Displaying publications 241 - 260 of 409 in total

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  1. Liew LK, Tan MP, Tan PJ, Mat S, Majid LA, Hill KD, et al.
    J Geriatr Phys Ther, 2018 1 31;42(3):123-129.
    PMID: 29381526 DOI: 10.1519/JPT.0000000000000155
    BACKGROUND AND PURPOSE: Exercise-based interventions, such as the Otago Exercise Program (OEP), are effective in preventing falls in the older adult. Previous studies evaluating the OEP have determined falls, lower limb strength, or balance outcomes but with lack of assessment of hand grip strength. The objective of this study is to evaluate the effect of OEP on hand grip strength alongside mobility and balance outcomes.

    METHODS: This was a single-center, prospective, and single-blind randomized controlled trial conducted at the University Malaya Medical Centre. Patients older than 65 years presenting to the hospital emergency department or geriatric clinic with 1 injurious fall or 2 falls in the past year and with impaired functional mobility were included in the study. The intervention group received a modified OEP intervention (n = 34) for 3 months, while the control group received conventional care (n = 33). All participants were assessed at baseline and 6 months.

    RESULTS: Twenty-four participants in both OEP and control groups completed the 6-month follow-up assessments. Within-group analyses revealed no difference in grip strength in the OEP group (P = 1.00, right hand; P = .55, left hand), with significant deterioration in grip strength in the control group (P = .01, right hand; P = .005, left hand). Change in grip strength over 6 months significantly favored the OEP group (P = .047, right hand; P = .004, left hand). Significant improvements were also observed in mobility and balance in the OEP group.

    CONCLUSIONS: In addition to benefits in mobility and balance, the OEP also prevents deterioration in upper limb strength. Additional benefits of exercise interventions for secondary prevention of falls in term of sarcopenia and frailty should also be evaluated in the future.

  2. Sagap I, Loo GH, Azman ZAM, Mazlan L, Gan SY, Eng HS, et al.
    Br J Nurs, 2022 Dec 15;31(22):S34-S42.
    PMID: 36519479 DOI: 10.12968/bjon.2022.31.22.S34
    BACKGROUND: Choice of ostomy appliances is based on multiple factors including economic considerations, individual patient requirements and lifestyle. A recently launched two-piece ostomy collection device with an extended tape border is expected to provide a long wear time and increase patients' sense of security.

    AIMS AND METHODS: A randomised controlled, non-blinded, cross-over study involving 38 patients (with colostomies and ileostomies) compared the test device to a similar device from the same manufacturer but without the tape border. The main objective was to assess wear time for non-inferiority as a measure of efficacy. Secondary efficacy assessment included peristomal skin condition using the DET (discolouration, erosion and tissue growth) score and patient acceptability, which was assessed through questionnaires using Likert-scale options. Safety was assessed according to the incidence and intensity of device-related adverse events, and the condition of the peristomal skin.

    RESULTS AND CONCLUSION: Analysis of results in the per-protocol population showed an average wear time of 4.5 days for both devices and demonstrated non-inferiority. DET scores were similar in both groups, and both had low rates of device-related adverse events, all of which related to peristomal skin. Patients said the devices were user friendly. While the two devices are similar, some patients may find one with an adhesive tape more suited to their needs.

  3. Syed Alwi SM, Mazlan M, Mohd Taib NA, Che Din N, Narayanan V
    PLoS One, 2022;17(11):e0277056.
    PMID: 36395277 DOI: 10.1371/journal.pone.0277056
    OBJECTIVE: Chemotherapy-related cognitive impairment (CRCI) is a well-known phenomenon among breast cancer survivors. Cognitive impairment among breast cancer survivors can significantly affect their quality of life and ability to function independently. However, there is a lack of specific and focused cognitive intervention to improve their cognitive performances. This study aimed to develop a tailored cognitive intervention framework module by adapting the attention and memory interventions from the Cognitive Rehabilitation Manual of the Brain Injury Interdisciplinary Special Interest Group (BI-SIG) of the American Congress of Rehabilitation Medicine (ACRM) and incorporating them with the relevant exercises for cognitive rehabilitation for Malaysian breast cancer survivors with CRCI based on the consensus agreement of the expert panel.

