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  1. Arshad M, Onn CW, Ahmad A, Mogwe G
    Front Big Data, 2025;8:1513027.
    PMID: 39981020 DOI: 10.3389/fdata.2025.1513027
    As the trend in the current generation with the use of mobile devices is rapidly increasing, online video streaming has risen to the top in the entertainment industry. These platforms have experienced radical expansion due to the incorporation of Big Data Analytics and Artificial Intelligence which are critical in improving the user interface, improving its functioning, and customization of recommended content. This paper seeks to examine how Big Data Analytics makes it possible to obtain large amounts of data about users and how they view, what they like, or how they behave. While customers benefit from this data by receiving more suitable material, getting better recommendations, and allowing for more efficient content delivery, AI utilizes it. As a result, the study also points to the importance and relevance of such technologies to promote business development, and user interaction and maintain competitiveness in the online video streaming market with examples of their effective application. This work presents a comprehensive investigation of the combined role of Big Data and AI and presents the necessary findings to determine their efficacy as success factors of existing and future video streaming services.
  2. Hafeez W, Wu S, Aziz N, Abbas Z, Imran M
    Sci Rep, 2025 Feb 19;15(1):6095.
    PMID: 39971985 DOI: 10.1038/s41598-025-89740-4
    To succeed in the global market, firms must prioritize quality over individual goals and preferences. Acceptance sampling is one of the two primary approaches for ensuring quality, which is used in statistical process control for attributes inspection of the product. In acceptance sampling based on predetermined acceptance criteria for inspection the lot is either accepted or not accepted. This research introduces a Bayesian double group sampling plan (BDGSP) for estimating average number of nonconforming products. Based on acceptance criteria the Poisson distribution is used to construct the likelihood function for both nonconforming and conforming products. To calculate the average probability of acceptance, the gamma distribution is used as a suitable prior distribution of the Poisson distribution. For various suggested producer's and consumer's risk levels four distinct quality regions are calculated. The producer's risk is related to acceptable quality level and consumer's risk is related to and limiting quality level. Operating characteristic curves are utilized to track the effects of changes in the values of the specified parameters. The applicability of the proposed plan for current industrial strategies is demonstrated using a real dataset.
  3. Sharma H, Padhi B, Sharif A, Bashir MF
    J Environ Manage, 2025 Mar;377:124639.
    PMID: 39993361 DOI: 10.1016/j.jenvman.2025.124639
    In response to escalating environmental challenges and the pressing need for sustainable energy solutions, policymakers are increasingly focusing on Green Total Factor Productivity (GTFP) as a vital metric for sustainable economic growth. The present study examines the role of GTFP in addressing both economic and environmental objectives by incorporating energy efficiency and pollution mitigation within productivity analysis. The study provides a comprehensive examination of GTFP, with emphasis on major determinants such as agglomeration, environmental regulation, industrial structure, and green finance. Our robust review approach allows us to report methodological and topical contributions through detailed documentation of research collaboration, co-citation analysis and thematic classifications. As environmental policymaking increasingly aim to integrate sustainable development goals, this study offers policymakers and researchers crucial insights into GTFP's capacity to harmonize productivity with environmental stewardship and underscores GTFP's essential role in fulfilling environmental commitments outlined in national and international sustainability frameworks.
  4. Latip MF, Syafiq S, Mohamad Khalil AF, Muhamad Ariffin MH
    Cureus, 2025 Jan;17(1):e77863.
    PMID: 39991408 DOI: 10.7759/cureus.77863
    The increasing prevalence of tibial plateau fractures has led more orthopedic surgeons to focus on effective reduction and stabilization, which requires thorough preoperative assessment. The advent of computed tomography (CT) scans and three-dimensional reconstruction has revolutionized fracture analysis, enabled precise delineation, and improved surgical planning. Historically, the tibial plateau classification based on 2D radiographs was the standard. However, the use of CT imaging has refined this with advancements in imaging, which categorizes fractures based on anatomical columns and cortical involvement. Recently, the classification has also included landmarks like the fibular tubercle and superficial medial collateral ligament, providing a more comprehensive quadrant-based classification. In practice, we utilized a single-incision approach to address anterolateral and posterolateral fragments simultaneously. This technique is recognized for its safety, minimizing risks to vital structures like the peroneal nerve and arteries. By preserving ligament integrity and neurovascular structures, tailored surgical approaches can optimize outcomes. Integrating advanced imaging techniques and refined classifications has significantly improved the management of tibial plateau fractures. These advancements allow surgeons to plan and execute surgeries with greater precision, enhancing patient outcomes. As the field evolves, ongoing research and innovation will likely lead to even more effective strategies, underscoring the importance of staying current with the latest orthopedic developments for optimal patient care.
  5. Ab Kadir MA, Abdul Manaf R, Mokhtar SA, Ismail LI
    PeerJ, 2025;13:e18851.
    PMID: 40061226 DOI: 10.7717/peerj.18851
    BACKGROUND: Leptospirosis is an endemic disease in countries with tropical climates such as South America, Southern Asia, and Southeast Asia. There has been an increase in leptospirosis incidence in Malaysia from 1.45 to 25.94 cases per 100,000 population between 2005 and 2014. With increasing incidence in Selangor, Malaysia, and frequent climate change dynamics, a study on the disease hotspot areas and their association with the hydroclimatic factors could enhance disease surveillance and public health interventions.

