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  1. Fulltext LACTIC ACID BACTERIA ISOLATED FROM LOCALLY PRODUCED VINEGARS AND THEIR ANTIBACTERIAL ACTIVITY AGAINST FOODBORNE BACTERIA
    AGNES LEE CHIU NEE, MOHD NIZAM LANI, ROZILA ALIAS, ZAITON HASSAN
    UMT Journal of Undergraduate Research, 2019;1(2):1-7.
    MyJurnal
    Vinegars are most widely used as preservatives in food industry. Vinegars are known for their health benefits; however, the roles of vinegar-associated microflora in locally produced vinegars are not well established. The objectives of this study are to isolate and identify the lactic acid bacteria (LAB) from black rice vinegar and coconut vinegar, measure their pH and titratable acidity, and determine their antibacterial activity. LAB was isolated using cultural method. Phenotypic characterization of LAB was carried out using Gram-staining, oxidase test, catalase test and API 50 CHL Kit. Results from API 50 CHL Kit confirmed that BRV03M strain from black rice vinegar and CV03M strain from coconut vinegar were Lactobacillus paracaseissp. paracasei. The identified bacteria in both samples were consistent as L. paracaseiusing 16S rDNAgene sequences with 93% and 99% similarity, respectively. The pH and titratable acidity percentage of both vinegars were also determined. The stability of Cell Free Supernatant-Lactic Acid Bacteria (CFS-LAB) strains within 14 days on their inhibition against selected pathogenic bacteria was determined using agar well diffusion method. The CFS-LAB strain isolated from black rice vinegar (BRV03M) was more stable within 14 days than coconut vinegar in inhibiting tested bacteria, suggesting this strain has great potential as natural antibacterial agents.
    Matched MeSH terms: Fatigue Syndrome, Chronic
  2. Fulltext Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome
    Ab Kahar MEPI, Muhammed J, Hitam WHW, Husin A
    Turk J Ophthalmol, 2020 12 29;50(6):371-376.
    PMID: 33389938 DOI: 10.4274/tjo.galenos.2020.83873
    Bartonella henselae is a recognized cause of neuroretinitis in cat scratch disease. Meanwhile, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome with Castleman disease (evidence of lymph node hyperplasia), is a chronic debilitating condition that predisposes to various superimposed infections. B. henselae neuroretinitis implicated in POEMS syndrome has not been reported previously. A 34-year-old asymptomatic man was referred for an eye assessment. Examination showed visual acuity of 6/18 in the right eye and 6/24 in the left eye. On fundus examination, both eyes exhibited typical features of neuroretinitis (optic disc swelling and incomplete macular star). There was otherwise no vitritis or chorioretinitis. Serology for B. henselae revealed high immunoglobulin M (IgM) titer (1:96) indicative of acute disease, and positive immunoglobulin G (IgG) (1:156). He was treated with oral azithromycin for 6 weeks and a short course of oral prednisolone. Subsequently, the visual acuity in both eyes improved with resolution of macular star. However, both optic discs remained swollen.
    Matched MeSH terms: POEMS Syndrome/complications*; POEMS Syndrome/diagnosis
  3. Fulltext Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface
    Abad IPL, Fam RL, Nguyen DT, Nowell CJ, Trinh PNH, Manallack DT, et al.
    Biomed Pharmacother, 2020 Dec;132:110860.
    PMID: 33059258 DOI: 10.1016/j.biopha.2020.110860
    Five different subunits of the human serotonin 3 (5-hydroxytrptamine 3; 5-HT3) receptor exist and these are present in both central and peripheral systems. Different subunits alter the efficacy of 5-HT3 receptor antagonists used to treat diarrhoea predominant-irritable bowel syndrome, chemotherapy induced nausea and vomiting and depression. Cell surface arrangement of 5-HT3 receptor complexes and the contribution of C, D and E subunits to receptor function is poorly understood. Here, we examine interactions of A and C subunits using 5-HT3 receptor subunits containing fluorescent protein inserts between the 3rd and 4th transmembrane spanning region. HEK293T cells that do not normally express 5-HT3 receptor subunits, were transiently transfected with A or C or both subunits. Patch clamp experiments show that cells transfected with either fluorescent protein tagged A or A and C subunits generate whole cell currents in response to 5-HT. These findings correlate with the apparent distribution of fluorescent protein tagged A and C subunits at or near cell surfaces detected using TIRF microscopy. In co-transfected cells, the A and C subunits are associated forming AC heteromer complexes at or near the cell surface and a proportion can also form A or C homomers. In conclusion, it is likely that both A homomers and AC heteromers contribute to whole cell currents in response to 5-HT with minimal contribution from C homomers.