    METHODS AND ANALYSIS: The Delphi consensus technique was conducted online to review and evaluate the framework module. A panel of experts, including rehabilitation medicine physicians, occupational therapists, and clinical psychologists in Malaysia, was invited to participate in this study. For each round, the expert consensus was defined as more than 90% of the expert panel agreeing or strongly agreeing with the proposed items.

    RESULTS: A total of 33 practitioners completed the three Delphi rounds. 72.7% of the expert panel have been practising in their relevant clinical fields for more than six years (M = 10.67, SD = 5.68). In Round 1, 23% of the experts suggested that the framework module for attention training required further improvements, specifically in the language (M = 1.97, SD = 0.75) and instructions (M = 2.03, SD = 0.71) provided. In Round 2, 15% of the experts recommended additional changes in the instruction (M = 2.15, SD = 0.67) for attention training. Amendments made to the framework module in line with the recommendations provided by the experts resulted in a higher level of consensus, as 94% to 100% of the experts in Round 3 concluded the framework module was suitable and comprehensive for our breast cancer survivors. Following the key results, the objectives were practical, and the proposed approaches, strategies, and techniques for attention and memory training were feasible. The clarity of the instructions, procedures, verbatim transcripts, and timeframe further enhanced the efficacy and utility of the framework module.

    CONCLUSIONS: This study found out that the cognitive intervention framework module for breast cancer survivors with cognitive impairment following chemotherapy can be successfully developed and feasible to be implemented using Delphi technique.

  4. Johari MAF, Mazlan SA, Nordin NA, Choi SB, Aziz SAA, Daud S, et al.
    Materials (Basel), 2022 Dec 01;15(23).
    PMID: 36500061 DOI: 10.3390/ma15238565
    Strain localization is a significant issue that poses interesting research challenges in viscoelastic materials because it is difficult to accurately predict the damage evolution behavior. Over time, the damage mechanism in the amorphous structure of viscoelastic materials leads to subsequent localization into a shear band, gradually jeopardizing the materials' elastic sustainability. The primary goal of this study is to further understand the morphological effects and the role of shear bands in viscoelastic materials precipitated by strain localization. The current study aims to consolidate the various failure mechanisms of a sample and its geometry (surface-to-volume ratio) used in torsional testing, as well as to understand their effects on stress relaxation durability performance. A torsional shear load stress relaxation durability test was performed within the elastic region on an isotropic viscoelastic sample made of silicon rubber and a 70% weight fraction of micron-sized carbonyl iron particles. Degradation was caused by a shear band of localized plasticity that developed microscopically due to stress relaxation durability. The failure pattern deteriorated as the surface-to-volume ratio decreased. A field-emission scanning electron microscope (FESEM) and a tapping-mode atomic force microscope (AFM) were used for further observation and investigation of the sample. After at least 7500 cycles of continuous shearing, the elastic sustainability of the viscoelastic materials microstructurally degraded, as indicated by a decline in stress performance over time. Factors influencing the formation of shear bands were observed in postmortem, which was affected by simple micromanipulation of the sample geometry, making it applicable for practical implementation to accommodate any desired performance and micromechanical design applications.
  5. Rachmawati D, Fahmi MZ, Abdjan MI, Wasito EB, Siswanto I, Mazlan N, et al.
    Molecules, 2022 Dec 15;27(24).
    PMID: 36558064 DOI: 10.3390/molecules27248935
    An anti-biofilm that can inhibit the matrix of biofilm formation is necessary to prevent recurrent and chronic Pseudomonas aeruginosa infection. This study aimed to design compounds with a new mechanism through competitive inhibitory activity against phosphomannomutase/phosphoglucomutase (PMM/PGM), using in vitro assessment and a computational (in silico) approach. The active site of PMM/PGM was assessed through molecular redocking using L-tartaric acid as the native ligand and other small molecules, such as glucaric acid, D-sorbitol, and ascorbic acid. The docking program set the small molecules to the active site, showing a stable complex formation. Analysis of structural similarity, bioavailability, absorption, distribution, metabolism, excretion, and toxicity properties proved the potential application of ligands as an anti-biofilm. In vitro assessment with crystal violet showed that the ligands could reach up to 95.87% inhibition at different concentrations. The nitrocellulose membrane and scanning electron microscopic visualization showed that the untreated P. aeruginosa biofilm was denser than the ligand-treated biofilm.
  6. Said AH, Mohd FN, Yusof MZ, Mohd Win NAN, Mazlan AN, Shaharudin AS
    Malays Fam Physician, 2022 Nov 30;17(3):64-73.
    PMID: 36606166 DOI: 10.51866/oa.75
    INTRODUCTION: Smartphone addiction is becoming a global concern affecting every part of society, including healthcare professionals. This study aimed to identify the prevalence of risk of smartphone addiction and its associated factors among medical and dental students in a public university in Malaysia.

