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  1. Abdurabuh A, Hamid MD, Che Hassan CR, Fatani MI
    J Multidiscip Healthc, 2024;17:5021-5033.
    PMID: 39507375 DOI: 10.2147/JMDH.S480496
    BACKGROUND: The impact of hospital accreditation on the organizational safety culture among healthcare workers, an essential indicator of patient safety, has yet to be directly quantified in Saudi Arabia's healthcare system. This study aims to investigate this impact to sustain and maintain a positive safety culture in Saudi Arabia's healthcare institutions.

    METHODS: A cross-sectional assessment was conducted in five public hospitals in Makkah. Three hundred forty healthcare workers participated using a self-administered questionnaire. Data were analyzed using descriptive statistics, ANOVA, one-sample t-test, and multiple regression for a comprehensive understanding.

    RESULTS AND DISCUSSION: Regression analysis revealed significant gender differences in patient safety ratings (B = 0.480, p < 0.001). Age positively influenced scores, with higher ages resulting in higher scores (B = 0.127, p = 0.041). The ratings were also associated with respondents' nationality (B = 0.169, p < 0.001) and education levels (B = -0.186, p < 0.001). Respondents rated disasters and training as the highest in patient safety culture, followed by facility safety and security, hazards and hazardous materials safety, utility and building safety, fire safety, and quality improvement. At the same time, leadership, commitment, and support received the lowest score.

    CONCLUSION: This study illustrates a strong connection between accreditation and improved patient safety, emphasizing the importance of quality improvement and leadership commitment. These insights can guide policymakers and healthcare executives in Saudi Arabia and similar countries toward developing a robust patient safety culture. It stresses the importance of considering human factors and organizational culture when developing patient safety models.

  2. Balan S, Koo K, Muhamad Hamdan MD, Lee SV
    Explor Res Clin Soc Pharm, 2022 Dec;8:100188.
    PMID: 36281358 DOI: 10.1016/j.rcsop.2022.100188
    BACKGROUND: Special approval medicines (SAMs) are medicines used with approval from the Director General of Health Malaysia when the therapeutic options within regulatory and formulary boundaries appear unsuitable or ineffective to treat the patients.

    OBJECTIVES: To examine and characterize the use of SAMs among children in a Malaysian tertiary care hospital.

    METHODS: The named-patient basis SAM application forms, cover letter, pharmacist review summary and patient monitoring forms available at the Pharmacy Department between 1st January 2019 and 31st December 2020 were reviewed. Unprocessed, unapproved and stock-basis applications were excluded. The outcome measures were categories, scope, off-label use and cost of SAM. Per-patient data were analyzed descriptively.

    RESULTS: Overall, 1010 patients (mean age of 8.7 ± 5.6 years) were involved in 328 SAMs applications. The most common SAMs pharmacological groups were nervous system (n = 371, 36.7%) and antineoplastic and immunomodulating agents (n = 332, 32.9%). Top three SAMs were melatonin (11.5%), scopolamine (7.6%) and cholecalciferol (7.1%). A total of 837 (82.9%) and 513 (50.8%) patients were involved in the SAMs applications for non-formulary and unregistered medicines, respectively. Unregistered, non-formulary medicines were applied for 47.3% (n = 478) of the patients. The majority of the scope for SAMs (64.7%) were to substitute the available alternatives in the national formulary which were ineffective or sub-optimal for the patients. Among the 262 patients with repeat applications, 93.8% reported disease or symptom improvement while 1.9% experienced side effects. Up to 17% of SAMs analyzed in this study were used for off-label indications. The total cost of the SAMs was RM8,748,358.38 (USD 2,090,418.86).

    CONCLUSION: The use of SAMs among children in this hospital involved unregistered, non-formulary medicines used to substitute the available alternatives in the formulary. A concerted effort is warranted in exploring supplementary mechanisms to enhance the medicine registration process and formulary system towards facilitating enhanced provision of treatment for children.

