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DDT-resistance in West African and Asian strains of Aedes aegypti (L.)

Inwang EE, Khan MA, Brown AW

Bull World Health Organ, 1967;36(3):409-21.
PMID: 5299673

The yellow fever mosquito Aedes aegypti has developed resistance to DDT in the Caribbean region and in South-East Asia, but not in West Africa. Therefore West African strains were compared with South-East Asian strains for their response to laboratory selection with DDT. It was found that West African strains were much slower to respond initially, but eventually could build up a high degree of DDT-resistance. By crossing and backcrossing with a susceptible marker-gene strain, it was found that this resistance was due to a single gene linked with the gene y (yellow) on chromosome 2 at a cross-over distance of approximately 35 units in an Upper Volta strain as in a Bangkok strain; interstrain crosses indicated that the gene was the same as that in a Trinidad strain and in one from Penang. Dieldrin-resistance could be readily induced in the Upper Volta strain and proved to be due to a gene also linked with y but at a crossover distance of approximately 25 units, comparable to that in Caribbean strains previously studied. Material from Karachi, West Pakistan, developed a dieldrin-resistance also showing 25% crossing over with y, and a DDT-resistance also linked with this chromosome-2 marker gene.
Fulltext An energy efficient simultaneous-node repositioning algorithm for mobile sensor networks

Khan MA, Hasbullah H, Nazir B, Khan IA

ScientificWorldJournal, 2014;2014:785305.
PMID: 25152924 DOI: 10.1155/2014/785305

Recently, wireless sensor network (WSN) applications have seen an increase in interest. In search and rescue, battlefield reconnaissance, and some other such applications, so that a survey of the area of interest can be made collectively, a set of mobile nodes is deployed. Keeping the network nodes connected is vital for WSNs to be effective. The provision of connectivity can be made at the time of startup and can be maintained by carefully coordinating the nodes when they move. However, if a node suddenly fails, the network could be partitioned to cause communication problems. Recently, several methods that use the relocation of nodes for connectivity restoration have been proposed. However, these methods have the tendency to not consider the potential coverage loss in some locations. This paper addresses the concerns of both connectivity and coverage in an integrated way so that this gap can be filled. A novel algorithm for simultaneous-node repositioning is introduced. In this approach, each neighbour of the failed node, one by one, moves in for a certain amount of time to take the place of the failed node, after which it returns to its original location in the network. The effectiveness of this algorithm has been verified by the simulation results.
Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats

Armenia, Sattar MA, Abdullah NA, Khan MA, Johns EJ

Auton Autacoid Pharmacol, 2008 Jan;28(1):1-10.
PMID: 18257746 DOI: 10.1111/j.1474-8673.2007.00412.x

1 The present study investigated the effect of streptozotocin-induced diabetes on alpha(1)-adrenoceptor subtypes in rat renal resistance vessels. 2 Studies on renal haemodynamics were carried out 7 days after the last streptozotocin. Changes in renal blood flow were recorded in response to electrical stimulation of the renal nerve (RNS) and a range of adrenergic agonists; noradrenaline (NA), phenylephrine (PE) and methoxamine (MTX), either in the absence or the presence of nitrendipine (Nit), 5-methylurapidil (MEU), chlorethylclonidine (CEC) or BMY 7378. 3 In non-diabetic animals, Nit, MEU and BMY 7378 significantly attenuated renal vasoconstriction induced by adrenergic agonists, while CEC showed a significant accentuation in RNS-induced responses without having a significant effect on responses to adrenergic agonists. In diabetic rats, renal vasoconstriction was also significantly reduced in Nit-, MEU- and BMY 7378-treated groups and CEC potentiated RNS-induced contractions caused a change similar to that observed in non-diabetic rats. BMY 7378 significantly (P < 0.05) attenuated the PE- and MTX-induced vasoconstrictions but did not cause any significant (P > 0.05) alteration in the RNS- and NA-induced responses. 4 The results showed functional co-existence of alpha(1A)- and alpha(1D)-adrenoceptors in the renal vasculature of SD rats irrespective of the presence of diabetes. A possible minor contribution of prejunctional alpha-adrenoceptor subtype has also been suggested in either experimental group, particularly possible functional involvement of alpha(1B)-adrenoceptor subtypes in non-diabetic SD rats.
Cisplatin-induced nephrotoxicity causes altered renal hemodynamics in Wistar Kyoto and spontaneously hypertensive rats: role of augmented renal alpha-adrenergic responsiveness