    Matched MeSH terms: Irritable Bowel Syndrome
  4. Fulltext Scalene myofascial pain syndrome mimicking cervical disc prolapse: a report of two cases
    Abd Jalil N, Awang MS, Omar M
    Malays J Med Sci, 2010 Jan;17(1):60-6.
    PMID: 22135529 MyJurnal
    Scalene myofascial pain syndrome is a regional pain syndrome wherein pain originates over the neck area and radiates down to the arm. This condition may present as primary or secondary to underlying cervical pathology. Although scalene myofascial pain syndrome is a well known medical entity, it is often misdiagnosed as being some other neck pain associated with radiculopathy, such as cervical disc prolapse, cervical spinal stenosis and thoracic outlet syndrome. Because scalene myofascial pain syndrome mimics cervical radiculopathy, this condition often leads to mismanagement, which can, in turn, result in persistent pain and suffering. In the worst-case scenarios, patients may be subjected to unjustifiable surgical intervention. Because the clinical findings in scalene myofascial pain syndrome are "pathognomonic", clinicians should be aware of ways to recognize this disorder and be able to differentiate it from other conditions that present with neck pain and rediculopathy. We present two cases of unilateral scalene myofascial pain syndrome that significantly impaired the patients' functioning and quality of life. This case report serves to create awareness about the existence of the syndrome and to highlight the potential morbidity due to clinical misdiagnosis.
    Matched MeSH terms: Thoracic Outlet Syndrome
  5. Penilaian Kualiti Jasad Batuan di Terowong Kedua Genting Sempah, Selangor Darul Ehsan (Rock Mass Quality Evaluation of the Second Tunnel at Genting Sempah, Selangor Darul Ehsan)
    Abdul Ghani Rafek, Khairuddin Nordin
    Sains Malaysiana, 1997;26.
    The new Genting Sempah tunnel represents an important part of the widening and upgrading of the main east-west road link between Kuala Lumpur on the west coast and Kuantan on the east coast of Peninsular Malaysia. The new tunnel is located between 18m to 30m north of the existing (old) tunnel which was constructed in 1975 and has a similar alignment. Engineering geological investigations and site characterization for the construction of the new tunnel were carried out in 1994 with drilling, aerial photograph interpretation, surface geological mapping, geophysical surveys and laboratory testing. Rock mass classification was carried out based on the Q classification system of Barton et at. (1974). Based on this classification, it was predicted that for the tunnel zone, 8.6 % of the length of the tunnel consisted of rock mass classified as very poor i.e. type two, 82.8% as extremely poor, i.e. type three and the remaining 8.6% as exceptionally poor, i.e. type four. Excavation of the tunnel between March 1995 and September 1996 together with engineering geological logging and rock mass classification revealed the following; type two, very poor 6.3%, type three, extremely poor 89.9%, type four, exceptionally poor 3.8%. These results show the general validity of the prediction of the rock mass quality.