  3. Bensenouci D, Merabet B, Ozkendir OM, Maleque MA
    Nanomaterials (Basel), 2022 Oct 05;12(19).
    PMID: 36234613 DOI: 10.3390/nano12193486
    Thermophotovoltaic conversion using heat to generate electricity in photovoltaic cells based on the detraction of thermal radiation suffers from many engineering challenges. The focus of this paper is to study the nanostructure of AlGaAsSb for thermophotovoltaic energy conversion using lattice-matched heterostructures of GaSb-based materials in order to overcome the current challenges. The XAFS spectroscopy technique was used to analyze electronic structures and optical properties of GaSb, (Al, In) GaSbAs. The XAFS spectroscopy analysis showed a powerful decay at peak intensity that reveals to be related to a loss in Sb amount and light As atoms replaced in Sb atoms by 25%. Moreover, it was found that Al/In doped samples have highly symmetric data features (same atomic species substitution). The narrow direct bandgap energy, Eg of Al0.125Ga0.875Sb0.75As0.25 material raised (0.4-0.6 eV) compared to conventional photovoltaic cell bandgap energy (which is generally less than 0.4 eV) with weak absorption coefficients. The thermoelectric properties of AlGaAsSb computed via Botlztrap code showed that the electrons made up the majority of the charge carriers in AlGaAsSb. This nanostructure material exhibited a higher and acceptable figure of merit and demonstrated a promising thermoelectric material for solar thermophotovoltaic applications.
  4. Zulastri MAM, Hafidz MI, Ismail MD, Zuhdi ASM
    Rev Cardiovasc Med, 2021 Jun 30;22(2):505-512.
    PMID: 34258919 DOI: 10.31083/j.rcm2202058
    In patients with acute heart failure (AHF), hemoconcentration has been suggested as a surrogate for volume changes (AHF). However, literatures comparing the outcome of AHF patients that achieved hemoconcentration during hospitalization with those that do not are limited. The aim of this research is to see if achieving hemoconcentration prior to discharge is linked to a lower risk of re-admission in AHF patients. 124 patients hospitalized in the Cardiology Unit, University Malaya Medical Centre (UMMC) for AHF between November 2019 and November 2020 were enrolled. Information on patients' clinical characteristics, laboratory values and in-hospital treatments were collected through electronic medical record. At admission and discharge, the change in hematocrit (HCT) levels was calculated, and patients were stratified based on two quantiles of delta HCT, either discharged with hemoconcentration (ΔHCT >1.5%) or without hemoconcentration (ΔHCT ≤1.5%). The study's outcome was AHF readmission after a 90-day follow-up period. Readmission was significantly associated with ejection fraction (p = 0.032) and HCT change (p = 0.005). Consecutively, logistic regression performed revealed that patients with haemoconcentration were 78.3% less likely to be readmitted than those without haemoconcentration (OR = 0.217, p = 0.003, 95% CI = 0.078-0.605) and Patients with a lower ejection fraction have a threefold greater chance of being readmitted than those with a preserved ejection fraction (OR = 3.316, p = 0.022, 95% CI = 1.188-9.256). In conclusion, among patients hospitalized and discharged for AHF, those that (i) do not achieve haemoconcentration and (ii) patients with a reduced ejection fraction were more likely to be readmitted with acute heart failure. Therefore, optimising patients' haematocrit levels prior to discharge may potentially reduce rehospitalizations among heart failure patients.
  5. Ishak AI, Kong LS, Yunus MRM, Bakar MZA
    Indian J Otolaryngol Head Neck Surg, 2023 Sep;75(3):2577-2580.
