Displaying publications 1 - 20 of 98 in total

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  1. Enhanced adsorption selectivity of Au(III) over Cu(II) from acidic chloride solutions by chitosan/palm kernel fatty acid distillate/magnetite nanocomposites
    Chang SH, Jampang AOA
    Int J Biol Macromol, 2023 Dec 01;252:126491.
    PMID: 37625756 DOI: 10.1016/j.ijbiomac.2023.126491
    This work aimed to develop a modified chitosan adsorbent with enhanced adsorption selectivity for Au(III) over Cu(II) from acidic chloride solutions using low-cost and green raw materials. Various adsorbents, i.e., chitosan powder, chitosan microbeads, chitosan/palm kernel fatty acid distillate (PKFAD) microcomposites, magnetite nanoparticles, and chitosan/PKFAD/magnetite nanocomposites (CPMNs), were first evaluated for their ability to adsorb Au(III) and Cu(II) from single- and binary-metal solutions across different pH levels, followed by parametric analysis of Au(III) and Cu(II) adsorption from binary- and multi-metal solutions onto CPMNs, Au(III) desorption from Au(III)-loaded CPMNs, and reusability of CPMNs. Finally, Au(III)-loaded CPMNs were characterized with SEM-EDX, XRD, FTIR, and XPS to confirm the proposed adsorption mechanisms. Among all the adsorbents studied, CPMNs exhibited outstanding performance in adsorbing Au(III) from an equimolar binary Au(III)-Cu(II) solution, achieving the highest equilibrium adsorption capacity of 0.479 mmol/g (94.4 mg/g) without reaching saturation. Under optimal adsorption conditions of pH 3, 1 g/L CPMN dosage, and 90 min contact time, CPMNs adsorbed 96 % of Au(III) with a selectivity over Cu(II) exceeding 99 %. CPMNs demonstrated excellent reusability, maintaining over 80 % adsorption and desorption efficiencies for 5 cycles. The proposed adsorption mechanisms of CPMNs for Au(III) encompass electrostatic attraction, hydrogen bonding, solvation, and reduction.
    Matched MeSH terms: Chlorides
  2. Synthesis and characterization of sago starch nanocrystal laurate as a food grade particle emulsifier
    Ahmad A, Fazial FF, Khalil HPSA, Fazry S, Lazim A
    Int J Biol Macromol, 2023 Jul 01;242(Pt 2):124816.
    PMID: 37182623 DOI: 10.1016/j.ijbiomac.2023.124816
    Starch nanocrystals (SNCs) are tiny particles that possess unique qualities due to their small size, such as increased crystallinity, thin sheet structure, low permeability, and strong resistance to digestion. Although sago starch nanocrystals (SNCs) are naturally hydrophilic, their properties can be modified through chemical modifications to make them more versatile for various applications. In this study, the esterification process was used to modify SNCs using lauroyl chloride (LC) to enhance their surface properties. Three different ratios of LC to SNC were tested to determine the impact on the modified SNC (mSNC). The chemical changes in the mSNC were analyzed using FTIR and 1H NMR spectroscopy. ##The results showed that as the amount of LC increased, the degree of substitution (DS) also increased, which reduced the crystallinity of the mSNC and its thermal stability. However, the esterification process also improved the hydrophobicity of the SNC, making it more amphiphilic. The emulsification capabilities of the mSNC were investigated using a Pickering emulsion, and the results showed that the emulsion made from mSNC-1.0 had better stability than the one made from pristine SNC. This study highlights the potential of SNC as a particle emulsifier and demonstrates how esterification can improve its emulsification capabilities.
    Matched MeSH terms: Chlorides
  3. Fulltext A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey
    Hashemi F, Hoepner L, Hamidinejad FS, Haluza D, Afrashteh S, Abbasi A, et al.
    Environ Sci Pollut Res Int, 2023 Jun;30(28):72368-72388.
    PMID: 37166731 DOI: 10.1007/s11356-023-27197-6
    COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation (p-value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87-2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74-1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90-2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused.