Hye Khan MA, Abdul Sattar M, Abdullah NA, Johns EJ

Exp. Toxicol. Pathol., 2007 Nov;59(3-4):253-60.
PMID: 17764917

The pathogenesis of cisplatin-induced renal failure is related to reduced renal blood flow due to severe tubular damage and enhanced renovascular resistance. It is also known that alpha(1)-adrenoceptors, the major subtype of alpha-adrenoceptors in renal vasculature play the pivotal role in regulating renal hemodynamics. With this background, we have hypothesized that the altered renal hemodynamics and enhanced renovascular resistance in cisplatin-induced renal failure might be caused by the altered alpha-adrenergic responsiveness with a possible involvement of alpha(1)-adrenoceptors in the renal vasculature. In a unique experimental approach with anesthetized rats, this study has therefore examined if there is any shift in the renovascular responsiveness to renal nerve stimulation and a series of alpha-adrenergic agonists in Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats with cisplatin-induced renal failure in comparison with their body weight-matched normal controls. Thirty-two male rats of both WKY (n=16) and SHR (n=16) origin with body weight 236+/-7.9 g received cisplatin (5mg/kg i.p.). The renal failure was confirmed in terms of significantly reduced renal blood flow, reduced creatinine clearance, increased fractional excretion of sodium, increased kidney index (all P<0.05) and tubular damage. After 7 days of cisplatin, the overnight fasted rats were anesthetized (sodium pentobarbitone, 60 mg/kg i.p.) and renal vasoconstrictor experiments were done. The changes in the vasoconstrictor responses were determined in terms of reductions in renal blood flow caused by electrical renal nerve stimulation or intrarenal administration of noradrenaline, phenylephrine and methoxamine. It was observed that in the cisplatin-treated renal failure WKY and SHR rats there were significant (all P<0.05) reductions in the renal blood flow along with significantly (P<0.05) higher renal adrenergic responsiveness as compared with their non-renal failure controls. The data showed that in the renal failure WKY and SHR rats, the altered renal hemodynamics might be caused by an augmented renal adrenergic responsiveness. The results obtained further led us to suggest that the augmented renal adrenergic responsiveness in the cisplatin-induced renal failure rats were possibly mediated by the alpha(1)-adrenoceptors.
Fulltext Estimation of out-of-pocket costs of patients at the methadone maintenance therapy clinic in Malaysia

Manan MM, Ali SM, Khan MA, Jafarian S

Pak J Pharm Sci, 2015 Sep;28(5):1705-11.
PMID: 26408891

Out-of-pocket (OOP) payments may burden Methadone Maintenance Clinic patients. Since treatment is fully subsidized by the government, financial constraint might lead to patients being made to pay or be given incentive for inconvenience of therapy. This study thus evaluates the characteristic and commitment of methadone therapy patient's in terms of OOP cost, Willingness-To-Pay (WTP) and Willingness-To-Accept (WTA) concept. This survey utilizes the questionnaire by Boris ova & Goodman (2003) on the OOP, WTP and WTA. The forty adult patient's selected medical records from year 2009-2011 were from an urban government methadone clinic. Subject's selection was by convenient sampling based on the predetermined criteria. Most were male (95%) and Malay (60%) was the predominant group. Patients were group into three income groups; ≤ RM1000, ≥ RM1000 -≤ RM2000 and ≥ RM3000. The average OOP cost per month was RM391.30 (s.d RM337.50), which is about 35% of employed patient's monthly income. The wide variation could be attributed by high inter-individual and significant differences between patients in terms of transport, times taken to clinic, cost per trip and weekly household income (p=<0.05). Patients with income of less than RM1000 showed the highest tendency to pay for treatment, asked for the least money for inconvenience and many are unwilling to accept any payments. These findings showed that WTP and WTA is less of a concern for patients in the low-income group. To conclude, OOP payment is not a treatment barrier for most of the urban MMT patients.
Fulltext The non-Newtonian maxwell nanofluid flow between two parallel rotating disks under the effects of magnetic field