    PMID: 37636741 DOI: 10.1007/s12070-023-03663-y
    Lymphoepithelial carcinoma (LEC) is a rare entity of malignancy. It has been associated with Epstein-Barr virus (EBV), and in regions where it is endemic, such as Southeast Asia, EBV is typically associated with nasopharyngeal carcinoma. The incidence of such malignancies in the young population is unusual. Here we report a 17-year-old with a 5-year history of a painless right submandibular mass presenting with a sudden increase in size for one month before surgery. Neck examination revealed a firm right submandibular gland measuring five by five cm, with an irregular surface, non-tender with normal overlying skin. We performed a fine needle aspiration cytology (FNAC), and he underwent computed tomography (CT) scan of the neck. He underwent a right submandibulectomy. Lymph nodes from levels I and II were also removed. The final histopathology was reported as LEC. Following this tissue diagnosis, another follow-up surgery, a modified radical neck dissection, was carried out for locoregional clearance. Postoperatively, he completed chemoradiotherapy treatment and is now on regular follow-up.
  6. Ahmed S, Hossain MA, Chong PHJ, Ray SK
    Sensors (Basel), 2024 Aug 19;24(16).
    PMID: 39205047 DOI: 10.3390/s24165353
    The Internet of Things (IoT) is a promising technology for sensing and monitoring the environment to reduce disaster impact. Energy is one of the major concerns for IoT devices, as sensors used in IoT devices are battery-operated. Thus, it is important to reduce energy consumption, especially during data transmission in disaster-prone situations. Clustering-based communication helps reduce a node's energy decay during data transmission and enhances network lifetime. Many hybrid combination algorithms have been proposed for clustering and routing protocols to improve network lifetime in disaster scenarios. However, the performance of these protocols varies widely based on the underlying network configuration and the optimisation parameters considered. In this research, we used the clustering parameters most relevant to disaster scenarios, such as the node's residual energy, distance to sink, and network coverage. We then proposed the bio-inspired hybrid BOA-PSO algorithm, where the Butterfly Optimisation Algorithm (BOA) is used for clustering and Particle Swarm Optimisation (PSO) is used for the routing protocol. The performance of the proposed algorithm was compared with that of various benchmark protocols: LEACH, DEEC, PSO, PSO-GA, and PSO-HAS. Residual energy, network throughput, and network lifetime were considered performance metrics. The simulation results demonstrate that the proposed algorithm effectively conserves residual energy, achieving more than a 17% improvement for short-range scenarios and a 10% improvement for long-range scenarios. In terms of throughput, the proposed method delivers a 60% performance enhancement compared to LEACH, a 53% enhancement compared to DEEC, and a 37% enhancement compared to PSO. Additionally, the proposed method results in a 60% reduction in packet drops compared to LEACH and DEEC, and a 30% reduction compared to PSO. It increases network lifetime by 10-20% compared to the benchmark algorithms.
  7. Khan AJ, Sabri BAM, Omar AFB, Ahmad MS
    Can J Dent Hyg, 2024 Oct;58(3):161-173.
    PMID: 39513095
    INTRODUCTION: Community-based rehabilitation (CBR) centres in Malaysia were established to enhance the quality of life of persons with disabilities (PWDs), including their health care. It is unknown to what extent PWDs have been taught about oral health care at CBR centres.