    METHODS: This ecological cross-sectional study utilised a geographic information system (GIS) and remote sensing techniques to analyse the spatiotemporal distribution of leptospirosis in Selangor from 2011 to 2019. Laboratory-confirmed leptospirosis cases (n = 1,045) were obtained from the Selangor State Health Department. Using ArcGIS Pro, spatial autocorrelation analysis (Moran's I) and Getis-Ord Gi* (hotspot analysis) was conducted to identify hotspots based on the monthly aggregated cases for each subdistrict. Satellite-derived rainfall and land surface temperature (LST) data were acquired from NASA's Giovanni EarthData website and processed into monthly averages. These data were integrated into ArcGIS Pro as thematic layers. Machine learning algorithms, including support vector machine (SVM), Random Forest (RF), and light gradient boosting machine (LGBM) were employed to develop predictive models for leptospirosis hotspot areas. Model performance was then evaluated using cross-validation and metrics such as accuracy, precision, sensitivity, and F1-score.

    RESULTS: Moran's I analysis revealed a primarily random distribution of cases across Selangor, with only 20 out of 103 observed having a clustered distribution. Meanwhile, hotspot areas were mainly scattered in subdistricts throughout Selangor with clustering in the central region. Machine learning analysis revealed that the LGBM algorithm had the best performance scores compared to having a cross-validation score of 0.61, a precision score of 0.16, and an F1-score of 0.23. The feature importance score indicated river water level and rainfall contributes most to the model.

    CONCLUSIONS: This GIS-based study identified a primarily sporadic occurrence of leptospirosis in Selangor with minimal spatial clustering. The LGBM algorithm effectively predicted leptospirosis hotspots based on the analysed hydroclimatic factors. The integration of GIS and machine learning offers a promising framework for disease surveillance, facilitating targeted public health interventions in areas at high risk for leptospirosis.

