Displaying publications 1 - 20 of 91 in total

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  1. iSegMSI: An Interactive Strategy to Improve Spatial Segmentation of Mass Spectrometry Imaging Data
    Guo L, Liu X, Zhao C, Hu Z, Xu X, Cheng KK, et al.
    Anal Chem, 2022 Oct 25;94(42):14522-14529.
    PMID: 36223650 DOI: 10.1021/acs.analchem.2c01456
    Spatial segmentation is a critical procedure in mass spectrometry imaging (MSI)-based biochemical analysis. However, the commonly used unsupervised MSI segmentation methods may lead to inappropriate segmentation results as the MSI data is characterized by high dimensionality and low signal-to-noise ratio. This process can be improved by the incorporation of precise prior knowledge, which is hard to obtain in most cases. In this study, we show that the incorporation of partial or coarse prior knowledge from different sources such as reference images or biological knowledge may also help to improve MSI segmentation results. Here, we propose a novel interactive segmentation strategy for MSI data called iSegMSI, which incorporates prior information in the form of scribble-regularization of the unsupervised model to fine-tune the segmentation results. By using two typical MSI data sets (including a whole-body mouse fetus and human thyroid cancer), the present results demonstrate the effectiveness of the iSegMSI strategy in improving the MSI segmentations. Specifically, the method can be used to subdivide a region into several subregions specified by the user-defined scribbles or to merge several subregions into a single region. Additionally, these fine-tuned results are highly tolerant to the imprecision of the scribbles. Our results suggest that the proposed iSegMSI method may be an effective preprocessing strategy to facilitate the analysis of MSI data.
    Matched MeSH terms: Diagnostic Imaging
  2. Fulltext Watermarking techniques used in medical images: a survey
    Mousavi SM, Naghsh A, Abu-Bakar SA
    J Digit Imaging, 2014 Dec;27(6):714-29.
    PMID: 24871349 DOI: 10.1007/s10278-014-9700-5
    The ever-growing numbers of medical digital images and the need to share them among specialists and hospitals for better and more accurate diagnosis require that patients' privacy be protected. As a result of this, there is a need for medical image watermarking (MIW). However, MIW needs to be performed with special care for two reasons. Firstly, the watermarking procedure cannot compromise the quality of the image. Secondly, confidential patient information embedded within the image should be flawlessly retrievable without risk of error after image decompressing. Despite extensive research undertaken in this area, there is still no method available to fulfill all the requirements of MIW. This paper aims to provide a useful survey on watermarking and offer a clear perspective for interested researchers by analyzing the strengths and weaknesses of different existing methods.
    Matched MeSH terms: Diagnostic Imaging/standards*
  3. Fulltext Utilization of Point-of-Care Ultrasound to Detect Splenic Microabscesses in Pediatric Melioidosis
    Sakulchit T, Ngu L, Chor YK, Ong GY
    Cureus, 2021 Mar 08;13(3):e13760.
    PMID: 33842136 DOI: 10.7759/cureus.13760
    Melioidosis is an infectious disease most commonly found in places with tropical climates. Definitive diagnosis can be confirmed by culture or pathological results of blood or infected organ. However, imaging study is helpful in providing early provisional diagnosis and guiding therapy. Point-of-care ultrasound can be currently performed bedside by non-radiological staff such as emergency physicians or intensivists. We present the case of a pediatric patient who got diagnosed with melioidosis after detection of multiple splenic and hepatic abscesses by point-of-care ultrasound, leading to early diagnosis and appropriate empirical antibiotic selection, resulting in good treatment outcome.
    Matched MeSH terms: Diagnostic Imaging
  4. Fulltext Use of shared care and routine tests in follow-up after treatment for localised cutaneous melanoma
    Lim WY, Turner RM, Morton RL, Jenkins MC, Irwig L, Webster AC, et al.
    BMC Health Serv Res, 2018 06 20;18(1):477.
    PMID: 29925350 DOI: 10.1186/s12913-018-3291-7
    BACKGROUND: Patients may decide to undertake shared care with a general practitioner (GP) during follow-up after treatment for localised melanoma. Routine imaging tests for surveillance may be commonly used despite no evidence of clinical utility. This study describes the frequency of shared care and routine tests during follow-up after treatment for localised melanoma.