Ahmadian A, Bilal M, Khan MA, Asjad MI

Sci Rep, 2020 Oct 13;10(1):17088.
PMID: 33051520 DOI: 10.1038/s41598-020-74096-8

The main feature of the present numerical model is to explore the behavior of Maxwell nanoliquid moving within two horizontal rotating disks. The disks are stretchable and subjected to a magnetic field in axial direction. The time dependent characteristics of thermal conductivity have been considered to scrutinize the heat transfer phenomena. The thermophoresis and Brownian motion features of nanoliquid are studied with Buongiorno model. The lower and upper disk's rotation for both the cases, same direction as well as opposite direction of rotation is investigated. The subsequent arrangement of the three dimensional Navier Stoke's equations along with energy, mass and Maxwell equations are diminished to a dimensionless system of equations through the Von Karman's similarity framework. The comparative numerical arrangement of modeled equations is further set up by built-in numerical scheme "boundary value solver" (Bvp4c) and Runge Kutta fourth order method (RK4). The various physical constraints, such as Prandtl number, thermal conductivity, magnetic field, thermal radiation, time relaxation, Brownian motion and thermophoresis parameters and their impact are presented and discussed briefly for velocity, temperature, concentration and magnetic strength profiles. In the present analysis, some vital characteristics such as Nusselt and Sherwood numbers are considered for physical and numerical investigation. The outcomes concluded that the disk stretching action opposing the flow behavior. With the increases of magnetic field parameter [Formula: see text] the fluid velocity decreases, while improving its temperature. We show a good agreement of the present work by comparing with those published in literature.
Fulltext Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment

Khan MA, Sattar MA, Abdullah NA, Johns EJ

Acta Pharmacol Sin, 2008 Feb;29(2):193-203.
PMID: 18215348 DOI: 10.1111/j.1745-7254.2008.00727.x

This study examined whether alpha1B-adrenoceptors are involved in mediating adrenergically-induced renal vasoconstrictor responses in rats with pathophysiological and normal physiological states.
Fulltext Numerical analysis of thermal conductive hybrid nanofluid flow over the surface of a wavy spinning disk

Ahmadian A, Bilal M, Khan MA, Asjad MI

Sci Rep, 2020 Nov 02;10(1):18776.
PMID: 33139760 DOI: 10.1038/s41598-020-75905-w

A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparticles. The purpose of the study is to improve the rate of thermal energy transmission for several industrial purposes. The wavy rotating surface increases the heat transmission rate up to 15%, comparatively to the flat surface. The subsequent arrangement of modeled equations is diminished into dimensionless differential equation. The obtained system of equations is further analytically expounded via Homotopy analysis method HAM and the numerical Parametric continuation method (PCM) method has been used for the comparison of the outcomes. The results are graphically presented and discussed. It has been presumed that the geometry of spinning disk positively affects the velocity and thermal energy transmission. The addition of hybrid nanoparticles (silver and magnesium-oxide) significantly improved thermal property of carrier fluid. It uses is more efficacious to overcome low energy transmission. Such as, it provides improvement in thermal performance of carrier fluid, which play important role in power generation, hyperthermia, micro fabrication, air conditioning and metallurgical field.
Developing critical thinking in STEM education through inquiry-based writing in the laboratory classroom

Jeon AJ, Kellogg D, Khan MA, Tucker-Kellogg G

Biochem Mol Biol Educ, 2021 01;49(1):140-150.
PMID: 32746505 DOI: 10.1002/bmb.21414