  6. Ajab H, Khan MH, Naveed P, Abdullah MA
    Int J Biol Macromol, 2025 Mar 06;307(Pt 1):141745.
    PMID: 40057091 DOI: 10.1016/j.ijbiomac.2025.141745
    With increased manufacturing activities and energy sector development, monitoring of heavy metal ion (HMI) pollution is becoming increasingly pressing. The discharge of metals from industrial effluents into the waterways could cause major economic and environmental disruption. In situ and on-site detection methods of trace HMIs can be effective countermeasures before the toxicity spreads out to larger areas, affecting the ecosystem. Conventional methods are often lacking in portability and costly. In contrast, electrochemical sensing, especially with nanoplatforms, is promising for trace detection of HMIs in complex media because of the ease of fabrication and adaptability of incorporating green technology. Appropriate electrode selection with suitable modifiers is crucial in complex medium analyses to overcome electrode fouling. In this review, the evolution from metal-based and carbon-based electrodes to advancements in electrode modification involving agro/biocomposite nanomaterials (NMs) such as cellulose, chitosan, and hydroxyapatite is discussed. The fabrication of nucleic acid-based aptasensors for analyzing HMIs and the adoption of smart systems based on microfluidics with high selectivity, operational stability, and sensitivity are highlighted. The challenges and future prospects for trace HMI determination based on electrochemical sensors in real complex media, including blood and industrial effluent or wastewater, are critically examined.
  7. Sreeramareddy CT, Shu Syuen MO, Hon MI, Daher AM
    Nicotine Tob Res, 2025 Jan 22;27(2):254-261.
    PMID: 39110887 DOI: 10.1093/ntr/ntae187
    INTRODUCTION: Data on e-cigarette (EC) and heated tobacco product (HTP) use and the reasons for their use are useful for policy making. We report comparable nationally representative estimates of EC and HTP use and their associated factors.

    AIMS AND METHODS: Global Adult Tobacco Survey data from Indonesia (2021), Kazakhstan (2019), and the Philippines (2021) were analyzed. The weighted prevalence rates and 95% CI of EC and HTP awareness, current use, and ever use, and their distribution by cigarette smoking status were calculated. Binary logistic regression analyses assessed socioeconomic, and tobacco control factors associated with EC and HTP use.

    RESULTS: The prevalence (%) of EC awareness, ever use and current use were 48.7-69.4, 3.6-8.8, and 1.9-3.0, respectively. The prevalence(%) of HTP awareness, ever use and current use were 2.7-21.7, 0.2-2.1, and 0.1-1.2, respectively. The main reasons for EC and HTP use were attractive flavors(45.8%-73.9%), less harmful than smoking(23.0%-70.1%), and enjoyment(40.8%-76.7%). Avoiding going back to smoking(0.9%-54.4%) and quitting smoking(19.4%-49.8%) were less frequently cited reasons (except in the Philippines). EC/HTP use was associated with younger age, higher education and wealth, current/past smoking, exposure to information about the dangers of tobacco use, and advertisements about tobacco products and smoke-free rules at home.

    CONCLUSIONS: The prevalence of EC and HTP use was higher among younger men with higher education and wealth, and current/past smoking. EC and HTP use should be closely monitored. Regulations to restrict the widespread marketing and sales of EC and HTP are needed to prevent the escalation of their use.

    IMPLICATIONS: The population-level data provide the benchmark for future monitoring use of e-cigarettes and HTPs and identify population subgroups for future surveillance in low- and middle-income countries. The association of EC/HTP use with tobacco control-related factors provides leads for policies that should be formulated and implemented to regulate the product contents, marketing, and sales of EC and HTP.

  8. Ishak MH, Jeffrey MJ, Ramli R, Abd Kadir NJ
    BMJ Case Rep, 2024 Dec 11;17(12).
    PMID: 39663129 DOI: 10.1136/bcr-2024-263125
    A woman in her early 20s presented with a huge pedunculated tumour of the vulva which had progressively increased in size over the course of 10 years. Clinical examination revealed a pedunculated solid mass arising from the right labia majora measuring 15×15 cm. CT scan showed a multilobulated mass arising from the right round ligament suggestive of an extrauterine fibroid. Tumour excision, vulvoplasty and inguinal repair were performed, and histopathological examination confirmed fibroid of lipoleiomyoma variant. This article reports a rare case of round ligament fibroid presenting as a huge pedunculated vulvar tumour.
  9. Fitri Abdul Razak MI, Fauzi FA, Zulkefli NAM
    Iran J Public Health, 2024 Dec;53(12):2768-2778.
    PMID: 39759210
    BACKGROUND: Community Health Volunteers (CHVs) are crucial in achieving universal health coverage and vital in public health activities, including the COMBI (Communication for Behavioral Impact) approach for dengue prevention and control and assessing the performance of COMBI CHVs are essential in evaluating the program effectiveness. We aimed to measure the level of performance and determine predictors of high-performance among COMBI CHVs in Kuala Lumpur and Putrajaya.