    Terowong kedua Genting Sempah merupakan suatu bahagian utama dalam pembesaran dan peningkatan taraf jalan timur-barat utama yang menghubungi Kuala Lumpur di pantai barat dan Kuantan di pantai timur Semenanjung Malaysia. Terowong kedua berkedudukan 18 m hingga 30 m ke utara terowong lama yang dibina pada tahun 1975 dan mempunyai penjajaran yang sama. Penyiasatan geologi kejuruteraan dan pemeriksaan tapak pembinaan terowong kedua dilaksanakan pada tahun 1994 dengan penggerudian, pentafsiran fotograf udara, pemetaan geologi permukaan, survei geofizik dan ujian makmal. Pengelasan kualiti jasad batuan dilakukan berdasarkan sistem pengelasan Q oleh Barton et al. (1974). Hasil pengelasan ini di zon terowong meramalkan 8.6% panjang terowong baru terdiri daripada jasad batuan berkualiti sangat rendah, iaitu jenis dua, 82.8% berkualiti tersangat rendah, iaitu jenis tiga manakala 8.6% panjang terowong terdiri daripada jasad batuan berkualiti luarbiasa rendah, iaitu jenis empat. Penggalian terowong di antara Mac 1995 dan September 1996 dengan rakaman geologi kejuruteraan dan pengelasan jasad batuan semasa penggalian menghasilkan keputusan seperti berikut; jenis dua, berkualiti sangat rendah 6.3%, jenis tiga, berkualiti tersangat rendah 89.9%, jenis empat, berkualiti luar biasa rendah 3.8%. Keputusan
    Matched MeSH terms: Macrophage Activation Syndrome
  6. Fulltext Treatment response in osmotic demyelination syndrome presenting as severe parkinsonism, ptosis and gaze palsy
    Abdul Halim S, Mohd Amin NA
    BMJ Case Rep, 2018 Oct 21;2018.
    PMID: 30344146 DOI: 10.1136/bcr-2018-225751
    Osmotic demyelination syndrome commonly affects the pons and infrequently involves the extrapontine region. We report a patient with severe hyponatraemia who developed osmotic demyelination syndrome as a consequence of rapid sodium correction. The condition manifested as acute severe parkinsonism, bilateral ptosis and gaze impairment. MRI revealed typical features of central pontine and extrapontine myelinolysis. The patient improved gradually after treatment with a combination of levodopa, intravenous immunoglobulin and dexamethasone. However, it is important to emphasise that the improvement of neurological symptoms is not necessarily causal with these experimental therapies.
    Matched MeSH terms: Syndrome
  7. Fulltext Metabolic syndrome in psychiatric patients with primary psychotic and mood disorders
    Abdul Hamid Abdul Rahman, Holifa Saheera Asmara, Hatta Sidi, Azlin Baharudin
    ASEAN Journal of Psychiatry, 2009;10(2):127-134.
    MyJurnal
    Objective: A study was conducted at the Universiti Kebangsaan Malaysia Medical Center (UKMMC) adult psychiatric clinic from June 2006 to December 2006. The aim was to assess the rate of the metabolic syndrome in a group of outpatients with mood disorders and schizophrenia and also to determine the relationship of this condition with sociodemographic factors and psychiatric illness characteristics.
    Methods: A total of 51 subjects agree to participate of which 100 were approached. The International Diabetes Federation (IDF)(2005) criteria are used for the diagnosis of metabolic syndrome and Diagnostic Statistical Manual Version IV (DSM-IV) criteria are used to made psychiatric diaognosis.
    Results: The prevalence of metabolic syndrome was found to be 37.2% and was significantly higher amongst mood disorders patient. However the metabolic syndrome is not associated with the anti psychotic therapy (p=0.41).
    Conclusion: This study suggests that it is important for the psychiatrist to monitor metabolic syndrome in any of their patients.
    Study site: Psychiatric clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
    Matched MeSH terms: Metabolic Syndrome X
  8. Strengthening acute coronary syndrome referral network: Insights from initiatives of Penang General Hospital cardiology centre
    Abdul Kader MAS
    Med J Malaysia, 2019 08;74(4):355-358.
    PMID: 31424052
    The importance of networking for the management of acute coronary syndrome (ACS) has been emphasised in the 2012 guidelines by the European Society of Cardiology (ESC) on ST-segment elevation myocardial infarction (STEMI). In Penang, the ACS referral network has the Penang General Hospital (PGH), a percutaneous coronary intervention (PCI)- capable hospital, with 14 other hospitals referring their patients for PCI to PGH on a daily basis. In one of its review regarding the referral methodology in the network, PGH's Cardiology centre observed gaps in the referral systems, which was leading to poor quality of referrals. To address these issues, the PGH Cardiology centre developed a standardised protocol and conducted a one-day workshop to educate medical officers about the standardised protocol. This commentary piece is a proof of this concept, and aims to share the experience and provide an overview on the initiatives by the PGH, which has resulted in improved quality of PCI referrals.