Laboratory pedagogy is moving away from step-by-step instructions and toward inquiry-based learning, but only now developing methods for integrating inquiry-based writing (IBW) practices into the laboratory course. Based on an earlier proposal (Science 2011;332:919), we designed and implemented an IBW sequence in a university bioinformatics course. We automatically generated unique, double-blinded, biologically plausible DNA sequences for each student. After guided instruction, students investigated sequences independently and responded through IBW writing assignments. IBW assignments were structured as condensed versions of a scientific research article, and because the sequences were double blinded, they were also assessed as authentic science and evaluated on clarity and persuasiveness. We piloted the approach in a seven-day workshop (35 students) at Perdana University in Malaysia. We observed dramatically improved student engagement and indirect evidence of improved learning outcomes over a similar workshop without IBW. Based on student feedback, initial discomfort with the writing component abated in favor of an overall positive response and increasing comfort with the high demands of student writing. Similarly, encouraging results were found in a semester length undergraduate module at the National University of Singapore (155 students).
Why research productivity of medical faculty declines after attaining professor rank? A multi-center study from Saudi Arabia, Malaysia and Pakistan

Guraya SY, Khoshhal KI, Yusoff MSB, Khan MA

Med Teach, 2018 09;40(sup1):S83-S89.
PMID: 29730951 DOI: 10.1080/0142159X.2018.1465532

OBJECTIVES: Research has shown a fall of research productivity of faculty after their promotion to professor rank. This study explores the factors that lead to this decline in research productivity of professors in medical discipline.
METHODS: A 20-item questionnaire was distributed online to medical professors of a Saudi, Malaysian and a Pakistani medical school. The participants were instructed to select their responses on a 5-point Likert's scale and the collected data was analyzed for quantitative and qualitative results.
RESULTS: Of 161, 110 responded; response rate of 68.3%. About 35% professors spent 1-4 hours and 2% spent 19-25 hours per week for research. As many as 7% did not publish a single article and 29% had published 10 or more articles after attaining professor rank. During the last two years, 44% professors had published 5 or more research articles. Majority pointed out a lack of research support and funds, administrative burden and difficulty in data collection as the main obstacles to their research.
CONCLUSIONS: This research has identified time constraints and insufficient support for research as key barriers to medical professors' research productivity. Financial and technical support and lesser administrative work load are some suggested remedies to foster the professors' research output.
Fulltext Bioremediation and Electricity Generation by Using Open and Closed Sediment Microbial Fuel Cells

Abbas SZ, Rafatullah M, Khan MA, Siddiqui MR

Front Microbiol, 2018;9:3348.
PMID: 30692985 DOI: 10.3389/fmicb.2018.03348

The industrial contamination of marine sediments with mercury, silver, and zinc in Penang, Malaysia was studied with bio-remediation coupled with power generation using membrane less open (aerated) and closed (non-aerated) sediment microbial fuel cells (SMFCs). The prototype for this SMFC is very similar to a natural aquatic environment because it is not stimulated externally and an oxygen sparger is inserted in the cathode chamber to create the aerobic environment in the open SMFC and no oxygen supplied in the closed SMFC. The open and closed SMFCs were showed the maximum voltage generation 300.5 mV (77.75 mW/m2) and 202.7 mV (45.04 (mW/m2), respectively. The cyclic voltammetry showed the oxidation peak in open SMFCs at +1.9 μA and reduction peak at -0.3 μA but in closed SMFCs oxidation and reduction peaks were noted at +1.5 μA and -1.0 μA, respectively. The overall impedance (anode, cathode and solution) of closed SMFCs was higher than open SMFCs. The charge transfer impedance showed that the rates of substrate oxidation and reduction were very low in the closed SMFCs than open SMFCs. The Nyquist arc indicated that O2 act as electron acceptor in the open SMFCs and CO2 in the closed SMFCs. The highest remediation efficiency of toxic metals [Hg (II) ions, Zn (II) ions, and Ag (I) ions] in the open SMFCs were 95.03%, 86.69%, and 83.65% in closed SMFCs were 69.53%, 66.57%, and 65.33%, respectively, observed during 60-80 days. The scanning electron microscope and 16S rRNA analysis showed diverse exoelectrogenic community in the open SMFCs and closed SMFCs. The results demonstrated that open SMFCs could be employed for the power generation and bioremediation of pollutants.
A novel Sm doped Cr2O3 sesquioxide-decorated MWCNTs heterostructured Fenton-like with sonophotocatalytic activities under visible light irradiation

Eshaq G, M A, Khan MA, Alothman ZA, Sillanpää M

J Hazard Mater, 2022 03 15;426:127812.
PMID: 34844808 DOI: 10.1016/j.jhazmat.2021.127812