    Matched MeSH terms: Chlorides/chemistry
  4. Removal of chloride ion from drinking water using Ag NPs-Modified bentonite: Characterization and optimization of effective parameters by response surface methodology-central composite design
    Moradi H, Sabbaghi S, Mirbagheri NS, Chen P, Rasouli K, Kamyab H, et al.
    Environ Res, 2023 Apr 15;223:115484.
    PMID: 36775091 DOI: 10.1016/j.envres.2023.115484
    The presence of chloride ion as an environmental pollutant is having a devastating and irreversible effect on aquatic and terrestrial ecosystems. To ensure safe and clean drinking water, it is vital to remove this substance using non-toxic and eco-friendly methods. This study presents a novel and highly efficient Ag NPs-modified bentonite adsorbent for removing chloride ion, a common environmental pollutant, from drinking water using a facile approach. The surface chemical properties and morphology of the pristine Na-bentonite and Ag NPs-Modified bentonite were characterized by field emission scanning electron microscopy (FESEM) and X-ray spectroscopy (EDX), X-Ray diffraction (XRD), Fourier transform infrared (FTIR), and zeta potential (ζ). To achieve maximum chloride ion removal, the effects of experimental parameters, including adsorbent dosage (1-9 g/L), chloride ion concentration (100-900 mg/L), and reaction time (5-25 h), were examined using the Response Surface Methodology (RSM). The chloride ion removal of 90% was obtained at optimum conditions (adsorbent dosage: 7 g/L, chloride ion concentration: 500 mg/L, and reaction time: 20 h). The adsorption isotherm and kinetics results indicated that the Langmuir isotherm model and pseudo-second-order kinetics were found suitable to chloride ion removal. Additionally, the regeneration and reusability of the Ag NPs-modified bentonite were further studied. In the regeneration and reusability study, the Ag NPs-modified bentonite has shown consistently ≥90% and ≥87% chloride ion removal even up to 2 repeated cycles, separately. Thus, the findings in this study provided convincing evidence for using Ag-NPs modified bentonite as a high-efficiency and promising adsorbent to remove chloride ion from drinking water.
    Matched MeSH terms: Chlorides
  5. Determination of biogenic amines in chicken, beef, and mutton by dansyl chloride microwave derivatization in Malaysia
    Yue CS, Lim AK, Chia ML, Wong PY, Chin JSR, Wong WH
    J Food Sci, 2023 Feb;88(2):650-665.
    PMID: 36624628 DOI: 10.1111/1750-3841.16404
    In this study, an improved dansyl-chloride derivatization technique using a microwave synthesizer was used for the qualitative and quantitative analyses of biogenic amine in the fresh meat samples. The derivatization technique was optimized in terms of temperature, reaction time, and spinning speed. The derivatization method together with a validated reversed-phase HPLC-DAD method was used for the determination of biogenic amines in chicken, beef, and mutton sold in the wet market. The results of the analyses showed that tryptamine, putrescine, and histamine were generally detected in all the three types of meat. Higher levels of histamine were found in chicken and beef. However, low levels of histamine were observed in mutton. Tyramine was either detected low or moderate in all the three types of meat. The biogenic amines of the fresh meat sold in the wet market is generally higher than the reported values. The mechanisms of biogenic amines-dansyl-chloride formation were investigated and proposed. PRACTICAL APPLICATION: The biogenic amine derivatization method was improved. The improved derivatization method can be potentially used for various food products beside meats for routine biogenic amine analyses due to its fast analysis time and simplicity. High levels of biogenic amines were generally found in the meat sold in the wet markets. However, proper handling of the raw meat can reduce the risk of infection.
    Matched MeSH terms: Chlorides
  6. Preliminary study on the toxicological response of red tilapia (Oreochromis niloticus) on landfill leachate treated with Tin(IV) chloride and Jatropha curcas
    Zainal SFFS, Aziz HA, Ramli SF, Omar FM
    Water Environ Res, 2022 Jan;94(1):e1667.
