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Antibacterial and antibiotic potentiating capabilities of extracts isolated from Burkillanthus malaccensis, Diospyros hasseltii and Cleisthanthus bracteosus against human pathogenic bacteria

Kathirvalu G, Chandramathi S, S A A, Atiya N, Begum S, Christophe W, et al.

Trop Biomed, 2023 Jun 01;40(2):152-159.
PMID: 37650400 DOI: 10.47665/tb.40.2.004

Antibiotics which once a boon in medicine and saved millions of lives are now facing an ever-growing menace of antibacterial resistance, which desperately needs new antibacterial drugs which are innovative in chemistry and mode of action. For many years, the world has turned to natural plants with antibacterial properties to combat antibiotic resistance. On that basis, we aimed to identify plants with antibacterial and antibiotic potentiating properties. Seventeen different extracts of 3 plants namely Burkillanthus malaccensis, Diospyros hasseltii and Cleisthanthus bracteosus were tested against multi-drug resistant Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Methicillinresistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA). Antibacterial activity of hexane, methanol and chloroform extracts of bark, seed, fruit, flesh and leaves from these plants were tested using, disk diffusion assay, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. Antibiotic potentiating capabilities were tested using time-kill assay. B. malaccensis fruit chloroform extract showed the biggest zone of inhibition against MRSA (13.00±0.0 mm) but C. bracteosus bark methanol extract showed the biggest inhibition zone against MSSA (15.33±0.6 mm). Interestingly, bark methanol extract of C. bracteosus was active against MRSA (8.7±0.6 mm), MSSA (7.7±0.6 mm) (Gram-positive) and A. baumannii (7.7±0.6 mm) (Gram-negative). Overall, the leaf methanol and bark methanol extract of C. bracteosus warrants further investigation such as compound isolation and mechanism of action for validating its therapeutic use as antibiotic potentiator importantly against MRSA and A. baumannii.
Algal-bacterial aerobic granular sludge for real municipal wastewater treatment: Performance, microbial community change and feasibility of lipid recovery

Purba LDA, Zahra SA, Yuzir A, Iwamoto K, Abdullah N, Shimizu K, et al.

J Environ Manage, 2023 May 01;333:117374.
PMID: 36758398 DOI: 10.1016/j.jenvman.2023.117374

Despite various research works on algal-bacterial aerobic granular sludge for wastewater treatment and resource recovery processes, limited information is available on its application in real wastewater treatment in terms of performance, microbial community variation and resource recovery. This study investigated the performance of algal-bacterial aerobic granular sludge on real low-strength wastewater treatment in addition to the characterization of microbial community and fatty acid compositions for biodiesel production. The results demonstrated 71% COD, 77% NH4+-N and 31% phosphate removal efficiencies, respectively. In addition, all the water parameters successfully met the effluent standard A, imposed by the Department of Environment (DOE) Malaysia. Core microbiome analyses revealed important microbial groups (i.e., Haliangium ochraceum, Burkholderiales and Chitinophagaceae) in bacterial community. Meanwhile the photosynthetic microorganisms, such as Oxyphotobacteria and Trebouxiophyceae dominated the algal-bacterial aerobic granular sludge, suggesting their important roles in granulation and wastewater treatment. Up to 12.51 mg/gSS lipid content was recovered from the granules. In addition, fatty acids composition showed high percetages of C16:0 and C18:0, demonstrating high feasibility to be used for biodiesel production application indicated by the cetane number, iodine value and oxidation stability properties.
Characteristics of algal-bacterial aerobic granular sludge treating real wastewater: Effects of algal inoculation and alginate-like exopolymers recovery

Zahra SA, Purba LDA, Abdullah N, Yuzir A, Iwamoto K, Lei Z, et al.