    METHODS: We randomly sampled 351 people with localised melanoma [American Joint Cancer Committee (AJCC) substages 0 - II] who had not had recurrent or new primary melanoma diagnosed from a total of 902 people diagnosed and treated for localised melanoma at a specialist centre in 2014. We interviewed participants by telephone about their experience of follow-up in the past year, and documented the proportion of patients who were undertaking shared care follow-up with a GP. We also recorded the frequency and type of investigations during follow-up. We calculated weighted estimates that are representative of the full inception cohort.

    RESULTS: Of the 351 people who were invited to participate, 230 (66%) people consented to the telephone interview. The majority undertook shared care follow-up with a GP (61%). People who choose to have shared care follow-up with a GP are more likely to be male (p = 0.006), have lower AJCC stage (p for trend = 0.02), reside in more remote areas (p for trend

    Matched MeSH terms: Diagnostic Imaging
  5. Fulltext Ultra-Wideband (UWB) Antenna Sensor Based Microwave Breast Imaging: A Review
    Mahmud MZ, Islam MT, Misran N, Almutairi AF, Cho M
    Sensors (Basel), 2018 Sep 05;18(9).
    PMID: 30189633 DOI: 10.3390/s18092951
    Globally, breast cancer is reported as a primary cause of death in women. More than 1.8 million new breast cancer cases are diagnosed every year. Because of the current limitations on clinical imaging, researchers are motivated to investigate complementary tools and alternatives to available techniques for detecting breast cancer in earlier stages. This article presents a review of concepts and electromagnetic techniques for microwave breast imaging. More specifically, this work reviews ultra-wideband (UWB) antenna sensors and their current applications in medical imaging, leading to breast imaging. We review the use of UWB sensor based microwave energy in various imaging applications for breast tumor related diseases, tumor detection, and breast tumor detection. In microwave imaging, the back-scattered signals radiating by sensors from a human body are analyzed for changes in the electrical properties of tissues. Tumorous cells exhibit higher dielectric constants because of their high water content. The goal of this article is to provide microwave researchers with in-depth information on electromagnetic techniques for microwave imaging sensors and describe recent developments in these techniques.
    Matched MeSH terms: Diagnostic Imaging
  6. Fulltext UWB Antenna with Enhanced Directivity for Applications in Microwave Medical Imaging
    Awan D, Bashir S, Khan S, Al-Bawri SS, Dalarsson M
    Sensors (Basel), 2024 Feb 18;24(4).
    PMID: 38400473 DOI: 10.3390/s24041315
    Microwave medical imaging (MMI) is experiencing a surge in research interest, with antenna performance emerging as a key area for improvement. This work addresses this need by enhancing the directivity of a compact UWB antenna using a Yagi-Uda-inspired reflector antenna. The proposed reflector-loaded antenna (RLA) exhibited significant gain and directivity improvements compared to a non-directional reference antenna. When analyzed for MMI applications, the RLA showed a maximum increase of 4 dBi in the realized gain and of 14.26 dB in the transmitted field strength within a human breast model. Moreover, it preserved the shape of time-domain input signals with a high correlation factor of 94.86%. To further validate our approach, another non-directional antenna with proven head imaging capabilities was modified with a reflector, achieving similar directivity enhancements. The combined results demonstrate the feasibility of RLAs for improved performance in MMI systems.
    Matched MeSH terms: Diagnostic Imaging
  7. The past, present and future of imaging in multiple sclerosis
    Ramli N, Rahmat K, Azmi K, Chong HT
    J Clin Neurosci, 2010 Apr;17(4):422-7.
    PMID: 20167498 DOI: 10.1016/j.jocn.2009.09.014
    Despite technological advances in imaging, multiple sclerosis (MS) remains a clinical diagnosis that is supported, but not replaced, by laboratory or imaging findings. However, imaging is essential in the current diagnostic criteria of MS, for prediction of the likelihood of MS for patients with clinically isolated syndromes, correlation with lesion pathology and assessment of treatment outcome. This article gives an overview of imaging in MS with particular emphasis on the role of MRI in various diagnostic imaging criteria. Novel imaging for MS using 3 Tesla field strengths, magnetization transfer imaging, diffusion tensor imaging, magnetic resonance spectroscopy and cell-specific contrast will be reviewed.