    PMID: 34842319 DOI: 10.1002/wer.1667
    This study was conducted to evaluate the effect of the toxicity levels of the coagulation and flocculation process on raw and treated leachate using acute toxicity tests. Tin tetrachloride (SnCl4 ) and the Jatropha curcas (JC) seed were used as coagulant and coagulant aid to remove concentrated suspended solids, SS (534 mg/L), color (19,297 Pt-Co), and chemical oxygen demand (COD) (4188 mg/L) in a stabilized landfill leachate. The toxicity effects on local red tilapia fish (Oreochromis niloticus) were investigated, which involved three main steps, namely, acclimatization, range-finding test, and short-term definitive test. The presence of JC seed (0.9 g/L) as a flocculant reduced the dosage of SnCl4 from 11.1 to 8.5 g/L and exhibited good removals of 99.78%, 98.53%, and 74.29%, respectively, for SS, color, and COD. The toxicity test indicated that only five fish died in the first 12 h for the treated sample compared with seven deaths for untreated leachate. In 96 h, a total of 42 and 31 mortality rates were noted for the raw and treated leachate samples, respectively. The treated sample could reduce the toxicity effects to the tested tilapia fish and is safe to be discharged at appropriate dilution concentrations. PRACTITIONER POINTS: Coagulation-flocculation by Tin (IV) chloride and Jatropha Curcas (JC) was investigated. Almost complete reduction of SS was obtained at 8.5 g/L of SnCl4 and 0.9 g/L of JC as flocculant. The toxicity effect was evaluated using red tilapia (Oreochromis niloticus) fish as the indicator. Treated leachate was considered acceptable as the number of dead fish was lower than the untreated leachate.
    Matched MeSH terms: Chlorides
  7. Fulltext The Potential Use of Nephelium lappaceum Seed as Coagulant-Coagulant Aid in the Treatment of Semi-Aerobic Landfill Leachate
    Aziz HA, Rahmat NS, Alazaiza MYD
    Int J Environ Res Public Health, 2021 Dec 31;19(1).
    PMID: 35010685 DOI: 10.3390/ijerph19010420
    Chemical-based coagulants and flocculants are commonly used in the coagulation-flocculation process. However, the drawbacks of using these chemical materials have triggered researchers to find natural materials to substitute or reduce the number of chemical-based coagulants and flocculants. This study examines the potential application of Nephelium lappaceum seeds as a natural coagulant-coagulant aid with Tin (IV) chloride (SnCl4) in eliminating suspended solids (SS), colour, and chemical oxygen demand (COD) from landfill leachate. Results showed that the efficiency of Nephelium lappaceum was low when used as the main coagulant in the standard jar test. When SnCl4 was applied as a single coagulant, as much as 98.4% of SS, 96.8% of colour and 82.0% of COD was eliminated at an optimal dose of 10.5 g/L and pH 7. The higher removal efficiency of colour (88.8%) was obtained when 8.40 g/L of SnCl4 was applied with a support of 3 g/L of Nephelium lappaceum. When SnCl4 was utilised as a coagulant, and Nephelium lappaceum seed was used as a flocculant, the removal of pollutants generally improved. Overall, this research showed that Nephelium lappaceum seed is a viable natural alternative for treating landfill leachate as a coagulant aid.
    Matched MeSH terms: Chlorides
  8. Influence of Jatropha curcas seeds as a natural flocculant on reducing Tin (IV) tetrachloride in the treatment of concentrated stabilised landfill leachate
    Zainal SFFS, Aziz HA, Omar FM, Alazaiza MYD
    Chemosphere, 2021 Dec;285:131484.