Chemosphere, 2023 Apr 04;329:138595.
PMID: 37023906 DOI: 10.1016/j.chemosphere.2023.138595

Limited information is available on the characteristics of algal-bacterial aerobic granular sludge (AGS) treating real wastewater, especially on its alginate-like exopolymers (ALE) production. In addition, the effect of target microalgae species inoculation on the system performance has not been fully understood. This study aimed to reveal the effect of microalgae inoculation on the characteristics of algal-bacterial AGS and its ALE production potential. Two photo-sequencing batch reactors (PSBR) were employed, namely R1 with activated sludge and R2 with Tetradesmus sp. and activated sludge being inoculated, respectively. Both reactors were fed with locally sourced municipal wastewater and operated for 90 days. Algal-bacterial AGS were successfully cultivated in both reactors. No significant difference was observed between the performances of R1 and R2, reflecting that the inoculation of target microalgae species may not be crucial for the development of algal-bacterial AGS when treating real wastewater. Both reactors achieved an ALE yield of about 70 mg/g of volatile suspended solids (VSS), indicating that a substantial amount of biopolymer can be recovered from wastewater. Interestingly, boron was detected in all the ALE samples, which might contribute to granulation and interspecies quorum sensing. The enrichment of lipids content in ALE from algal-bacterial AGS treating real wastewater reveals its high resource recovery potential. Overall, the algal-bacterial AGS system is a promising biotechnology for simultaneous municipal wastewater treatment and resource (like ALE) recovery.
Fulltext Stability of glycated haemoglobin (HbA1c) measurements from whole blood samples kept at -196°C for seven to eight years in The Malaysian Cohort study

Abdullah N, Goh YX, Othman R, Ismail N, Jalal N, Wan Sallam WAF, et al.

J Clin Lab Anal, 2023 Apr;37(8):e24898.
PMID: 37243371 DOI: 10.1002/jcla.24898

OBJECTIVE: Glycated haemoglobin (HbA1c) is a standard indication for screening type 2 diabetes that also has been widely used in large-scale epidemiological studies. However, its long-term quality (in terms of reproducibility) stored in liquid nitrogen is still unknown. This study is aimed to evaluate the stability and reproducibility of HbA1c measurements from frozen whole blood samples kept at -196°C for more than 7 years.
METHODS: A total of 401 whole blood samples with a fresh HbA1c measurement were randomly selected from The Malaysian Cohort's (TMC) biobank. The HbA1c measurements of fresh and frozen (stored for 7-8 years) samples were assayed using different high-performance liquid chromatography (HPLC) systems. The HbA1c values of the fresh samples were then calculated and corrected according to the later system. The reproducibility of HbA1c measurements between calculated-fresh and frozen samples was assessed using a Passing-Bablok linear regression model. The Bland-Altman plot was then used to evaluate the concordance of HbA1c values.
RESULTS: The different HPLC systems highly correlated (r = 0.99) and agreed (ICC = 0.96) with each other. Furthermore, the HbA1c measurements for frozen samples strongly correlate with the corrected HbA1c values of the fresh samples (r = 0.875) with a mean difference of -0.02 (SD: -0.38 to 0.38). Although the mean difference is small, discrepancies were observed within the diabetic and non-diabetic samples.
CONCLUSION: These data demonstrate that the HbA1c measurements between fresh and frozen samples are highly correlated and reproducible.
Fulltext Efficacy of Harmonic Scalpel Versus Bipolar Diathermy in Hemorrhoidectomy: A Systematic Review and Meta-Analysis of Nine Randomized Controlled Trials

Albazee E, Alenezi A, Alenezi M, Alabdulhadi R, Alhubail RJ, Ahmad Al Sadder K, et al.

Cureus, 2023 Feb;15(2):e34734.
PMID: 36755770 DOI: 10.7759/cureus.34734

Hemorrhoidectomy is one of the most common surgical interventions to remove the third and fourth degrees of prolapse hemorrhoid. We carried out this systematic review and meta-analysis of the randomized controlled trials (RCTs) to comprehensively evaluate the efficacy of harmonic scalpel (HS) versus bipolar diathermy (BD) methods in terms of decreasing intraoperative and postoperative morbidities among patients undergoing hemorrhoidectomy. Suitable citations were found utilizing digital medical sources, including the CENTRAL, Web of Science, PubMed, Scopus, and Google Scholar, from inception until December 2022. Only RCTs that matched the inclusion requirements were selected. We used the updated Cochrane risk of bias (ROB) tool (version 2) to assess the quality of the involved citations. The Review Manager (version 5.4 for Windows) was used to perform the pooled analysis. Data were pooled and reported as mean difference (MD) or risk ratio (RR) with a 95% confidence interval (CI) in random-effects models. Overall, there was no significant difference between HS and BD in terms of decreasing intraoperative morbidities like operative time, intraoperative blood loss, mean duration of hospital stay, and mean duration of first bowel movement (P>0.05). Similarly, the rate of postoperative complications like pain, bleeding, urinary retention, anal stenosis, flatus incontinence, and wound edema; was similar in both groups with no significant difference (P>0.05). In conclusion, our pooled analysis revealed there was no substantial difference between HS and BD in terms of intraoperative and postoperative endpoints. Additional RCTs with larger sample sizes are needed to consolidate the power and quality of the presented evidence.
Cardiovascular complications in a diabetes prediction model using machine learning: a systematic review