    METHOD: This cross-sectional study was conducted among pre-clinical medical and dental students using convenience sampling. Questions regarding sociodemographic profile and responses to the Smartphone Addiction Scale Short Version (SAS-SV) and Depression, Anxiety and Stress Score questionnaire (DASS-21) were collected. Multiple logistic regression testing was used to analyse the factors associated with smartphone addiction.

    RESULTS: We invited 409 pre-clinical medical and dental students to participate voluntarily, resulting in a response rate of 80.2%. The prevalence of high-risk smartphone addiction among the participants was 47.9%. Male participants, participants who used smartphones mainly for social media, and participants with depressive symptoms were more likely to have a high risk of smartphone addiction. Medical students, participants who spent less than 3 hours per day on a smartphone, and participants who used smartphones for education-related activities were less likely to have a high risk of smartphone addiction.

    CONCLUSION: Smartphone addiction prevalence among pre-clinical medical and dental students was high. Therefore, the authorities should overcome this problem by implementing early measures.

  7. Dam VSKE, Mohamad S, Hassan NFHN, Mazlan MZ
    Acta Medica (Hradec Kralove), 2022;65(3):112-117.
    PMID: 36735889 DOI: 10.14712/18059694.2022.27
    Iatrogenic laryngotracheal trauma is a potentially fatal complication of endotracheal intubation, especially in an emergency setting. Symptoms are almost always related to speech, breathing, and swallowing. Hoarseness being the commonest symptom, while shortness of breath and stridor always signify more devastating injury. We present a case of iatrogenic subglottic and tracheal stenosis, which was misdiagnosed in the emergency department during the first visit. This case report highlights the importance of salient history and thorough examination with a high index of suspicion in a stridorous case with a recent history of intubation. Early detection and management are vital to avoid a life-threatening event.
  8. Muhammad Husin MJ, Mazlan N, Shalom J, Saud SN, Abdullah Sani MS
    PMID: 34181157 DOI: 10.1007/s11356-021-15099-4
    The widespread presence of microplastics has caused significant concerns on their potential effects on marine ecosystems. Microplastics are classified as plastic products of less than 5 mm in size and are known to be one of the most dangerous aquatic debris to marine species. Sea cucumbers are deposit feeders living in sediment regions and benthic zone that may collect microplastics in low-energy environments. This research aims to evaluate the types of microplastic isolated from the intestine of Stichopus horrens in Malaysia. This species is selected because it is mainly found in this island. Pulau Pangkor is one of the leading tourism destinations on the small islands is facing increasing numbers of tourists and development and it is useful for sustainable study. A total of 20 S. horrens samples collected from Pulau Pangkor, Malaysia were dissected, and their intestines were collected for digestion. Microplastics were extracted using NaOH and filtered using filter paper. Microplastic identification was conducted on the based of the physical characteristics (colour, shape, size) and chemical characterisation was evaluated using FTIR for polymer functional groups. A total of 1446 unit of microplastics were found in S. horrens. Among various types and colours, fibre (90%) and black (59%) were dominant amongst the various particles identified. The majority of microplastics sizes were 0.51 μm and 1-2 μm. Two polymer materials were identified, namely polyethylene and poly(methyl methacrylate). As a conclusion, the findings of the study will serve as primary data for pollution indicators in respective islands. The microplastics could impact the immune system and upset gut's balance of human.
  9. Khodzori FA, Mazlan NB, Chong WS, Ong KH, Palaniveloo K, Shah MD