    Matched MeSH terms: Diagnostic Imaging/methods*
  8. Fulltext The Lancet Commission on diagnostics: transforming access to diagnostics
    Fleming KA, Horton S, Wilson ML, Atun R, DeStigter K, Flanigan J, et al.
    Lancet, 2021 Nov 27;398(10315):1997-2050.
    PMID: 34626542 DOI: 10.1016/S0140-6736(21)00673-5
    Matched MeSH terms: Diagnostic Imaging*
  9. Fulltext Strategies for radiology departments in handling the COVID-19 pandemic
    Ashari MA, Zainal IA, Zaki FM
    Diagn Interv Radiol, 2020 Jul;26(4):296-300.
    PMID: 32352915 DOI: 10.5152/dir.2020.20232
    The world is facing an unprecedented global pandemic in the form of the coronavirus disease 2019 (COVID-19) which has ravaged all aspects of life, especially health systems. Radiology services, in particular, are under threat of being overwhelmed by the sheer number of patients affected, unless drastic efforts are taken to contain and mitigate the spread of the virus. Proactive measures, therefore, must be taken to ensure the continuation of diagnostic and interventional support to clinicians, while minimizing the risk of nosocomial transmission among staff and other patients. This article aims to highlight several strategies to improve preparedness, readiness and response towards this pandemic, specific to the radiology department.
    Matched MeSH terms: Diagnostic Imaging/standards; Diagnostic Imaging/trends
  10. Fulltext Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
    Fadzli F, Rahmat K, Ramli MT, Rozalli FI, Hooi TK, Fadzli AN, et al.
    Medicine (Baltimore), 2021 Apr 23;100(16):e25297.
    PMID: 33879660 DOI: 10.1097/MD.0000000000025297
    To evaluate the clinical and imaging findings of papillary breast neoplasm and review the pathologic correlation at a tertiary center.Retrospective study of patients diagnosed with benign and malignant papillary lesions between 2008 to 2018. 147 patients were identified with histology diagnosis of papillary lesions. The clinical, imaging, and pathological characteristics were reviewed.Patient cohort included 147 women diagnosed with papillary lesions (mean age at diagnosis 53.8 years) and were divided into 3 histology groups (benign, atypical, and malignant). Common clinical presentations were breast lump (n = 60) and nipple discharge (n = 29), 48 patients were asymptomatic.Only 37 were detected as a mass lesion on mammogram. The presence of mass lesion on mammogram was the most common feature in all 3 papillary lesion groups, and with the presence of asymmetric density, were the 2 mammographic features significantly associated (P 
    Matched MeSH terms: Nipple Discharge/diagnostic imaging
  11. Sim-to-Real: Employing ultrasonic guided wave digital surrogates and transfer learning for damage visualization
    Alguri KS, Chia CC, Harley JB
    Ultrasonics, 2021 Mar;111:106338.
    PMID: 33338729 DOI: 10.1016/j.ultras.2020.106338
    Wavefield imaging is a powerful visualization tool in nondestructive evaluation for studying ultrasonic wave propagation and its interactions with damage. To isolate and study damage scattering, damage-free baseline data is often subtracted from a wavefield. This is often necessary because the damage wavefield can be orders of magnitude weaker than the incident waves. Yet, baselines are not always accessible. When the baselines are accessible, the experimental conditions for the baseline and test data must be extremely similar. Researchers have created several baseline-free approaches for isolating damage wavefields, but these often rely on specific experimental setups. In this paper, we discuss a flexible approach based on ultrasonic guided wave digital surrogates (i.e., numerical simulations of incident waves) and transfer learning. We demonstrate this approach with two setups. We first isolate reflections from a circular, 2 mm diameter half-thickness hole on a 10 × 10 cm steel plate. We then isolate 8 circular, half-thickness holes of various diameters from 1 mm to 40 mm on a 60 × 60 cm steel plate. The second plate has a non-square geometry and the data has multi-path reflections. With both data sets, we isolate damage reflections without explicit experimental baselines. We also briefly illustrate the comparison of our dictionary learning method with wavenumber filtering technique which is often used to enhance the defect wavefields.
    Matched MeSH terms: Diagnostic Imaging
  12. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia
    Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, et al.