Kee OT, Harun H, Mustafa N, Abdul Murad NA, Chin SF, Jaafar R, et al.

Cardiovasc Diabetol, 2023 Jan 19;22(1):13.
PMID: 36658644 DOI: 10.1186/s12933-023-01741-7

Prediction model has been the focus of studies since the last century in the diagnosis and prognosis of various diseases. With the advancement in computational technology, machine learning (ML) has become the widely used tool to develop a prediction model. This review is to investigate the current development of prediction model for the risk of cardiovascular disease (CVD) among type 2 diabetes (T2DM) patients using machine learning. A systematic search on Scopus and Web of Science (WoS) was conducted to look for relevant articles based on the research question. The risk of bias (ROB) for all articles were assessed based on the Prediction model Risk of Bias Assessment Tool (PROBAST) statement. Neural network with 76.6% precision, 88.06% sensitivity, and area under the curve (AUC) of 0.91 was found to be the most reliable algorithm in developing prediction model for cardiovascular disease among type 2 diabetes patients. The overall concern of applicability of all included studies is low. While two out of 10 studies were shown to have high ROB, another studies ROB are unknown due to the lack of information. The adherence to reporting standards was conducted based on the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) standard where the overall score is 53.75%. It is highly recommended that future model development should adhere to the PROBAST and TRIPOD assessment to reduce the risk of bias and ensure its applicability in clinical settings. Potential lipid peroxidation marker is also recommended in future cardiovascular disease prediction model to improve overall model applicability.
Banana pseudo-stem biochar derived from slow and fast pyrolysis process

Abdullah N, Mohd Taib R, Mohamad Aziz NS, Omar MR, Md Disa N

Heliyon, 2023 Jan;9(1):e12940.
PMID: 36704268 DOI: 10.1016/j.heliyon.2023.e12940

This study evaluated the properties of banana pseudo-stem (BPS) biochar derived from two different types of pyrolysis. The fast pyrolysis experiment was performed using a worktable-scale fluidized-bed reactor, while a bench-scale fixed-bed reactor was used in the slow pyrolysis experiment. The preliminary analysis shows that the feedstock contains 80.6 db wt% of volatile matter, 12.5 db wt% of ash and 33.6% of carbon content. Biochar yield reduces as the pyrolysis temperature elevates for both pyrolysis experiments. Fast pyrolysis yields a higher percentage of biochar (40.3%) than biochar yield obtained from the slow pyrolysis experiment (34.9 wt%) at a similar temperature of 500 °C. The evaluation of biochar derived at 500 °C shows that the biochar obtained from the slow pyrolysis process has higher carbon content, heating value, and surface area with lower ash content. Meanwhile, FESEM images show significant differences in surface morphology and the number of pores for biochar derived from fast and slow pyrolysis. These findings indicate the potential and suitability of BPS biochar derived from the slow pyrolysis process in applications such as soil amelioration and solid biofuel.
Fulltext The prevalent factors of anxiety in women undergoing mammography

Jaafar Sidek MA, Amajid K, Loh YS, Rosli MA, Hashim IS, Mohd Suffian NA, et al.