    Biomolecules, 2023 Mar 06;13(3).
    PMID: 36979419 DOI: 10.3390/biom13030484
    Sponges are aquatic, spineless organisms that belong to the phylum Porifera. They come in three primary classes: Hexactinellidae, Demospongiae, and Calcarea. The Demospongiae class is the most dominant, making up over 90% of sponge species. One of the most widely studied genera within the Demospongiae class is Xestospongia, which is found across Southeast Asian waters. This genus is of particular interest due to the production of numerous primary and secondary metabolites with a wide range of biological potentials. In the current review, the antioxidant, anticancer, anti-inflammatory, antibacterial, antiviral, antiparasitic, and cytotoxic properties of metabolites from several varieties of Southeast Asian Xestospongia spp. were discussed. A total of 40 metabolites of various natures, including alkaloids, fatty acids, steroids, and quinones, were highlighted in X. bergquistia, X. testudinaria, X. muta, X. exigua, X. ashmorica and X. vansoesti. The review aimed to display the bioactivity of Xestospongia metabolites and their potential for use in the pharmaceutical sector. Further research is needed to fully understand their bioactivities.
  10. Nazmi N, Abdul Rahman MA, Yamamoto S, Ahmad SA, Zamzuri H, Mazlan SA
    Sensors (Basel), 2016 Aug 17;16(8).
    PMID: 27548165 DOI: 10.3390/s16081304
    In recent years, there has been major interest in the exposure to physical therapy during rehabilitation. Several publications have demonstrated its usefulness in clinical/medical and human machine interface (HMI) applications. An automated system will guide the user to perform the training during rehabilitation independently. Advances in engineering have extended electromyography (EMG) beyond the traditional diagnostic applications to also include applications in diverse areas such as movement analysis. This paper gives an overview of the numerous methods available to recognize motion patterns of EMG signals for both isotonic and isometric contractions. Various signal analysis methods are compared by illustrating their applicability in real-time settings. This paper will be of interest to researchers who would like to select the most appropriate methodology in classifying motion patterns, especially during different types of contractions. For feature extraction, the probability density function (PDF) of EMG signals will be the main interest of this study. Following that, a brief explanation of the different methods for pre-processing, feature extraction and classifying EMG signals will be compared in terms of their performance. The crux of this paper is to review the most recent developments and research studies related to the issues mentioned above.
  11. Jafri NF, Mohd Salleh K, Ahmad Ghazali N, Nyak Mazlan NS, Ab Halim NH, Zakaria S
    Int J Biol Macromol, 2023 Sep 18;253(Pt 4):126971.
    PMID: 37729993 DOI: 10.1016/j.ijbiomac.2023.126971
    To date, the utilization of carboxymethyl cellulose (CMC) fibers are only restricted to weak mechanical application such as wound dressing. Physically, CMC has a weak mechanical strength due to the high hydrophilicity trait. However, this flaw was saved by the extensive number of reactive functional groups, allowing this macromolecule to form linkages with chitosan to ensure its versatility. This work successfully fabricated CMC-chitosan fiber via dissolution, crosslinking, dry-jet wet-spinning extrusion, and coagulation processes. Chitosan was constituted with CMC fiber in two approaches, coating, and inclusion at various concentrations. Morphologically, chitosan incorporation has triggered agglomerations and roughness toward CMC fibers (CMCF). Chemically, the interaction between CMC and chitosan was proved through FTIR analysis at peaks 1245 cm-1 (ECH covalent crosslinking), while 3340 cm-1 and 1586 cm-1 were due to ionic and hydrogen bonding. The result from analysis showed that at higher chitosan concentrations, the chitosan-included CMC fiber (CMCF-I) and chitosan-coated CMC fiber (CMFC) were mechanically enhanced (up to 86.77 and 82.72 MPa), thermally more stable (33 % residual mass), and less hydrophilic compared to the plain CMCF. The properties of CMC-chitosan fibers have opened up vast possible applications, especially as a reinforcement in a watery medium such as a hydrogel.
