021.130700

Abstract

Present study prepared curcumin-loaded nanoliposomes using bovine milk, krill phospholipids and cholesterol; and investigated the effects of cholesterol on membrane characteristics, storage stability and antibacterial properties of the curcumin nanoliposomes. Bovine milk phospholipids which have higher saturation than krill phospholipids resulted in formation of curcumin-loaded nanoliposomes with higher encapsulation efficiency (84.78%), larger absolute value of zeta potential and vesicle size (size: 159.15 ± 5.27 nm, zeta potential: -28.3 ± 0.62 mV). Cholesterol helps to formation of a more hydrophobic, compact and tighter bilayer membrane structure which improved the storage stability of nanoliposomes under alkaline (66.25 ± 0.46%), heat (43.25 ± 0.69%) and sunlight (49.44 ± 1.78%) conditions. In addition, curcumin-loaded nanoliposomes can effectively target infectious bacteria which secrete pore-forming toxins such as Staphylococcus aureus by causing the bacterial cell wall to lysis. Findings from present work can guide future development of novel antibacterial agents for use in food preservation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.