    OBJECTIVE: This qualitative study investigated the perceptions of CBR managers regarding the level of training in oral health care received by CBR workers, the current oral health care program for PWDs, and the barriers and enablers in providing oral health education, care, and services for PWDs in CBR centres.

    METHODS: A semi-structured interview questionnaire and face-to-face in-depth interviews were conducted with CBR managers (n = 9) from 9 districts in Kuala Lumpur and Selangor, Malaysia, to seek their views on the focus topics. Audiorecorded interviews were transcribed verbatim, and transcripts were analysed in MAXQDA software. Qualitative data were analysed via thematic analysis.

    RESULTS: Interview content analysis revealed 4 themes, 11 subthemes, and 13 codes. The 4 identified themes were oral health care education and training for CBR workers, oral health care programs and protocol for CBR trainees (PWDs), barriers and enablers to care.

    CONCLUSION: In all CBR centres, CBR workers and PWDs receive an oral health presentation, training in oral health care, and are provided with treatment by a dentist assigned by the Ministry of Health. No specific programs, training or special courses were provided by the Department of Social Welfare. Several personal, professional, and social factors were identified as affecting the provision of oral health care to the PWDs.

  8. Nasir MS, Yahya ARM, Noh NAM
    PMID: 39538032 DOI: 10.1007/s00449-024-03103-3
    The study focused on rhamnolipid production by batch fermentation of Pseudomonas aeruginosa USM-AR2 in a 3-L stirred-tank reactor (STR) using palm sludge oil (PSO) as the sole carbon source. The impact of various agitation rates towards the dispersion of PSO in the medium was evaluated to improve biomass growth and rhamnolipid production. A mechanical foam collection and recycling system was designed and retrofitted to the STR to overcome severe foam formation during fermentation. The maximum biomass produced was 11.29 ± 0.20 g/L obtained at 400 rpm, while the maximum rhamnolipid production was 5.06 ± 1.17 g/L at 600 rpm, giving a rhamnolipid productivity of 0.023 g/L/h. High agitation enhances substrate availability by breaking the hydrophobic semi-solid PSO into smaller substrate particles, increasing surface contact area, thus facilitating the PSO utilisation by P. aeruginosa USM-AR2, thereby inducing rhamnolipid production. This study further demonstrates the ability of rhamnolipid to solubilize and disperse sludge oil, which typically remains a solid at room temperature, in the liquid medium. GCMS analysis showed that five fatty acids, namely palmitic acid, myristic acid, stearic acid, methyl ester and linoleic acid, have been utilised. The rhamnolipid showed an oil spreading test result of 160 mm of waste engine oil displacement compared to control using distilled water that remained non-displaced, and a critical micelle concentration (CMC) of 17 mg/L. In emulsification index (E24) assay, the rhamnolipid was shown to emulsify toluene (66.7% ± 7.2), waste engine oil (58.3% ± 7.2), kerosene (41.8% ± 4.8) and n-hexane (33.1% ± 5.7). UPLC analysis on rhamnolipid revealed a congener mixture of rhamnolipid, namely di-rhamnolipid and mono-rhamnolipid mixture. This is the first report on the employment of an integrated foam control reactor system with PSO as the carbon source for rhamnolipid production by P. aeruginosa USM-AR2 culture.
  9. Anuar TS, Moktar N, Salleh FM, Al-Mekhlafi HM
    PMID: 26863854
    Clinical manifestations of giardiasis vary from asymptomatic infection to chronic diarrhea. A total of 611 stool samples from Aboriginal participants residing in Jelebu, Gerik and Temerloh States, Malaysia, ages 2 to 74 years were screened for Giardia intestinalis using microscopic examination and sequence analysis of a fragment of nested-PCR amplified triosephosphate isomerase (tpi) gene. Demographic data was collected through a structured questionnaire. tpi was successfully amplified from 98/110 samples microscopically positive for G. intestinalis, with 62 and 36 belonging to assemblage A and B, respectively. There is a significant correlation between assemblage A and symptomatic infection only in participants of < 15 years of age. In the other age group, host factors may have more effects on the presence of clinical signs and symptoms than G. intestinalis assemblage types.
  10. Kamaliah MD, Bhajan MA, Dzarr GA
    PMID: 16124446
