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Oral Candidal Load and Oral Health Status in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Case-Cohort Study

Khijmatgar S 1 , Belur G 2 , Venkataram R 2 , Karobari MI 3 , Marya A 4 , Shetty V 5 Show all authors , Chowdhury A 6 , Gootveld M 7 , Lynch E 8 , Shetty S 1 , Shenoy S 5 , K Chaithra 5 , Chowdhury CR 1

Affiliations 

  • 1 NITTE (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Department of Oral Biology and Genomic Studies, Mangalore, India
  • 2 NITTE (Deemed to be university), KS Hegde Medical College and Hospital, Department of Pulmonary Medicine, Mangalore, India
  • 3 Conservative Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia
  • 4 Department of Orthodontics, Faculty of Dentistry, University of Puthisastra, Phnom Penh, Cambodia
  • 5 NITTE (Deemed to be University), KS Hegde Medical College and Hospital, Department of Microbiology, Mangalore, India
  • 6 Global Child Health, King's College London, UK
  • 7 Health and Life Science, De Montfort University, The Gateway, Leicester LE1 9BH, UK
  • 8 School of Dental Medicine, University of Nevada, Las Vegas, USA
Biomed Res Int, 2021;2021:5548746.
PMID: 34545329 DOI: 10.1155/2021/5548746

Abstract

Objective: The objective of this study was to determine the candidal load of the patients with Chronic Obstructive Pulmonary Disease (COPD) and evaluate the oral health status of subjects with COPD. Material and Methods. N = 112 COPD subjects and N = 100 control subjects were included in the study. The selection of COPD cases was confirmed based on the set criteria from the American College of Physicians. The oral health status was assessed as per WHO criteria to determine the score of decayed, missing, and filled teeth (DMFT), significant caries index (SiC), community periodontal index and treatment needs (CPITN), and oral hygiene index-simplified (OHI-S). Gram staining was performed to identify Candida using the whole saliva. Quantitative evaluation of the candidal load was carried out using Sabouraud Dextrose Agar (SDA). Chrome agar was used to differentiate between the commensal carriages. A statistical analysis paired t-test and 95% confidence interval (CI) for proportions was carried out using STATA software.

Results: Candidal growth was found in 21.42% (n = 24) of COPD cases and 1.1% (n = 11) of control cases (p < 0.05) (95% CI 0.45, 0.59). The DMFT score was 8.26 in COPD subjects and 4.6 in controls, the SiC score was 16.42 in COPD subjects and 10.25 in controls, and the CPITN score for both COPD and control cases was score 2.

Conclusion: In conclusion, there was a higher candidal load among subjects suffering from COPD. Theophylline medication can be a risk factor for increased candidal load in COPD patients.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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