Novel Sm doped Cr2O3 decorated MWCNTs nanocomposite photocatalyst was successfully prepared by a facile hydrothermal method for metoprolol (MET) degradation. A heterogeneous photo -Fenton like system was formed with the addition of H2O2 for ultrasonic irradiation (US), visible light irradiation (Vis) and dual irradiation (US/Vis) systems. The intrinsic characteristics of Sm doped Cr2O3 decorated MWCNTs nanocomposite was comprehensively performed using state-of-art characterization tools. Optical studies confirmed that Sm doping shifted the absorbance of Cr2O3 towards the visible-light region, further enhanced by MWCNTs incorporation. In this study, degradation of metoprolol (MET) was investigated in the presence of Cr2O3 nanoparticles, Sm doped Cr2O3 and Sm doped Cr2O3 decorated MWCNTs nanocomposites using sonocatalysis and photocatalysis and simultaneously. Several different experimental parameters, including irradiation time, H2O2 concentration, catalyst amount, initial concentration, and pH value, were optimized. The remarkably enhanced sonophotocatalytic activity of Sm doped Cr2O3 decorated MWCNTs could be attributed to the more formation of reactive radicals and the excellent electronical property of Sm doping and MWCNTs. The rate constant of degradation using sonophotocatalytic system was even higher than the sum of rates of individual systems due to its synergistic performance based on the kinetic data. A plausible mechanism for the degradation of MET over Sm-Cr2O3/MWCNTs is also demonstrated by using active species scavenger studies and EPR spectroscopy. Our findings imply that (•OH), (h+) and (•O2-) were the reactive species responsible for the degradation of MET based on the special three-way Fenton-like mechanism and the dissociation of H2O2. The durability and stability of the nanocomposite were also performed, and the obtained results revealed that the catalysts can endure the harsh sonophotocatalytic conditions even after fifth cycles. Mineralization experiments using the optimized parameters were evaluated as well. The kinetics and the reaction mechanism with the possible reasons for the synergistic effect were presented. Identification of degraded intermediates also investigated.
Robust stabilization of underactuated nonlinear systems: A fast terminal sliding mode approach

Khan Q, Akmeliawati R, Bhatti AI, Khan MA

ISA Trans, 2017 Jan;66:241-248.
PMID: 27884392 DOI: 10.1016/j.isatra.2016.10.017

This paper presents a fast terminal sliding mode based control design strategy for a class of uncertain underactuated nonlinear systems. Strategically, this development encompasses those electro-mechanical underactuated systems which can be transformed into the so-called regular form. The novelty of the proposed technique lies in the hierarchical development of a fast terminal sliding attractor design for the considered class. Having established sliding mode along the designed manifold, the close loop dynamics become finite time stable which, consequently, result in high precision. In addition, the adverse effects of the chattering phenomenon are reduced via strong reachability condition and the robustness of the system against uncertainties is confirmed theoretically. A simulation as well as experimental study of an inverted pendulum is presented to demonstrate the applicability of the proposed technique.
A new implicit high-order iterative scheme for the numerical simulation of the two-dimensional time fractional Cable equation

Khan MA, Alias N, Khan I, Salama FM, Eldin SM

Sci Rep, 2023 Jan 27;13(1):1549.
PMID: 36707653 DOI: 10.1038/s41598-023-28741-7

In this article, we developed a new higher-order implicit finite difference iterative scheme (FDIS) for the solution of the two dimension (2-D) time fractional Cable equation (FCE). In the new proposed FDIS, the time fractional and space derivatives are discretized using the Caputo fractional derivative and fourth-order implicit scheme, respectively. Moreover, the proposed scheme theoretical analysis (convergence and stability) is also discussed using the Fourier analysis method. Finally, some numerical test problems are presented to show the effectiveness of the proposed method.
Fulltext Do geopolitical risk and energy consumption contribute to environmental degradation? Evidence from E7 countries

Husnain MIU, Syed QR, Bashir A, Khan MA

Environ Sci Pollut Res Int, 2022 Jan 30.
PMID: 35094268 DOI: 10.1007/s11356-021-17606-z