    PMID: 34261011 DOI: 10.1016/j.chemosphere.2021.131484
    Stabilised leachate usually contains lower concentration of organic compounds than younger leachate; it has low biodegradability and generally unsuitable for biological treatment. The effectiveness of tetravalent metal salts in a coagulation-flocculation (C-F) process is still inclusive. Application of natural coagulants as an alternative to the chemical could reduce chemical usage, is less costly, and environmentally friendly. Hence, the objective of the current research is to examine the possibility of reducing the amount of Tin (IV) chloride (SnCl4) as a primary coagulant by adding Jatropha curcas (JC) as a flocculant as a sole treatment through the C-F process in treating concentrated suspended solids (SS) (547 mg/L), colour (19,705 Pt-Co) and chemical oxygen demand (COD) (4202 mg/L) in stabilised landfill leachate. The work also aims to evaluate the sludge properties after treatment. Functional groups, such as carboxylic acids, hydroxyl and amine/amino compounds (protein contents), were detected in the JC seed to facilitate the C-F process by neutralising the charge pollutant in water and cause the possibility of hydrogen bonding interaction between molecules. The combination of JC seed (0.9 g/L) as a flocculant reduced the dosage of SnCl4 as a coagulant from 11.1 g/L to 8.5 g/L with removals of 99.78%, 98.53% and 74.29% for SS, colour and COD, respectively. The presence of JC improved the sludge property with good morphology; the particles were in a rectangular shape, had clumps and strong agglomeration. These properties of sludge proved that JC seed could enhance the adsorption and bridging mechanism in the C-F procedure.
    Matched MeSH terms: Chlorides
  9. Anthropogenic emissions of atomic chlorine precursors in the Yangtze River Delta region, China
    Yi X, Yin S, Huang L, Li H, Wang Y, Wang Q, et al.
    Sci Total Environ, 2021 Jun 01;771:144644.
    PMID: 33736175 DOI: 10.1016/j.scitotenv.2020.144644
    Chlorine radical plays an important role in the formation of ozone and secondary aerosols in the troposphere. It is hence important to develop comprehensive emissions inventory of chlorine precursors in order to enhance our understanding of the role of chlorine chemistry in ozone and secondary pollution issues. Based on a bottom-up methodology, this study presents a comprehensive emission inventory for major atomic chlorine precursors in the Yangtze River Delta (YRD) region of China for the year 2017. Four primary chlorine precursors are considered in this study: hydrogen chloride (HCl), fine particulate chloride (Cl-) (Cl- in PM2.5), chlorine gas (Cl2), and hypochlorous acid (HClO) with emissions estimated for twelve source categories. The total emissions of these four species in the YRD region are estimated to be 20,424 t, 15,719 t, 1556 and 9331 t, respectively. The emissions of HCl are substantial, with major emissions from biomass burning and coal combustion, together accounting for 68% of the total HCl emissions. Fine particulate Cl- is mainly emitted from industrial processing, biomass burning and waste incineration. The emissions of Cl2 and HClO are mainly associated with usage of chlorine-containing disinfectants, for example, water treatment, wastewater treatment, and swimming pools. Emissions of each chlorine precursor are spatially allocated based on the characteristics of individual source category. This study provides important basic dataset for further studies with respect to the effects of chlorine chemistry on the formation of air pollution complex in the YRD region.
    Matched MeSH terms: Chlorides
  10. Synthesis of metallic mixed 3R and 2H Nb1+xS2 nanoflakes by chemical vapor deposition
    Mohmad AR, Hamzah AA, Yang J, Wang Y, Bozkurt I, Shin HS, et al.
    Faraday Discuss, 2021 Apr 01;227:332-340.
    PMID: 33523053 DOI: 10.1039/c9fd00132h
    In this work, we report the synthesis and characterization of mixed phase Nb1+xS2 nanoflakes prepared by chemical vapor deposition. The as-grown samples show a high density of flakes (thickness ∼50 nm) that form a continuous film. Raman and X-ray diffraction data show that the samples consist of both 2H and 3R phases, with the 2H phase containing a high concentration of Nb interstitials. These Nb interstitials sit in between the NbS2 layers to form Nb1+xS2. Cross-sectional Energy Dispersive Spectroscopy analysis with transmission electron microscopy suggests that the 2H Nb1+xS2 region is found in thinner flakes, while 3R NbS2 is observed in thicker regions of the films. The evolution of the phase from 2H Nb1+xS2 to 3R NbS2 may be attributed to the change of the growth environment from Nb-rich at the start of the growth to sulfur-rich at the latter stage. It was also found that the incorporation of Nb interstitials is highly dependent on the temperature of the NbCl5 precursor and the position of the substrate in the furnace. Samples grown at high NbCl5 temperature and with substrate located closer to the NbCl5 source show higher incorporation of Nb interstitials. Electrical measurements show linear I-V characteristics, indicating the metallic nature of the Nb1+xS2 film with relatively low resistivity of 4.1 × 10-3Ω cm.