    We present an interesting and rare case of a diabetic patient who developed extensive unilateral emphysematous pyelonephritis (EPN) which was caused by fungal infection. The diagnosis was confirmed on computed tomography (CT) scan of the abdomen. Repeated urine cultures grew Candida albicans but no other organisms were isolated. The patient remained febrile and unwell despite parenteral broad spectrum antibiotics and antifungal treatment. She underwent nephrectomy and then made a good clinical recovery.
  11. Husna A, Miah MA, Zakaria L, Nor NMIM
    Curr Microbiol, 2024 Aug 16;81(10):308.
    PMID: 39150554 DOI: 10.1007/s00284-024-03823-5
    Rice is the main staple food crops for the Malaysian population. Rice is also susceptible to bakanae diseases caused by some Fusarium species and reducing yield, and quality of rice also profit. In this study, several rice fields were surveyed to collect Fusarium isolates associated with bakanae disease. The morphological features of Fusarium andiyazi isolates found on infected rice plants were identified in this investigation. For biological species identification, MAT-1 (Mating type idiomorphs) bearing isolates were crossed with MAT-2 isolates. Crossing was succeeded between cross of two different mating type bearing field isolates. Consequently, there is a possibility of exchange of genetic material within the F. andiyazi population in Malaysia. The identity of the isolates was further determined up to the species level by comparing DNA sequences and phylogenetic analysis of two genes. The phylogenetic analyses of the joined dataset of translation elongation factor 1-alpha (TEF1-α) and RNA polymerase subunit II (RPB2) revealed that all the isolates were F. andiyazi. In pathogenicity tests, F. andiyazi were found to be pathogenic on the susceptible rice cultivars MR211 and MR220. Inoculated rice seedling produced typical bakanae symptom like elongation, thin and yellow leaves. F. andiyazi was further confirmed as pathogenic species by Ultra High-Performance Liquid Chromatography (UPLC) detection of Gibberellic acid (GA3) and Fusaric acid. In this study, F. andiyazi strains have been identified as the responsible pathogen for causing rice bakanae disease in Malaysia and it is the first report of F. andiyazi, as a pathogenic species on rice in Malaysia.
  12. Hossain MB, Faruque MRI, Islam SS, Islam MT
    Sci Rep, 2021 Sep 29;11(1):19331.
    PMID: 34588523 DOI: 10.1038/s41598-021-98703-4
    Metamaterial with negative permittivity demonstrate excellent performance in cutting-edge technology. Thus, this study modified the double dumbbell-shaped split-ring resonator (MDD-SRR) based negative permittivity for satellite communications. The proposed MDD-SRR unit cell comprises a square-shaped split-ring resonator and two dumbbell-shaped rings. Some parts of the outer square ring were extended to enlarge the electrical length which altered the inductance of the metamaterial unit cell. The dimension of the proposed unit cell is 9 × 9 × 1.524 mm3, fabricated on a Rogers RT6002 (lossy) substrate material. Based on the results, five resonances for the transmission coefficient were achieved at frequencies of 2.896 GHz, 8.11 GHz, 9.76 GHz, 12.48 GHz and 13.49 GHz, including the S, X and Ku band satellite communication frequency bands through numerical simulation in a high-frequency electromagnetic simulator Computer Simulation Technology (CST) microwave studio. Negative permittivity at frequencies ranging from 2.896-3.76 GHz, 8.11-8.592 GHz, 9.76-10.784 GHz, 12.496-12.768 GHz, 13.504-14.4 GHz, were observed and extracted using the Robust and Nicolson-Ross-Weir (NRW) methods. Meanwhile, an effective medium ratio (EMR) measured at 11.51 to 2.896 GHz specified the goodness of the metamaterial unit cell for satellite communication with higher bandwidth and gain. The simulated, circuit model and measured results that were compared for validation purposes indicated that the simulation results, the equivalent circuit model results and measured results occupied each other. Moreover, the numerical simulation of the double dumbbell-shaped metamaterial unit cell was performed using a High-Frequency Structure Simulator (HFSS) to confirm the results. To evaluate the parametric study, the proposed unit cell was subjected to change different substrate types, change of split gap of rings, change of direction of electromagnetic field propagation, and structural optimization. In conclusion, the S, X and Ku-bands in the proposed metamaterial are competent for satellite communications as they are also investigated using an array of a unit cell.
  13. Yusof KM, Groen K, Rosli R, Avery-Kiejda KA
    Front Cell Dev Biol, 2021;9:732415.