Environmental degradation is frequently cited as one of the eminent issues in the modern era. To limit environmental degradation, prior literature discerns several macroeconomic, socio-economic, and institutional factors that affect environmental degradation. However, the relationship between geopolitical risk and environmental degradation is understudied in the previous literature. To fill this gap, the inquiry at hand aims to scrutinize the influence of geopolitical risk on environmental degradation for E7 countries while controlling the effect of renewable energy, non-renewable energy, and GDP. Further, we utilize both the ecological footprint and CO2 emissions as proxies of environmental degradation and employ second-generation panel methods for robust findings. In addition to this, the present study uses augmented mean group (AMG) estimator to provide long-run relationship among the selected variables. The findings from the AMG estimator expound that there exists environmental Kuznets curve (EKC) for E7 countries. Moreover, renewable energy ameliorates environmental quality because it plunges both ecological footprint and CO2 emissions. On the contrary, non-renewable energy consumption escalates both ecological footprint and CO2 emissions. Finally, geopolitical risk tends to decrease CO2 emissions as well as ecological footprint. Our findings deduce a few policy implications to replenish environmental quality. For instance, the share of renewables in the energy mix should be surged to ameliorate the environmental quality. Further, to control both the geopolitical risk and environmental degradation at the same time, policymakers should put forward reforms and initiatives (e.g., policies to escalate R&D, technological innovations, and tax exemptions on imports of renewables) that can help to improve environmental quality without affecting geopolitical risk. At times of low geopolitical risk, environmental degradation will surge; therefore, the rate of environmental control taxes should be increased by the policymakers.
Fulltext Factors affecting repurchase intention of organic food among generation Z (Evidence from developing economy)

Bhutto MY, Khan MA, Sun C, Hashim S, Khan HT

PLoS One, 2023;18(3):e0281527.
PMID: 36961791 DOI: 10.1371/journal.pone.0281527

Organic food has gained much importance due to consumers' rising environmental and health concerns. Purchase intention of organic food has been explored widely, but the repurchase intention of organic food has gained little attention among researchers. So, it has become important to explore repurchase intention among generation Z; a generation considered more educated and aware of rising environmental concerns. Generation Z is more tech-savvy and brand conscious, so its impact on repurchase intention through consumer satisfaction has been explored. The data in this paper was collected from 400 respondents through a structured questionnaire in Islamabad, Pakistan. We used the PLS-SEM approach for data analysis and results; we found that social media influence and brand purchase impact brand awareness and positively impact brand awareness on consumer satisfaction. Moreover, it is also found that consumer satisfaction positively impacts the repurchase intention of organic food. Our study found that Generation Z has a strong social media influence, so marketers' managers must consider and address the issues when consumers consider social media for their concerns and suggestion.
Fulltext Surface Study of CuO Nanopetals by Advanced Nanocharacterization Techniques with Enhanced Optical and Catalytic Properties

Khan MA, Nayan N, Shadiullah, Ahmad MK, Soon CF

Nanomaterials (Basel), 2020 Jul 02;10(7).
PMID: 32630689 DOI: 10.3390/nano10071298

In the present work, a facile one-step hydrothermal synthesis of well-defined stabilized CuO nanopetals and its surface study by advanced nanocharacterization techniques for enhanced optical and catalytic properties has been investigated. Characterization by Transmission electron microscopy (TEM) analysis confirmed existence of high crystalline CuO nanopetals with average length and diameter of 1611.96 nm and 650.50 nm, respectively. The nanopetals are monodispersed with a large surface area, controlled morphology, and demonstrate the nanocrystalline nature with a monoclinic structure. The phase purity of the as-synthesized sample was confirmed by Raman spectroscopy and X-ray diffraction (XRD) patterns. A significantly wide absorption up to 800 nm and increased band gap were observed in CuO nanopetals. The valance band (VB) and conduction band (CB) positions at CuO surface are measured to be of +0.7 and -1.03 eV, respectively, using X-ray photoelectron spectroscopy (XPS), which would be very promising for efficient catalytic properties. Furthermore, the obtained CuO nanopetals in the presence of hydrogen peroxide ( H 2 O 2 ) achieved excellent catalytic activities for degradation of methylene blue (MB) under dark, with degradation rate > 99% after 90 min, which is significantly higher than reported in the literature. The enhanced catalytic activity was referred to the controlled morphology of monodispersed CuO nanopetals, co-operative role of H 2 O 2 and energy band structure. This work contributes to a new approach for extensive application opportunities in environmental improvement.
Fulltext Influence of combined hypertension and renal failure on functional alpha(1)-adrenoceptor subtypes in the rat kidney