    Matched MeSH terms: Chlorides
  11. Chloride reduction by water washing of crude palm oil to assist in 3-monochloropropane-1, 2 diol ester (3-MCPDE) mitigation
    Lakshmanan S, Yung YL
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2021 Mar;38(3):371-387.
    PMID: 33596165 DOI: 10.1080/19440049.2020.1842516
    Chloride reduction in crude palm oil (CPO) of greater than 80% was achieved with water washing conducted at 90°C. Inorganic chloride content in CPO was largely removed through washing, with no significant reduction in the organic chloride. Phosphorous content of CPO reduced by 20%, while trace elements such as calcium, magnesium and iron were also reduced in the washing operation. The 3-MCPDE formed in the refined, bleached and deodorised palm oil displayed (RBDPO) a linear relationship with the chloride level in washed CPO, which could be represented by the equation y = 0.91x, where y is 3-MCPDE and x represents the chloride in RBDPO refined from washed CPO. In plant scale trials using 5% water at 90°C, mild acidification of the wash water at 0.05% reduced chloride by average 76% in washed CPO. Utilising selected bleaching earths, controlled wash water temperature and wash water volume produced low chloride levels in RBDPO. Chloride content less than 1.4 mg kg-1 in plant RBDPO production was achieved, through physical refining of washed CPO containing less than 2 mg kg-1 chloride and would correspond to 3-MCPDE levels of 1.25 mg kg-1 in RBDPO. The 3-MCPDE reduced further to 1.1 mg kg-1 as the chloride level of washed CPO decreased below 1.8 mg kg-1. Chloride has been shown to facilitate the 3-MCPDE formation and its removal in lab scale washing study has yielded lower 3-MCPDE levels formed in RBDPO. In actual plant operations using washed CPO, 3-MCPDE levels below 1.25 mg kg-1 were achieved consistently in RBDPO.
    Matched MeSH terms: Chlorides/chemistry*
  12. Fulltext The Role of Zinc Chloride in Enhancing Mechanical, Thermal and Electrical Performance of Ethylene Vinyl Acetate/Carbonized Wood Fiber Conductive Composite
    Mohd Pisal MH, Osman AF, Jin TS, Rahman RA, Alrashdi AA, Masa A
    Polymers (Basel), 2021 Feb 17;13(4).
    PMID: 33671304 DOI: 10.3390/polym13040600
    Carbonized natural filler can offer the production of low cost composites with an eco-friendliness value. The evolving field of electronics encourages the exploration of more functions and potential for carbonized natural filler, such as by modifying its surface chemistry. In this work, we have performed surface modification on carbonized wood fiber (CWF) prior to it being used as filler in the ethylene vinyl acetate (EVA) composite system. Zinc chloride (ZnCl2) with various contents (2 to 8 wt%) was used to surface modify the CWF and the effects of ZnCl2 composition on the surface morphology and chemistry of the CWF filler were investigated. Furthermore, the absorptive, mechanical, thermal, and electrical properties of the EVA composites containing CWF-ZnCl2 were also analyzed. SEM images indicated changes in the morphology of the CWF while FTIR analysis proved the presence of ZnCl2 functional groups in the CWF. EVA composites incorporating the CWF-ZnCl2 showed superior mechanical, thermal and electrical properties compared to the ones containing the CWF. The optimum content of ZnCl2 was found to be 6 wt%. Surface modification raised the electrical conductivity of the EVA/CWF composite through the development of conductive deposits in the porous structure of the CWF as a channel for ionic and electronic transfer between the CWF and EVA matrix.