  12. Ahmad R, Khairul Nizam Mazlan M, Firdaus Abdul Aziz A, Mohd Gazzali A, Amir Rawa MS, Wahab HA
    Saudi Pharm J, 2023 Jun;31(6):874-888.
    PMID: 37234341 DOI: 10.1016/j.jsps.2023.04.006
    Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macrocarpa especially in Asia reflects the usage of diverse extraction techniques, particularly modern approaches. In this review article, the extraction methods and solvents relevant to P. macrocarpa were discussed, with the extent of its pharmacological activities. Recent bibliographic databases such as Google Scholar, PubMed, and Elsevier between 2010 and 2022 were assessed. Based on the findings, the pharmacological studies of P. macrocarpa are still pertinent to its traditional uses but primarily emphasise anti-proliferative activity especially colon and breast cancer cells with low toxicity and fruit as the most studied plant part. The utilization of modern separation techniques has predominantly been aimed at extracting mangiferin and phenolic-rich compounds and evaluating their antioxidant capacity. However, the isolation of bioactive compounds remains a challenge, leading to the extensive utilization of the extracts in in vivo studies. This review endeavors to highlight modern extraction methods that could potentially be used as a point of reference in the future for exploring novel bioactive compounds and drug discovery on a multi-scale extraction level.
  13. Liang Y, Mazlan NS, Mohamed AB, Mhd Bani NYB, Liang B
    PLoS One, 2023;18(3):e0282913.
    PMID: 36917591 DOI: 10.1371/journal.pone.0282913
    The aging population is a common problem faced by most countries in the world. This study uses 18 years (from 2002 to 2019) of panel data from 31 regions in China (excluding Hong Kong, Macao, and Taiwan Province), and establishes a panel threshold regression model to study the non-linear impact of the aging population on economic development. It is different from traditional research in that this paper divides 31 regions in China into three regions: Eastern, Central, and Western according to the classification standard of the National Bureau of Statistics of China and compares the different impacts of the aging population on economic development in the three regions. Although this study finds that the aging population promotes the economy of China's eastern, central, and western regions, different threshold variables have dramatically different influences. When the sum of export and import is the threshold variable, the impact of the aging population on the eastern and the central region of China is significantly larger than that of the western region of China. However, when the unemployment rate is the threshold variable, the impact of the aging population on the western region of China is dramatically higher than the other regions' impact. Thus, one of the contributions of this study is that if the local government wants to increase the positive impact of the aging population on the per capita GDP of China, the local governments of different regions should advocate more policies that align with their economic situation rather than always emulating policies from other regions.
  14. Z Mazlan M, A H Ismail M, Ali S, Salmuna ZN, Wan Muhd Shukeri WF, Omar M
    Anaesthesiol Intensive Ther, 2021;53(3):207-214.
    PMID: 34006044 DOI: 10.5114/ait.2021.104300
    INTRODUCTION: This study was conducted to assess the efficacy of point-of-care (POC) procalcitonin (PCT) serial measurement in determining the antibiotic treatment duration in patients with ventilator-associated pneumonia (VAP).