Front Psychiatry, 2023;14:1085115.
PMID: 37791131 DOI: 10.3389/fpsyt.2023.1085115

BACKGROUND: Breast cancer is the most common cancer among women in Malaysia. Anxiety is one factor that deters women from participating in mammography. This study aimed to assess the anxiety level and its associated factors in women undergoing mammography.
METHODS: A three-month cross-sectional study was conducted using self-administered questionnaires, encompassing socio-demographic details, clinical characteristics, and the State-Trait Anxiety Inventory.
RESULTS: The mean age of the participants was 57 years old (SD ±10.098). Repeat mammograms consisted of 48.8% of the participants. One-third (35.7%) of them had a history of breast disease. Most participants (84.5%) did not have a positive family history of breast cancer. The proportion of participants with moderate and high anxiety levels was 41.8%. The cause of anxiety was mainly due to the fear of the results (69%), while familiarity with the procedure reduced anxiety among respondents. Socio-demographic and clinical factors were not significantly associated with anxiety levels. However, a statistically significant positive correlation was found between state and trait anxiety scores (r = 0.568, p = 0.001, n = 213).
LIMITATIONS: The urban setting and absence of questions on the location of origin in the study may have excluded data from the rural population. This may have prevented a true representation of the Malaysian population.
CONCLUSION: The findings suggest a better understanding of the procedures involved as well as the subsequent disease management would be beneficial in alleviating anxiety prior to, during, and post-mammogram.
Fulltext Bilateral metachronous breast malignancies: Malignant phylloides and invasive breast carcinoma-a case report

Abdullah N, Rizuana IH, Goh JHL, Lee QZ, Md Isa N, Md Pauzi SH

Front Oncol, 2023;13:1034556.
PMID: 37035170 DOI: 10.3389/fonc.2023.1034556

A 57-year-old Malay nullipara initially presented with a right breast lump that was increasing in size but defaulted follow-up. Two years later, she developed a contralateral breast lump. She only returned to the hospital when the right breast lump had become painful, 4 years from its onset. The biopsy of the right breast lump was a phylloides tumor and that of the left breast lump was a carcinoma. She had bilateral palpable axillary lymph nodes. She underwent bilateral mastectomy and axillary dissection. The pathology report confirmed the right breast lesion to be a malignant phylloides and the left breast lesion to be a carcinoma (pT3N2). She declined adjuvant treatment. A year after the surgical operation of the metachronous lesions, she had a right chest wall recurrence with widespread pulmonary metastases. She was given palliative chemotherapy but succumbed several months later.
Fulltext METER (Mental health emergency response) program: Findings of psychological impact status and factors associated with depression, anxiety and stress among healthcare workers in public hospital in Malaysia during the COVID-19 pandemic

Muhamad NA, Subhas N, Mustapha N, Abdullah N, Muhamad Rasat MA, Ab Ghani RM, et al.

PLOS Glob Public Health, 2023;3(4):e0001823.
PMID: 37058465 DOI: 10.1371/journal.pgph.0001823

INTRODUCTION: The COVID-19 pandemic has become the greatest challenge of the new millennium. Most healthcare workers (HCWs) experienced unprecedented levels of workload since the pandemic. This study aims to identify the prevalence and factors of depression, anxiety and stress among HCWs in Malaysian healthcare facilities in the midst of the pandemic due to the SARs-CoV-2.
METHODS: An emergency response programme on mental health was conducted from June to September 2020. A standardized data collection form was distributed among the HCWs in the government hospital in Klang Valley. The form contained basic demographic information and the self-reported Malay version of the Depression, Anxiety and Stress scale (BM DASS-21).
RESULTS: Of the1,300 staff who attended the Mental Health and Psychosocial Support in Covid-19 (MHPSS COVID-19) programme, 996 staff (21.6% male, 78.4% female) completed the online survey (response rate: 76.6%). Result showed that staff aged above 40 years old were almost two times more likely to have anxiety (AOR = 1.632; 95% CI = 1.141-2.334, p:0.007) and depression (AOR = 1.637; 95% CI = 1.1.06-2.423, p:0.014) as compared to staff who were less than 40 years old. Those who had direct involvement with COVID-19 patients were likely to suffer stress (AOR = 0.596; 95% CI = 0.418-0.849, p:0.004), anxiety (AOR = 0.706; 95% Ci = 0.503-0.990, p:0.044) and depression (AOR = 0.630; 95% Ci = 0.427-0.928, p:0.019). HCWs with stress (AOR = 0.638; 95% CI of 0.476-0.856, p = 0.003), anxiety (AOR = 0.720; 95% CI 0.542-0.958, p = 0.024) and depression (AOR = 0.657; 95% CI 0.480-0.901, p = 0.009) showed less confidence to treat critically ill patients and need psychological help during outbreak.
CONCLUSION: This study showed the importance of psychosocial support to reduce psychological distress among HCWs when working or coping during the COVID-19 pandemic or outbreak.
Fulltext Development and Validation of a New Gadget Addiction Scale (Screen Dependency Scale) among Pre-School Children in Malaysia