    Matched MeSH terms: Chlorides
  13. Fulltext Induction of Caspase-Mediated Apoptosis in HepG2 Liver Carcinoma Cells Using Mutagen-Antioxidant Conjugated Self-Assembled Novel Carbazole Nanoparticles and In Silico Modeling Studies
    Anand K, Abdul NS, Ghazi T, Ramesh M, Gupta G, Tambuwala MM, et al.
    ACS Omega, 2021 Jan 12;6(1):265-277.
    PMID: 33458478 DOI: 10.1021/acsomega.0c04461
    In this study, novel self-assembled carbazole-thiooctanoic acid nanoparticles (CTNs) were synthesized from amino carbazole (a mutagen) and thiooctanoic acid (an antioxidant). The nanoparticles were characterized using hyperspectral techniques. Then, the antiproliferative potential of CTNs was determined in HepG2 liver carcinoma cells. This study employed a solvent-antisolvent interaction method to synthesize a spherical CTN of size less than 50 nm. Moreover, CT was subsequently capped to gold nanoparticles (AuNPs) in the additional comparative studies. The CT derivative was synthesized from carbazole and lipoic acid by the amide bond formation reaction using a coupling agent. Furthermore, it was characterized using infrared (IR), 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH4. The CTAuNPs were characterized using ultraviolet-visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.
    Matched MeSH terms: Chlorides
  14. Fulltext Data for the industrial and municipal environmental wastes hazard contaminants assessment with integration of RES2D techniques and Oasis Montaj software
    Arifin MH, Kayode JS, Ismail KI, Abdullah M, Embrandiri A, Nazer SM, et al.
    Data Brief, 2020 Dec;33:106595.
    PMID: 33318980 DOI: 10.1016/j.dib.2020.106595
    Industrial, and municipal wastes are part of the main sources of environmental hazards as well as groundwater and surface water pollutions. If not well composed, treated, and safely disposed, it could permeate through the subsurface lithologies by reaching down to the underground water aquifers, particularly in zones of unprotected aquifer units. Pollutants, most especially the landfills leachates that encompassed organic contaminants, ammonia, nitrates, total nitrogen, suspended solids, heavy metals and soluble inorganic salts, i.e., soluble nitrogen, sulphur compound, sulphate and chlorides, could posed undesirable environmental impacts due to inappropriate disposals that may give rise to gaseous fumes and leachate formations. An electrical resistivity geophysical technique utilizing the RES2D no-invasive, cost-effective and rapid method of data collection was integrated with the 3D Oasis Montaj software to approximate the volume of the generated rectangular prism model of the contaminants delineated from mixtures of the industrial, and municipal wastes plumes to be 312,000 m 3.
    Matched MeSH terms: Chlorides
  15. Fulltext Photocatalytic Properties of Graphene/Gold and Graphene Oxide/Gold Nanocomposites Synthesized by Pulsed Laser Induced Photolysis
    Chen LH, Shen HT, Chang WH, Khalil I, Liao SY, A Yehye W, et al.
    Nanomaterials (Basel), 2020 Oct 07;10(10).
    PMID: 33036455 DOI: 10.3390/nano10101985
    Graphene (Gr)/gold (Au) and graphene-oxide (GO)/Au nanocomposites (NCPs) were synthesized by performing pulsed-laser-induced photolysis (PLIP) on hydrogen peroxide and chloroauric acid (HAuCl4) that coexisted with Gr or GO in an aqueous solution. A 3-month-long aqueous solution stability was observed in the NCPs synthesized without using surfactants and additional processing. The synthesized NCPs were characterized using absorption spectroscopy, transmission electron microscopy, Raman spectroscopy, energy dispersive spectroscopy, and X-ray diffraction to prove the existence of hybrid Gr/Au or GO/Au NCPs. The synthesized NCPs were further evaluated using the photocatalytic reaction of methylene blue (MB), a synthetic dye, under UV radiation, visible light (central wavelength of 470 nm), and full spectrum of solar light. Both Gr/Au and GO/Au NCPs exhibited photocatalytic degradation of MB under solar light illumination with removal efficiencies of 92.1% and 94.5%, respectively.