    J Am Med Dir Assoc, 2014 Feb;15(2):95-101.
    PMID: 24461239 DOI: 10.1016/j.jamda.2013.11.025
    Sarcopenia, a newly recognized geriatric syndrome, is characterized by age-related decline of skeletal muscle plus low muscle strength and/or physical performance. Previous studies have confirmed the association of sarcopenia and adverse health outcomes, such as falls, disability, hospital admission, long term care placement, poorer quality of life, and mortality, which denotes the importance of sarcopenia in the health care for older people. Despite the clinical significance of sarcopenia, the operational definition of sarcopenia and standardized intervention programs are still lacking. It is generally agreed by the different working groups for sarcopenia in the world that sarcopenia should be defined through a combined approach of muscle mass and muscle quality, however, selecting appropriate diagnostic cutoff values for all the measurements in Asian populations is challenging. Asia is a rapidly aging region with a huge population, so the impact of sarcopenia to this region is estimated to be huge as well. Asian Working Group for Sarcopenia (AWGS) aimed to promote sarcopenia research in Asia, and we collected the best available evidences of sarcopenia researches from Asian countries to establish the consensus for sarcopenia diagnosis. AWGS has agreed with the previous reports that sarcopenia should be described as low muscle mass plus low muscle strength and/or low physical performance, and we also recommend outcome indicators for further researches, as well as the conditions that sarcopenia should be assessed. In addition to sarcopenia screening for community-dwelling older people, AWGS recommends sarcopenia assessment in certain clinical conditions and healthcare settings to facilitate implementing sarcopenia in clinical practice. Moreover, we also recommend cutoff values for muscle mass measurements (7.0 kg/m(2) for men and 5.4 kg/m(2) for women by using dual X-ray absorptiometry, and 7.0 kg/m(2) for men and 5.7 kg/m(2) for women by using bioimpedance analysis), handgrip strength (<26 kg for men and <18 kg for women), and usual gait speed (<0.8 m/s). However, a number of challenges remained to be solved in the future. Asia is made up of a great number of ethnicities. The majority of currently available studies have been published from eastern Asia, therefore, more studies of sarcopenia in south, southeastern, and western Asia should be promoted. On the other hand, most Asian studies have been conducted in a cross-sectional design and few longitudinal studies have not necessarily collected the commonly used outcome indicators as other reports from Western countries. Nevertheless, the AWGS consensus report is believed to promote more Asian sarcopenia research, and most important of all, to focus on sarcopenia intervention studies and the implementation of sarcopenia in clinical practice to improve health care outcomes of older people in the communities and the healthcare settings in Asia.
    Matched MeSH terms: Diagnostic Imaging
  13. Fulltext Salivary and imaging-based biomarkers of radiation therapy-induced xerostomia
    Atif S, Wahab NA, Ghafoor S, Saeed MQ, Ahmad A
    J Pak Med Assoc, 2021 Mar;71(3):938-942.
    PMID: 34057953 DOI: 10.47391/JPMA.1115
    Biomarkers are anatomical characteristics or naturally occurring measurable molecules indicating physiological or pathological state of an individual. These biomarkers have the potential to detect or predict diseases at an early stage, which is particularly beneficial in timely management of common complications of radiation therapy done in head and neck cancer treatment regime. Xerostomia is one of the most common oral complaints of radiation therapy. Saliva has an abundance of protein biomarkers; however, those related to post-radiation therapy xerostomia need to be explored further. Textural and imaging-based biomarkers are helpful in predicting xerostomia in such patients. This narrative review provides an account of salivary protein and imaging-based biomarkers of radiation therapy-induced xerostomia in head and neck cancer patients.
    Matched MeSH terms: Diagnostic Imaging
  14. Roux-en-Y gastric bypass for lower esophageal submucosal cancer in an obese diabetic patient
    Almulaifi AM, Lee WJ, Hong PE
    Surg Obes Relat Dis, 2014 Nov-Dec;10(6):e73-5.
    PMID: 25002323 DOI: 10.1016/j.soard.2014.04.013
    Matched MeSH terms: Diagnostic Imaging
  15. Fulltext Role of Penile Doppler as a Diagnostic Tool in Penile Fracture
    Hassali MA, Nouri AI, Hamzah AA, Verma AK