    PMID: 34733847 DOI: 10.3389/fcell.2021.732415
    Secondary lymphedema is characterized by lymphatic fluid retention and subsequent tissue swelling in one or both limbs that can lead to decreased quality of life. It often arises after loss, obstruction, or blockage of lymphatic vessels due to multifactorial modalities, such as lymphatic insults after surgery, immune system dysfunction, deposition of fat that compresses the lymphatic capillaries, fibrosis, and inflammation. Although secondary lymphedema is often associated with breast cancer, the condition can occur in patients with any type of cancer that requires lymphadenectomy such as gynecological, genitourinary, or head and neck cancers. MicroRNAs demonstrate pivotal roles in regulating gene expression in biological processes such as lymphangiogenesis, angiogenesis, modulation of the immune system, and oxidative stress. MicroRNA profiling has led to the discovery of the molecular mechanisms involved in the pathophysiology of auto-immune, inflammation-related, and metabolic diseases. Although the role of microRNAs in regulating secondary lymphedema is yet to be elucidated, the crosstalk between microRNAs and molecular factors involved in the pathological features of lymphedema, such as skin fibrosis, inflammation, immune dysregulation, and aberrant lipid metabolism have been demonstrated in several studies. MicroRNAs have the potential to serve as biomarkers for diseases and elucidation of their roles in lymphedema can provide a better understanding or new insights of the mechanisms underlying this debilitating condition.
  14. Ali AM, Ngadi MA, Al Barazanchi II, JosephNg PS
    Sensors (Basel), 2023 Jul 15;23(14).
    PMID: 37514720 DOI: 10.3390/s23146426
    Traffic systems have been built as a result of recent technological advancements. In application, dependable communication technology is essential to link any system needs. VANET technology is used to communicate data about intelligent traffic lights, which are focused on infrastructure during traffic accidents and mechanisms to reduce traffic congestion. To ensure reliable data transfer in VANET, appropriate routing protocols must be used. This research aims to improve data transmission in VANETs implemented in intelligent traffic lights. This study investigates the capability of combining the DSDV routing protocol with the routing protocol AODV to boost AODV on an OMNET++ simulator utilizing the 802.11p wireless standard. According to the simulation results obtained by analyzing the delay parameters, network QoS, and throughput on each protocol, the DSDV-AODV routing protocol performs better in three scenarios compared to QoS, delay, and throughput parameters in every scenario that uses network topology adapted to the conditions on the road intersections. The topology with 50 fixed + 50 mobile nodes yields the best results, with 0.00062 s delay parameters, a network QoS of 640 bits/s, and a throughput of 629.437 bits/s. Aside from the poor results on the network QoS parameters, the addition of mobile nodes to the topology influences both the results of delay and throughput metrics.
  15. Kabir MZ, Tayyab H, Erkmen C, Mohamad SB, Uslu B
    J Biomol Struct Dyn, 2023 Aug 02.
    PMID: 37529911 DOI: 10.1080/07391102.2023.2239931
    Biomolecular association of an anticancer drug, leflunomide (LEF) with human serum albumin (HSA), the leading ligands carrier in human circulation was characterized using biophysical (i.e., fluorescence, absorption and voltammetric) methods and computational (i.e., molecular docking and molecular dynamics simulation) techniques. Evaluations of fluorescence, absorption and voltammetric findings endorsed the complex formation between LEF and HSA. An inverse relationship of Stern-Volmer constant-temperature and hyperchromic shift of the protein's absorption signal with addition of LEF confirmed the LEF quenched the HSA fluorescence through static process. Moderate nature of binding strength (binding constant = 2.76-4.77 × 104 M-1) was detected towards the LEF-HSA complexation, while the association process was naturally driven via hydrophobic interactions, van der Waals interactions and hydrogen bonds, as evident from changes in entropy (ΔS= + 19.91 J mol-1 K-1) and enthalpy (ΔH = - 20.09 kJ mol-1), and molecular docking assessments. Spectral analyses of synchronous and three-dimensional fluorescence validated microenvironmental fluctuations near Trp and Tyr residues upon LEF binding to the protein. LEF association with HSA significantly defended temperature-induced destabilization of the protein. Although LEF was found to attach to HSA at Sudlow's sites I and II, but exhibited greater preference toward its site I, as detected by the investigations of competitive site-marker displacement. Molecular dynamics simulation assessment revealed that the complex attained equilibrium throughout simulations, showing the LEF-HSA complex constancy.Communicated by Ramaswamy H. Sarma.