    Matched MeSH terms: Chlorides
  16. A revisit to the effects of zinc salt on skin burn wound healing to reflect the risks in current pharmaceutical care
    Osman MAH, Wong TW, Anuar NK
    J Dermatolog Treat, 2020 Sep;31(6):651-654.
    PMID: 31264929 DOI: 10.1080/09546634.2019.1639607
    The lower limit of soluble zinc content that can possibly be applied onto a wounded skin as a healing promoter was not known. This study examined skin wound healing process of rats inflicted by partial thickness thermal burn wound as a function of applied soluble zinc contents (0.1 ml of zinc chloride solution 0.01% (w/w) or 5.0% (w/w)). The size, surface morphology and histological profiles of wound beds of untreated rats and those treated with zinc chloride solutions were characterized. A soluble zinc content as low as 10.5 μg/cm2 of skin negated skin wound healing when compared to the untreated rats. This was alarming as the commercial products currently in the market are formulated with a high level of zinc content. Albeit the zinc salt employed was water-insoluble, a minute fraction of soluble zinc might be available to the treatment sites. This could be partially responsible for the late adverse effects such as pruritis and inflammation reported with calamine/diphenhydramine lotion, medicated shampoo, Olay Complete defense moisturizing lotion and Zineryt® topical solution. The skin irritation was likely a resultant oxidative stress action of soluble zinc, where a small fraction could be adequate to negate the skin homeostasis.[Figure: see text]Key messagesZinc is essentially a cofactor for skin collagen formation.Soluble zinc content as low as 10.5 μg/cm2 of skin irritates skin and negates burn wound healing.Skin irritation of commercial products relates to minute soluble zinc content availability.
    Matched MeSH terms: Chlorides
  17. Report - Synthesis of new antibacterial agents encompassing tosyl, piperidine, propanamide and 1,3,4-oxadiazole functionalities
    Sattar A, Aziz-Ur-Rehman -, Abbasi MA, Siddiqui SZ, Rasool S, Ali Shah SA
    Pak J Pharm Sci, 2020 Jul;33(4):1697-1705.
    PMID: 33583804
    A series of propanamide compounds 6a-l was derived by N-substitution reactions, encompassing tosyl, piperidine and 1,3,4-oxadiazole moieties. The intended array of compounds 6a-l was afforded by a series of five steps reaction scheme. 1-Tosylpiperidin-4-carboxylate (1) was synthesized by the reaction of tosyl chloride (a) with ethyl isonipecotate (b) under mild basic conditions. Compound 1 was subjected to nucleophillic substitution by hydrazine to synthesize 1-tosylpiperidin-4-carbohydrazide (2). The compound, 5-(1-tosylpiperidin-4-yl)-1,3,4-oxadiazole-2-thiol (3) was synthesized by intermolecular cyclization of compound 2 by CS2 under strong basic conditions. The target compounds, 6a-l, were finally synthesized from 3 by reacting with different electrophiles, 5a-l, in an aprotic polar solvent with sodium hydride as an activator. The different propanamoyl electrophiles, 5a-l, were synthesized by the reaction of different aromatic and aliphatic amines, 4a-l, with 3-bromopropionyl chloride under mild basic conditions. The structural elucidation was carried out using modern spectroscopic techniques including IR, 1H-NMR and EI-MS. The antibacterial potential of synthesized compounds was assessed against five bacterial strains. Compounds 6a, 6c, 6d, 6e and 6f were found to be potent antibacterial agents.
    Matched MeSH terms: Chlorides
  18. Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2-propenyl]piperazine as suitable antibacterial agents
    Abbasi MA, Ijaz M, Aziz-Ur-Rehman -, Siddiqui SZ, Ali Shah SA, Shahid M, et al.
    Pak J Pharm Sci, 2020 Jul;33(4):1609-1616.