    J Med Ultrasound, 2018 03 28;26(1):48-51.
    PMID: 30065514 DOI: 10.4103/JMU.JMU_9_18
    Penile fracture is defined as a traumatic rupture of either corpus cavernosum or the tunica albuginea; sometimes it can be both. It may be caused by exotic masturbation acts, sexual intercourse, or other trauma to this area. This can be accompanied by injury to the urethra, which is the cause of hematuria as a symptom for some patients. Typically, diagnosis of penile rupture or fracture depends on clinical examination and history told by the patients. We are stating the importance of medical imaging in the diagnosis of patients with penile fracture by presenting a case of patient suffered from penile fracture after a fall on his penis where it affected the erection of two-third of his penis. In which, the proper diagnosis by imaging studies and taking actions accordingly can save the patients from unnecessary surgeries that indeed increase the bill of the medical care directly and indirectly. Therefore, most patients can be diagnosed cost-effectively and treated surgically without a need to delay surgery, which is often the case if one was to resort to other investigations. Investigations such as retrograde urethrography for suspected urethral injury should only be used when the diagnosis of penile fracture is in doubt.
    Matched MeSH terms: Diagnostic Imaging
  16. Reflection coefficient detection of simulation models for microwave imaging simulation system
    Chew KM, Sudirman R, Seman N, Yong CY
    Biomed Mater Eng, 2014;24(1):199-207.
    PMID: 24211899 DOI: 10.3233/BME-130800
    The study was conducted based on two objectives as framework. The first objective is to determine the point of microwave signal reflection while penetrating into the simulation models and, the second objective is to analyze the reflection pattern when the signal penetrate into the layers with different relative permittivity, εr. Thus, several microwave models were developed to make a close proximity of the in vivo human brain. The study proposed two different layers on two different characteristics models. The radii on the second layer and the corresponding antenna positions are the factors for both models. The radii for model 1 is 60 mm with an antenna position of 10 mm away, in contrast, model 2 is 10 mm larger in size with a closely adapted antenna without any gap. The layers of the models were developed with different combination of materials such as Oil, Sandy Soil, Brain, Glycerin and Water. Results show the combination of Glycerin + Brain and Brain + Sandy Soil are the best proximity of the in vivo human brain grey and white matter. The results could benefit subsequent studies for further enhancement and development of the models.
    Matched MeSH terms: Diagnostic Imaging/instrumentation; Diagnostic Imaging/methods*
  17. Fulltext Radon concentration in workplace indoor air
    Abdullah Mohd Noh, Nordin Ayoub, Siti Zurina Mat Noor, Norhafizah Zahari, Mardhiyati Mohd Yunus
    Journal of Occupational Safety and Health, 2019;16(1):19-25.
    MyJurnal
    Radon exists naturally in the air. It can accumulate inside the buildings which may affect the indoor air quality. Radon is a radioactive gas that produces alpha particles during decay time. The alpha particles might cause harm to the human lungs and stomach. Inhalation of radon is one of the causes of lung cancer disease. Samples of inhaled radon in different rooms at the workplace were taken hourly through a passive diffusion chamber. The detection method was done using Alpha Spectrometry. The short term measurement was applied in the study to monitor the average weekly radon reading in different rooms in the Medical Imaging Laboratory of the University of Selangor (UNISEL). All tested rooms showed the existence of radon gas with different concentrations. Some of them showed the maximum reading of radon concentration which was higher than the radon action level of 148Bq/m3 or 4pCi/l. Their weekly average of radon concentration is contributing almost 50% of the accumulated radon concentration in the laboratory. It is highly recommended that monitoring the concentration of radon in indoor air is performed to ensure it is at a safe and healthy level.
    Matched MeSH terms: Diagnostic Imaging
  18. Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
    Chan BT, Yeoh HK, Liew YM, Dokos S, Al Abed A, Chee KH, et al.
    Coron Artery Dis, 2018 06;29(4):316-324.
    PMID: 29261521 DOI: 10.1097/MCA.0000000000000596
    OBJECTIVE: This study investigated the intraventricular flow dynamics in ischaemic heart disease patients.