    Matched MeSH terms: Acute Coronary Syndrome/therapy*
  9. Dental care access among individuals with Down syndrome: a Malaysian scenario
    Abdul Rahim FS, Mohamed AM, Marizan Nor M, Saub R
    Acta Odontol Scand, 2014 Nov;72(8):999-1004.
    PMID: 25029211 DOI: 10.3109/00016357.2014.936036
    The purpose of this cross-sectional study was to assess the legal representatives' perceptions on dental care access of individuals with Down syndrome (DS) compared to their non-DS siblings in Peninsular Malaysia.
    Matched MeSH terms: Down Syndrome/complications*
  10. Fulltext Malocclusion and orthodontic treatment need evaluated among subjects with Down syndrome using the Dental Aesthetic Index (DAI)
    Abdul Rahim FS, Mohamed AM, Nor MM, Saub R
    Angle Orthod, 2014 Jul;84(4):600-6.
    PMID: 24417495 DOI: 10.2319/062813-480.1
    OBJECTIVE: To determine the prevalence of malocclusion and need for orthodontic treatment among persons with Down Syndrome (DS).

    MATERIALS AND METHODS: Study participants were 113 persons with DS from the selected community-based rehabilitation center who fulfilled the inclusion and exclusion criteria. Ten occlusal characteristics of the Dental Aesthetic Index (DAI) were measured on study models to determine the degree of malocclusion. A single score represented the dentofacial anomalies, determined the level of severity, and determined the need for orthodontic treatment.

    RESULTS: Crowding in the anterior maxillary and mandibular arch was the main malocclusion problems among the subjects with DS. Comparison between age group and genders revealed no significant differences in four categories of orthodontic treatment need (P > .05).

    CONCLUSION: Most of the subjects with DS (94; 83.2%) had severe and very severe malocclusion, which indicated a desirable and mandatory need for orthodontic treatment.

    Matched MeSH terms: Down Syndrome/epidemiology*
  11. Fulltext The Aetiology And Management Of ChronicIdiopathic Facial Pain: A Review
    Abdul Rahman, Z.A.
    Ann Dent, 1998;5(1):-.
    MyJurnal
    Chronic idiopathic facial pain is the diagnosis given to a group of orofacial pain of psychogenic origin which includes atypical facial pain, facial-arthromyalgia, atypical odontalgia and oral dysaesthesia. Despite various biochemical findings, the condition remains poorly understood, but we have begun to understand the nature of these patients. This review discusses the possible aetiology of the disease through various biochemical and clinical findings. The contribution of behavioural and psychological factors to the clinical course of the disease are described. The type of adverse life events that predispose people to the disease and their potency are briefly mentioned. The current diagnostic approach for the disease is also mentioned. Treatment includes antidepressant medication, physiotherapy, bite-guards and analgesics. The problems encountered in the long-term management and outcome studies of these patients include drop-outs, non-compliance and denial.
    Matched MeSH terms: Burning Mouth Syndrome
  12. Polyps! Polyps! And More Polyps! - The First Case of Cronkhite-Canada Syndrome in Malaysia
    Abdul Rani R, Hussin FR, Hamzaini AH, Isa MR, Raja Ali RA
    Med J Malaysia, 2016 02;71(1):37-8.
    PMID: 27130745
    Cronkhite-Canada Syndrome (CCS) is a syndrome characterised by a constellation of signs including but not limited to onychodystrophy of the finger and toe nails, skin hyperpigmentation and alopecia. Endoscopic features showed hamartomatous polyps involving all segments of the gastrointestinal tract with the characteristic exception of being oesophageal sparring. These polyps show confirmation by the presence of eosinophils and mast cells at the lamina propria upon histological studies.
    Matched MeSH terms: Syndrome
  13. Irritable bowel syndrome and inflammatory bowel disease overlap syndrome: pieces of the puzzle are falling into place
    Abdul Rani R, Raja Ali RA, Lee YY
    Intest Res, 2016 Oct;14(4):297-304.