    PMID: 33583794
    In the planned research work, the nucleophilic substitution reaction of 1-[(E)-3-phenyl-2-propenyl]piperazine (1) was carried out with different sulfonyl chlorides (2a-g) at pH 9-10 to synthesize its different N-sulfonated derivatives (3a-g). The structures of the synthesized compounds were characterized by their proton-nuclear magnetic resonance (1H-NMR), carbon-nuclear magnetic resonance (13C-NMR) and Infra Red (IR) spectral data, along with CHN analysis. The inhibition potential of the synthesized molecules was ascertained against two bacterial pathogenic strains i.e. Bacillus subtilis and Escherichia coli. It was inferred from the results that some of the compounds were very suitable inhibitors of these bacterial strains. Moreover, their cytotoxicity was also profiled and it was outcome that most of these molecules possessed moderate cytotoxicity.
    Matched MeSH terms: Chlorides
  19. Fulltext Hypocalcemia, hypochloremia, and eosinopenia as clinical predictors of leptospirosis: A retrospective study
    Fish-Low CY, Balami AD, Than LTL, Ling KH, Mohd Taib N, Md Shah A, et al.
    J Infect Public Health, 2020 Feb;13(2):216-220.
    PMID: 31455598 DOI: 10.1016/j.jiph.2019.07.021
    BACKGROUND: Underestimation of leptospirosis cases is happening in many countries. The most common factor of underreporting is misdiagnosis. Considering the limitations of direct detection of pathogen and serological diagnosis for leptospirosis, clinical features and blood tests though non-specific are usually referred in making presumptive diagnosis to decide disease management.

    METHODS: In this single-centre retrospective study, comparative analysis on clinical presentations and laboratory findings was performed between confirmed leptospirosis versus non-leptospirosis cases.

    RESULTS: In multivariate logistic regression evidenced by a Hosmer-Lemeshow significance value of 0.979 and Nagelkerke R square of 0.426, the predictors of a leptospirosis case are hypocalcemia (calcium <2.10mmol/L), hypochloremia (chloride <98mmol/L), and eosinopenia (absolute eosinophil count <0.040×109/L). The proposed diagnostic scoring model has a discriminatory power with area under the curve (AUC) 0.761 (p<0.001). A score value of 6 reflected a sensitivity of 0.762, specificity of 0.655, a positive predictive value of 0.38, negative predictive value of 0.91, a positive likelihood ratios of 2.21, and a negative likelihood ratios of 0.36.

    CONCLUSION: With further validation in clinical settings, implementation of this diagnostic scoring model is helpful to manage presumed leptospirosis especially in the absence of leptospirosis confirmatory tests.

    Matched MeSH terms: Chlorides/blood*
  20. Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
    Raza H, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Hassan M, Abbas Q, et al.
    Bioorg Chem, 2020 01;94:103445.
    PMID: 31826809 DOI: 10.1016/j.bioorg.2019.103445
    In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (2) in aqueous basic medium to give various electrophiles, 4-chloro-N-(substituted-phenyl)butanamides (3a-e). These electrophiles were then coupled with 1-[(E)-3-phenyl-2-propenyl]piperazine (4) in polar aprotic medium to attain the targeted N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides (5a-e). The structures of all derivatives were identified and characterized by proton-nuclear magnetic resonance (1H NMR), carbon-nuclear magnetic resonance (13C NMR) and Infra-Red (IR) spectral data along with CHN analysis. The in vitro inhibitory potential of these butanamides was evaluated against Mushroom tyrosinase, whereby all compounds were found to be biologically active. Among them, 5b exhibited highest inhibitory potential with IC50 value of 0.013 ± 0.001 µM. The same compound 5b was also assayed through in vivo approach, and it was explored that it significantly reduced the pigments in zebrafish. The in silico studies were also in agreement with aforesaid results. Moreover, these molecules were profiled for their cytotoxicity through hemolytic activity, and it was found that except 5e, all other compounds showed minimal toxicity. The compound 5a also exhibited comparable results. Hence, some of these compounds might be worthy candidates for the formulation and development of depigmentation drugs with minimum side effects.
    Matched MeSH terms: Chlorides
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