    METHODS: A cross-sectional study was conducted in 2023 among 285 COMBI CHVs from 5 health operational zones in Kuala Lumpur and Putrajaya. The CHVs were stratified proportionately, with 45.5% of respondents randomly selected from each stratum based on their zones. Self-administered questionnaires assessed their performance level and associated factors, including training, supervision, knowledge, motivation, and job satisfaction. Chi-square and Multiple Logistic Regression tests were used to determine the factors and predictors of high-performance COMBI CHVs.

    RESULTS: The prevalence of high-performance COMBI CHVs was 59.3%, significantly associated with training factors (experience, duration, and adequacy of training), supervision factors (being supervised, supervision frequency, and encouragement from supervision), motivation and job satisfaction level. As for significant predictors, having at least one day of training (AOR=14.557), being supervised by medical personnel (AOR=4.997), having a high motivation level (AOR=5.538) and having a high job satisfaction level (AOR=4.562) were more likely to have a high-performance level.

    CONCLUSION: Training duration, supervisor background, motivation and job satisfaction can contribute to high-performance levels among COMBI CHVs, which can applied in evidence-based policies and strategies for performance improvement and more effective community healthcare delivery.

  10. Nasuruddin H, Che Yusoff MA, Che Ahmad A, Rosdi MH
    Cureus, 2024 Nov;16(11):e73848.
    PMID: 39691140 DOI: 10.7759/cureus.73848
    The increasing prevalence of proximal humerus fractures in the elderly population, particularly osteoporotic fractures, necessitates a biomechanical evaluation of Kirschner wire (K-wire) configurations used in percutaneous fixation. This study investigates the stability of different K-wire configurations and examines the effect of wire size and type (smooth vs. threaded). Using 27 synthetic humeri models, we compare three configurations as follows: four parallel ascending K-wires (box-type), two ascending and two descending K-wires, and a combination of both. Results show that adding descending K-wires significantly enhances stability, particularly against torsional forces. This study highlights the importance of wire type and configuration in stabilizing proximal humerus fractures. Multiplanar constructs with descending K-wires, especially threaded ones, offer better stability. These insights help improve surgical techniques for elderly and osteoporotic patients, but further research using cadaver models is needed for clinical validation.
  11. Maskur M, Prihanto AA, Firdaus M, Kobun R, Nurdiani R
    Ital J Food Saf, 2025 Jan 20;14(1).
    PMID: 39882994 DOI: 10.4081/ijfs.2025.12994
    The formation of histamine in food is influenced by temperature, and histamine growth can be inhibited by maintaining a cold chain. However, simply relying on temperature control is insufficient, as certain bacteria can produce the enzyme histidine decarboxylase even at temperatures below 5°C. To address this issue, various methods, such as modified atmosphere packaging, high hydrostatic pressure, and irradiation, have been developed to control histamine in fishery products. However, these methods often require significant investments. Therefore, there is a need for a cost-effective solution to overcome this problem. This review explores a cost-effective solution through the utilization of bioactive compounds derived from underexplored seaweeds. Seaweed bioactive compounds, either in their pure form or as extracts, offer a promising alternative method to regulate histamine generation in fishery products due to their antibacterial activity, and this review provides comprehensive insights into the potential of different seaweed-derived bioactive compounds as inhibitors of histamine production, detailing their diverse applications in fishery products. It also explores the mechanism by which bioactive compounds prevent histamine formation by bacteria, focusing on the potential of seaweed bioactive compounds to inhibit bacterial histidine decarboxylase. Future trends in the inhibition of histidine decarboxylation are also discussed. The bioactive compounds considered, such as flavonoids, alkaloids, terpenes, and phenolic acids, exhibit their antibacterial effects through various mechanisms, including the inhibition of DNA and RNA synthesis, disruption of cytoplasmic and cell membranes, and inhibition of enzymes by reacting with sulfhydryl groups on proteins. In conclusion, the integration of underexplored seaweeds in fishery product preservation represents a promising and innovative approach for future food safety and sustainability.
  12. Suleiman MA, Zaini MAA, Mu'azu ND
    PMID: 40181669 DOI: 10.1080/15226514.2025.2484292
    Pomegranate peel waste in the forms of raw biomass, biochar and activated carbon has been explored as adsorbents in water treatment. This review examined and discussed published works between 2008 and 2024 that focused on the utilization of pomegranate peel waste adsorbents with emphasis on preparation strategies, characterization techniques and applications. The thermal and chemical activation have shown to improve the structural and chemical properties of the resultant adsorbent materials to effectively adsorb various pollutants such as dyes, heavy metals, organics, inorganic nonmetals, and pharmaceuticals from water. The performance was compared and the avenues for future research was highlighted to shed insight into the potential of pomegranate peel adsorbents for environmental protection.
  13. Hassan A, Daniyal M, Marzo RR, Aljuaid M, Shahid D
    BMC Public Health, 2025 Apr 03;25(1):1268.
    PMID: 40181270 DOI: 10.1186/s12889-025-21880-8
    BACKGROUND OF THE STUDY: Player Unknown's Battlegrounds (PUBG), a popular and widely played multiplayer online game, has generated interest and concern about its effects on the physical health of its players. This study explores the relationship between factors like cultivation level, gaming disorder, migraine and associated symptoms, sleep quality, and life quality of PUBG players.