  16. Mukhtar A, Yasir ASHM, Nasir MFM
    Heliyon, 2023 Aug;9(8):e18674.
    PMID: 37554836 DOI: 10.1016/j.heliyon.2023.e18674
    Complex computer codes are frequently used in engineering to generate outputs based on inputs, which can make it difficult for designers to understand the relationship between inputs and outputs and to determine the best input values. One solution to this issue is to use design of experiments (DOE) in combination with surrogate models. However, there is a lack of guidance on how to select the appropriate model for a given data set. This study compares two surrogate modelling techniques, polynomial regression (PR) and kriging-based models, and analyses critical issues in design optimisation, such as DOE selection, design sensitivity, and model adequacy. The study concludes that PR is more efficient for model generation, while kriging-based models are better for assessing max-min search results due to their ability to predict a broader range of objective values. The number and location of design points can affect the performance of the model, and the error of kriging-based models is lower than that of PR. Furthermore, design sensitivity information is important for improving surrogate model efficiency, and PR is better suited to determining the design variable with the greatest impact on response. The findings of this study will be valuable to engineering simulation practitioners and researchers by providing insight into the selection of appropriate surrogate models. All in all, the study demonstrates surrogate modelling techniques can be used to solve complex engineering problems effectively.
  17. Mazlee MTF, Heidelberg T, Ariffin A, Zain SM
    Carbohydr Res, 2023 Oct;532:108923.
    PMID: 37598565 DOI: 10.1016/j.carres.2023.108923
    In the attempt to create a delivery system for an alkali-cation stimulated drug release, a computational study was conducted, aiming for the evaluation of synthetic access towards glycolipid crown ethers analogs and their potential for coordination-induced changes of packing constraints for molecular assemblies. The results disfavor amide-linkages for the creation of macrocycles around the inter-glycosidic bond of a disaccharide. Conformational changes upon cation coordination of the macrocycle decrease the intersection area for easily accessible macrocycles based on lactose. This leads to shrinking intersection areas upon alkali complexation. Maltose-based analogs, on the other hand, exhibited the targeted increase of the glycolipid intersection area and, hence, may be considered as a promising resource.
  18. Mozumder MK, Jasmine UH, Haque MA, Haque S
    PLoS One, 2023;18(8):e0289597.
    PMID: 37582101 DOI: 10.1371/journal.pone.0289597
    BACKGROUND: Homosexual individuals are at high risk of suicide, but there is a shortage of data from developing countries to confirm this. Estimates on mental health and suicide risk among male homosexuals in Bangladesh are needed to generate awareness and to plan services accordingly.

    METHOD: We assessed mental health and suicidal behavior of 102 self-identified homosexual males from a community-based organization that works with the sexual minority population.

    RESULTS: One-third of the participants (32.4%) had experienced attempted suicide, and almost half (47.1%) had a history of suicidal ideation and self-harm (40.2%). Compared to a heterosexual sample, homosexual males had poorer mental health as they scored higher on Beck Hopelessness Scale (Cohen's d = 0.29) and General Health Questionnaire (GHQ) (Cohen's d = 0.57). The results revealed positive correlations between self-harm, suicidal ideation and suicide attempt scores. Participants with history of suicide attempt, suicide ideation and self-harm reported worse general health, more social dysfunction, and severe depression than those without such history.

    CONCLUSION: Suicidality and mental health conditions among homosexual males in Bangladesh have appeared to be alarming. Given the concerns, we offer some recommendations for practitioners and social workers who are serving this population in Bangladesh.

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