Abdul Hadi A, Roslan SR, Mohammad Aidid E, Abdullah N, Musa R

Int J Environ Res Public Health, 2022 Dec 16;19(24).
PMID: 36554796 DOI: 10.3390/ijerph192416916

BACKGROUND: Excessive screen time in young children is associated with many harmful consequences including screen dependency. Research has shown a worrying prevalence of media-related dependency among adolescents and pre-school children. There are a few available questionnaires among adolescents but none for pre-school children. This study aimed to design and validate a questionnaire to assess screen dependency among pre-school children aged 4 to 6 years old.
METHODOLOGY: A cross-sectional two-phase study was carried out to develop the scale. In phase 1, a preliminary parent-report measure questionnaire was developed in Bahasa Malaysia. Later, it was sent to four experts for content validity followed by face validity. In Phase 2, a total of 386 parents of pre-school children aged 4 to 6 years old, split into two samples, were involved in the field study for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA).
RESULT: Sample 1 was used to perform EFA to determine the factorial structure of the SDS. All items with a factor loading of >0.4 were included. Sample 2 was used to perform the CFA. RMSEA and CFI analysis showed that the SDS has a good fit and confirms the dimensional structure found via EFA. The final questionnaire consists of 15 items with a 4 factors' structure and has excellent internal consistency reliability.
CONCLUSIONS: The Screen Dependency Scale (SDS) is a reliable and valid questionnaire to detect screen dependency among pre-school children aged 4 to 6 years old in Malaysia.
The diversity of rhizospheric bacterial communities associated with Trichoderma-treated rice fields

Abdullah NS, Doni F, Chua KO, Mispan MS, Saiman MZ, Mohd Yusuf Y, et al.

Lett Appl Microbiol, 2022 Dec;75(6):1645-1650.
PMID: 36073093 DOI: 10.1111/lam.13832

Microbial-based fertilizer has been widely used as a healthier and better alternative to agrochemical products. However, the effects of biofertilizers on the rhizospheric microbiota has rarely been investigated. Thus, the aim of this study was to investigate the effects of symbiotic fungus Trichoderma asperellum SL2-based inoculant on the soil bacterial population through next generation sequencing using a metabarcoding approach. The treatment plots were treated with T. asperellum SL2 spore suspension, while the control plots were treated with sterilized distilled water. The results showed similar bacterial microbiome profiles in the soil of control and T. asperellum SL2-treated plots. In conclusion, the application of the T. asperellum SL2 inoculant had not exerted a negative impact towards the bacterial population as similar observation was reflected in control plots. Nonetheless, future research should be conducted to investigate the effects of repeated application of T. asperellum SL2 over a longer period on the rice microbiota communities.
Six marine thecate Heterocapsa (Dinophyceae) from Malaysia, including the description of three novel species and their cytotoxicity potential

Hanifah AH, Teng ST, Law IK, Abdullah N, Chiba SUA, Lum WM, et al.

Harmful Algae, 2022 Dec;120:102338.
PMID: 36470602 DOI: 10.1016/j.hal.2022.102338

Thirty-four strains of Heterocapsa were established from Malaysian waters and their morphologies were examined by light, scanning, and transmission electron microscopy. Three species, H. bohaiensis, H. huensis, and H. rotundata, and three new species, H. borneoensis sp. nov., H. limii sp. nov., and H. iwatakii sp. nov. were described in this study. The three species were differentiated morphologically by unique characteristics of cell size, shape, displacement of the cingulum, shape and position of nucleus, the number and position of pyrenoids, and body scale ultrastructure. The species delimitations were robustly supported by the molecular data. A light-microscopy-based key to species of Heterocapsa is established, with two major groups, i.e., species with a single pyrenoid, and species with multiple pyrenoids. Bioassays were conducted by exposing Artemia nauplii to Heterocapsa densities of 1-5 × 105 cells mL-1, and treatments exposed to H. borneoensis showed naupliar mortality, while no naupliar death was observed in the treatments exposed to cells of H. bohaiensis, H. huensis, H. limii, and H. iwatakii. Naupliar death was observed during the initial 24 h for both tested H. borneoensis strains, and mortality rates increased up to 50% after 72-h exposure. This study documented for the first time the diversity and cytotoxic potency of Heterocapsa species from Malaysian waters.
Distinct microRNA expression pattern in breast cancer cells following anti-neoplastic treatment: A systematic review and functional analysis of microRNA target genes