    METHODS: This cross-sectional study included 500 PUBG players, categorized into Lower, Medium, and High PUBG Users. Data were collected using a self-administered questionnaire, including the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and a gaming disorder screening tool. The Multilayer Perceptron (MLP) methodology was applied to analyze the factors influencing migraine symptoms, sleep quality, and quality of life.

    RESULTS: Participants of the study were categorized into lower PUBG users (LPU), medium PUBG users (MPU), and high PUBG users (HPU). Among study participants reporting migraine pain, 259 (51.8%) reported that they were HPU. By examining daytime sleepiness using the ESS, Higher normal Day sleep (DS) was observed in 78 (15.9%) HPU. The cultivation level of PUBG showed a very weak positive correlation with experiencing migraine pain or associated headache symptoms (r = 0.034, p = 0.454). In contrast, the gaming disorder of PUBG showed a weak negative correlation with PSQI (r = -0.092, p = 0.041). The higher levels of gaming disorder are slightly associated with poorer sleep quality. The results of the MLP model suggested that daily PUBG use was the most contributing factor to migraine and related symptoms followed by gaming disorder, gaming addiction, PSQI, and ESS.

    CONCLUSION: The study concluded that PUBG playing contributes to migraine and its associated symptoms although is not significant it contributes to less sleep quality and lower quality of life.