    PATIENTS AND METHODS: Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI.

    RESULTS: The results obtained showed no significant differences in intraventricular flow variables between the healthy group and the patients with normal ejection fraction group, whereas considerable reductions in kinetic energy (KE) fluctuation index, E' (P<0.001) and vortex KE (P=0.003) were found in the patients with reduced ejection fraction group. In multivariate analysis, only vortex KE and infarct size were significantly related to LV ejection fraction (P<0.001); furthermore, vortex KE was correlated negatively with energy dissipation, energy dissipation index (r=-0.44, P=0.021).

    CONCLUSION: This study highlights that flow energetic indices have limited applicability as early predictors of LV progressive dysfunction, whereas vortex KE could be an alternative to LV performance.

    Matched MeSH terms: ST Elevation Myocardial Infarction/diagnostic imaging
  19. Fulltext Preparing effective illustrations. Part 2: photographs, images and diagrams
    Ng KH, Peh WC
    Singapore Med J, 2009 Apr;50(4):330-4; quiz 335.
    PMID: 19421674
    In part two of "Preparing effective illustrations", the other three categories, viz. photographs, radiological images and diagrams, are discussed. Illustrations provide visual information to supplement the results in a scientific paper, and create a visual impact that can improve the readability of a paper. This article provides some basic guidelines to assist authors in preparing effective photographs, radiological images and diagrams.
    Matched MeSH terms: Diagnostic Imaging*
  20. Pre-operative ultrasonographic prediction of hamstring autograft size for anterior cruciate ligament reconstruction surgery
    Mohd Asihin MA, Bajuri MY, Ahmad J, Syed Kamaruddin SF
    Ceylon Med J, 2018 03 31;63(1):11-16.
    PMID: 29754479
    Objectives: To evaluate the feasibility of ultrasonographic examination in predicting 4-strand semitendinosus and gracilis tendon (4S-STG) autograft size preoperatively in anterior cruciate ligament reconstruction and to evaluate the use of anthropometric measurement to predict the 4-strand semitendinosus and gracilis tendons (4S-STG) autograft size pre-operatively in anterior cruciate ligament reconstruction.

    Method: Twenty-seven patients were included in this study conducted from 1st January to 31st December 2013. All patients were skeletally mature and scheduled to undergo primary anterior cruciate ligament reconstruction using 4S-STG autograft. Ultrasonographic examination of semitendinosus and gracilis tendons to measure the cross sectional area was conducted and anthropometric data (weight, height, leg length and thigh circumference) was measured one day prior to surgery. True autograft diameters were measured intraoperatively using closed-hole sizing block in 0.5 mm incremental size.

    Results: There is a statistically significant correlation between the measured combined cross sectional area (semitendinosus and gracilis tendons) and 4S-STG autograft diameter (p = 0.023). An adequate autograft size (at least 7 mm) can be obtained when the combined cross sectional area is at least 15 mm2. There was no correlation with the anthropometric data except for thigh circumference (p = 0.037). Autograft size of at least 7 mm can be obtained when the thigh circumference is at least 41 mm.

    Conclusions: Both combined cross sectional area (semitendinosus and gracilis tendons) and thigh circumference can be used to predict an adequate 4S-STG autograft size.

    Matched MeSH terms: Hamstring Tendons/diagnostic imaging*
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