    PMID: 27799880
    Irritable bowel syndrome (IBS), a common gastrointestinal disorder involving the gut-brain axis, and inflammatory bowel disease (IBD), a chronic relapsing inflammatory disorder, are both increasing in incidence and prevalence in Asia. Both have significant overlap in terms of symptoms, pathophysiology, and treatment, suggesting the possibility of IBS and IBD being a single disease entity albeit at opposite ends of the spectrum. We examined the similarities and differences in IBS and IBD, and offer new thoughts and approaches to the disease paradigm.
    Matched MeSH terms: Irritable Bowel Syndrome
  14. Fulltext Dyke-Davidoff-Masson syndrome: a case report
    Abdul Rashid AM, Md Noh MSF
    BMC Neurol, 2018 May 29;18(1):76.
    PMID: 29843624 DOI: 10.1186/s12883-018-1079-3
    BACKGROUND: Dyke-Davidoff-Masson syndrome is a rare condition of unknown frequency resulting from brain injury due to a multitude of causes; especially in early life. Characteristics include cerebral hemiatrophy/hypoplasia, contralateral hemiparesis, seizures, and compensatory osseous hypertrophy.

    CASE PRESENTATION: We present a case of a 13-year-old girl who initially presented with headaches, followed by episodic complex-partial seizures; which was controlled via medication. She also had right sided hemiparesis. Computed tomography (CT) showed evidence of left parieto-temporal infarct with cerebral atrophy. Complementary magnetic resonance imaging (MRI) did not reveal additional information. Workup for young stroke was negative. Upon further evaluation by Neuroradiology, features suggesting Dyke-Davidoff-Masson syndrome were confirmed. Patient has been under Neurology follow up since.

    CONCLUSIONS: Due to its rarity, Dyke-Davidoff-Masson syndrome may easily be missed by the majority of treating clinicians. Knowledge of its features on imaging enables timely and accurate diagnosis - allowing appropriate management.

    Matched MeSH terms: Syndrome
  15. Fulltext Human coronaviruses: ophthalmic manifestations
    Abdul-Kadir MA, Lim LT
    BMJ Open Ophthalmol, 2020;5(1):e000630.
    PMID: 33195813 DOI: 10.1136/bmjophth-2020-000630
    The 2019 novel coronavirus which causes severe acute respiratory syndrome (SARS) known as SARS-CoV-2 still remains as a global pandemic since its discovery and continues to spread across the world, given how highly contagious the virus is. We reviewed various articles that explore eye involvement in COVID-19 and other human coronaviruses, its human manifestations in comparison to animal studies and potential mechanism of viral entry into the eye surface. Evidence of animal studies depicted various complications of coronaviruses infection into the eyes, in both anterior and posterior segments of the eye. Conjunctival inflammation remains uncommon in association with COVID-19, with other ophthalmic findings. The risk of transmission via the ocular surface remains likely low, though it is inarguably present based on preliminary finding of viral load in ocular samples and expression of ACE2 on the ocular surface. Testing the tears sample for diagnosing SARS-CoV-2 was unreliable due to limitations of the testing kits and conflicting evidence of the viral titre in the ocular samples. Further larger, more precise and specific studies are required to allow us to better understand the pattern of virulence underlying the associations of SARS-CoV-2 in the eye despite its rare occurrence. This review article aims to enhance better awareness among clinicians regarding ocular manifestations associated with COVID-19 and necessary precautions should be implemented to minimise the risk of person-to-person especially in the nosocomial setting.
    Matched MeSH terms: Severe Acute Respiratory Syndrome
  16. Fulltext Gigantism of the lower limb in Klippel-Trenaunay syndrome: anatomy of the lateral marginal vein
    Abdul-Rahman NR, Mohammad KF, Ibrahim S
    Singapore Med J, 2009 Jun;50(6):e223-5.