  14. Tubussum H, Hashim HM, Javaid MU, Marimuthu M
    Work, 2025 Mar;80(3):1304-1318.
    PMID: 40297878 DOI: 10.1177/10519815241289761
    BackgroundWorkplace bullying and organizational culture are two crucial factors that can significantly affect organizational performance. Understanding the interplay between these variables is imperative for creating conducive work environment and enhancing overall productivity. Additionally, demographic variables such as gender, age, designation, and work experience may also influence these dynamics within an organizational setting.ObjectiveThis study aims to investigate the influence of demographic variables on the relationship between workplace bullying, organizational culture, and organizational performance. Specifically, it examines three primary hypotheses: the impact of workplace bullying on organizational performance, the influence of organizational culture on organizational performance, and the moderating role of organizational culture in the relationship between workplace bullying and organizational performance.MethodsData were collected from academic staff members at 20 public universities in Malaysia, resulting in 626 responses. Structural Equation Modelling (SEM) was applied to test the primary hypotheses while the Partial Least Squares Multigroup Analysis (PLS-MGA) was employed through SmartPLS to explore the effect of demographic variables on the identified structural paths of the model.ResultsThe findings indicate a significant negative impact of workplace bullying and a significant positive effect of organizational culture on organizational performance. Moreover, the analysis reveals notable variations across demographic subgroups. Additionally, the moderating effect of organizational culture demonstrates distinctions between subgroups based on varying levels of work experience, particularly between those with less than 10 years of experience and those with over 20 years.ConclusionsThis study provides valuable insights into the complex relationships among workplace bullying, organizational culture, and organizational performance within Malaysian public universities. The findings underscore the moderating influence of organizational culture and the contextual impact of demographic variables, shedding light on strategies for fostering a supportive work environment and enhancing overall organizational effectiveness.
  15. Ahmad NA, Mohd Ali MA, Tengku Shahdan TS
    PLoS One, 2025;20(8):e0328481.
    PMID: 40811349 DOI: 10.1371/journal.pone.0328481
    INTRODUCTION: As Malaysia transitions into an ageing society, older adults increasingly face challenges in acquiring digital literacy, which impacts their ability to engage with essential online services, financial transactions, healthcare applications and communication platforms. The percentage of individuals aged 65 and above in Malaysia rose from 7.2% in 2022 to 7.4% in 2023, highlighting the growing needs for digital inclusion among this demographic. While internet adoption among older individuals is increasing, many still struggle due to psychological, cognitive, and physical barriers. Factors such as low self-efficacy, fear of complexity, and age-related physical limitations hinder their effective use of digital applications. Despite government initiatives such as MyDigital and the Malaysia Digital Economy Blueprint, gaps in digital literacy persist among older adults. Research suggests that intergenerational programs (IPs), where younger individuals assist older adults in learning digital skills, can bridge this gap. These programs promote collaborative learning, reduce social isolation, and foster meaningful intergenerational relationships. However, existing instructional strategies within IPs often fail to accommodate the specific learning needs and preferences of older adults, limiting their effectiveness. Addressing these instructional gaps is essential to ensuring older adults' successful integration into the digital world.

    AIMS: This study aims to investigate the preferences of older adult individuals in Malaysia regarding digital applications and to propose effective intergenerational instructional strategies that enhance their digital learning experiences.

    METHODS: This qualitative study explores older adults' preferences for digital applications and their experiences with intergenerational instructional strategies in Malaysia. A total of 26 older adults and 13 young instructors participated in digital applications workshops at two Pusat Aktiviti Warga Emas (PAWE) centres on August, 2024. Older adults were paired with young instructors in small groups to guide them in using digital applications through hands-on learning. Data collection involved semi-structured interviews before and after the sessions, as well as observations. Thematic analysis is used to analyse interview data, identifying key insights into improving digital learning for older adults in Malaysia.

    RESULTS: The study, conducted at two PAWE centres in Perak, Malaysia, explored intergenerational digital learning between 26 older adults (ages 59-82) and 13 young instructors (ages 20-24). Findings highlight the importance of structured instructional strategies, including interactive learning, direct instruction, and clear communication, to enhance digital literacy among older adults. Personalized learning approaches, small group discussions, and adapting content to individual needs improve engagement and comprehension. Smartphone familiarity plays a key role, with participants favouring WhatsApp and Facebook for communication. Older adults face challenges such as fear of complexity, physical limitations, and security concerns, while young instructors benefit from training to improve communication and instructional skills. The program fosters confidence, intergenerational bonding, and digital inclusion, demonstrating the value of tailored learning strategies in bridging the digital divide.