    MATERIAL AND METHODS: One hundred patients were randomly recruited and then further randomly divided into two groups of 50 patients each. The first group used the POC PCT test along with the standard sepsis parameter monitoring, while the second group had the standard monitoring only (C-reactive protein [CRP] level, total white count, temperature and tracheal aspirate culture). Serial PCT test results and CRP levels were monitored on days 1, 3, 7 and 9. The patients were followed up for 28-day mortality.

    RESULTS: Eighty-five patients completed the trial, of whom 43 were in the PCT group and 42 were in the control group. The PCT group had a significantly lower mean (SD) antibiotic treatment duration (10.28 [2.68] days) than the control group (11.52 [3.06]). The mean (SD) difference was -1.25 (95% confidence interval [CI], -2.48 to 0.01; t-statistic [df] = -1.997 [83]; P = 0.049). The PCT group also had a higher number of antibiotic-free days alive during the 28 days after VAP onset than the control group (mean [SD], 10.79 [7.61] vs. 8.72 [6.41]). The Sequential Organ Failure Assessment score was the sole factor for the decrease in duration after VAP onset (regression coefficient β [95% CI], -0.70 [-1.19 to -0.20]; P = 0.006).

    CONCLUSIONS: The POC procalcitonin test can reduce the antibiotic treatment duration in patients with VAP.

  15. Ho SF, Tan SJ, Mazlan MZ, Iberahim S, Lee YX, Hassan R
    Diagnostics (Basel), 2023 Jul 21;13(14).
    PMID: 37510189 DOI: 10.3390/diagnostics13142445
    Sepsis is a major cause of mortality and morbidity in intensive care units. This case-control study aimed to investigate the haematology cell population data and extended inflammatory parameters for sepsis management. The study included three groups of patients: sepsis, non-sepsis, and healthy controls. Patients suspected of having sepsis underwent a Sequential Organ Failure Assessment (SOFA) evaluation and had blood drawn for blood cultures, complete peripheral blood counts (CBC), and measurements of various markers such as C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6). We observed significant changes in numerous CBC parameters and extended inflammation parameters (EIPs), in addition to significant biochemical analysis markers CRP and IL-6 in sepsis cohorts. Multiple logistic regression analyses showed that combining different CBC parameters and EIPs were effective to profile these patients. Two different models have been developed using white blood cell counts and their extended parameters. Our findings indicate that the absolute counts of white blood cells, and the EIPs which reflect their activation states, are important for the prediction and assessment of sepsis, as the body responds to an insult that triggers an immune response. In an emergency situation, having timely updates on patient conditions becomes crucial for guiding the management process. Identifying trends in these specific patient groups will aid early diagnosis, complementing clinical signs and symptoms, especially as CBC is the most commonly ordered test in a diagnostic workup.
  16. Rusmita SA, Zulaikha S, Mazlan NS, Mohd Dali NRSB, Cahyono EF, Ramadhani I
    PLoS One, 2023;18(11):e0286629.
    PMID: 38011115 DOI: 10.1371/journal.pone.0286629
    The market for the halal food and beverage industry sector has experienced rapid growth in recent years, which indicate excellent investment opportunities. This paper examine the effect of Technical Efficiency (TE) on firm value in 5 selected influential countries in halal food and beverage sector based on Global Islamic Economy Report 2020. Two steps estimation was used to run the data, using the Stochastic Frontier Analysis (SFA) model to determine the company's TE and panel data to test the effect of TE through firm value. The results show that Indonesia has the highest score for TE (62%), followed by Pakistan (59%), South Africa (57%), Malaysia (55%), and Singapore (52%), which means, in general, there is inefficiency in allocating resources over 38% up to 48% and needs to be improved by halal food and beverage companies in. Regarding panel data, all countries sample except Pakistan highlight that TE significantly affect company value. It indicates that the crucial part of managing efficiency can be a sign in stock market performance. The result shows that company managers should set efficiency strategies to their business process for creating sustainability and increase their value in the capital market. As for investors, this TE can be used as an indicator before choosing company stocks; if the company is efficient, then it is worthy of being one of the portfolio assets. Form the government side, the finding can help them to set appropriate policy setting to boost halal food and beverages industry such as giving subsidy or incentive to increase the efficiency ability of halal food and beverage companies and identify the industry's strength by comparing the result of TE between 5 countries.
  17. Khairunnisa-Atiqah MK, Salleh KM, Hair AHA, Mazlan NSN, Mostapha M, Zakaria S
    Int J Biol Macromol, 2023 Dec 31;253(Pt 8):127518.
    PMID: 37865379 DOI: 10.1016/j.ijbiomac.2023.127518
    Cotton thread therapeutic properties as a wound dressing can be enhanced by utilising carboxymethyl cellulose-nanoparticles (CMC/NPs) colloidal solution as a coating solution. Nanoparticles such as graphene oxide (GO), graphene quantum dots (GQD), and silver nanoparticles (AgNP) stability in CMC was investigated through the rheological analysis and UV-Vis spectroscopy of the colloidal solutions. Citric acid (CA) acted as a crosslinker and was utilised to crosslink the colloidal solution with cotton thread. These CMC/NPs coated threads were subjected to mechanical properties and antibacterial activity analysis. Results obtained indicate less nanoparticle agglomeration and were stable in the CMC-based nanofluid. CMC/NPs rheological study suggested that colloidal solutions exhibited shear thinning behaviour and behaved as non-Newtonian fluids with n 
  18. Woei TJ, Mazlan R, Tamil AM, Rosli NSM, Hasbi SM, Hashim ND, et al.
    Int Tinnitus J, 2023 Dec 04;27(1):75-81.
    PMID: 38050889 DOI: 10.5935/0946-5448.20230013
    OBJECTIVE: The purpose of this study was to compare the reliability and accuracy of chirp-based Multiple Auditory Steady State Response (MSSR) and Auditory Brainstem Response (ABR) in children.