    PMID: 19551303
    The Klippel-Trenaunay syndrome is a combination of venous and capillary malformations associated with soft tissue and/or bony limb hypertrophy, with or without lymphatic malformations. Although persistent foetal veins are rare, the persistence of the lateral marginal vein is a common association in this syndrome. It results in venous hypertension, which gives rise to venous varicosities, which are commonly seen in this syndrome. This is a case report of a 28-year-old man with Klippel-Trenaunay syndrome, with persistence of the lateral marginal vein, affecting his right lower limb. He was treated with an above-knee amputation. The amputated limb was dissected to demonstrate the anatomy of the lateral marginal vein. To the best of the authors' knowledge, the gross anatomy of the lateral marginal vein has not been previously reported.
    Matched MeSH terms: Klippel-Trenaunay-Weber Syndrome/complications*; Klippel-Trenaunay-Weber Syndrome/radiography*
  17. Fulltext Transient abnormal myelopoiesis with life-threatening complications
    Abdul-Wahab, J., Naznin, M, Norlelawati, A.T., Amir Hamzah, A.R.
    International Medical Journal Malaysia, 2006;5(2):1-6.
    MyJurnal
    Transient abnormal myelopoiesis (TAM) occurs in approximately 10% of neonates with Down syndrome. In most cases it resolves spontaneously. Life threatening complications such as cardiopulmonary and liver diseases have been described. We present here two cases which suggest that management of TAM in selected cases will have to be more aggressive.
    Matched MeSH terms: Down Syndrome
  18. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats
    Abdulghani M, Hussin AH, Sulaiman SA, Chan KL
    Reprod Biol, 2012 Jul;12(2):247-55.
    PMID: 22850474 DOI: 10.1016/s1642-431x(12)60089-8
    The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited persistent diestrous as well as ovaries containing cystic follicles. Upon treatment with TAF 273, fewer animals showed irregular estrous cycles and there was less follicular morphological damage. The reversal effect may be derived from the anti-estrogenic properties of the plant quassinoids.
    Matched MeSH terms: Polycystic Ovary Syndrome/chemically induced; Polycystic Ovary Syndrome/drug therapy*
  19. Fulltext Preliminary report on somatostatin receptor imaging in rare endocrine tumours
    Abdullah BJJ, Paramsothy M, Khir ASM, Chan SP
    Med J Malaysia, 2000 Jun;55(2):169-73.
    PMID: 19839144
    Our preliminary experience of Somatostatin Receptor Positive Tumour Scintigraphy (SRPTS) in the management of some rare neuroendocrine tumours is highlighted. Six patients were evaluated using SRPTS. A single patient each with Zollinger-Ellison syndrome, recurrent medullary carcinoma of thyroid and Stage IV neuroblastoma. Two patients with phaeochromocytoma, and one patient with suspected insulinoma were evaluated. SRPTS was useful in three of the six patients studied i.e. patient with gastrinoma, recurrent medullary carcinoma of thyroid and metastatic neuroblastoma. SRPTS although expensive is a useful and cost-effective approach of rare endocrine tumours and it role as a first line tool in the diagnosis is discussed.
    Matched MeSH terms: Zollinger-Ellison Syndrome/diagnosis; Zollinger-Ellison Syndrome/physiopathology; Zollinger-Ellison Syndrome/radionuclide imaging*; Zollinger-Ellison Syndrome/ultrasonography
  20. Superior vena cava obstruction bypass - an alternative technique using bovine pericardial conduit: a case report
    Abdullah F, Adeeb S
    Heart Surg Forum, 2003;6(3):E50-1.
    PMID: 12821439
    An alternative technique of superior vena cava obstruction bypass using bovine pericardial conduit is described. The patient in this case had recurrent bilateral thrombophlebitis and thrombosed saphenous veins. Most of the surgical techniques reported in the literature so far have described the use of polyethylene terephthalate (Dacron) graft, polytetrafluoroethylene graft, autologous pericardial patch, and spiral vein graft. The use of synthetic grafts has been plagued with high rates of thrombosis. The pathology, clinical presentation, surgical technique, and outcome are discussed.
    Matched MeSH terms: Superior Vena Cava Syndrome/drug therapy; Superior Vena Cava Syndrome/surgery*
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