  16. Islam MK, Hoque MN, Musa K, Binti Zulkifli NH
    PLoS One, 2025;20(8):e0327744.
    PMID: 40748881 DOI: 10.1371/journal.pone.0327744
    This study aims to examine the impact of energy consumption, i.e., coal and gas, on environmental sustainability by utilizing CO2 emissions as a proxy to emphasize Environmental, Social, and Governance (ESG) practices in the electricity supply company of Malaysia. To do so, we collect time series data from Tenaga Nasional Berhad (TNB) Sustainability Reports spanning 2016-2021. Since the data is short time series data, this study deploys the Prais-Winsten (AR1) regression technique, which is able to produce robust estimates from the short data. Besides, this method is also able to overcome the issues of heteroscedasticity and autocorrelation issues in the dataset. Additionally, we also employ the Ordinary Least Square (OLS) regression method to check the robustness of our estimation. The findings of the study reveal that energy consumption, i.e., coal and gas, strongly affects the environmental sustainability channel through CO2 emissions. The result indicates that the electricity supply company of Malaysia still aggravates the environmental degradation using coal and gas in energy production, while the study also shows from the long-run trends that the sector has considerably decreased the CO2 emissions in recent years by 0.60%. Since the emission is still significant, this study emphasizes the need for a cautious approach to energy sources in order to reduce environmental effects. The study suggests that policymakers should review the existing energy use and CO2 emissions policy to strengthen environmental sustainability and ESG standards in Malaysia's electricity generation industry, reduce dependency on fossil fuels, and hasten the adoption of renewable energy sources.
  17. Shah MI, AbdulKareem HKK, Ishola BD, Abbas S
    Environ Sci Pollut Res Int, 2023 Feb;30(10):26063-26077.
    PMID: 36350445 DOI: 10.1007/s11356-022-23871-3
    This paper empirically examines the effects of energy, natural resources, agriculture, political constraint and regional integration on CO2 emissions in four ASEAN (Association of Southeast Asian Nations) countries of Cambodia, Malaysia, Indonesia and Thailand. We distinguish between renewable and fossil fuel energy consumption to see their individual impacts on CO2 emissions. The study employed a panel data from 1990 to 2019 derived from sources such as World Development Indicators, which were then analysed using Common-Correlated Effect Mean Group (CCEMG) and Augmented Mean Group (AMG) estimates. The findings show that renewable energy consumption has a negative impact on CO2 emissions while fossil fuel energy degrades the environment. The role of natural resources was found to be favourable for environmental quality with the impact of agriculture being found to be detrimental. For regional trade integration, its influence was not significant enough to offset CO2 emission. Furthermore, we discovered that political constraint induces CO2 emission. Based on the result, it is recommended that the selected ASEAN countries promote the use of renewable energy and clean technologies in their manufacturing processes, conserve natural resources, adopt eco-friendly political policies and intensify regional integration to accelerate the achievement of the SDGs.
  18. Zia S, Saleem M, Asif M, Hussain K, Butt BZ
    Inflammopharmacology, 2022 Dec;30(6):2211-2227.
    PMID: 36223063 DOI: 10.1007/s10787-022-01048-1
    Rheumatoid arthritis is a chronic inflammatory disorder of polyarticular tissues, characterised by progressive synovitis. Its prolonged treatment imparts a huge burden on the healthcare system and results in toxicity, which necessitates the search for safe, efficacious and cost-effective therapies. Diospyros malabarica (Desr.) Kostel is traditionally used for anti-inflammatory purposes; however, to the best of our knowledge, there is no detailed study reporting the in vivo anti-inflammatory potential of this plant. Therefore, in the current study, the methanol extract of D. malabarica (Desr.) Kostel fruit (mDMF) was evaluated for its antioxidant, anti-inflammatory and anti-arthritic potentials, along with its underlying mechanisms. The antioxidant activity was evaluated by DPPH assay. Total phenolic and flavonoid contents were estimated via