Qatrun Nada D, Masniza ML, Abdullah N, Marlini M, Elias MH, Pathmanathan SG, et al.

Malays J Pathol, 2022 Dec;44(3):367-385.
PMID: 36591707

Breast cancer remains a significant cause of mortality in females worldwide, despite advances in technology and treatment. MicroRNA expression in breast cancer is studied both as potential biomarkers and for therapeutic purposes. Accumulated evidence revealed microRNA profile of various types of cancer cells following antineoplastic treatment. The progression of research in this area provides better understanding on the anti-cancer mechanism of various natural compounds and drugs specifically on the microRNA regulation. Hence, we aim to systematically review differentially expressed microRNA in MCF-7, a commonly studied breast cancer cell line, after treatment with anti-neoplastic agents. Relevant keywords were used to screen for research articles that reported on the differentially expressed microRNAs in experimental models of MCF-7 before and after anti-neoplastic treatment. Target genes of microRNAs were identified from MiRTarbase and further in silico functional analysis of the target genes were performed using DAVID bioinformatic resources. Two upregulated microRNAs (mir-200c and let-7d) and 3 downregulated microRNAs (mir-27a, mir-27b and mir-203) were identified by highest number of studies. Three microRNAs (let-7a, mir-23a and mir-7) showed inconsistent direction of expression. Genes functional analysis revealed the regulatory effect of microRNA on genes related to angiogenesis, hypoxia, P53, FoxO and PI3K-AKT signalling. Clusters of genes associated to the pathway of angiogenesis, cancers, cell proliferation and apoptosis were noted through protein-protein interaction analysis. MicroRNAs, especially the mir-200c, let-7d, mir-27a, mir-27b and mir-203 from this review could be further validated experimentally to serve as molecular target or biomarkers for anti-neoplastic therapy.
Fulltext A Theory Planned Behaviour of Study on Improving Abdominal Bloating among the Malays Population: A Qualitative Study

Abdullah N, Kueh YC, Kuan G, Yahaya FH, Lee YY

Malays J Med Sci, 2022 Dec;29(6):77-88.
PMID: 36818903 DOI: 10.21315/mjms2022.29.6.8

BACKGROUND: Abdominal bloating (AB) is a common medical complaint known to diminish patients' quality of life. However, lifestyle and behavioural changes could mitigate its expression and severity. This study sought to explore the health beliefs, intentions and health-promoting behaviours among people with AB in Kelantan, Malaysia.
METHODS: The theory of planned behaviour (TPB) was employed to explore the factors that influence the management of adults with AB, namely health beliefs and intentions. An interview guide was developed by adapting the TPB and the findings of prior studies concerning the factors associated with AB management. All eligible participants took part in in-depth interviews.
RESULTS: The mean age of the participants was 32.5 years old (standard deviation [SD] = 14.19 years old) and the majority of participants were female (58.3%). The themes and sub-themes that emerged following the application of the TPB framework represented the qualitative results of this study, which indicated that the health beliefs, intentions and health-promoting behaviours observed among people with AB were closely related.
CONCLUSION: The findings of this study suggest that the adoption of a healthy lifestyle could be an effective means of improving AB. Thus, it is vital to implement a health education programme that promotes health-related beliefs and intentions in order to trigger health-promoting behaviour among people with AB.
Fulltext Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis

Sharzehan MAK, Sito H, Abdullah N, Alexiou A, Papadakis M, Jamal R, et al.