    METHODS: The prospective clinical study was conducted at Selayang Hospital (SH) and Hospital Canselor Tuanku Muhriz (HCTM) within one year. A total of 38 children ranging from 3 to 18 years old underwent hearing evaluation using ABR tests and MSSR under sedation. The duration of both tests were then compared.

    RESULTS: The estimated hearing threshold of frequency specific chirp MSSR showed good correlation with ABR especially in higher frequencies such as 2000 Hz and 4000Hz with the value of cronbach alpha of 0.890, 0.933, 0.970 and 0.969 on 500Hz, 1000Hz, 2000Hz and 4000Hz. The sensitivity of MSSR is 0.786, 0.75, 0.957 and 0.889 and specificity is 0.85, 0.882, 0.979 and 0.966 over 500Hz, 1000Hz, 2000Hz and 4000Hz. The duration of MSSR tests were shorter than ABR tests in normal hearing children with an average of 35.3 minutes for MSSR tests and 46.4 minutes for ABR tests. This can also be seen in children with hearing loss where the average duration for MSSR tests is 40.0 minutes and 52.0 minutes for ABR tests.

    CONCLUSION: MSSR showed good correlation and reliability in comparison with ABR especially on higher frequencies. Hence, MSSR is a good clinical test to diagnose children with hearing loss.

  19. Hapipi NM, Mazlan SA, Ubaidillah U, Abdul Aziz SA, Ahmad Khairi MH, Nordin NA, et al.
    Int J Mol Sci, 2020 Mar 05;21(5).
    PMID: 32151055 DOI: 10.3390/ijms21051793
    Chemically crosslinked hydrogel magnetorheological (MR) plastomer (MRP) embedded with carbonyl iron particles (CIPs) exhibits excellent magnetic performance (MR effect) in the presence of external stimuli especially magnetic field. However, oxidation and desiccation in hydrogel MRP due to a large amount of water content as a dispersing phase would limit its usage for long-term applications, especially in industrial engineering. In this study, different solvents such as dimethyl sulfoxide (DMSO) are also used to prepare polyvinyl alcohol (PVA) hydrogel MRP. Thus, to understand the dynamic viscoelastic properties of hydrogel MRP, three different samples with different solvents: water, DMSO, and their binary mixtures (DMSO/water) were prepared and systematically carried out using the oscillatory shear. The outcomes demonstrate that the PVA hydrogel MRP prepared from precursor gel with water shows the highest MR effect of 15,544% among the PVA hydrogel MRPs. However, the samples exhibit less stability and tend to oxidise after a month. Meanwhile, the samples with binary mixtures (DMSO/water) show an acceptable MR effect of 11,024% with good stability and no CIPs oxidation. Otherwise, the sample with DMSO has the lowest MR effect of 7049% and less stable compared to the binary solvent samples. This confirms that the utilisation of DMSO as a new solvent affects the rheological properties and stability of the samples.
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