colorimetric and high-performance liquid chromatography (HPLC) methods. Different doses (250, 500 and 750 mg/kg) of mDMF were used to evaluate the anti-inflammatory and anti-arthritis actions in acute inflammatory (carrageenan and histamine-induced paw oedema) and Freund's complete adjuvant (FCA)-induced arthritis rat models. Levels of various pro- and anti-inflammatory biomarkers were estimated using ELISA and RT-PCR techniques. Paw samples were used for different histopathological and radiographic studies. Qualitative phytochemical and HPLC analyses indicated the presence of various polyphenolic compounds in mDMF, which exhibited marked antioxidant activity in the DPPH assay. mDMF showed time-dependent anti-inflammatory and anti-arthritic effects in in vivo models. ELISA assay data showed significant (p 
  19. Saqib SU, Raza MZ, Evans C, Bajwa AA
    J Robot Surg, 2023 Feb;17(1):73-78.
    PMID: 35325433 DOI: 10.1007/s11701-022-01400-1
    Robotic colorectal surgery allows for better ergonomics, superior retraction, and fine movements in the narrow anatomy of the pelvis. Recent years have seen the uptake of robotic surgery in all pelvic surgeries specifically in low rectal malignancies. However, the learning curve of robotic surgery in this cohort is unclear as established training pathways are not formalized. This study looks at the experience and learning curve of a single laparoscopic trained surgeon in performing safe and effective resections, mainly for low rectal and anal malignancies using the da Vinci robotic system by evaluating metrics related to surgical process and patient outcome. A serial retrospective review of the robotic colorectal surgery database, in the University Hospital Coventry and Warwickshire (UHCW), was undertaken. All 48 consecutive cases, performed by a recently qualified colorectal surgeon, were included in our study. The surgical process was evaluated using both console and total operative time recorded in each case along with the adequacy of resections performed; in addition, patient-related outcomes including intraoperative and postoperative complications were analyzed to assess differences in the learning curve. Forty eight sequential recto-sigmoid resections were included in the study performed by a single surgeon. The cases were divided into four cohorts in chronological order with comparable demographics, tumour stage, location, and complexity of the operation (mean age 65, male 79%, and female 29%). The results showed that the mean console time dropped from 3 to 2.5 h, while total operative time dropped from 6 h to 5.5 h as the surgeon became more experienced; however, this was not found to be statistically significant. In addition, no significant difference in pathological staging was seen over the study period. No major intra-op and post-op complications were observed and no 30-day mortality was recorded. Moreover, after 30 cases, the learning curve developed the plateau phase, suggesting the gain of maximum proficiency of skills required for robotic colorectal resections. The learning curve in robotic rectal surgery is short and flattens early; complication rates are low during the learning curve and continue to decrease with time. This shows that with proper training and proctoring, new colorectal surgeons can be trained in a short time to perform elective colorectal pelvic resections.
  20. Aamir M, Pervaiz T, Aslam A, Mustafa AG, Shahzad S
    J Obstet Gynaecol Res, 2026 Oct;52(10):e70521.
    PMID: 42888179 DOI: 10.1111/jog.70521
    AIM: Polyendocrine metabolic ovarian syndrome (PMOS) is a common endocrine disorder affecting women of reproductive age. It is associated with various lifestyle and psychological factors. The research aims to evaluate the impact of dietary patterns, physical activity, and stress levels on the severity of PMOS.

    METHODS: The current study used a cross-sectional study design, and data were collected from 384 PMOS patients attending selected healthcare facilities in Lahore. Participants were recruited through a non-probability convenience sampling. Data were collected using a self-structured questionnaire. The Kruskal-Wallis H test was used to assess the differences in dietary patterns, physical activity, and stress levels across PMOS severity groups. Statistical significance was considered at p 

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