Sci Rep, 2022 Nov 23;12(1):20149.
PMID: 36418904 DOI: 10.1038/s41598-022-24398-w

CYP2E1 encodes an enzyme that participates in the activation of several carcinogenic substances. Thus, numerous studies have investigated the association between CYP2E1 polymorphisms and colorectal cancer (CRC) risk, but inconclusive results have been obtained. We performed a meta-analysis to precisely evaluate the relationship of CYP2E1 rs2031920, rs3813867, and rs6413432 polymorphisms with the susceptibility to CRC. Scopus, Web of Science and PubMed databases were searched to identify eligible studies, and the association between the polymorphisms and CRC risk was then quantitatively synthesized using different genetic models. Eighteen studies with 23,598 subjects were selected for inclusion into the analysis. Significant association between rs2031920 and an increased CRC risk was observed in homozygous (OR = 1.496, 95% CI 1.177-1.901, P = 0.001), recessive (OR = 1.467, 95% CI 1.160-1.857, P = 0.001) and allele (OR = 1.162, 95% CI 1.001-1.349, P = 0.048) models. Significant association was not found for rs3813867 and rs6413432 (P > 0.05). In conclusion, our results suggest that rs2031920, but not rs3813867 and rs6413432, is associated with the risk of CRC.
Fulltext Surface-Oxidised Carbon Nanofibre-Based Nanofluids: Structural, Morphological, Stability and Thermal Properties

Mohd Saidi N, Abdullah N, Norizan MN, Janudin N, Mohd Kasim NA, Osman MJ, et al.

Nanomaterials (Basel), 2022 Nov 07;12(21).
PMID: 36364698 DOI: 10.3390/nano12213922

The reputation of nanofluids as a convenient heat transfer media has grown in recent years. The synthesis of nanofluids is often challenging, particularly carbon-based nanofluids, due to the rapid agglomeration of the nanoparticles and the instability of the nanofluids. In this regard, surface modification and surfactant addition are potential approaches to improve the physical and thermal properties of carbon-based nanofluids that have been studied and the structural, morphological, and thermal characteristics of surface-oxidised carbon nanofibre (CNF)-based nanofluids has been characterised. Commercial CNF was first subjected to three different acid treatments to introduce surface oxygen functional groups on the CNF surface. Following the physical and thermal characterisation of the three surface-oxidised CNFs (CNF-MA, CNF-MB, and CNF-MC), including Raman spectroscopy, Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), and field emission scanning electron microscopy (FESEM), the CNF-MB was selected as the best method to synthesise the surface-oxidised CNF-based nanofluid. A total of 40 mL of ultrapure water was used as a pure base fluid and mixed with the surface-oxidised CNF at a concentration range of 0.1-1.0 wt.%, with a fixed of 10 wt.% amount of polyvinylpyrrolidone (PVP). The thermal conductivity of CNF-based nanofluid was then characterised at different temperatures (6, 25, and 40 °C). Based on the results, surface oxidation via Method B significantly affected the extent of surface defects and effectively enhanced the group functionality on the CNF surface. Aside from the partially defective and rough surface of CNF-MB surfaces from the FESEM analysis, the presence of surface oxygen functional groups on the CNF wall was confirmed via the Raman analysis, TGA curve, and FTIR analysis. The visual sedimentation observation also showed that the surface-oxidised CNF particles remained dispersed in the nanofluid due to the weakened van der Waals interaction. The dispersion of CNF particles was improved by the presence of PVP, which further stabilised the CNF-based nanofluids. Ultimately, the thermal conductivity of the surface-oxidised CNF-based nanofluid with PVP was significantly improved with the highest enhancement percentage of 18.50, 16.84, and 19.83% at 6, 25, and 40 °C, respectively, at an optimum CNF concentration of 0.7 wt.%.
Fulltext IoT-Based Waste Management System in Formal and Informal Public Areas in Mecca

Abdullah N, Al-Wesabi OA, Mohammed BA, Al-Mekhlafi ZG, Alazmi M, Alsaffar M, et al.