Hye Khan MA, Sattar MA, Abdullah NA, Johns EJ

Br J Pharmacol, 2008 Mar;153(6):1232-41.
PMID: 18246093 DOI: 10.1038/bjp.2008.13

This study investigated whether the alpha(1)-adrenoceptor responsiveness of the renal vasculature was altered in the state of hypertension combined with renal failure.
Fulltext The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

Attiq A, Yao LJ, Afzal S, Khan MA

Int Immunopharmacol, 2021 Dec;101(Pt B):108255.
PMID: 34688149 DOI: 10.1016/j.intimp.2021.108255

The coronavirus disease (COVID-19) has once again reminded us of the significance of host immune response and consequential havocs of the immune dysregulation. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) inflicts severe complications to the infected host, including cough, dyspnoea, fever, septic shock, acute respiratory distress syndrome (ARDs), and multiple organ failure. These manifestations are the consequence of the dysregulated immune system, which gives rise to excessive and unattended production of pro-inflammatory mediators. Elevated circulatory cytokine and chemokine levels are accompanied by spontaneous haemorrhage, thrombocytopenia and systemic inflammation, which are the cardinal features of life-threatening cytokine storm syndrome in advanced COVID-19 diseases. Coronavirus hijacked NF-kappa B (NF-κB) is responsible for upregulating the expressions of inflammatory cytokine, chemokine, alarmins and inducible enzymes, which paves the pathway for cytokine storm. Given the scenario, the systemic approach of simultaneous inhibition of NF-κB offers an attractive therapeutic intervention. Targeted therapies with proteasome inhibitor (VL-01, bortezomib, carfilzomib and ixazomib), bruton tyrosine kinase inhibitor (acalabrutinib), nucleotide analogue (remdesivir), TNF-α monoclonal antibodies (infliximab and adalimumab), N-acetylcysteine and corticosteroids (dexamethasone), focusing the NF-κB inhibition have demonstrated effectiveness in terms of the significant decrease in morbidity and mortality in severe COVID-19 patients. Hence, this review highlights the activation, signal transduction and cross-talk of NF-κB with regard to cytokine storm in COVID-19. Moreover, the development of therapeutic strategies based on NF-κB inhibition are also discussed herein.
Fulltext Review on the demographic and social impact of methadone-medication therapy on Malaysian patients

Manan MM, Ali SM, Khan MA, Jafarian S, Hameed MA

Pak J Pharm Sci, 2013 Jul;26(4):841-6.
PMID: 23811468

This study is an observational cross-sectional study aimed to examine the possible demographic and social characteristics of patients enrolled at the Methadone Maintenance Therapy Adherence Clinic (MMTAC) in Malaysia. Medical records from year 2009 - 2011 were Reviewed. Demographic, social characteristics and laboratory examinations such as age, gender, race, clinic attendances and urine analysis were recorded. Subjects were selected by means of convenient sampling but based on the specified inclusion and exclusion criteria. Data were analyzed by either Chi-square test, Fisher's exact test Mann-Whitney U-test, with the limit of significance was set at p < 0.05. Demographically, this study found that the ratio of Malays, Chinese and Indian enrolled to the MMTAC program is similar to the distribution of races in Malaysia. Their starting age for drug use was between 14-35 years and the age to enrolment between 30-58 years. Socially, many are unemployed, lowly educated and married. Most are drug users with a high percentage of HCV accompanied with impaired liver function. Retention rate was 87% but illicit drug use was at 57.50%. However, percentage of employment increased significantly after therapy. The study managed to identify several demographical and social distributions of patients attending the MMTAC. Although attendance rate was high, many were on illicit drug use. Nevertheless, employment rate improved significantly.
Study site: government methadone clinic in Klang, Selangor, Malaysia

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