Int J Environ Res Public Health, 2022 Oct 11;19(20).
PMID: 36293647 DOI: 10.3390/ijerph192013066

Urban areas worldwide are in the race to become smarter, and the Kingdom of Saudi Arabia (KSA) is no exception. Many of these have envisaged a chance to establish devoted municipal access networks to assist all kinds of city administration and preserve services needing data connectivity. Organizations unanimously concentrate on sustainability issues with key features of general trends, particularly the combination of the 3Rs (reduce waste, reuse and recycle resources). This paper demonstrates how the incorporation of the Internet of Things (IoT) with data access networks, geographic information systems and combinatorial optimization can contribute to enhancing cities' administration systems. A waste-gathering approach based on supplying smart bins is introduced by using an IoT prototype embedded with sensors, which can read and convey bin volume data over the Internet. However, from another perspective, the population and residents' attitudes directly affect the control of the waste management system. The conventional waste collection system does not cover all areas in the city. It works based on a planned scheme that is implemented by the authorized organization focused on specific popular and formal areas. The conventional system cannot observe a real-time update of the bin status to recognize whether the waste level condition is 'full,' 'not full,' or 'empty.' This paper uses IoT in the container and trucks that secure the overflow and separation of waste. Waste source locations and population density influence the volume of waste generation, especially waste food, as it has the highest amount of waste generation. The open public area and the small space location problems are solved by proposing different truck sizes based on the waste type. Each container is used for one type of waste, such as food, plastic and others, and uses the optimization algorithm to calculate and find the optimal route toward the full waste container. In this work, the situations in KSA are evaluated, and relevant aspects are explored. Issues relating to the sustainability of organic waste management are conceptually analyzed. A genetic-based optimization algorithm for waste collection transportation enhances the performance of waste-gathering truck management. The selected routes based on the volume status and free spaces of the smart bins are the most effective through those obtainable towards the urgent smart bin targets. The proposed system outperforms other systems by reducing the number of locations and smart bins that have to be visited by 46% for all waste types, whereas the conventional and existing systems have to visit all locations every day, resulting in high cost and consumption time.
Fulltext Perceptions of Quality of Life during the Pandemic: A Case Study on B40 Single Mothers

Zakaria SM, Abdullah N, Md Akhir N, Amin AS, Mohd Shukry ANA, Abdul Rashid MR, et al.

Int J Environ Res Public Health, 2022 Sep 27;19(19).
PMID: 36231521 DOI: 10.3390/ijerph191912219

During the pandemic, the lives of B40 single mothers were severely affected, especially in terms of social, economic, and psychological factors. The reduction of income caused by the crisis has forced single mothers and their children to live frugally and without luxury. They also had to perform more than one job at a time during the pandemic to meet their children's needs. A qualitative study has been conducted to explore the perceptions of quality of life during the pandemic among B40 single mothers. Respondents were selected based on demographic characteristics established before the study. A focus group discussion has been conducted on ten (10) B40 single mothers in Balik Pulau, Penang. Single mothers were selected based on purposive sampling. They had to meet the inclusive criteria required to participate in the study, specifically: aged between 20 and 60 years old, belonged to the B40 income category, had children under 18 years old living together, and became single mothers due to divorce or death of husbands. The focused group discussion explored issues related to qualities of life during the pandemic. B40 single mothers expressed their concern about access to health facilities, security in residence, children's education, and economic stability. These areas of life quality have been significantly affected especially during Movement Control Order (MCO). In short, the quality of life of these single mothers has been significantly affected by the pandemic. Their vulnerability towards stress, anxiety, and depression have worsened due to financial issues. Besides the need for emotional and social support, this study found that these single mothers entail financial support.
Discovering future research trends of aerobic granular sludge using bibliometric approach

Purba LDA, Md Khudzari J, Iwamoto K, Mohamad SE, Yuzir A, Abdullah N, et al.

J Environ Manage, 2022 Feb 01;303:114150.
PMID: 34864588 DOI: 10.1016/j.jenvman.2021.114150

The advantageous characteristics of aerobic granular sludge (AGS) have led to their increasing popularities among academics and industrial players. However, there has been no bibliometric report on current and future research trends of AGS. This study utilized the available reports of AGS in the Scopus database for comprehensive bibliometric analyses using VOSviewer software. A total of 1203 research articles from 1997 to 2020 were analyzed. The dominance of the Netherlands and China were revealed by the high number of publications and citations. Nevertheless, the Netherlands exhibited higher average citation per article at 76.4. A recent process of AGS involving biochar and algal addition were also identified. Meanwhile, the application of AGS for antibiotic containing wastewater as well as possibility of resource recovery were recently reported and was expected to expand in the future. It was suggested that application of AGS would develop further along with the development of sustainable wastewater treatment process.

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